Modified alpha-beta Chimeric OligoDNA as a Unique Class of TFO
für 53.10€ kaufen ··· 9783846532461 ··· 1036187465 ··· A series of novel alpha-beta chimeric oligodeoxynucleotides bearing either an intercalator-conjugated nucleobase located at the internal 4-nt linker region or an anthraquinone-conjugated propionic acid as a non-nucleosidic backbone unit at the internal linker region was synthesized. The UV-melting experiments reveled that the obtained modified chimera TFOs formed remarkably stable alternate-stranded triplex. On the other hand, modified TFOs bearing non-nucleosidic intercalator-conjugate possessed two diastereomers formed substantially stable alternate-stranded triple helix almost regardless of the stereochemistry of the incorporated non-nucleosidic backbone unit. The sequence discrimination ability and thermodynamic stability of some TFOs were also examined. Hersteller: LAP Lambert Academic Publishing Marke: LAP Lambert Academic Publishing EAN: 9783846532461 Kat: Hardcover/Naturwissenschaften, Medizin, Informatik, Technik/Medizin Lieferzeit: Sofort lieferbar Versandkosten: Ab 20¤ Versandkostenfrei in Deutschland Icon: https://www.inforius-bilder.de/bild/?I=%2BE7ZPj4BVne7spYBlc1549OG7qxVCUdEpY7zX7yuMjo%3D Bild: