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Simultaneous Estimation of Drugs by RP-HPLC

für 53.10€ kaufen ··· 9783843375153 ··· 10361101224 ···
A new, simple, rapid, selective, precise and accurate isocratic RP-HPLC assay has been developed for simultaneous estimation of Ciprofloxacin Hydrochloride, Ofloxacin, Tinidazole and Ornidazole in tablet formulations. The separation was achieved by using C-18 column (Phenomenax, 250 x 4.6mm i.d.) coupled with a guard column of same material, in mobile phase Acetonitrile: Water: Tri ethylamine (25:75). The pH of mobile phase was adjusted to 6.0 ± 0.1 with 50% ortho phosphoric acid. The flow rate was 1.0 mL.min-1 and the separated drugs were detected using UV detector at the wavelength of 300 nm. The retention time of Ciprofloxacin Hydrochloride, Ofloxacin, Tinidazole, and Ornidazole was noted to be 2.7, 3.5, 4.5 and 5.8 min, respectively, indicative of rather shorter analysis time. The method was validated as per ICH guidelines. The proposed method was found to be accurate, reproducible, and consistent. It was successfully applied for the analysis of these drugs in marketed formulations and could be effectively used for the routine analysis of formulations containing any one of the above drugs, or a combination, without any alteration in the chromatographic conditions.
Hersteller: LAP Lambert Academic Publishing
Marke: LAP Lambert Academic Publishing
EAN: 9783843375153
Kat: Hardcover/Naturwissenschaften, Medizin, Informatik, Technik/Medizin
Lieferzeit: Sofort lieferbar
Versandkosten: Ab 20¤ Versandkostenfrei in Deutschland
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5: Ab 20¤ Versandkostenfrei in Deutschland
6: LAP Lambert Academic Publishing
7: Simultaneous Estimation of Drugs by RP-HPLC
:::: Hardcover/Naturwissenschaften, Medizin, Informatik, Technik/Medizin
···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray
···· aufgenommen: 09.10.2020 · 00:31:04
···· & überprüft: 12.11.2020 · 20:46:25
: Simultaneous : Estimation :

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