für 48.80€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Die Verarbeitung thermoplastischer Kunststoffe mit Hilfe von Einschneckenplastifizier-aggregaten stellt eines der am häufigsten angewendeten Verfahren in der Kunststofftechnik dar. Durch Simulationsprogramme können Plastifizierprozesse kosten- und zeiteffektiv optimiert und der dazu notwendige Versuchsaufwand reduziert werden. Die Basis hierzu bilden mathematisch physikalische Modelle, mit deren Hilfe sich das reale Prozessverhalten beschreiben lässt. Die vorliegende Arbeit beschäftigt sich vornehmlich mit den Prozessgrößen Durchsatz und Antriebsleistung, deren Vorhersage Aufschluss über die erforderliche Baugröße der verfahrenstechnischen Einheit bzw. des Antriebsaggregats sowie die geeignete Wahl der einzustellenden Maschinenparameter geben. Naturgemäß sind Modellvorstellungen immer mit gewissen Vereinfachungen behaftet und demzufolge nur für einen eingeschränkten Bereich gültig. Daher werden Plastifiziereinheiten üblicherweise in die Funktionszonen Feststoffförderung, Aufschmelzen sowie Schmelzeförderung unterteilt, die sich hinsichtlich der dort ablaufenden physikalischen Vorgänge wesentlich voneinander unterscheiden. Im Wesentlichen wurde bei dieser Arbeit das Ziel verfolgt, einzelne, funktionszonenbezogene Durchsatz- bzw. Leistungsmodelle zu verbessern bzw. neu zu schaffen. Zu den behandelten Themen zählten die Erweiterung der Feststofffördermodelle in Nutbuchsenextrudern mit Wendelnuten, die Durchsatz- und Leistungsberechnung im Aufschmelzbereich für wandgleitende Materialien und die Berücksichtigung nichtisothermer Einflussgrößen bei der Prozessberechnung im Schmelzeförderbereich. Ergänzend zum bislang vorliegenden Kenntnisstand bzgl. des Fördervorgangs in Nutbuchsenextrudern mit Wendelnuten wurden bei den in dieser Arbeit durchgeführten theoretischen und experimentellen Untersuchungen sowohl reibschlüssige als auch formschlüssige Fördermechanismen betrachtet. Es stellte sich heraus, dass Granulate im Gegensatz zu Pulvern eher zur vorteilhaften formschlüssigen Förderung neigen, welche bei flachen Zylindernuten besonders ausgeprägt auftritt. Bei der Generierung von Prozessmodellen für wandgleitende Materialien kommt der Aufschmelzzone der Plastiziereinheit eine besondere Bedeutung zu, da aufgrund des Vorhandenseins dünner Schmelzefilme in diesem Bereich höhere Schubspannungen auftreten als in komplett schmelzegefüllten Schneckenzonen. Die Vorhersagen der vorgenommenen analytischen Modellierung zeigen, dass im Vergleich zu Wandhaftung mit einem geringeren Druckaufbauvermögen sowie einem reduzierten Leistungsumsatz zu rechnen ist. Zur Beschreibung des Schmelzeförderbereichs hat sich bewährt, Regressionsmodelle von Strömungssimulationsergebnissen zur schnellen und genauen Lösungsfindung einzusetzen. In dieser Arbeit wurden dazu erstmals reduzierte Versuchspläne auf der Basis nichtisothermer FEM-Simulationsrechnungen eingesetzt. Die nichtisotherme Betrachtungsweise führte dabei generell zu einem Rückgang der berechneten Antriebsleistung, was im Einklang mit den zuvor untersuchten theoretischen Zusammenhängen stand und zu einer Erhöhung der Simulationsgüte beitrug. ····· 10361107534
für 48.80€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Among many other interesting reactions, molybdenum (Mo) hydroxylases catalyze regioselective hydrocarbon oxyfunctionalizations, for which typically oxygenases are employed in synthetic applications. However, oxygenase-based processes are often limited by oxygen mass transfer, cofactor regeneration, and/or enzyme instability due to the formation of reactive oxygen species. As Mo-hydroxylases produce, rather than consume reducing equivalents during substrate hydroxylation and use water, rather than molecular oxygen as oxygen donor, these enzymes have a high potential for overcoming limitations encountered with oxygenases. The potential and feasibility of these enzymes for preparative applications was investigated in the frame of this thesis with quinoline 2-oxidoreductase (Qor) and quinaldine 4-oxidase (Qox) serving as model enzymes. Up-to-date, several Mo-hydroxylases have been described, but rarely applied on industrial scale. For specific quinaldine hydroxylation to 4-hydroxyquinaldine, different Qox-based biocatalysts, reaction conditions, and key process parameters have been evaluated. The use of 1-dodecanol as carrier solvent and Qox-containing P. putida KT2440 as biocatalyst enabled high productivities (~0.4 g ltot -1 h-1 ) in a 0.5-L bioreactor setup without active aeration. Further evaluation of the key process parameters showed that inhibition by 1-dodecanol and the product was the most critical factor affecting process performance. As a proof of concept, the Qox-based process was coupled to downstream processing, including supercritical carbon dioxide treatment for breaking the stable emulsion followed by liquid-liquid extraction and crystallization allowing the isolation of 138 mg product with high purity (>99.9%). Furthermore, completely anaerobic quinoline hydroxylation was achieved with nitrate as electron acceptor using Qor-containing P. putida 86 expressing the nitrate reductase genes of P. aeruginosa. The achieved rate (7 U gCDW -1) shows the remarkable potential of Mohydroxylase-containing whole cells for O2-independent C-H oxyfunctionalizations. In conclusion, the development of an efficient integrated process and the first preparative O2independent C-H oxyfunctionalization by means of Mo-hydroxylase-containing microbial cells augur well for the development of efficient industrial oxyfunctionalization processes with reduced O2-demand in close future. ····· 10361107524
für 45.80€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The ambition of this work is to contribute towards the scientific background and understanding required to enable a knowledge-based design of self-lubricating tool coatings. The strategy is to apply ab initio calculations to identify transition metal oxides, so-called Magnéli phases, that possess low friction coefficients and therefore can act as solid lubricants, and to alloy TiAlN with these elements by sputter deposition. These Magnéli phase oxides are expected to form on the surface of the as-alloyed TiAlN tool coating during metal cutting processes and provide lubrication without the necessity to use additional, fluid lubricating agents. Thus, more precisely, the objective of this work is to contribute towards understanding the correlation between composition, structure, elastic properties and decohesion energies of transition metal Magnéli phase oxides, namely vanadium, tungsten and molybdenum oxides, and correlate these with the electronic structure thereof. Furthermore, as the second step, the follow up objective is to contribute towards understanding the correlation between composition, structure and mechanical properties of cubic TiAlN alloyed with such Magnéli phase forming elements. Here, tungsten is chosen as a demonstrator, therefore cubic TiAlN-WNx thin films are investigated. ····· 10361107519
für 49.80€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Any material properties, in principle, can be reproduced or predicted by performing firstprinciples calculations. Nowadays, however, we are dealing with complex alloy compositions and processes. The complexities cannot be fully described by first-principles, because of the limited computational power. The primary objective of this study is to investigate an important engineering problem, solid solution strengthening, in a simplified manner. The simplified scheme should allow fast and reliable prediction of the solid solution strengthening. ····· 10361107516
für 45.80€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Zur Reinigung von Schmierölen sind konventionelle Filter weit verbreitet. Diese besitzen jedoch eine starke Abhängigkeit zwischen Differenzdruck und Wechselintervall. Tellerseparatoren hingegen zeigen im Vergleich zu Filtern bei entsprechender Dimensionierung ein konstantes Differenzdruckniveau über lange Zeiträume. Bisher ist der Transport der Partikel im Inneren des Separators insbesondere in Bezug auf den Transport der abgeschiedenen Partikel im Detail noch nicht vollständig verstanden. Daher wurden detaillierte Untersuchungen des Tellerseparators vor dem Hintergrund der Schmierölreinigung durchgeführt. Das Ziel der Untersuchungen ist es, Grundlagen für die Produktentwicklung zu erarbeiten. Für eine geeignete Konstruktion und Dimensionierung von Tellerseparatoren ist es wichtig, das Abscheideverhalten der Partikel zu kennen. Hierfür sollen detaillierte Untersuchungen die Wege, die Partikel während der Abscheidung verfolgen, aufzeigen. Im Fokus der Untersuchungen stehen der Abscheidegrad und der Differenzdruck des Tellerseparators. Zur Erweiterung und Vertiefung des Wissenstands über Tellerseparatoren muss zunächst der Separator als Ganzes betrachtet werden. Es werden numerische Untersuchungen mit der Finite Volumen Methode unter Verwendung von numerischen Strömungssimulationen (Computational Fluid Dynamics, kurz CFD) durchgeführt genauso wie experimentelle Untersuchungen. Die Sedimentation von Partikeln im Tellerseparator wird zunächst unter der Annahme von geringen Feststoffkonzentrationen numerisch simuliert. Zur Berechnung dieser Mehrphasenströmung bestehend aus Feststoffpartikeln und Schmieröl wird das Euler-Lagrange-Model verwendet. Die numerischen Berechnungen werden außerdem mit experimentellen Untersuchungen verglichen. Die Ergebnisse der Untersuchungen des gesamten Tellerseparators führen zu weiteren detaillierten Untersuchungen des Transports der separierten Partikel. Weiterführende Untersuchungen demonstrieren, dass Partikel, die im Tellerpaket abgeschieden werden, weiter zum obersten Spalt im Tellerpaket transportiert werden. Erst dort werden die Partikel zu der äußeren Gehäusewand transportiert. In Folge des Transports der abgeschiedenen Partikel von Spalt zu Spalt steigt die Feststoffkonzentration spaltweise von unten nach oben an. Um den Einfluss der steigenden Feststoffkonzentrationen auf das Absetzverhalten der Partikel im Tellereinzelspalt zu bestimmen, werden experimentelle als auch numerische Untersuchungen durchgeführt. In diesem Fall wird lediglich ein Einzelspaltmodel der Geometrie betrachtet. Für hohe Feststoffkonzentrationen wird bei der numerischen Berechnung der Mehrphasenströmung das Euler-Euler-Model verwendet, welches eine Reduzierung des Berechnungsaufwand gegenüber dem Euler-Lagrange-Model ermöglicht. Die Ergebnisse zeigen einen verbesserten Abscheidegrad bei steigender Feststoffkonzentration. ····· 10361107467
für 45.80€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray In this thesis a structured and standardized approach for the process design of plant-based extractions has been developed. This approach is founded on laboratory experiments performed in a standard apparatus to determine extraction kinetics for the best solvent and the targeted solute with regard to the solubility, selectivity as well as factors like regulatory constraints and consumer demands. As a benchmark, two different raw materials, pepper berries and vanilla beans, with different physical properties of the target compounds and the raw materials have been examined to cover a wide range of typical botanical variable feeds. Furthermore, mass balances have been set up for water, solvent, raw material and target compounds on a laboratory scale. A rigorous model supported by botanical investigations has been developed to predict percolation results. After determining the desorption isotherm the model has been validated with short residence time percolation experiments. With the aid of this validated model percolation experiments with long residence times can be predicted and different process scenarios calculated. A combination of design of experiments and rigorous modelling in combination with a standard equipment and experimental model parameter determination provides a fast and robust experimental design on the one hand and the precondition for a process parameter data-based learning curve on the basis of rigorous modelling in the mid- or long-term on the other hand. ····· 10361107445
für 45.80€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Methyl acetate is a by-product during the production of poly(vinyl)alcohol (PVA). Per ton of PVA 1.68 tons of methyl acetate are produced. 1 Since methyl acetate is of limited industrial importance and methanol is a feedstock for PVA synthesis, the most attractive way would be to convert methyl acetate into methanol and n-butyl acetate, since n-butyl acetate is an important solvent for plastics, resins, gums and coatings. n-Butyl acetate can also be used as extracting agent, intermediate in organic synthesis or in the photographic industry. 2 One of the possibilities to obtain the desired products would be the transesterification of methyl acetate with n-butanol, which leads to n-butyl acetate and methanol. Due to the two binary maximum pressure azeotropes, 3 namely methanol - methyl acetate and n-butanol - n-butyl acetate, a conventional process with reaction followed by separation would cause a huge separation effort. Additionally, the low chemical equilibrium constant (close to unity) would result in low conversion and high capital costs. An alternative would be the application of reactive distillation or the combination of the reaction step with a membrane-separation process, e.g. pervaporation, to separate the reaction products from the reactants and therefore overcome the azeotropes and chemical equilibrium limitations. Besides kinetic information for the chemical reaction, reliable information about the heat and mass-transfer, the vapor-liquid equilibrium behavior, the various pure component properties and chemical equilibrium is required. To describe the pervaporation process the separation properties of the applied membrane like flux, separation factor or enrichment factor are needed. ····· 10361107301
für 48.80€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Magnesium recycling processes typically are based on the use of fluxes, mostly containing MgCl2, KCl, NaCl and CaF2. It is state of the art that application of salt flux in contact with magnesium scrap leads inevitably to the formation of a sludge so called `black dross` containing the both metallic and oxidic magnesium as well as salt components. Up to now it has not been yet possible to recycle this sludge economically. Such the investigation to recover metallic magnesium as well as part of the salt flux from this sludge is the task of this work. The main targets are to decrease the metal/salt loss and to enhance the metallic coagulation with the aim of increasing the recycling efficiency of the entire magnesium recycling cycle with the scope of the environmental requirements for a sustainable process. The results of using lab- as well as pilot-scale experiments lead to an almost zero-waste-process, which closes the existing gap in the magnesium recycling loop. ····· 10361107268
für 48.80€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Ziel dieser Arbeit war die Entwicklung und Optimierung von Niedertemperatur (T ····· ····· ····· ····· ····· ····· ····· ····· ····· ····· ····· ····· ····· ····· ····· ····· ····· 10361107234
für 48.80€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Im Fokus dieser Arbeit steht das Potential an NE-Metallen im Hausmüll, der weitläufig als Restmüll bezeichnet wird. Im Hausmüll, also dem Restabfall, werden nicht gezielt NE-Metalle angereichert, allerdings finden sich die NE-Metalle aufgrund von Fehlwürfen aus getrennt zu erfassenden Abfallströmen in der Senke Hausmüll. Durch die Behandlungsverfahren für Hausmüll werden aktuell rd. 20 % der enthaltenen NE-Metalle zurückgewonnen. Verfahrenstechnisch ist es jedoch durch Einsatz entsprechender Techniken möglich, die Rückgewinnung von Hausmüll enthaltenen NE-Metallen zu steigern. Da jedoch in Deutschland eine über die Jahre von Gesetzgeber und Wirtschaft geprägte Entsorgungsinfrastruktur aufgebaut wurde, muss eine NE-Metallpotentialermittlung die vorhandene Infrastruktur und deren primäre aufbereitungstechnische Aufgaben, wie die Inertisierung oder die Herstellung einer mittelkalorischen Fraktion, berücksichtigen. Durch diese Potentialermittlung wird, im Gegensatz zu einer rechnerischen Potentialermittlung über Metallgehalt und theoretischen Wirkungsgrad von Prozessen, der technische Wirkungsgrad der vorhandenen Behandlungsanlagen berücksichtigt. Betrachtet wird die Zugriffsebene für NE-Metalle in mechanisch-biologischen Abfallbehandlungsanlagen, in der rd. 30 Ma.-% des deutschen Hausmülls entsorgt werden. Die restlichen 70 Ma.-% des Hausmülls werden in Müllverbrennungsanlagen entsorgt, so dass sich die Zugriffsebene für NE-Metalle in diesem Pfad hinter den Verbrennungsprozess in die MVA-Rostaschenaufbereitung verschiebt, die ebenfalls in diesem Zusammenhang betrachtet wird. Zur Ermittlung des Rückgewinnungspotentials für NE-Metalle werden Ergebnisse aus Versuchen zu den unterschiedlichen Zugriffsebenen herangezogen. Durch Versuche im Technikumsmaßstab konnten die anlagentechnischen Möglichkeiten der Abtrennung von NE-Metallen aus Rostaschen ermittelt werden. Des Weiteren wurden NE-Metallschrotte aus mechanisch biologischen Abfallbehandlungsanlagen und der Rostaschenaufbereitung auf deren Zusammensetzung hin untersucht, so dass eine realistische Abschätzung des Wertstoffgehaltes erzeugter NE-Metallschrotte möglich wurde. ····· 10361107232
für 71.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The share market of hydrogen is increasing with the implementation of fuel cell systems and the growing demand for zero-emission fuels. Hydrogen production by using metal catalyst will need to increase with this growing market. However, some carbon is deposited on the catalyst but there was a window of operation where the deposited carbon did not have too great an effect on hydrogen production under different conditions. Carbon formation deactivates the catalyst, resulting in short life cycles. In order to improve process performance, in particular minimizing catalyst deactivation caused by carbon formation and maximizing the yield of hydrogen product, the addition of the promoters to catalyst is the most familiar method. The book is focused on the art of the promoters application on metal catalyst for hydrogen production from the methane steam reforming process at high pressure and the steam iron process over promoted Fe-oxide based catalyst. ····· 10361102923
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Synthesis of nano-scale/polymer core-shell particles, as LPA for unsaturated polyester and vinyl ester resins by the Z supported RAFT were investigated. CTA, BSPA was covalently attached to the surface of silica gel to make Si-BSPA and the RAFT polymerization subsequently occurred on the silica surface to form silica/polymer core-shell particles. BSPA was prepared from the potassium salt of 3-mercaptopropionic acid with excess of carbon disulfide, followed by the addition of benzyl bromide. The product was isolated by acidification of solution with hydrochloric acid. Before grafting of CTA on the silica gel, it was needed to activate the silica surface by boiling with hydrochloric acid. The nano-scale silica particle was synthesized by a two-stage hydrolysis of silicon powder in aqueous medium. The structure and morphology of the silica particles were characterized via TEM, DLS, and FT-IR. Si-BSPA was synthesized by reaction of the functionality of the surface by reacting the activated silica particles with 4-(chloromethyl) phenyltrimethoxysilane. RAFT polymerization of MA mediated by Si-BSPA was investigated, where of the initial concentration of monomer. ····· 10361102791
für 71.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray In Indo-Pak subcontinent, there have been fairly organized efforts for pharmacological studies in the physiologically active plants constituents. Various centers have been established in both Pakistan and India for systematic studies on medicinal plants. The most recent and sophisticated amongst them is the H.E.J. Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, where bioassay directed isolation studies of active constituents from various natural sources, especially from plants are routinely carried out. These studies have already resulted in isolation hundred of new natural products possessing potential for the treatment of serious human ailments like aids, cancer, tumor, diabetes, hypertension etc. The work embodied in this book is mainly dealt with the isolation and characterization of chemical constituents from three medicinal plants and their possible biological activities. The isolated compounds whether new or have been previously reported in the literature, were characterized by using various sophisticated spectroscopic techniques ····· 10361102539
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray This Book Contain a reveiw and research details on Stimuli sensitive hydrogels. These hydrogels are based on a concept of phase transformation of solution into viscous gel due to presence of stimuli i.e. pH, Temperature, Ionic concentration etc. Here , we are studying about Ophthalmic Hydrogels which are initially liquid in container but transforms into viscous gel when instilled into eye cavity due to the stimuli i.e.change in pH. Basic composition of hydrogels are API, poly acrylic acid polymer, viscolizers, chealating agents, isotonic agents etc. ····· 10361102487
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray In this research we are introducing a novel approach to clustering data. Two or more records identified separately actually represent the same real world entity. Data clustering is the process in which groups of the records are not predefined. The proposed technique takes input symptoms form the doctors and extract the disease and its related multiple profiles of disease treatment stored in data ware house. But using clustering approach it divides all profiles into the related groups. Expert system only select three best ranking profiles by using one-way clustering and finally the expert system extract the treatment of the disease using two-way clustering. Data clustering is very crucial for business as information is the life blood of every organization. If data having dirt that miss guides the analysts during decision making which is disaster for the health of businesses. ····· 10361102376
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Up-to-date semi-refined and refined vegetable oils are the predominant feedstocks for the production of biodiesel. However, their relatively high costs render the resulting fuels unable to compete with petroleum derived fuel. In this book, the production of fatty acid methyl esters (FAME biodiesel) from soapstock, a byproduct of edible oil refining, have been analyzed. A hydrolysis route is used to produce FAMEs from cottonseed soapstock. The method involved complete saponification of soapstock followed by drying and making as a pulverized powder. Esterification of saponified, dried and pulverized soapstock with methanol was held in the presence of sulfuric acid as a catalyst. FAME products were purified as in a sequence of centrifuge at 4200 rpm, neutralization, methanol recovery in rotary evaporator, and absorption with anhydrous magnesium sulfate to dry water and silica gel to adsorb free fatty acid (FFA) in a bed column. The book also contains optimum production conditions and preliminary economic evaluation indicating that a soapstock-biodiesel can be used as a complimentary fuel for countries such as Ethiopia which depend entirely on importing petroleum. ····· 10361102318
für 71.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Liquid-liquid flow finds a number of applications in chemical petrochemical, food and pharmaceutical industries. In addition, there is a growing interest to transport heavy crude by utilizing a particular distribution of oil and water known as core annular flow. Despite the increasing applications, the literature on liquid-liquid flow is relatively scarce and the present work attempts to investigate the physics of flow through extensive experimentation and numerical analysis. ····· 10361101808
für 53.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Miniaturized analytical systems using chip electrochromatography (CEC) have been of great interest over the past decade. This book describes the development of aligned carbon nanotubes and photopolymerizable silica solgel (PSG) as novel stationary phase for CEC separations. First part reports the localized growth of CNTs using multi- phasic catalyst deposition in -channels. CNT characterization using raman spectroscopy, optical and electron microscopy is also detailed. Further , proof-of-concept separations using reversed phase as well as solid phase extraction onto the CNT bed are illustrated. The next part describes PSG developed as stationary phase for CEC. The engineering parameters governing morphology of PSG is explained. Characterization with electron microscopy, thermal porometry, nitrogen adsorption and calorimetry is further detailed. Additionally, computational models and confocal microscopy is conceptualized for studying the fluid dynamics. PSG formulations incorporating methoxysilanes to bind with affinity ligands is also reported. Finally, innovations in optical detection, chip material and induced pressure flow systems are enumerated. ····· 10361101777
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray In this research work, new comprehensive models for prediction of physical properties (viscosity and density) of systems of different alkanolamines were developed. To predict the mass transfer rates and designing and operation of the gas treating units, the accurate determination of the physical properties and modeling of the system plays important role. The physical property of system of aqueous solution of different alkanolamines was modeled using Artificial Neural Network. This has significantly reduced the need for further physicochemical properties measurements for the large number of other potentially interesting alkanolamines blends. ····· 10361101700
für 71.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Hevea brasiliencis has been the only commercial source of natural rubber. Glutathione S-transferases (GSTs) are a group of detoxification enzymes which protects plants and other organisms against wide variety of xenoboitic compounds. We have isolated a cDNA clone (called Hevea GST clone-1) that encodes a Phi class GST from the leaf tissues of Hevea. The Hevea GST clone-1 was sequenced. The cDNA was 954 bp in length and the longest open reading frame within the sequence starts with ATG at osition 82. The open reading frame contained 643 nucleotides and encoded a peptide of 219 amino acids with calculated mass of 24,853 Da. When compared with the well-documented rat liver classes of GST, the similarity was bserved for amino acids at position 50 95. As expected,the amino acid sequence at position 140 170, which is well conserved within the plant GSTs, had no clear similarity with the rat classes. The presence of Ser- 12 at the active site and the trio Glu-Ser-Arg at position 67,68,69 (part of G-site) shows that the sequence encoded by the glutathione S-transferase of Hevea clone-1 belongs to the plant specific class Phi. ····· 10361101495
für 53.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Actualmente existe un gran interés en la producción industrial de plásmidos para uso médico, con aplicación en terapia génica y vacunas de tercera generación. Éstas técnicas consisten básicamente en transferir en forma eficiente un gen clonado en el plásmido, a células receptoras del cuerpo humano, para que codifique la síntesis de una proteína que al expresarse, realice una acción inmunizante o terapéutica. Los plásmidos como vectores no virales, se han considerado una alternativa para la prevención, tratamiento y cura de enfermedades hereditarias o adquiridas como, por ejemplo, hemofilia y sida. En este libro se presentan y analizan dos bioprocesos para la producción de DNA plasmídico, basados en tecnología de membranas con el propósito de facilitar su escalamiento y mejorar su sustentabilidad. Parte del análisis, consiste en evaluar la dinámica de las columnas de membranas de adsorción utilizando modelos de transporte y simulación con Matlab. Este libro es particularmente útil para estudiantes de licenciatura y posgrado de ingeniería química, bioquímica o biotecnología, interesados en bioprocesos para la producción de biomoléculas. ····· 10361101372
für 53.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Nucleic acids-based next generation biopharmaceuticals (i.e., oligonucleotides, siRNA) are potential therapeutic agents have ability to cope with various incurable diseases. However, several biological barriers present a challenge for efficient gene delivery. Inception of nanotechnology now offer numerous non-viral vectors that have been fabricated and found capable of transmitting the biopharmaceuticals into the cell and even into specific subcellular compartments like mitochondria. This book illustrates novel chemically modified polyallylamine and polyethylenimine based nano- vectors for enhanced gene delivery. Modification of these polymers using imidazolyl and polysaccharides such as hyaluronic acid, chondroitin sulfate and heparin not only improve cytotoxicity index but also provides site-specificity for cell-type specific gene delivery. Incorporation of targeting moiety minimizes the chance of potential adverse effects and also reduces the amount the amount of dose required to achieve desired therapeutic effects. Recent developments in formulation of efficient drug carriers showed potential to develop gene therapy again diseases like cancer. ····· 10361101323
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Bioreactors are the heart of any bioprocess operations. Currently there is a growing need for an efficient production of recombinant human therapeutic proteins worldwide. Most of the biotechnology based industries prefer Pichia pastoris as a host system for producing recombinant human therapeutic proteins because of the high cell density and product yield obtained from this particular species. This book explains the step by step approach for designing a bioreactor for producing recombinant human proteins through Pichia pastoris. The protein used in our study is only a model for this work. The novel design calculation methods presented in this book is very easy to learn and easy for the designers and students to design an efficient bioreactor for producing any proteins or enzymes in an industrial scale by only changing the few variables such as the empirical formula of the microbe and product of interest, operating conditions etc. ····· 10361101298
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Convective and microwave-vacuum drying are the two drying techniques which have been well implemented for the drying of foodstuffs since years. One interesting question is how the combination of those two drying techniques can help to improve the quality of dried foodstuffs. The combination of convective and microwave-vacuum drying was implemented with a new modular drying processor to dry red bell pepper and model food in such a way which could result in minimising the degradation of vitamin C. In three sets of combined processes, the products were convective dried up to 70 % (first set), 50 % or 40 % (second set) and 30 % (third set) of initial weight at first and followed by microwave-vacuum drying till 15 % w.b. moisture content. The determined convective drying curves were used to calculate the Fick`s and self diffusion coefficients of those foodstuffs to get an overview of the diffusional behaviour of water. These analyses would help food manufacturers for implementing proper drying technique to preserve red bell pepper for different processing requirements. At the same time model food could be used for proper evaluation of the degradation kinetics of vitamin C during drying. ····· 10361101242· 1 · ::::: · 4 ·· 5 ·· 6 ·· 7 ·· 8 ·· 9 ·· 10 · ::::: · 13 ·
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