für 17.00€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Die `Grundlagen der Organischen Chemie` sind als Begleittext für die Grundvorlesung in Organischer Chemie an der LMU München gedacht. Nach einem einleitenden Kapitel zur Bindungssituation in organischen Molekülen werden in der Folge alle wichtigen Stoffgruppen der organischen Chemie besprochen: Alkane, Halogenalkane, Alkene, Alkine, Diene, Aromaten, Alkohole, Ether, Thioalkohole und Thioether, Amine, Aldehyde und Ketone, Kohlenhydrate, Carbonsäuren und Derivate, Aminosäuren, Nucleinsäuren und Isoprenoide. Für alle diese Stoffgruppen werden grundlegende Nomenklaturfragen, Stoffeigenschaften und typische Reaktionsweisen besprochen. Übergreifende Themen werden an geeigneter Stelle in Zusatzkapiteln vorgestellt: Thermodynamik und Kinetik chemischer Reaktionen, Elementaranalyse organischer Verbindungen, optische Aktivität und Stereochemie, Polymere, UV/Vis-Spektroskopie und Chromatographie. ····· 10361108183
····· lezzter Preis 17.95€ ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Das hier vorgestellte Praktikum basiert auf dem von S. Hünig, G. Märkl und J. Sauer aus dem Jahr 1979. Integriert bedeutet, dass es sich nicht um ein klassisches Kochbuch handelt. Alle Aspekte, die bei einem Experiment in wissenschaftlichem Neuland in Betracht gezogen werden müssen, sind bereits in den Praktikumsversuch integriert. Spektroskopie, Diskussion der relevanten Spektren im Hinblick auf mehrere denkbare Reaktionsprodukte, theoretische Durchdringung der verschiedenen Reaktionsabläufe, letztlich Formulierung der Reaktionsmechanismen.Das I.O.C.-Praktikum ist nach Reaktionstypen gegliedert, die Versuche in den Unterkapiteln sind - sofern möglich - zielführend zum Reaktionsmechanismus miteinander vernetzt. Dieser Aufbau soll ebenfalls forschungsnahe Bedingungen simulieren. Im ausgedruckten Text werden nach allgemeinen Kapiteln (Sicherheit, Standard-Reaktionsapparaturen, Musterversuch mit Betriebsanweisung, Musterprotokoll) die Titel der in den 7 Kapiteln mit 24 Unterkapiteln angebotenen 154 Versuche mit Formelbildern aufgelistet. Die einzelnen Kapitel werden in Übersichten theoretisch behandelt, in den Einführungen zu den Unterkapiteln wird die syntheseorientierte Chemie abgehandelt. Die Übersichten und Einführungen sind das Kernstück des gedruckten Textes, sie bieten ein Grobraster der organischen Chemie. Sie enthalten umfangreiche Literatursammlungen (Monographien, Übersichtsartikel, Primärliteratur), die deutlich über die Voraussetzungen für ein erstes organisches Praktikum hinausgehen, die aber dem Buch Nachschlagewert sichern. In den letzten Jahrzehnten haben der Schutz der Umwelt, die Sicherheit beim Umgang mit Chemikalien als Gefahrstoffen und beim Arbeiten im Labor immer größere Bedeutung erlangt. Chemische Praktikamüssen dem Rechnung tragen. Versuche mit problematischen Chemikalien im Praktikum mussten ersetzt werden durch umweltfreundlichere, zugleich aktuelle und moderne Vorschriften. Zur Verringerung der Entsorgungsproblematik wurde die Zahl der eingesetzten Solventien auf wenige, nicht toxische verringert, die überdies durch Redestillation gereinigt und wieder verwendet werden können. Die Beschreibung der eingesetzten Reaktionsapparaturen wird durch einfache Symbole visualisiert, welche die Funktionstüchtigkeit der Apparaturen sicherstellen sollen. Am I.O.C.-Praktikum hat eine Gruppe um Prof. Sustmann (Essen) in Kooperation mit den Regensburger und Würzburger Autoren und mit finanzieller Unterstützung der BfU mitgearbeitet. ····· 10361158640
····· lezzter Preis 19.95€ ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Spielerisch Chemie lernen mit Cartoons! Alle, die für Abitur, Uni oder Berufsweiterbildungen organische Chemie verstehen wollen (müssen) finden hier einen idealen Einstieg. Dieses Buch lässt Begeisterung für die Chemie aufkommen. Die macchiato-Reihe steht mit über 100.000 verkauften Exemplaren für ein erfolgreiches pädagogisches Konzept, mit Cartoons und Humor wertvolle Einsichten und Aha-Momente auszulösen. Dadurch wird aus frustrierendem Büffeln ein Lernen mit Verständnis und Spaß. Organische Chemie macchiato präsentiert auf ungewöhnliche Weise den grundlegenden Lehrstoff der organischen Chemie. Chemische Alltagsphänomene werden aufgegriffen und mit theoretischem Wissen verknüpft. Dies erleichtert den Zugang zur Theorie und lässt das Gelernte anwenden. Analogien, Cartoons und Mind maps ermöglichen das Verstehen komplexer chemischer Zusammenhänge. In Übungen kann sich der Leser vergewissern, ob das Gelernte auch verstanden wurde. ····· 10361185105
····· lezzter Preis 25.65€ ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Die vorliegende Arbeit beschäftigt sich mit der Synthese und Strukturaufklärung von schwefel- bzw. phosphorverbrückten Komplexen der Elemente Erbium, Gadolinium und Samarium. Dabei wurden neben der Röntgenstrukturanalyse auch spektroskopische Methoden zur Charakterisierung der neu synthetisierten Verbindungen angewandt. Als erfolgreiche Methode zur Darstellung mehrkerniger Seltenerdmetall-Komplexe hat sich der Einsatz von Cyclopentadienyl-Liganden zur Absättigung der Metallatome bewährt. So konnten im ersten Teil der Arbeit durch den Einsatz von Phosphiniden- bzw. Thiolato-Liganden drei- bis vierkernige Komplexe dargestellt und charakerisiert werden. Im zweiten Teil der Arbeit wurden durch gezielte Hydrolyse sauerstoffverbrückte Komplexe synthetisiert, wobei das Hauptaugenmerk auf der Darstellung der Zwischenstufen auf dem Wege zum Oxid (Ln2O3) lag. Im letzten Teil der Arbeit wurden im Hinblick auf die Einführung von Eisen oder Kupfer in das vorhandene Syntheseschema das Reaktionsverhalten der Übergangsmetall-Ionen gegenüber Phosphiniden- bzw. Thiolato-Liganden untersucht. ····· 10361192527
für 26.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Los oxiranos juegan un papel importante como intermedios en síntesis orgánica, porque su reacción de apertura, tanto con electrófilos como con nucleófilos, permite la obtención de compuestos 1,2-difuncionalizados y la formación de nuevos enlaces carbono carbono. Esta reactividad química es responsable de la actividad biológica que exhiben los compuestos que contienen esta función. Así, determinados glicosil glicidoles (oxiranos derivados de alquenil glicósidos) presentan actividad citotóxica y pueden ser utilizados como agentes alquilantes en la quimioterapia anticancerosa.8 Por otra parte, los oxiranos pueden transformarse en otros compuestos de interés biológico, como los a-hidroxi-b-aminoácidos derivados de la isoserina. Los derivados de la isoserina constituyen el fragmento esencial en productos naturales de alto valor terapéutico.15,16 Los casos más relevantes son el taxol, anticanceroso, y sus derivados, cuya cadena lateral es N-acil-(2R,3S)-fenilisoserina la bestatina, un dipéptido modificador de la respuesta inmunológica, en el que uno de los aminoácidos es el ácido (2S,3R)-3-amino-3-fenil-2- hidroxibutanoico, y una serie de tripéptidos... ····· 103611330
für 26.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Los carbohidratos son las materias primas básicas para la síntesis de poliamidas, poliésteres, poliuretanos...., la utilización de productos naturales como materiales de partida para la obtención de polímeros tiene la doble finalidad de hacerlos menos dependientes de las materias primas fósiles de naturaleza perecedera y de favorecer la biodegradabilidad y biocompatibilidad de los mismos. De esta forma, su impacto medioambiental es menor que el de los polímeros clásicos,(Fishman, 1994). En el caso de los carbohidratos, cobra importancia la gran abundancia de los azúcares naturales, su diversidad estructural, su múltiple funcionalidad, su inocuidad para la salud humana y la hidrofilia de los materiales resultantes que aseguran una mayor degradabilidad hidrolítica (Gopferich, 1996). En este trabajo se presenta una posible alternativa a los clásicos materiales poliméricos a partir de monómeros de azúcar. ····· 103613124
····· lezzter Preis 26.10€ ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Los glicales y sus derivados desempeñan un papel importante en la química de los compuestos de hidratos de carbono como precursores en la síntesis estereoselectiva de O-glicósidos, oligosacáridos, S-glucósidos, 2-desoxinucleosides, C-glucósidos, C-nucleósidos, glucopéptidos, y lactosas , -insaturadas. Diversos autores han estudiado la preparación 2-hidroxiglicales22, así como su capacidad de reacción en ciclopropanación, epoxidación, hidroboración23. Sin embargo, los antecedentes de síntesis de 2-aminoglicales y sus derivados son escasos, y se refieren a procedimientos no generales. Nuestro grupo de investigación describió por primera vez un procedimiento de interés general para la síntesis de 2- (N-acil-N-alquil) -2-amino-1,5-anhidro-4,6-O-(R)-bencilidén-2-desoxi-D-eritro-hex-1-en-3-ulosas,20 a través de una reacción de oxidación de una variedad de N,N-disustituidos-2-aminoazúcares. Estos resultados iniciales tenían por objetivo demostrar la simplicidad y la eficacia del método, que se llevó a cabo con buenos rendimientos químicos y sin la formación de subproductos. Los compuestos obtenidos, además del sistema funcional 2-aminoglical contienen una función cetona en la posición 3 ····· 1036123789
für 26.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray La síntesis de compuestos orgánicos enantioméricamente puros que permitan descartar actividades biológicas no deseadas por parte de uno de los enantiómeros, es uno de los objetivos principales de la industria farmacéutica actual. El uso en esta industria de compuestos ampliamente distribuidos en la naturaleza, ha llevado a la autora a centrarse en la síntesis de compuestos enantiopuros como las alilaminas, habitualmente empleadas como fungicidas, y los beta-aminoalcoholes, utilizados en la preparación de un amplio número de compuestos biológicamente activos. En el presente trabajo se ha logrado desarrollar, partiendo de sustratos de fácil acceso y bajo coste como son los alfa-aminoácidos, una preparación de alilaminas y beta-aminoalcoholes, sencilla general y eficaz, permitiendo que los datos y técnicas aportados puedan ser aplicados en posteriores estudios y en el desarrollo de futuros productos farmacológicos. ····· 1036189691
für 26.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray La quiralidad es una característica fundamental presente en la naturaleza incluso en el medio ambiente abundan las características asimétricas. Además, la quiralidad es una propiedad intrínsecamente relacionada con el desarrollo de los seres vivos y tanto los metabolitos primarios (aminoácidos, azúcares) como los metabolitos secundarios producidos por plantas y microorganismos son compuestos quirales que se presentan enantioméricamente puros. Muchos de estos metabolitos secundarios actúan como fármacos en mamíferos superiores, ya que interaccionan de manera específica con los receptores biológicos quirales, los cuales están constituidos por complejas organizaciones estructurales como las hélices y las láminas. ····· 1036191100
für 26.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Este texto recoge los resultados de investigación de la actividad antioxidante de los flavonoides aislados de las hojas y corteza de Bauhinia kalbreyeri Harms, conocida en la etnoafarmocología colombiana como `casco de vaca`. Los resultados observados en la aplicación de las distintas pruebas de actividad antioxidante muestran que en gran parte la actividad biológica evaluada guarda relación con el contenido de compuestos fenólicos y a su vez, la corteza rindió el mayor contenido de este tipo de metabolitos secundarios, siendo el agua el solvente más apropiado para extaerlos. El trabajo fue desarrollado por integrantes del grupo de Investigación en Productos Naturales (GIPRONUT) de la Universidad del Tolima (Colombia, con el apoyo financiero de la Oficina de Investigaciones y desarrollo científico. ····· 10361117345
····· lezzter Preis 26.60€ ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Die Chemie und Physik von Metallverbindungen, insbesondere des Galliums, in ungewöhnlichen, subvalenten Oxidationsstufen steht im Fokus dieses Buches. Es enthält detaillierte Beschreibungen der Darstellung und Charakterisierung neuartiger Verbindungen des Galliums, die sich durch ihre geometrische und elektronische Struktur auszeichnen. Dabei treten auch sogenannte `metalloide` Verbindungen auf, die dem metallischen Festkörper ähnelnde Topologien innerhalb ihres Metallgerüsts aufweisen. Diese `Cluster`-Verbindungen enthalten einen Kern aus untereinander gebundenen Metallatomen, die durch eine Hülle organischer Substitueneten sterisch und kinetisch stabilisiert werden. Die Strukturaufklärung der isolierbaren Reaktionsprodukte erlaubt einen Einblick in den möglichen Entstehungsweg dieser Verbindungen aus Metallsubhalogeniden, der mit Hilfe quantenchemischer Modellierungen nachgezeichnet werden kann. Einige der beschriebenen Verbindungen lassen sich über den Vergleich mit bekannten Spezies in die bekannte Systematik von metalloiden Galliumclusterverbindungen einreihen. Zudem kann der Kenntnisstand zu Kriterien der Entstehung von Clusterverbindungen in Lösung fundamental erweitert werden: Es gelingt der Nachweis der besonderen Stabilisierung von Clustern durch bestimmte elektronische Zustände im Metallkern und Einflüsse der Substituenten auf Strukturen und Volumina der Metallatome im Clusterzentrum.Die Präparation und Charakterisierung metalloider Verbindungen stellt nicht den Abschluss der Untersuchungen, sondern vielmehr den Beginn und die Grundlage für detaillierte Studien an derartigen Systemen dar: Physikalische Untersuchungen an einem großen metalloiden Clustersystem liefern tiefere Einblicke in das (supra-)leitende Verhalten von Clustern im Kristall. Im Rahmen dieser Arbeit sind erstmals genaue Myonenspinresonanzmessungen an einer hochreinen Probe einer Ga84-Clusterverbindung möglich. Diese und frühere Messungen erlauben eine umfangreiche Diskussion zu Eigenschaften der Einzelcluster und des Kollektivs, die wiederum durch theoretische Modellierungen ergänzt und begleitet wird, um erstmals die besonderen temperaturabhängigen Merkmale der größten metalloiden Gallium¬cluster¬spezies prinzipiell erklären zu können. Außerdem zeigt diese Arbeit, dass durch Variation der eingesetzten Substituentspezies beziehungsweise einer Änderung der Behandlung der Stammlösungen auch ganz neue Systeme zugänglich sind.Zum einen wird eine völlig neuartige GaII-Spezies mit isolierten, nanoseparierten Spinsystemen dargestellt, charakterisiert und untersucht, die neben ungewöhnlichen Struktureigenschaften und der bisher unbekannten Form der Stabilisierung eines einzelnen zweiwertigen Galliumkations vor allem durch ihre physikalischen Eigenschaften fasziniert. So sind für diese neben ungepaarten Elektronenspins auch Wechselwirkungen zwischen diesen einzelnen Zentren (über 1 nm hinweg) und makroskopische Magnetisierungs¬phänomene im Kristall nachweisbar. Des Weiteren erlaubt die Darstellung und Isolierung eines neuartigen, funktionalisierten Galliumclusters weitgehende Einblicke in mögliche Wechselwirkungen zwischen größeren Metalleinheiten im Kristall. Dabei zeigt sich eine ungewöhnliche eindimensionale Anordnung durch elektronische Interaktionen zwischen Einzelclustern, die für zukünftige Anwendungen von Interesse sein könnten. Zusätzlich kann die Bandbreite an möglichen Substitutionsreaktionen an Hauptgruppenmetallclustern durch die gezeigten Ergebnisse systematisch erweitert werden. Insgesamt lassen sich durch diese Arbeit für neuartige Galliumverbindungen in ungewöhnlichen Oxidationsstufen zahlreiche Prinzipien, Strukturen, Bildungswege und Wechselwirkungen zwischen kleinen Metalleinheiten im Kristall besser verstehen.Damit wird auch die Grundlage für weitere Arbeiten in diesem Gebiet gelegt, die einerseits die Strukturvielfalt durch Übertragung der gefundenen Synthesetechniken auf zusätzliche Eduktkombinationen erweitern sollten und andererseits neue Eigenschaften dieser bisher weitgehend unbekannten und auch vom physikalischen Standpunkt faszinierenden Verbindungen aufklären sollten. ····· 10361169655
für 26.90€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Carl Wilhelm Scheele (1742 - 1786) war ein deutsch-schwedischer Apotheker und Chemiker, der zeitlebens nach chemischen Verbindungen suchte. Mit seinen Studien und Experimenten gelang es ihm unter anderem, einen wichtigen Beitrag zur Entdeckung des Sauerstoffs und Stickstoffs zu leisten. Dokumentiert hat Scheel diese Ergebnisse in dem hier vorliegenden Buch, das von dem Chemiker und Nobelpreisträger Wilhelm Ostwald veröffentlicht wurde. Sorgfältig bearbeiteter Nachdruck der Originalausgabe von 1894. ····· 10361139492
····· lezzter Preis 26.90€ ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Dieses Buch beinhaltet zunächst eine kurze Einführung in die Organische Chemie. Organische Grundkenntnisse sind die Voraussetzung, um nicht nur Kraftstoffe und Schmierstoffe zu verstehen, sondern im Besonderen die Polymerchemie für Polymerwerkstoffe.Die Vorlesung `Polymerwerkstoffe` wird im Maschinenbaustudium in einem höheren Semester angeboten.Allgemeine chemische Grundkenntnisse für Chemie im Nebenfach findet man im Buch 1 `Chemie für Maschinenbau - Anorganische Chemie für Werkstoffe und Verfahren`. ····· 10361164317
für 28.90€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray In Anleitung zur Darstellung organischer Präparate hat der Chemiker Emil Fischer eine Fülle verschiedener Versuchsaufbauten zusammengetragen. Detailliert beschreibt er Auswahl und Anordnung der Präparate, wobei Leichtigkeit, Schnelligkeit sowie nicht zuletzt Gefahrlosigkeit der Experimente angemessen berücksichtigt wird. Fischers Werk ist ein nützlicher Leitfaden für Lehrende und Studierende.Sorgfältig bearbeiteter Nachdruck der Originalausgabe von 1893. ····· 10361139261
····· lezzter Preis 29.95€ ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Das Übungsbuch Organische Chemie orientiert sich an der Kapitelstruktur des Lehrbuchs Organische Chemie und enthält umfassende Übungsaufgaben mit ausführlichen Lösungen. Das Übungsbuch richtet sich an die Studierenden in Bachelor-Studiengängen, die ihre knappe Zeit effizient und effektiv zur Vorlesungsvor- und nachbereitung sowie zur Prüfungsvorbereitung nutzen müssen.
····· lezzter Preis 29.95€ ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Der komplette Stoff der ersten beiden Bachelor-Semester in knapper, übersichtlicher Form.Die Basis der Organischen Chemie für Anfänger: Fokus liegt auf dem Verständnis der grundlegenden Konzepte anstatt auf dem Auswendiglernen von Detailreaktionen.Klare Kapitelstruktur: kurze Einführung in die Reaktionsklasse, Vorstellung der wichtigsten Reaktionspartner und -mechanismen, übersichtliche Zusammenfassungen der Take-Home-Messages zur PrüfungsvorbereitungNEU: Jetzt mit pericyclischen Reaktionen ····· 10361185216
····· lezzter Preis 32.31€ ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Es el tercer estudio realizado en seguimiento de una población contaminada con plomo y que por las recomendaciones propuestas ha cambiado el perfil de contaminación de plomo en sangre en niños. Se puede mencionar que es uno de los estudios ambientales de éxito por los resultados plasmados en este trabajo, y para complementar la posible explicación del impacto del plomo sobre el desarrollo psicomotriz, se realizó un estudio de perfil tiroideo, cuyos resultados se discuten, así como la posible influencia en cada parámetro de perfil tiroideo. ····· 1036124202
für 33.90€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray In dem hier vorliegenden Werk veröffentlicht der deutsche Mineraloge Heinrich Adolf Baumhauer (1848 1926) eine Auswertung von ihm durchgeführten Ätzfiguren an Kristallen. In seinen Ergebnissen gibt er eine Übersicht über die wichtigsten Resultate der Anwendung der Ätzmethode. Ergänzt werden diese durch die Darlegung einer Reihe von speziellen Ätzerscheinungen an 12 verschiedenen kristallischen Stoffen.Sorgfältig bearbeiteter Nachdruck der Originalausgabe von 1894. ····· 10361139121
····· lezzter Preis 34.20€ ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Cycloadditions of azomethine ylides with olefins provide a short, attractive route to pyrrolidine units with the potential to control the relative and absolute configuration by means of a chiral catalyst. Grigg and co-workers have pioneered the use of chiral transition metal complexes to induce enantioselective cycloadditions of this type. However, stoichiometric amounts of metal complexes were employed in this work.39a,41Paying regard to Griggs investigations it was intended to develop a system which gives asymmetric induction using catalytic amounts of chiral transition metal complexes. A first screening of different transition metal sources showed promising results for Cu(I) and Ag(I) species. The application of their complexes with several members of different ligand classes to the 1,3-dipolar cycloaddition reaction directed the interest towards phosphinooxazoline (PHOX) ligands. The catalysts derived from the two different metals and PHOX ligand 39 induced enantioselectivity in both cases (Scheme 46, Table 28). Subsequent investigations demonstrated that also the use of the analogous Au(I) catalyst led to the formation of enantioenriched pyrrolidines. ····· 10361169631
für 35.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray En los últimos años se ha convertido en un área emergente el empleo de catalizadores quirales en la reacción de epoxidación. En este campo, el uso de dioxiranos quirales constituye un proceso catalítico atractivo. Los dioxiranos pueden ser generados in situ a partir de cetonas y peroxomonosulfato de potasio (Oxone). Cuando se emplea una cetona quiral, su reacción con Oxone produce un dioxirano quiral que puedan reaccionar de forma selectiva por una de las caras enantiotópicas del alqueno que se utilice como sustrato. Después de la transferencia del átomo de oxígeno por parte del dioxirano al alqueno, la cetona quiral puede ser recuperada con alto rendimiento, sin pérdida de actividad, y por lo tanto puede ser empleada en otra reacción de epoxidación. El diseño de nuevas cetonas quirales para obtener con éxito el control de la estereoquímica en las reacciones de epoxidación mediada por dioxiranos es una cuestión importante en este ámbito. Los dioxiranos tienen dos sitios de reacción, la restricción de la posible competencia entre ellos es un factor importante en el curso de estereoquímica, y debe tenerse en cuenta durante el proceso de diseño de la cetona. ····· 103611961
für 35.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray En esta Tesis iniciamos una línea completamente nueva basada en la búsqueda de antimetabolitos del pirofosfato de farnesilo. Éste es el sustrato de numerosos enzimas importantes en rutas biosintéticas claves para el metabolismo de las celulas y de los organismos. Así, es transformado por la escualeno sintetasa en escualeno, precursor de todos los esteroides. Inhibir la escualeno sintetasa podría ayudar a controlar el nivel de colesterol en los organismos superiores o podría interferir en el crecimiento bacteriano en el caso de las escualenos sintetasas procariotas. Por otra parte, el pirofosfato de farnesilo es sustrato de la farnesiltransferasa, responsable de la farnesilación, y por tanto, activación, de proteínas, como la RAS, que juegan un papel clave en la transducción de señales. Esta transducción de señales está descontrolada en las células cancerosas. La inhibición de la farnesilación, al no activar a RAS, detiene el proceso de transducción y lleva a la célula cancerosa a la muerte... ····· 1036190988
für 35.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Una investigación centrada en la síntesis y evaluación farmacológica de derivados N-alquilados de (±)-4-metiltioanfetamina, ((±)-MTA), un liberador selectivo de serotonina no neurotóxico e inhibidor selectivo reversible de MAO-A. Además se resolvieron los enantiómeros de (±)-MTA. Se sintetizaron moléculas con distintos largos de cadena N-alquílica. Todos los compuestos obtenidos fueron evaluados en cuanto a su capacidad como inhibidores de MAO-A, resultando ser todos los derivados racémicos menos potentes que MTA. (+)-MTA es la molécula más activa de las evaluadas y dos veces mas potente que el compuesto racémico, (-)-MTA es 20 veces menos activa que la mezcla racémica. La inhibición de MAO-A es reversible en todos los casos. En cuanto a la inhibición de MAO-B, ninguna de las drogas evaluadas fue activa, excepto NAMTA y esto no cambió por preincubación, lo que indica que la falta de inhibición de MAO-B es independiente del tiempo. Los derivados monoalquilados fueron evaluados en sus propiedades neurotóxicas sobre células de cultivo. Presentaron baja toxicidad comparables con aquellos que presenta l-deprenil, usada actualmente en el tratamiento de la enfemedad de Parkinson. ····· 10361137025
für 35.91€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The first part of the present review is devoted to the synthesis of 2-aroyl-3-aryl aziridines. Scientists are interested in these classes of heterocyclic compounds, first of all by their photochromic properties and high sensitivity towards UV-VIS irradiation. In addition, these compounds are interesting from the viewpoint of reactivity, chemo- and regio-selectivity, stereochemistry and many other. The last part is concerned with chemical behavior of 2-aroyl-3-aryl aziridines in numerous organic reactions including photochemical transformations, cycloadditions, rearrangements, regio- and stereo-selectivity, 1,3-diolar reaction, ring expansion, ring opening, deamination and other. ····· 1036121193
für 35.91€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray This book describes the synthesis of amidines and imidate esters from 2-oxy/amino-4`-benzonitrile, thiosemicarbazone from 2-oxy-4`-benzaldehyde, dimethylaminomethylene ketone and chalcone from 2-oxy-4`-acetylphenyl derivatives of 1,4-benzodiazepine (2.094-2.100). The structures of all compounds have been established by elemental analysis (Carbon, Hydrogen, Nitrogen and Sulfur), IR, 1H NMR, and Mass spectral data. ····· 1036188259
für 35.91€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Anticancer properties of naturally occurring (2R, 3R)-(-)-1-methoxyspirobrassinol methyl ether and their synthetic amino analogs inspired us to study the synthesis of new target compounds with a C-C bond in the 2-position of indole rather than a C-N or C-O bond. The goal was efficiently achieved by electrophilic - nucleophilic 3,2-difunctionalisation of 1-methoxybrassinin in the presence of bromine and Grignard reagent leading to the formation of cis-(±)- and trans-(±)-C-C analogs of 1-methoxyspirobrassinol methyl ether. The formation of magnesium bromide, during the bromine initiated spirocyclization followed by addition of Grignard reagent, played the crucial role in the formation of acyclic products rather then spirocyclized brassinins. Finally, the anticancer activities of new prepared compounds were measured in order to show the importance of a heteroatom in the 2-substituted indole on the anticancer activity of spirobrassinols and acyclic brassinins. ····· 1036192046
für 41.90€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Mit Die Diastasen und ihre Rolle in der Praxis trägt der Enzymologe Jean Effront dem immer größer werdendem wissenschaftlichen Interesse seiner Zeit an der chemischen Fermentation Rechnung. Effront, der als erster den Standardprozess, der zum Beschleunigen der Fermentation von Bier genutzt wird, aufgezeigt hat, legt eine ganzheitliche Darstellung der Enzyme der Kohlenhydrate sowie der Oxydasen vor. Seine Zielgruppe sind sowohl alle wissenschaftlichen Interessierten als auch praktisch Interessierte, beispielsweise aus der Gährungsindustrie.Sorgfältig bearbeiteter Nachdruck der Originalausgabe von 1900. ····· 10361139347
····· lezzter Preis 44.00€ ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Der deutsch-schwedische Chemiker Carl Wilhelm Scheele (1742-1786) gilt als Entdecker von zahlreichen chemischen Verbindungen und Elementen, wie zum Beispiel Sauerstoff, Stickstoff, Chlor und Mangan sowie Glycerin, Chlor- und Schwefelwasserstoff und Milchsäure. Noch heute wird Scheele in der Pharmazie- und Chemiegeschichtsschreibung als einer der wichtigsten Vertreter und als einer der glänzendsten Experimentatoren angesehen. Zeit seines Lebens war Scheele praktizierender Apotheker und führte in seiner Freizeit in seinen Tagebucheintragen schätzungsweise zwischen 15.000 und 20.000 chemische Experimente durch. Die Liebe zur Forschung kostete ihn schließlich das Leben. Er starb aufgrund der geschmacklichen Erforschung von chemischen Verbindungen, u.a. Blausäure und Quecksilber. Lediglich in Chemische Abhandlungen von der Luft und dem Feuer publizierte Scheele seine Ergebnisse. Es blieb sein einziges Buch. ····· 10361159275
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Synthesis of newer biological active compounds especially antimicrobial agents are now a day s very important task for researcher because day by day microbes are developing their resistant power against particular drugs. Out of so many drugs molecule 1,4-dihydropyridines contain moderate to excellent activity against micro organism. So by keeping in focus in this book some newer 1,4-Dihydro pyridines are synthesized, characterised and their antimicrobial activity is given. By showing the result It is concluded that some of the synthesized derivatives of pyridine contain excellent activity compare to standard drug and also in this work some newer chemical intermediates are synthesized by using simple and conventional method which will be helpful to the research scholar for synthesizing other heterocyclic compounds ····· 10361242
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Dianions and masked dianions represent important building blocks for the regioselective formation of carbon-carbon bonds. Cyclocondensation reactions of 1,3-bis(silyl enol ethers) with different mono(silyl enol ethers) provide an elegant approach for the synthesis of various complex carba- and heterocycles from simple starting materials. A variety of functionalized and sterically encumbered triarylmethanes were prepared by combination of FeCl3-catalyzed benzylations of 1,3-diketones and formal [3+3] cyclocondensation reactions of 1,3-bis(silyl enol ethers) and 3-benzyl-1-silyloxy-1-en-3-ones. Subsequently, 4-methoxy-, 4-chloro and 4-flulro-substituted triarylmethanes are prepared The products are not readily available by other methods. In addition, functionalized diarylmethanes have been also prepared by cyclocondensation of 1.3-bis(silyl enol ethers) with with respective 3-benzyl-1-silyloxy-1-en-3-ones. Further more, dianions were converted to useful cyclic structure of pyranones with functionalized benzaldehydes providing a new strategy. Varius pyranones were synthecized containing 3-bromo-, 4-Methyl-, 4Phenyl-, 4-methoxy- and 4-hydoxy-phenyle groups. ····· 10361500
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Azo dyes are the most important class of dyes, comprising over 50 % of total dyestuff`s production. In the early days, with the discovery of Mauve by Sir W.H. Perkins in 1856, colorants have made significant differences in one s life and have become a part of human sensation. Consequently research on synthetic dyes was pursued by various chemists and scientists and has evolved sound basics for the foundation of the colorants industry. As a result in the last 125 years synthetic dyes have been prepared in bewildering number and variety. However, the recent developments has appeared in the literature [1,2] pursuing the several couplers designed to give disperse azo dyes suitable for polyester and cotton fibers and several patents documented for the applications of different coupling components in the synthesis of azo dyes [3,4]. Perusal of literature indicates the azo dyes based on derivatives of hydroxybenzophenone useful as U.V. absorber [5]. This has prompted to undertake the systematic work on disperse azo dyes derived from such derivatives of hydroxybenzophenone as couplers. The work is comprised into Synthesis, Characterization and their applications on fibers. ····· 10361951
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The book entitled `Naturally occurring alkaloids and iridoids: Chemistry and biological importance` contains the overview about the bio-active alkaloids and iridoids. Since, these class of natural products having significant medicinal values, so the complete chemistry including biosynthesis and the structure elucidation on the basis of advanced NMR techniques has been discussed in brief. The isolation techniques for these constituents are being highly emphasized. Their role in the plants and animals and detailed classification are also included in the text. This is a reference book which contains more than 300 references. The book is a summary of various significant researches and other contributions in the form of reviews and books, and the source of the facts discussed in the book are being cited in the text. The matter of this book would be helpful for postgraduate students as well as researcher working in the field of natural products chemistry. ····· 1036119018
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Some new spiro -Lactam and thiazolidinone derivatives were prepared from the reaction of new heterocyclic compound with different aromatic amine to give Schiff bases followed by cycloaddition reaction with chloroacetyl chloride and/or mercaptoacetic acid to give spiro -Lactam derivatives and spiro thiazolidinone. Also Isolated -Lactam and Isolated thiazolidinone were prepared by the reaction of Schiff bases with chloroacetyl chloride and/or mercaptoacetic acid, pyrazolo. Isoxazolo, pyrimidino, pyrimidin thiono Incorporating thieno pyrimidine has been synthesized by cyclocondensation addition reaction of hydrazine hydrate, phenyl hydrazine, hydroxylamine hydrochloride, urea and thiourea ····· 1036121579
····· lezzter Preis 44.10€ ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Los polímeros sintéticos de origen petroquímico han tenido un fuerte impacto en casi todas las actividades desarrolladas por el ser humano. Sin embargo, su uso ha traído como consecuencia dos grandes inconvenientes que aún permanecen sin resolver. Por una parte, está el uso de fuentes no renovables en su producción y, por otra parte, en vista de que estos materiales son inertes hacia los microorganismos, está el destino final de los desechos provenientes de los plásticos convencionales. Esto último ha provocado graves problemas de contaminación ambiental, lo cual ha hecho que el interés por la síntesis de materiales poliméricos biodegradables, haya aumentado en las últimas décadas. Desde el punto de vista de su degradabilidad en contacto con tejido vivos o bajo condiciones ambientales, los poliésteres alifáticos constituyen el tipo de poliésteres sintéticos mas atractivos. Para su síntesis química se usan los métodos de policondensación y la polimerización por apertura de anillo. Este libro está enfocado en los diferentes tópicos relacionados con este último tipo de polimerización, desde los aspectos mecanísticos hasta las aplicaciones que se le dan a los poliésteres. ····· 1036123112
····· lezzter Preis 44.10€ ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Carbohydrate fatty acid esters,ever served as food additive, are found to show remarkable antibacterial activity, while the regioselective synthesis of sugar fatty acid esters is normally achieved with enzyme method.In this book a novel regioselective synthesis method is described, the glucoside esters were efficently and conveniently synthesized with high regioselectivity using stanlyene method, general factors affecting regioselectivity has been examined in detail. The antibacterial activity were also assessed toward these snythesized esters, the findings showed that the lauroyl derivatives has a specific antibacterial effect against Staphylococcus aureus. The effect was found to be dose dependent. This work provides a new idea to the regioselective synthesis of carbohydrate fatty acid esters, may arouse interest towards those engaged in research in this field. ····· 1036124775
····· lezzter Preis 44.10€ ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray 4-Thiazolidinones are one of the emerging classes of heterocyclic privileged scaffold. Because of their biological importance, several methods have been developed for the synthesis of 4-thiazolidinone skeleton. The only method reported for solid phase synthesis of 4-thiazolidinones is by C. P. Holmes. A careful survey of the literature revealed that solid-phase synthesis of 4-thiazolidinone with a suitable methodology has not been reported yet. The challenge is to develop a solid phase methodology that affords fast and easy generation of combinatorial library of 4-thiazolidinones, with high yield and appropriate diversity. There are three major points for diversification in 4-thiazolidinone scaffold pointed out providing an opportunity to explore different substituent at these positions. Therefore, the present study makes an effort towards the synthesis of a library of 4-thiazolidinones and 4-metathiazanones with suitable diversity at one, two or three points with the use of suitable coupling agents and other reagents. ····· 1036124835
····· lezzter Preis 44.10€ ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray There has been growing menace of antibiotic resistance in recent past owing to a number of reasons such as self medication and non-compliance on parts of patients with regard to complete dosage regimen. Medicinal chemists are hard pressed to bring about new molecules to cater to this need. 1,3-pyrimidine derivatives have been explored by a number of scientists worldwide and such these derivatives have emerged potential lead molecules for development of newer antimicrobial moieties. The present work reports the syntheses and evaluation of some 2-(6 -fluorobenzothiazol-2 -ylamino)-4,6-(disubstituted thiouriedo) -1,3-pyrimidine derivatives. Some of the synthesized derivatives showed excellent activity against Gram +ve bacteria Staphyllococcus aureus, Bacillus subtilis, and Gram -ve bacteria Escherichia coli and Pseudomonas aeruginosa. The contents of this book must make an excellent read for those interested in antibiotic research and allied interests. ····· 1036125089
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Number of methods are known for the the synthesis of the natural product 7-Methoxy-2-[4-(methoxy)phenyl)-l-benzofuran-5-carboxaldehyde are known. It is conveniently synthesized by using Intramolecular Wittig reaction of ester. Reductive amination is one of the versatile method for the synthesis of secondary or tertiary amines from aldehydes or ketones by using suitable reducing agent in one-pot fashion. This reaction has been carried out at room temperature and in acidic medium (by using acetic acid). 7-Methoxy-2-[4-(methoxy)phenyl)-l-benzofuran-5-carboxaldehyde was reacted with 3-fluoroaniline in ethylene dichloride in presence of catalytic amount of acetic acid forming 3-fluoro-N-{[7-methoxy-2-(4-methoxyphenyl)-1-benzofuran-5-yl]methyl}aniline. It is novel benzofuran amine. It`s HPLC method validation has been carried out and apply to series of compounds. ····· 1036186583
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The present investigation comprises a survey covering the biological activities of compounds containing the indole ring system, with particular reference to indole-2-carboxylate and pyridazinoindole derivatives. The Microwave assistance of selected reactions has profouned effect on the speed of reactions. The structures of new compounds were confirmed by both analytical and spectral data. substituted indolylthiazolidinones were evaluated for their anticonvulsant as well as tranquilizing activities. The results show that, all tested compounds protected significantly against the strychnine induced convulsion and one compound has anticonvulsant activity similar to diazepam. Furthermore, substituted indolylthiazolidinones exhibited muscular incoordination (tranquilizing activity) this was indicated by significantly decrease falling time from vehicle treated group. The activities of synthesized compounds against representative Gram positive, negative bacteria and fungi were tested by by the disk diffusion method. ····· 1036186796
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Malaria statistics have become familiar. It is estimated that 300 to 500 million malaria infections occur annually, 90% of these in sub-Sahara Africa. A third of those visiting rural dispensaries are seeking treatment for malaria. Malaria accounts for between 20 and 50% of all admissions in African health services, with the poorest countries bearing the greatest burden of morbidity and mortality. Studies in a number of African countries have shown that the emergence of the chloroquine-resistant malaria parasites is associated with a two-fold increase in malaria deaths, but in one study in Mlomp Senegal, it was shown that malaria mortality in children under the age of four increased 11-fold within six years of the emergence of the chloroquine-resistance. The emergence of drug-resistant strains of Plasmodium falciparum has resulted in an urgent need to develop new antimalarial chemotherapeutic agents. Hence, the research for new drugs against this disease has become a pressing, global demand. ····· 1036188319
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Gas Chromatography-Mass Spectrometry (GC-MS)is a sophisticated, quick and reliable analytical technique for the separation, identification and quantitative determination of complex mixtures of compounds in general and essential oils in particular. The volatility and polarity of essential oil components make capillary GC-MS the technique of election for their analysis. Compound identification by GC-MS is mainly based on mass spectra or by chromatographic data (Kovats indices, linear retention indices, relative retention time) measurable with FID (flame ionization detector) or TCD (thermal conductivity detector) or better by both. Enantioselective or chiral recognition (ES-GC-MS)of essential oil components is one of the most important achievements reached in essential oil analysis during recent times enabling to determine the enantiomeric excess (EE) in an essential oil sample. The present work reports the essential oil composition of some unexplored aromatic plants like Rhododendron lepidotum, Nepeta laevigata and Artemisia pallens growing in Jammu and Kashmir. ····· 1036189012
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Advances in the chemistry of chlorosulphonyl isocyanate (CSI) contributed by the author`s research group at Indian Institute of Technology, Kanpur (1976-94) are highlighted and reviewed in this work. The applications of chlorosulphonyl isocyanate are covered by a large number of patents form several countries around the world viz Belgium, Britain, Canada, China, Europe, France, Germany, India, Italy, Netherlands, Spain, Switzerland, and USA. Chlorosulphonyl Isocyanate has been employed for the synthesis of a large variety of compounds, which are associated with a broad range of useful properties including in therapeutics. ····· 1036189018
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Considerando que muchas benzofenonas naturales y sintéticas poseen reconocida actividad antimicrobiana, se realizó la síntesis de nuevos derivados bencilestannilados funcionalizados a través de la reacción de Barbier y su posterior uso como sustratos en la rección de acoplamiento Stille, a través de la generación de enlaces Csp3-Csp2, bajo diferentes condiciones de reacción para la síntesis de estructuras bencilarílicas que forman parte de estructuras de importancia farmacológica. También se realizó la reacción en condiciones sonoquímicas y por microondas, probando en última instancia la reacción de acoplamiento libre de catalizador de paladio a fin de establecer los alcances de la inducción sonoquímica y de microondas. Finalmente la oxidación del centro bencílico de los diarilmetanos obtenidos, permite obtener las benzofenonas sustituidas de interés, las cuales representan una aproximación sintética corta y flexible a nuevos antibióticos, o a la producción de análogos, los cuales podrían ser luego testeados para determinar en qué grado afecta la variación estructural su actividad antimicrobiana. ····· 1036191198
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Petroleum is an extremely complex mixture of hydrocarbon compounds with minor amounts of nitrogen-, oxygen-, and sulfur-containing compounds as well as trace amounts of metal-containing compounds. Four Egyptian crude oils were collected from four oil fields namely Shokeir-22, West Ashrafi, Hana-3 and Arta-4 from the province of Gulf of Suez were characterized through petroleum measurements and chromatographic analysis. The physicochemical properties of the studied crude oils were achieved using standard test methods (ASTM, UOP and/or IP). The poly aromatic fractions of the four oil samples were analyzed via high performance liquid chromatography (HPLC). The paraffinic fraction of West Ashrafi crude oil is subjected to Gas chromatography-Flame ionization detector (GC-FID) to determine the carbon distribution of normal and branched paraffinic hydrocarbons and physicochemical properties to study the source and composition of crude oil then it subjected to Gas chromatography-Mass spectrometry (GC-MS) to determine the biological marker compounds (steranes and hopanes) to characterize the type of organo-facies, oil classes, depositional environments and the degree of thermal maturity. ····· 1036191816
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The book entitled Triterpenoids: an important bioactive class of natural products is based on the general view about triterpenoids. This book contains background, introduction, nomenclature, chemical tests, classification, biological importance, biosynthesis, extraction, isolation, characterization of triterpenoids and bibliography. This book deals mainly with the biosynthesis, bioactivity and characterization of triterpenoids. The chemical structure of various triterpenoids including recently discovered are being given in the book. The preparation of this book has been done with great care of previous research on triterpenoids. A brief discussion from several researches has been given in the book and the bibliography has given for further reading about the topic. This book is important for students as well as phytochemists working in the field of isolation and bioactivity of triterpenoids. We hope this book would give the idea about triterpenoids and their application in medicine. We certified that the matter of this book is not original or from our own work but this is based on previously published work and the sources of the same have been cited in the text. ····· 1036192339
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Hydantoins and thiohydantoins exhibit a wide range of biological activities, including anticonvulsant, antiarrhythmic, anti-inflammatory, and antidiabetic prop erties, as well as herbicidal and fungicidal activity. The formation of a carbon nitrogen bond is of importance for the synthesis of nitrogen-containing natural products and biologically active systems. As part of our study on the development of new routes to heterocyclic systems, we now report on the synthesis of functionalized hydantoins and thiohydantoins. ····· 1036192558
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Synthesis of new six and five membered heterocyclic compounds including oxygen and nitrogen was reported and following compounds were synthesized: 1.Synthesis of novel tetrahydrobenzo[4,5]imidazo[2,1-b]chromeno[4,3,2-de]quinazoline 3 and benzothiazole-2-ylamino-xanthenone derivatives 5 2. Synthesis of different pyrano-pyrazole derivatives 4 and 5 3. Synthesis of benzo[4,5]imidazo[1,2-a]chromeno[4,3-d]pyrimidine-6-one 6, triazolo[1,5-a]pyrimidin-5-one 7 and pyrido[2,3-d]pyrimidine-2,4,7-trione derivatives 8 4. Synthesis of benzochromeno-pyrazole derivatives 5 and 6 5. Synthesis of spiroacenaphthylene derivatives 4. ····· 1036198344
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray A novel series of Substituted Erythromycin derivatives (5-7) were synthesized by methylation of substituted S-MOP (4) The structures of the synthesized compounds were established by IR, 1H NMR, 13C NMR and Mass spectroscopical data. All the synthesized compounds were screened for their in-vitro antibacterial activity against Gram-positive, Gram-negative bacteria. The investigation of antibacterial screening data revealed that most of the compounds tested have demonstrated congruent activity against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, and Klebsiella as compared with the standard Erythromycin. Among the series, compounds 7 exhibited excellent an antibacterial activity profile as compared with the standard. In summary, preliminary results indicate that some of the newly synthesized title compounds exhibited promising antibacterial activities and they warrant more consideration as prospective antimicrobials. ····· 1036199084
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Getting into hot water usually isn t thought of as desirable, but a growing number of chemist and chemical engineers are suggesting just that as away to make organic synthesis more environmentally benign. Water near or above its critical point (374°C, 218 atm) is attracting increased attention as a medium for organic chemistry. Water is a unique solvent its chemical and physical properties vary considerably at high temperatures and pressure when compared to water at ambient condition. Two bromobenzenes were prepared by reaction of the corresponding 1,2-dichlorobenzene or 1,2,4-trichlorobenzene with 48% hydrobromic acid under superheated aqueous conditions. Halogen exchange in 1,2-dichlorobenzene to 1-bromo-2-chlorobenzene and 1,2-dibromobenzene has been completed under neutral and acidic conditions, using sodium bromide or hydrogen bromide as source of bromide. The response of halogen exchange in 1,2-dichlorobenzene to the presence of iron(III) chloride (FeCl3) and nickel(II) chloride (NiCl2) as catalysts was examined. ····· 1036199779
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The identification and quantification of carbohydrate content in aqueous solutions and biological systems are of great interest and importance. The polar nature and large sizes of some carbohydrates can cause difficulties in identification and separation processes. Problems include long retention times and degradation during separation procedures, such as gas chromatography (GC). This project has developed methodology for an optimal quantification and identification procedure. We have derivatized carbohydrates to improve detection limits and resolution in standard GC and gas chromatography and mass spectrometry (GC/MS) analysis. This method has allowed for the identification and the separation of a synthetic mixture of 18 compounds, the qualitative identification and quantification of trace carbohydrate content in rat urine, and the analysis of cellular membrane permeability of a disaccharide. This study has the potential to make identification and quantification in biochemistry and medicinal chemistry less time-consuming and more accurate. ····· 10361100258
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The present work describes preparation, optimization and characterization of pectin grafted poly (vinylpyrrolidone) hydrogels and pectin grafted poly (N-isopropylacrylamide) followed by controllable theophylline drug release. The gels were prepared in the presence of N,N` methylenebisacrylamide (MBAA) crosslinker and ceric ammonium nitrate (CAN) initiator under N2 atmosphere. Hydrogels were characterized by FTIR, TGA, DSC, XRD and SEM. In vitro controllable release of theophylline model drug was studied using different [NVP]/[MBAA] ratios, different [NIPAAm]/[MBAA] ratios and different polymerization temperatures at two pH values, namely 5.5 and 7.4. The optimum conditions for colon-targeted vehicles that could provide the least theophylline release at pH 5.5, and the most theophylline release at pH 7.4, for pectin-g-PVP were as follows: [NVP]/[MBAA] = 4.33, polymerization temperature = 10 °C and %G = 62.2. While for pectin- g-PNIPAAm were as follows: [NIPAAm]/[MBAA] = 47.34, polymerization temperature = 10 °C and %G = 50.5. Such promising hydrogel characteristics may play the key role in many future drug release implementations. ····· 10361100739
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Dr Amit Parashar was born in 1980 in Mathura (Uttar- Pradesh), India. He received his B. S., M. S., degrees From Agra University, Agra, India and Ph. D degrees from the Department of Chemistry, The University of Bundelkhand under the supervision by Professor S.K. Gupta,Head, Bipin Bihari College ,Jhansi and Co- Supervision by Professor Ashok Kumar,Head, St John`s College, Agra After spending with Professor S.K. Gupta and Professor Ashok Kumar as a research associate in India , He joined Department of Engineering Chemistry, Uttar Pradesh Technical University, Lucknow ,India. In 2009, he moved to G. L. Bajaj Group of Institutions, School of Faculty of Engineering, Professor Parashar has studied based on Fruit Chemistry and Biochemistry. His current research interests include the science of Nutrient chemistry, Green chemistry, Atmospheric chemistry, Coordinate chemistry, Electrode kinetics. He is working as a Research guide and international Referee for eminent journals. His international publications are 32.Currently working as a Reader at G.L. BAJAJ Group of Institutions,Mathura, India ····· 10361100790
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray A comprehensive discussion on phytosterol composition, metabolism, functions, precursor roles and mechanism of action are given in this book. Another key aspect of the study constitutes difference of faces of antioxidant capacity of an array of free and conjugated phytosteroids of Solanum xanthocarpum and Solanum nigrum, and withasteroids of Withania somnifera has been assessed. Four standard sets of assays, namely, reduction of ABTS, DPPH, FRAP and superoxide radical, have been used. The contribution, in this regard, of metal ions, naturally-complexed with the phytosteroids and withasteroids, has also been evaluated. The findings suggest the contribution of naturally occurring metallo-organic complexes in human well being. The mechanisms suggested for the antioxidant actions of the compounds project the role of molecular architecture of free and conjugated steroids. This study is not at all yet another experiment of antioxidant activity of phytosteroids. Here, it involves the key feature that metal ion conjugation improves the bioactivity of phytosteroids which was manifested in the antioxidant assay systems. This aspect was never been dealt before. ····· 10361100958
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray This book describes Opto-electronic properties of three new carbazole based co-polymers that can be implemented as host in phosphorescence polymer light-emitting diode. We present absorption, steady-state emission and time resolved emission spectroscopy of carbazole based conjugated polymers. The decay kinetics of triplet emission of the co-polymers was observed after optical excitation. Several findings such as optical band-gap, singlet to singlet transition energies, triplet to triplet transition energies, exchange energies ( EST), Stoke`s shift have been presented. The onset of absorption is at 3.10-3.25 eV for P1, P2 and P3 polymers respectively. One emission band originating from singlet excited state is observed at RT. The gaps between singlet and triplet excited states are 0.44-0.47 eV. From decay kinetics the triplet excited state life-times were found to be several orders of ms at 10-13 K that reduces to less than 3 ms at room temperature. At room temperature delayed fluorescence has been observed for all three polymers. An energy band diagram including lower lying excited states has been constructed and compared. ····· 10361101138
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The calix[4]resorcinarene chemistry is mainly developed and focused in two directions: synthesis and applications of host-guest complexes by intermolecular forces and in construction of supramolecular assemblies. Interest in calix[4] resorcinarenes has grown rapidly also because of the numerous derivatization that can be created through relatively simple synthetic procedures. Substitution on the calix[4]resorcinarenes alters their properties and application.The introduction of chelating group such as hydroxamic acid on calix[4] resorcinarenes may further enhance the complexing ability for a large number of metal ions including transition metal and rare earth elements.With this in view, four new calix[4]resorcinarene-hydroxamic acids by substitution at the phenolic hydroxy groups have been synthesized. These, calix[4]resorcinarenes- hydroxamic acids are used for the complexation, separation, membrane transportation, and preconcentration of metal ions like V(V), La(III), Ce (IV), Th(IV), and U(VI). These elements are also determined in standard reference materials, soil, rock, and seawater samples ····· 10361101153
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray In the scenario of rising global warming, there is a need of control in carbon emission as well as maintaining carbon sequestration mechanism at global level. Community forestry, which is one of the successful forestry programs in Nepal, has remarkable contribution on storage and sequestration of carbon from the atmosphere. The findings presented in this book highlight the importance of the community forests in term of environmental value. The study shows that carbon content in below ground including soil organic carbon and root biomass was 1.496 times greater than above ground and under-growth biomass organic carbon in Shorea robusta (Sal) dominant community forest of inner Dang Deukhuri valley. The finding shows the potential revenue foregone for carbon sequestration through forest conservation in these areas was high concerning the possibility of selling carbon sequestration services of forest ecosystem in international market. This book is of great interest for general readers to policy makers, professionals and students working in the sector of climate change and natural resource management. ····· 10361101421
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray A novel series of compounds have been synthesized by reacting 2 amino,4 phenyl thiazole and substituted benzaldehyde. The structures of the synthesized compounds were confirmed by IR, 1H-NMR, mass spectroscopy (MS) and their purity were ascertained by TLC and elemental analysis. The biological evaluation of these compounds shown the presence of anti-bacterial and anti-fungal activity in compounds. ····· 10361102132
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Surfactants have many uses in textile processing, used as wetting agents, detergents, emulsifiers, dispersing agents etc. and can be used universally under all conditions. Textile is versatile, therefore processes are conducted in type of conditions, being highly acidic to highly basic, room temperature to as high as 220oC in thermosol dyeing, also can start form acidic pH and end at alkaline pH. Therefore it is needed to formulate a universal chemical which can be work equally well under all process conditions. Surfactants can be ionic and non-ionic, advantage of nonionic being that they can be used under basic and acidic conditions as well as water hardness, but lacks the resistance against temperature. Ionic has the advantage of aqueous solubility under higher temperature, but lacks the flexibility of being used under all pH values and resistance against water hardness. Therefore, we have proposed of substituting organic solvents to surfactants. ····· 10361102279
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The influence of introducing 1,3,4-thiadiazole and phthalyl groups as a pending groups into the repeating unit of PVC has been studied on the bases of photostability measurements. The photostability of modified. polymers were studied by monitoring the carbonyl Index, polyene index and hydroxyl index, All results obtained indicated that PI, PII, PIII, PIV and PV gave lower growth rate of ICO, IPO and IOH with irradiation time with respect to unmodified PVC film (control). The following trends of photostability are obtained PIPIIPIIIPIVPV According to the experimental results several reaction mechanisms were proposed depending on the presence of 1,3,4-thiadiazole and phthalyl groups moieties in the polymer chain. The mode of chain scission was also investigated by measuring the variation of average viscosity molecular weight with irradiation time for modified PVC. The degree of deterioration ( ) and the average number of chain scission (S) values were also calculated. ····· 10361102672
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray In recent years emphasis has been given on effective utilisation of naturally available and renewable resources for the development of raw materials for various polymer based products. Cashew Nut Shell Liquid (CNSL) and one of its ingredients cardanol has been successfully exploited for the development of phenolic resins for the manufacture of different industrial products. Since cardanol is phenol with meta substituted aliphatic unsaturated long chain, it can be properly modified to a high molecular weight nucleophilic compound containing flexible as well as rigid molecular chains. Such a nucleophilic high molecular weight compound can react with a diisocyanate which is an electrophile to give polyurethane. Therefore by carefully synthesising the high molecular weight nucleophilic compound with different molecular size, functionality and structure, it is possible to develop polyurethanes having wide range of physico-chemical and mechanical properties as well as high performance characteristics, such as long term stability under ageing conditions. ····· 10361113300
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The present work describes synthesis of copper alginate-cotton cellulose and chitosan attached cotton composite fibers and detailed investigation of antimicrobial action against the model bacteria E.coli. The fibers were prepared by different techniques. The resulting fibers were investigated for their biocidal action against E.coli, by using zone inhibition and colonies counting method. Finally, fibers were reduced with sodium borohydride to yield copper nanoparticles- loaded composite fibers and investigated for biocidal action. It was found that these fibers possessed both, the fair mechanical strength and antibacterial action. The extent of biocidal action was found to depend upon the amount of Cu(II) loaded and concentration of alginate into cotton- cellulose fibers. The fibers showed higher Cu(II) release in physiological fluid as compared to distilled water. Copper alginate-cotton cellulose (CACC) fibers show fair mechanical strength and release copper ions in the presence of physiological fluid and protein solution. These fibers have great potential to be used as dressing materials. ····· 10361113375
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray To enhance the student experience, the University of South Carolina, Department of Chemistry and Biochemistry, has adopted several new experiments into the curriculum of the organic chemistry majors and honors laboratories. Each experiment involves a particular reaction, or reactions, for which the theory is thoroughly explained throughout the body of this text. All work within is the culmination of experimental trial and error in the procedural design of successful, reproducible experiments in organic chemistry. The challenge was to develop successful semimicroscale techniques using only the resources, apparatus, and instrumentation readily available to the students, while confining them to the laboratory time constraints. ····· 10361113474
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray In order to conserve plant species, there is a need to highlight other important sustainable exploitations of these species by documenting and validating the uses. This study was undertaken to determine the oil content and its characteristics for selected 11 wild plants species chosen because they are among the dominant plant species in the primary forest of Kahuzi-Biega National Park and surrounding areas in Kivu Region, Democratic Republic of Congo. The plant seed oil contents reported in this study were found high compared to some food crops such as soybean and olive seed. Some of the oils of the plants studied here have potential for use in food because of their essential fatty acids content and some other oils showed good promise in use in cosmetics. These plant oils may also be sources for very long chain fatty acids which also have important chemotaxonomic significance. ····· 10361115198
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Acridone derivatives containing 1, 3, 4-oxadiazole and 1, 3, 4-thiadiazole rings are synthesized.Diphenylamine-2,4`-dicarboxylic acid [1] is obtained in a high yield by refluxing a mixture of 4-aminobenzoic acid and 2-chloro benzoic acid in the presence of catalytic amount of copper oxide. 9(10H)-Acridone-2-carboxylic acid [2] is synthesized in ring closure reaction by heating compound [1] in sulfuric acid followed by basic hydrolysis.Reaction of compound [2] with thiosemicarbazide in the presence of phosphorus oxychloride gave 2-[5-amino-1, 3, 4-thiadiazole-2-yl]-9(10H)-acridone ····· 10361115566
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray On the basis of bis(1H-indol-5-yl)methane derivatives 2,2`-diethoxycarbonyl-bis(indol-5-yl)methane and 2,2`-diethoxycarbonyl-3,3`-bisdimethyl- bis(indol-5- yl)methane were obtained 3,3`- bisphenylpiperazinomethyl, 3,3`-biscyanomethyl derivatives, tetracarboxylic acid and its tetraethylester. And on the basis of 2,2`- diethoxycarbonyl-3,3`-diformyl-bis(indol-5-yl)methane bisisonicotinoylhydrazone. The following reactions were studied: piperazinomethylation reaction of 2,2`- diethoxycarbonyl-bis(indol-5-yl)methane, alkylation reactions of phenylpiperazine and KCN with 2,2`- diethoxycarbonyl-3,3`-bisdimethylaminomethyl- bis(indol-5-yl)methane, alkaline hydrolysis and acid alcoholysis reactions of 2,2`-diethoxycarbonyl-3,3`- di(cyanomethyl)- bis(indol-5-yl)methane. The corresponding compounds were obtained. The condensation reactions of 2,2`-diethoxycarbonyl-3,3`- diformyl- bis(indol-5-yl)methane with isonicotinoylhydrazide, aniline and its mono- nitroderivatives. The structure of the obtained compounds was established on the basis of spectral data. ····· 10361115736
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray As a model for interactions present in the active site of orotidine-5 -monophosphate decarboxylase (ODCase), we investigated the effects of substrate destabilization by a nearby negative charge and stabilization of the carbanion intermediate, due to hydrogen bonds to the carbonyl groups (O-2 and O-4) of orotic acid and its decarboxylation product, using ab initio calculations. Results from these models were comparable with available data, suggesting that the magnitude of the decarboxylation rate enhancement depends on a combination of the charge distance and hydrogen bonding effects. We found that the dipole moment of the proton donor may also play a significant role, implying that the key to the rest of the catalysis lie within the specific interactions of the substrate and the surrounding residues. ····· 10361117986
····· lezzter Preis 44.10€ ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray An extensive literature assessment is done and it is obvious that the methods are accessible for Ranitidine. HPLC is very expensive instrument and are not available in every laboratory. While UV/Visible spectrophotometer is a common instrument of all pharmaceutical analytical laboratory. Spectrophotometric analysis methods available for Ranitidine are tedious, time consuming and not much sensitive in term of precision and accuracy. It becomes essential to develop new rapid and cost effective methods that spectrophotometric determination would be simple, accurate, precise and sensitive. The newly developed analytical methods can be used in research institutions, Quality control in pharmaceutical industries, Approved testing laboratories and Bioequivalence studies. ····· 10361118259
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Medicinal Chemistry, an evolving andinterdisciplinary field, plays a key role inpharmaceutical research. It involves the study oftherapeutically active compounds.This text bookprovides a concise introduction to medicinalchemistry suitable for undergraduate students. Thebook focuses mainly on examples and illustrates theprinciples and mechanisms with the liberal use oftables and figures. Each chapter begins with a briefintroduction to the disease, drug classification,detailed subsections on different classes thatinclude mechanism of action, therapeutic uses andstructure activity relationships (SAR), among others. ····· 10361118654
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray This book focuses on the structure elucidation of pentacyclic triterpenes using to two essential techniques, Nuclear Magnetic Resonance and Mass Spectrometry. The Carbon-13 NMR data of most of the classes of pentacyclic triterpenes and their mass fragmentation pattern is provided and the characteristic 13C NMR signals and mass fragmentation peaks have also been described. Thus by comparing the data of an unknown pentacyclic triterpene with the data of the known pentacyclic triterpenes provided in this book may help to narrow down the search for the structure of the compound. ····· 10361118751
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The rapid progress in the field of organic conducting materials has found possible applications for sensors and molecular electronics. Among them both conducting polymers and carbon nanotubes, specifically Single Walled Carbon Nanotubes and Multi Walled Carbon Nanotubes, are good candidates for these applications. Their associations can lead to the synthesis of materials called nanocomposites which resemble the whole physical and chemical properties of the starting ones. This book is therefore focused on the fabrication of nanocomposites materials, based on polyaniline derivatives and multi-walled carbon nanotubes, by means of standardized oxidative polymerization, and the subsequent characterizations by different techniques to asses the physical and chemical properties of the synthesised materials. ····· 10361119233
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray This study involved a survey on the use of dithiocarbamates in agriculture practices in Bukavu Region and the determination of their residues in vegetables (tomatoes and cabbages) from five main sites supplying Bukavu town with vegetables. Analytical method based on HPLC-UV, developed by Codex Committee on pesticide residues was employed for the analysis of mancozeb residues from vegetables samples (tomatoes and cabbages) collected from Bukavu region in DRC. The laboratory analysis showed a Limit of Detection of 0.01 mg/kg, the recoveries ranged from 73.5 to 82.1 % for cabbages and 64.0 to 66.9 % for tomatoes. The concentration of the residues expressed as mancozeb (the factor conversion for mancozeb derivative = 1.13) in tomatoes varied (in mg/ kg) from no detectable values (ND) to 1.33 for Kamanyola, ND to 1.87 for Nyangezi, 1.44 to 3.99 for Katana, 1.54 to 4.06 for Miti and ND to 4.65 for Mudaka samples. The average values ± SD (Standard Deviation) in mg/ kg for the five study sites were 0.89 ± 0.35, 1.31 ± 0.44, 2.48 ± 1.02, 2.71 ± 0.82 and 3.25 ± 1.25 respectively. ····· 10361119320
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Thin-film organic semiconductor devices such as organic light emitting diodes (OLEDs) and organic photovoltaics can be fabricated in a variety of ways, including physical vapor deposition (PVD). PVD is a process for depositing thin films of precisely controlled thicknesses and material compositions onto a substrate in a vacuum system. Resistively heated crucibles, referred to as boats, are commonly used to heat source materials to a sufficient temperature to cause vaporization or sublimation. These boat designs typically contain a single opening which results in a conical vapor stream for coating both a substrate and a nearby thickness and rate sensor. In this study, a new boat design incorporating a dual vapor stream, where one vapor stream is pointed toward the sensor and the other is directed toward the substrate in an orthogonal orientation, were investigated. This design is intended to provide particularly useful features for the fabrication of organic thin-films of complex compositions involving multiple components. It is also designed to reduce material waste by shortening the source to substrate distance. ····· 10361119444
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The utility of nitrones in synthetic organic chemistry has been widely illustrated. The nitrone moiety can be regarded as a 3 centered dipolar 4 system, which enables 1,3-dipolar cycloaddition reactions with different dipolarophilic reagent to occur. 1,3-dipolar cycloaddition reaction between a nitrone and an olefinic dipolarophiles is an efficient method for the synthesis of isoxazolidine and isoxazoline ring systems. Nitrones are also versatile intermediates for the synthesis of natural products and many biologically interesting molecules. Owing to the labile nature of the N O bond under mild reducing conditions, isoxazolidines provide easy access to a variety of fascinating 1,3-difunctional amino alcohols. To run a chemical reaction under an environment friendly condition is a challenge now-adays. The development of environmentally benign chemical processes (aqueous phase synthesis, microwave induced reactions and ionic liquids as solvent) have received much attention in recent years. ····· 10361133602
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Over the last few years, a wide range of biologically active carbazole alkaloids have been isolated from plant sources. Many of these natural products manifest a variety of biological activities. In addition to their use in medicinal chemistry, carbazoles have attracted increasing attention from the community of material scientists owing to their potential in photophysical and optoelectronic applications. Polyvinylcarbazole (PVK) has been extensively investigated for its use in photorefractive materials and xerography, while N-ethylcarbazole (ECz) was recognized as an effective charge-transporting functional plasticizer for PVK and other doped polymers. In view of these important applications, we set out to develop an anionic cycloaddition for the carbazole synthesis and to apply the method to the synthesis of naturally occurring carbazoles. The dissertation results should be useful to researchers and especially to students and professionals in organic chemistry, material chemistry or medicinal chemistry fields. ····· 10361135653
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The stereochemistry control of radical reactions has been a field of intense investigations in the last 20 years. Rules have been proposed to rationalize the results, interestingly these rules parallels the ones formerly developed for ionic and concerted reactions. The use of captodative radicals combined with phenylseleno group transfer reaction is a powerful tool which allows a wide range of chain reaction in intra and inter molecular manner. In this book we will present several aspects of these type of radical generated form selenylated alpha hydroxy acids derivatives. These reaction have been studied using different substrates. A new method of obtaining optically pure dioxalones is also presented. These reactions might be very useful during delicate steps of total synthesis of natural products. Organic chemists could find very useful some of the application that are represented in this book especially the good stereoselectivity control that these reaction have. ····· 10361135704
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Superstructures are large sized molecules which exist and function at and beyond the nanoscale. By utilizing a diverse array of intermolecular interactions as the information source for assembly processes, large number of complex nanoscale structures and superstructures with a variety of forms and functions has been constructed which exhibit the same principles as exhibited by biological systems i.e. self organization, self assembly and self synthesis processes. In this book, 2,4-(1H,3H) pyrimidinedione (uracil) based new entities have been designed and synthesized which have capability of recognition of other entities and undergoing self organization. ····· 10361146484
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray In this research work, synthesis of Schiff bases was carried by simple synthetic route. In the first step, the synthesis of dialdehyde 4, 4`-(propane-1, 3-diylbis (oxy)) dibenzaldehyde was done through simple reaction, from which three products were obtained and the desired dialdehyde was isolated by column chromatography. Using this dialdehyde, a series of pharmacologically important Schiff bases were synthesized. ····· 10361146644
····· lezzter Preis 44.91€ ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray El control químico de plagas mediante el empleo de plaguicidas suele tener consecuencias negativas tanto en la salud humana como en el medioambiente. La alelopatía ofrece una interesante alternativa al control químico de plagas mediante el empleo de sustancias de origen vegetal. En el presente trabajo de investigación se evaluó la actividad aleloquímica de diferentes extractos, sub extractos y fracciones Funastrum gracile (Decaisne) Schlechter (Asclepiadaceae), un espécimen vegetal oriundo Sudamérica, sobre semillas de diferentes especies vegetales, y la actividad germicida contra bacterias fitopatógenas. Para tal fin se recurrió a diferentes técnicas de naturaleza físico químicas, químicas, bioquímicas y microbiológicas, pudiendo inferir así las potenciales aplicaciones agronómicas de los productos derivados de Funastrum gracile como plaguicidas naturales no contaminantes. ····· 1036123960
für 45.80€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Die vorliegende Arbeit befasst sich mit der Darstellung, dem Koordinationsverhalten und den grundlegenden Reaktivitätseigenschaften von Calciumallylverbindungen. Beispiele für katalysierte Reaktionen werden diskutiert, um das Anwendungsspektrum abzuschätzen. Der erste Teil beschreibt die Darstellung von 1-Alkenylkomplexen von Calcium, sowie deren Strukturmerkmale in Lösung und im Festkörper. Modellreaktionen mit CO2, Carbonylverbindungen und Iod zeigen eine hohe Reaktivität gegenüber Elektrophilen auf. Die Isolierung eines Alkylkomplexe wird kurz beschrieben. Der zweite Teil legt das Koordinationsverhalten von Bis(allyl)calcium in der Gegenwart von (Aza)Kronenethern dar. Trotz der Isolierung eines außergewöhnlichen Kronenetheraddukts mit einem s- und einem p-gebundenen Allylliganden im Festkörper, resultiert die hohe Basizität in rascher Zersetzung durch Etherspaltung. Der dritte Teil dieser Arbeit berichtet über Reaktionen von Bis(allyl)calcium mit Brønstedund Lewis-Säuren und die in situ Erzeugung von Calciumallyl-Monokationen. Während Verbindungen des [Ca(C3H5)]+-Kations leicht zu generieren sind, wird deren Isolierung durch schnellen Ligandenaustausch zugunsten der homoleptischen Spezies verhindert. Ein kurzer Vergleich der Aktivität in der Olefinpolymerisation ist gegeben. Der Grundtyp, Bis(allyl)calcium ist aktiv in der Polymerisation von 1,3-Butadien, jedoch nicht in der Polymerisation von Ethylen. Ionenverbindungen des Calciumallyl-Monokations zeigen in den gleichen Reaktionen keine Polymerisationsaktivität. Der vierte Teil beschäftigt sich mit der Reaktivität von Bis(allyl)calcium gegenüber Pyridin, Furan und ihren Derivaten. Eine Serie von Insertions- und C-H Bindungsaktivierungsprodukten wurde durch die Reaktion mit N-Heteroaromaten isoliert. Die Produkte wurden charakterisiert und ihr Bildungsmechanismus zeugt von einer ausgeprägten Balance zwischen Nukleophilie und Basizität der eingesetzten Calciumverbindungen. Die Reaktivität gegenüber Furanen ist undefiniert und resultiert in der Bildung einer Mischung unbekannter Produkte. Der letzte Teil dieser Arbeit beschreibt die Reaktivität von Calciumallylkomplexen gegenüber Diwasserstoff, Silanen und anderen Hydridtransferreagentien. Ein Augenmerk wird auf die Isolierung und Charakterisierung eines kationischen Calciumhydridclusters mit einem hypervalenten Hydridosilikat-Anion gesetzt. Die Reaktion zu einem Ketylradikalkomplex deutet auf eine Aktivität in redox-Reaktionen hin. Diese außergewöhnliche Verbindung katalysiert die Hydrierung eines endständigen Olefins mit H2 unter milden Bedingungen. ····· 10361107608
für 45.80€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray In this work, investigations and optimizations of the filamentous fungus Caldariomyces fumago as enzyme production host were performed. For UV mutagenesis experiments with C. fumago, UV irradiation parameters were determined. A survival curve was recorded and an irradiation time of 4 min was chosen for all following UV experiments leading to a survival rate of 21 %. By colony screening of randomly mutagenized C. fumago cells 6 albino (white) mutants displaying a slight growth reduction on solid media were isolated. In production media these strains were red-colored due to the production of the heme-containing chloroperoxidase (CPO). Their culture supernatant samples lacked the intense black fungal pigment thereby enabling to follow the formation of CPO by visual inspection of the medium color and simplifying downstream processing. Surprisingly, elimination of the undesirable pigmentation was accompanied by improved CPO secretion. Namely, the CPO content in the culture supernatant samples of the white C. fumago mutants increased significantly faster compared to the wild type. To examine the nature of the black pigment of the C. fumago wild-type strain several inhibitors commonly used to block the synthesis of different pigment in fungi were tested. The addition of 50 µg ml-1 tricyclazole, a specific inhibitor of the 1,8-dihydroxynaphthalene (D2HN) melanin synthesis pathway, induced a significant color change of the C. fumago wild type mycelium proposing the black pigment of C. fumago to be D2HN melanin. A further C. fumago mutant was isolated which was slightly greenish on fructose minimal medium and grew slower in comparison to the wild type. The supernatant sample lacked the Soret band typical for the heme group of the CPO and nearly no CPO activity could be detected. SDS-PAGE analysis of mutant culture supernatant sample showed production of a 38 kDa protein while wild type samples contain the 42 kDa CPO protein. Protein identification using nanoLC-ESI-MS/MS was performed and based on 3 peptides the protein was identified as CPO. In addition, the CPO gene was sequenced. However, no differences in the CPO gene sequence of wild type and mutant were found indicating a post-translational defect in protein maturation. Deglycosylation experiments using CPO from wild type and cpo1 were carried out. After removing N-linked oligosaccharides from wild type CPO a protein band at 38 kDa was detected. These results reveal that the mutant protein lacks the heme group as well as the N-glycans. Addition of different amounts of tunicamycin, an antibiotic that blocks N-linked glycosylation of proteins, to C. fumago wild type cultures did either lead to a strong reduced growth behavior when a too high concentration was applied or had no influence on CPO activity and no visible change in protein size on SDS-PAGE gels was obtained. To select transformants of C. fumago for the development of more efficient transformation systems based on auxotrophic markers the URA3 gene encoding 5`-orotidine monophosphate decarboxylase (OMPD) was chosen. Mutants lacking OMPD activity could be easily selected after UV irradiation since they are able to grow in the presence of 5-FOA but require the addition of uracil or uridine to the medium. Fifty-three strains were isolated and their growth properties were examined by plating on different media. Three strains showed the growth properties which are dedicated to uracil or uridine auxotrophic mutants having a defective URA3 gene. Those cells were transformed with a plasmid containing the URA3 gene either of A. nidulans or C. fumago. However, no complementation of the auxotrophy of any of the 3 strains was achieved. Since mutants with a defective URA5 gene also show the determined growth properties it was assumed that the URA5 gene is affected. Experiments of expressing horseradish peroxidase (HRP) and the carotenoid cleaving peroxidase MsP2 from Marasmius scorodonius using the highly efficient and specific secretion apparatus of C. fumago were performed. Due to the lack of CPO knock-outs strains, the C. fumago wild type strain had to be used in the present work. The construct for the expression of HRP consisted of the N-terminal signal peptide of CPO and the C-terminal propeptide of CPO. The constructs for MsP2 consisted either of the N-terminal secretion signal of CPO or of MsP2 and the C-terminal propeptide of CPO was absent or present. The constructs were transformed into the rDNA region of the C. fumago genome. For all constructs of both enzymes no visible protein bands were detected on SDS-PAGE gels. Enzyme assays specific for HRP and MsP2 were developed. However, no enzyme activity was detected for exemplarily chosen transformants. Several limits of heterlogous gene expression using C. fumago are discussed. ····· 10361107991
für 48.80€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Die Lebensdauer von Elastomeren auf Basis von Polydienen wird maßgeblich durch thermisch-oxidative Alterungsprozesse bestimmt. Um die zeitabhängige Funktionsfähigkeit und Lebensdauer von Elastomeren richtig einzuschätzen und verbessern zu können, besteht deshalb großes Interesse an der Charakterisierung der kinetik und an mechanistischen Erkenntnissen zur oxidativen Alterung. Dafür wird in dieser Arbeit die im Bereich der Elastomere selten eingesetzte Messmethode der Chemilumineszenz (CL) eingesetzt. Die Methode nutzt die Emission von Lichtquanten, welche im Verlaufe der Oxidation von Polymeren durch intermediär gebildete Spezies entstehen. Die emittierte Lichtintensität ist mit der Konzentration der betreffenden Spezies im angeregten Zustand propoertional. Daher kann sowohl der Anfangszustand als auch der Verlauf der oxidativen Prozesse über dieses Prinzip erfasst werden. Mit der Methode kann die Stabilität eines Polymers durch den OIT-Wert (oxidation induction time) quantitativ ermittelt und die Kinetik der Oxidationsreaktion festgestellt werden. ····· 10361107384
für 49.41€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Nativnye pentaciklicheskie triterpenoidy lupanovogo ryada (betulin, betulinovaya kislota) sostavlyajut vazhnyj klass biologicheski aktivnyh soedinenij s shirokim spektrom biologicheskogo i farmakologicheskogo dejstviya. Osobyj interes k jetim soedineniyam vyzvan ih protivoopuholevymi svojstvami. Betulinovaya kislota i ee nekotorye sinteticheskie proizvodnye otnosyatsya k gruppe veshhestv `mitokanov`, protivorakovyh soedinenij, izbiratel`no destabilizirujushhih mitohondrii i inducirujushhih apoptoz rakovyh kletok. Kniga posvyashhena issledovaniyam, napravlennym na modifikaciju struktury betulinovoj kisloty s cel`ju usileniya ee citotoxicheskoj aktivnosti. V pervoj glave proanalizirovany raboty, opublikovannye v jetom napravlenii za poslednie 10-15 let. Vo vtoroj glave obsuzhdajutsya rezul`taty issledovanij, poluchennye avtorami knigi. Jeti issledovaniya napravleny na razrabotku metodov sinteza kon#jugatov betulinovoj kisloty s lipofil`nym trifenilfosfonievym kationom - predpolagaemym sredstvom dostavki triterpenoida v mitohondrii opuholevyh kletok. Kniga rasschitana na himikov-organikov, rabotajushhih v oblasti napravlennogo sinteza, prirodnyh soedinenij, medicinskoj himii, aspirantov i studentov himicheskih vuzov. ····· 1036118549
für 49.41€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Malignant tumours represent one of the most common human diseases and despite revolutionary strides in therapeutic sciences, the clinical prognosis of cancer still remains relatively poor. This therefore leaves ample space for the development of new therapeutic leads or strategies for the improvement of drugs that are currently in use. Among the current targets for chemotherapy, alongside DNA, microtubules have a prominent role to play. Since tubulin-containing structures are crucial in a number of cellular functions, microtubules have represented a good target for chemotherapy. A number of drugs, mainly of natural origin including vinblastine, colchicine and paclitaxel have emerged to target microtubules at various binding sites. Similarly, the compounds that bind with the DNA-based targets like Top I and Top II (e.g. camptothecin & podophyllotoxin derived analogues) also represent the main therapeutic leads to circumvent malignant tumours. This book gives an overview of natural products in cancer chemotherapy and attempts to achieve new leads for future research have been discussed. ····· 1036198482
für 49.41€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Steroids play important roles in the human body, including, but not limited to: controlling meiosis, fat storage, protein and carbohydrate metabolism, muscle growth, immune function and nerve cell membrane chemistry. Almost one-third of all currently prescribed medications contain steroid skeleton e.g. Proellex, Chronocort, Corticosteroids etc. Many medicinally important steroid derivatives do not occur in nature and must be synthesized in the laboratory. The modification of steroid skeleton or fusion of any heterocyclic ring system such as triazolidinones, oxathiolanes, and carbohydrate group, to steroid was found to augment the biological and industrial revolution as it results in change of electronic and molecular properties and have shown marked biological activities like anti-cancer, antimicrobial, antimalarial and anti-HIV. Thus, innumerable methods are necessary to develop across to find the better analogues of steroid natural products to show the potent biological activities. The purpose of the present book is to incorporate advances in the area of organic synthesis. ····· 10361132885
für 49.80€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Der über die letzten Jahre immer häufigere Nachweis außergewöhnlicher biologischer Aktivitäten hat marine Naturstoffe in den Fokus der Forschung gerückt. Unter diesen Stoffen stellen die ausschließlich in marinen Schwämmen vorkommenden Pyrrol-Imidazol-Alkaloide mit ihren bis heute bekannten 120 Vertretern eine der größten Alkaloidklassen dar. Zwischen 2004 und 2009 wurde diese Klasse durch die Isolierung von neunzehn neuen Verbindungen, die unter dem Gruppennamen der Nagelamide zusammengefasst wurden, erweitert. Viele dieser Nagelamide zeigen antibakterielle, fungizide oder gegenüber der Proteinphosphatase 2A inhibitorische Wirkung. Um eine späte, in früheren Synthesen von Pyrrol-Imidazol-Alkaloiden dann unmögliche Einführung der 2-Aminogruppe zu vermeiden, wurden zwei neue Imidazolbausteine synthetisiert, die bereits eine geschützte 2-Aminogruppe aufweisen. Mit diesen Bausteinen konnten in Pd-katalysierten Kreuzkupplungen neben dem Tautomer von Hydroxyoroidin auch neue Derivate der unbekannten 2-Aminourocaninsäure in guter Ausbeute erhalten werden. Diese konnten zwar in Diels-Alder-Reaktionen als Dienkomponente eingesetzt oder durch Bestrahlung in ihre Z-Isomere überführt, jedoch nicht dimerisiert werden. Versuche, die Bis(imidazolyl)-Teilstruktur der Nagelamide durch metallorganische Kupplung eines 4-Acylimidazols und 4-lod-5-vinylimidazols aufzubauen, stellten sich unter den gewählten Bedingungen als schwierig heraus. Eine doppelte Grignard-Reaktion an unterschiedlich geschützten lodimidazolen lieferte schließlich Bis(imidazolyl)carbinole in sehr guten Ausbeuten. Maßgebliche Erweiterungen und zahlreiche Optimierungen ermöglichten die Synthese von Bis-(2-aminoimidazolyl)propenen in nur fünf Stufen mit einer Gesamtausbeute von bis zu 27%. Die Darstellung dieser Teilstrukturen könnte neben einem schnellen Zugang zur ersten Totalsynthese mehrerer Nagelamide auch Ausgangspunkt für einen neuen Zugang zu anderen Alkaloiden ähnlicher Struktur - z. B. dem Ageliferin - sein. ····· 10361107378
für 49.80€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Die große Herausforderung in der chemischen Synthese liegt in der effizienten Darstellung gewünschter Produkte bei gleichzeitiger Minimierung des Energieaufwandes und chemischer Abfälle, was sich insbesondere auf die Ökonomie und Ökologie industrieller Prozesse auswirkt. Der Einsatz von Katalysatoren ermöglicht viele, thermisch nur schwer zu realisierende, chemische Umsetzungen in hoher Effizienz, indem sie Aktivierungsbarrieren verringern und milde Reaktionsbedingungen, sowie eine hohe Produktselektivität und Ausbeute ermöglichen. Vorteilhafterweise werden oft nur sehr geringe Mengen an Katalysator benötigt und dieser durch die Reaktion selbst nicht verbraucht, sondern höchstens mit der Zeit desaktiviert. Eine weitere Möglichkeit chemische Abfälle und Energiekosten zu reduzieren stellt die Anwendung von Eintopfsynthesen dar, bei der mehrere chemische Reaktionen zu Sequenzen zusammengefasst werden, sodass die einzelnen Transformationen im gleichen Reaktionsgefäß kontrolliert ablaufen. Mittels dieses Verfahrens ist es möglich auf die Isolierung von Zwischenprodukten und damit auf die Anwendung von sehr kostenaufwändigen physikalischen Trennoperationen zu verzichten. Florian Erver stellt in diesem Buch eine ganze Reihe Cobalt-katalysierter Reaktionen vor, welche die einfache aber sehr selektive Addition von simplen und zumeist kommerziell verfügbaren Startmaterialien wie Acrylaten, Alkinen, Alkenen, Dienen und Aldehyden zu komplexen, organischen Bausteinen erlauben. Die eingesetzten Cobalt-Komplexe zeichnen sich dabei durch ihren sehr einfachen Aufbau, ihre somit gute Verfügbarkeit, sowie ihre sehr gute Lagerstabilität und Handhabbarkeit aus. In dieser Arbeit werden nicht nur innovative und schnelle Wege zu Heterocyclen, Polyenen und komplexen, tricyclischen Systemen präsentiert, sondern auch neuartige Mehrkomponentenreaktionen vorgestellt. Die Kombination des Prinzips der Eintopfsynthese mit dem der Katalyse führte schließlich zum Konzept der multiplen Cobaltkatalyse, mittels derer bis zu fünf verschiedene Komponenten in einer Sequenz bestehend aus vier Transformationen selektiv unter Ausbildung von fünf C-C-Bindungen zu einem einzigen Produkt verknüpft werden konnten. Desweiteren wird in diesem Buch die erste Synthese der beiden Naturstoffe Credneramid A und B, sowie ihrer biologischen Vorstufe, Crednersäure, vorgestellt. Nachdem Anfang des Jahres 2012 von ihrer Isolation und Strukturaufklärung, sowie ihrer biologischen Aktivität berichtet wurde, stellt der Autor in diesem Buch gleich zwei verschiedene, sehr kurze und effiziente Synthesewege vor, bei der die Anwendung zweier homogener Katalysatoren in Wettbewerb gesetzt wird. Leser mit Interesse auf dem Bereich der organischen Chemie, insbesondere auf dem Gebiet der homogenen Katalyse, der Eintopfreaktionen, sowie der Naturstoffsynthese, werden an diesem Buch viel Freude haben. ····· 10361107628
····· lezzter Preis 49.95€ ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray SpektroskopieDas Buch - jetzt in der günstigen `Bafög`-Ausgabe - bietet alle relevanten Informationen und Erklärungen zur Spektroskopie, die für die Bachelor-Studiengänge Chemie und Biochemie von Bedeutung sind: Die physikalischen und chemischen Grundlagen der diversen spektroskopischen Methoden werden ausführlich erläutert, aber auch die jüngeren instrumentellen Entwicklungen, Methoden und Verfahren vorgestellt, um dem Studenten einen Bezug zur aktuellen Praxis zu vermitteln.Neben den Grundlagen für das Bachelor-Studium beschäftigt sich der Text an vielen Stellen auch mit weiterführenden und komplexeren Fragestellungen, die für die Master-Studiengänge sowie für praktizierende Naturwissenschaftler und Spektroskopiker von Interesse sein können. So wird jedes Themengebiet zunächst von Beginn an eingeführt wird, bevor komplexere Zusammenhänge, Methoden und Verfahren zur Sprache kommen. Daher bildet das Buch die Verbindung von Anfängerlehrbuch und spezialisierten Monographien.Besonders hervorzuheben ist die große Zahl der Übungsaufgaben zu den einzelnen Kapiteln und vor allem die Sammlung praxisnaher kombinierter Übungsaufgaben (online), in denen zu einer strukturellen Fragestellung jeweils die Spektren aller vier in diesem Buch behandelten Methoden gegeben werden.INHALT:Einführung in die spektroskopische StrukturaufklärungTeil I: KernspinresonanzspektroskopieTeil II: MassenspektrometrieTeil III: SchwingungsspektroskopieTeil IV: ElektronenabsorptionsspektroskopieTeil V: Kombinierte Aufgaben (online)IndexAUTOREN:JOSEPH B. LAMBERT ist Professor für Chemie an der Trinity University, San Antonio, Texas. SCOTT GRONERT lehrt an der Virginia Commonwealth University, Richmond, Virginia. HERBERT F. SHURVELL ist emeritierter Professor der Queen`s University in Kingston, Ontario. DAVID A. LIGHTNER IST lehrt an der University of Nevada, Reno, Nevada.Die Fachlektoren sind DIETMAR KUCK, Professor für Organische Chemie an der Universität Bielefeld, und HEINRICH MARSMANN, emeritierter Professor der Universität Paderborn. Sie haben bei der Bearbeitung der vorliegenden deutschen Ausgabe den Text, die Übungsaufgaben und die Abbildungen gegenüber dem amerikanischen Original an vielen Stellen gründlich überarbeitet und präzisiert und so eine in vielerlei Hinsicht optimierte Ausgabe geschaffen.ZIELGRUPPE:Studenten der Chemie, Haupt- und Nebenfach
COMPANION WEBSITE:Für Dozenten:Alle Abbildungen des BuchsFür Studenten:Lösungen zu allen Übungsaufgaben im BuchÜber 100 Seiten mit praxisnahen kombinierten Übungsaufgaben inklusive Lösungen ····· 10361185212
für 53.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray This Thesis discusses the basic principles of Lithographic techniques incorporating the use of positive and negative photoresists applications, synthetic techniques of photo imaging compounds and light sensitive materials, uses of novel chlorinating agents at mild conditions, direct esterification of sulfonicacid or salts, photochemical studies of photo activating compounds, resolution and optimization of the photo imaging compounds in nanolithographic applications. Preparative and HPLC standardization methods of photo activating compounds. Synthesis of photo acid generators for nanotechnology applications, these are used in the microelectronic industry. The microelectronic industry has made remarkable progress with the development of integrated circuit (IC) technology. Although EUV lithography at 13.5 nm wavelength has emerged as a promising candidate to meet the resolution requirements of the microelectronic industry roadmap, yet the development of advanced photoresist materials with all of the required imaging properties is still challenging and is one of the major subjects of current nanolithography research. ····· 1036118666
für 53.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The topic of this project is related to the investigation, design and development of novel synthetic methods and pathways to natural antioxidants and their synthetic analogues that can be utilized as pharmaceuticals, nutraceuticals and preservation agents for food and feed, particularly marine lipids. Distinctive interest is paid to the development and exploration of phenolic and benzoquinone class of compounds such as coenzyme Q10 (CoQ10) and Idebenol. Focal point is the development of practical, efficient, and cost-effective synthetic methods and pathways that will employ cheap and readily available materials, and `green` conditions and reagents. A novel total synthesis to Idebenone is concluded while the development of a synthetic path leading to CoQ10 has also been explored. Among the deliverables are: a) a novel `green` bromination protocol for activated arenes b) an oxidation protocol leading to two versatile intermediates c) a purification protocol of Heck coupling post-reaction mixtures for transition metal catalyst based on organic solvent nanofiltration and d) a palladium catalyzed Heck coupling protocol performed under microwave irradiation. ····· 1036119072
für 53.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray This monograph introduces the excellent application of olefin metathesis approah for total synthesis biologically potent 10-membered lactone derived natural products, such as (+)-Mueggelone (a novel inhibitor of fish development), Herbarumin-I (Which interacts with bovine-brain calmodulin and inhibited the activation of the calmodulin-dependent enzyme cAMP phosphodiesterase and should have physiological effects of agrochemical and medicinal interest), and Stagonolides (which were shown to be a nonhost-speci c but selective phytotoxin. Leaves of C. arvense were most sensitive and leaves of tomato and pepper (both Solanaceae) were less sensitive to stagonolide, and demonstrated to be a strong inhibitor of root growth in seedlings of C. arvense and some other Asteraceae species). Herbarumins & Stagonolides could be served as eco-friendly effective plant pathogens compared to environmentally restricted chemical herbicides. This monograph is unique in dealing with the synthetic protocols for above natural products utilizaing olefin metathesis including full experimental procedures, analytical data, complete referenece sections and most useful for all synthetic organic chemists. ····· 1036119583
für 53.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The presence of more water solublising group is characteristics of anionic mono azo dyes. Sulphonic groups are used almost exclusively for this purpose because these are readily accessible and are strong electrolytes and therefore almost completely dissociated in all acidity ranges occurring in the aqueous solution. These dyes are widely used for paper and leather, and their metal salts are used as pigments. The term `Acid Dyes` denotes a large group of anionic dyes with a relative low molecular weight that carry 1 to 3 sulphonic acid groups. They are mainly mono azo compounds but also includes bisazo, triphenyl methine, 4-oxoquinazoline derivatives and other name `Acid Dyes` is derived from the dyeing process, they are applied to wool [1-4], silk [5,6] and nylon. A solvent dye is a dye which is soluble in an organic solvent and is commonly introduced in the form of a solution in an organic solvent. Solvent dyes [1-2] are used to impart colour to organic solvents, hydrocarbon fuels, waxes, lubricants, plastics, and other hydrocarbon based non-polar materials. Their molecules are typically non-polar or little polar and they do not undergo ionization in solvent. ····· 1036120695
für 53.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Inflammatory diseases and cancer are serious health problems for mankind. Many antiinflammatory and a few anticancer drugs are available in the market. Most of the drugs used clinically have serious side effects and hence there is a development of safer antiinflammatory and more active anticancer drugs. In continuation of our work in this direction, we have synthesized a number of pyridine, pyrazine, pyrimidine, pyrimidobenzimidazole, hemin & hematoporphyrin derivatives and evaluated them for their antiinflammatory, analgesics and/or anticancer activities. A few of them are very potent towards analgesics and antiinflammarory activites and one patent was also done on Thiazoline derivatives possessing anti-inflammatory and analgesic activities and their method of preparation. ····· 1036121174
····· lezzter Preis 53.10€ ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The considerable biological and medicinal activities have prompted considerable research aimed at developing synthetic routes to these ring systems.A search contains a selection of the recently reported synthetic methods for the preparation of thiadiazole derivatives and their reactions with different reagents. The intoduction part contains a selection of the recently reported synthetic methods for the preparation of thiadizole derivatives and their reactions with different reagents and their biological activities.The various possible thiadizoles are 1,2,3- thiadizole,1,2,4- thiadizole,1,2,5- thiadizole and 1,3,4- thiadizole.Then in the second part , N-(5-(cyano methyl)-1,3,4- thiadizol-2-yl)benzamide was prepared and we have investigate its reactivity towards different reagents. ····· 1036125066
····· lezzter Preis 53.10€ ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Provision of food has always been a challenge facing mankind. A major cornerstone in this challenge is the competition from insect pests. While some pest associated losses occur when the crops are standing in the farms or greenhouses, others are caused during storage in grain elevators, storage bins and granaries. The extracts of the root barks of Detarium microcarpum Guill&Perr and Sclerocarya birrea (A.Rich) Hochst have found traditional use for treatment of human ailments and diseases and as antifeedants against stored product pests. ····· 1036125294
für 53.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The work of the book is devoted to a study of a series of organic reactions from readily available and less costly starting materials such as coumarins, pyrazoles, and chromones. These heterocyclic compounds were readily converted to polyketomethylene compounds by treatment with active methylene compounds such as triacetic acid lactone, dimedone, 3-methyl-1-phenyl-5-pyrazolone and nitrogenous bases such as hydrazine hydrate, phenyl-hydrazine, hydroxylamine respectively under different reaction conditions and the structures of all new compounds were identified on the basis of IR, NMR, and mass spectroscopy. Some of these synthesized compounds have been investigated for anti-inflammatory, analgesic, antipyretic and antibacterial activities. Most of the compounds have been found to possess significant activities and their effect was compared with the standard drugs. ····· 1036191817
für 53.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The present work entails the synthesis of different cross-conjugated (CC) heterodiene systems, and their transformations in various heterocyclic compounds using the hetero Diels-Alder (HDA) methodology. One of the main highlights of present work includes the development of simple and convenient procedure for the synthesis of stable CC azatrienes, and their tandem [2+2] cycloadditions and highly facile [3,3] sigmatropic Cope rearrangements with conjugated ketenes, leading to facile synthesis of various functionalized azocinone derivatives. A generalized and relevant study regarding the reactivity of thiazolic diazadienes with different ketenes was also conducted, and a remarkable increase in reactivity was observed with the introduction of electron donating group across the carbonyl group. Considering the biological and medicinal importance of C-5 or C-6 substituted pyrimidinones, the dienyl moiety of thiazolopyrimidinones was utilized further in Diels-Alder cycloadditions with both symmetrical and unsymmetrical dienophiles. Additionally, the synthesis of various pyrans, thiopyrans, thiophenes, thiazoles, 1,3-thiazines etc. is also described. ····· 1036192135
für 53.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The same quandary faces the researcher who wishes to become acquainted with the biologic activity characteristic of some pyrazolo[3,4-d]pyrimidines. There thus seemed to be a place for a book that would cover specifically the chemical manipulations involved in the synthesis of pyrazolo[3,4-d]pyrimidines. A book then was intended that would supplement both the available medicinal and organic chemistry texts. Comprehensive coverage of both the preparation and biologic activity of all pyrazolo[3,4-d]pyrimidines reported in the literature to show such activity would lead to a truly enormous treatise. Also, a book was then extend to explain a new methods for synthesis and biological activity of some new heterocyclic systems containing pyrazolo[3,4-d]pyrimidines. The structure of these compounds was established on the basis of their elemental analysis and spectral data. The synthesized compounds are tested in vitro for their antimicrobial activity compared with the standard antibiotics Ampicillin and Tarivid, and fungicide Mycostatin. ····· 10361100817
für 53.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray In this work synthesis and characterization of a novel series of compounds, polymers containing 1,3,4-thiadiazole and 1,2,4-triazole units are described. All of these materials in this study are characterized by FTIR, 1HNMR, 13CNMR, Mass and UV spectroscopy. The liquid crystalline properties of the prepared compounds were verified using differential scanning calorimeter (DSC) and hot-stage optical polarizing microscopy (OPM). The first series of this study containing two 1,3,4-thiadiazole Schiff bases rings connected with two terminal alkoxyphenyl rings. These compounds exhibited eneantiotripic nematic and smectic phases while other compounds did not exist any liquid crystalline behaviours. To comparison the liquid crystalline behaviour of these compounds, the two series having the azoxy groups instead of azomethine groups was synthesized. The difference between the azomethine compounds with that of azoxy group, The latter compounds did not show any liquid crystalline properties. Polyesters and polyethers were also prepared and found that all polymers did not show liquid crystalline properties but simply go to the glass transition temperatures Tg and then to isotropic melt. ····· 10361101050
für 53.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Most of practical charge transporting polymers and low-molar-mass materials used in electrophotography are hole-transporting. Among them arylamines and hydrazones have got most attention of researchers. One of the most secure ways of the preparation of solvent resistant electrophotographic materials is cross-linking or photopolymerization. For this charge-transporting compounds with reactive functional groups are needed. This book which is based on a research study conducted in Lithuania gives an insight to photoinitiated cationic polymerization of vinyl ethers and oxiranes bearing electronically active substituents using iodonium, sulfonium salts and iron-arene complex as photoinitiators.In the next part of work a series of new hydrazones aromatic amines containing reactive vinyloxyethyl group have been designed and synthesized. A set of new amorphous hole-transporting molecular materials have been prepared using the newly synthesized vinyloxyethyl-substituted hydrazones. All the newly synthesized compounds have been fully characterized by a set of spectroscopic methods. Their thermal and photoelectric properties have been studied. ····· 10361101627
für 53.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The synthesis part of this work is divided into three different parts: Part One: This part involved the synthesis of 3-biphenyl-4-ylimidazo[1,2-a]pyridine [1], 3-phenylimidazo[1,2-a]pyridine [2], and other compounds, directly from the starting material. Part Two: This part involved the synthesis of N-carbamoyl-N2-pyridin-2-ylglycinamid [12], N-(4-biphenyl-4-yl-1,3-oxazol-2-yl)-N2-pyridine -2-ylglyciamide [13], and other compounds, from the reaction of 2-aminopyridine with ethylchloroacetate to yield ethyl-N-pyridin-2-ylglycinate [11], this compound was used as precursors. Part Three: This part involved the synthesis of 2-[(pyridine-2-ylamino)methyl]-4,5-dihydro-6H-1,3,4- oxadiazine-6-one [17], 3-[(pyridine-2-ylamino)methyl]1,6-dihydro-1,2,4- triazin-5(2H)-one [18], 5-[(pyridine-2-ylamino)methyl]-1,3,4-oxadiazole-2- thiol [19], and other compounds, starting from 2-(pyridine-2-ylamino)acetohydrazide [16]. This compound was prepared from refluxing ethyl-N-pyridin-2-ylglycinate [11] with hydrazine hydrate. ····· 10361102618
für 53.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Organic nanoparticles have attracted tremendous research interests over the past few years owing to their special properties which lie between the properties of molecules and those of bulk material. The electronic properties of organic nanoparticles differ fundamentally from those of inorganic ones. Organic nanocrystals allow much increased variability and flexibility in synthesis of materials, preparation of nanoparticles, and investigation of their physico-chemical properties. The ordered periodic mesoscopic materials allow the construction of composites with many guest types like organic molecules or polymers. These guest/host materials combine high stability of the inorganic host system, new structure forming mechanism due to the confinement of guests in well-defined pore channels. This book consists of two parts. The first part of this study constitute synthesis and photophysical characterization of fluorescent organic nanoparticles of conjugated compounds and rod-coil molecules. The second part deals with the self-assembled organic-inorganic functional hybrid nanocomposites. This book is useful for the materials scientists and for inter-disciplinary research. ····· 10361102973
····· lezzter Preis 53.10€ ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The extreme cytotoxicity of natural enediyne antibiotics is attributed to the ability of the (Z)-3-ene-1,5-diyne fragment incorporated into a 10- or 9-membered ring cyclic system to undergo Bergman cyclization and producing dDNA-damaging p-benzyne diradical. The rate of this reaction strongly depends on the ring size. Thus 11-membered ring enediynes are stable, 10-membered ring analogs undergo slow cycloaromatization under ambient conditions or mild heating. Very little is known about reactivity of 9-membered ring enediynes due to their instability. We have developed thermally stable photo-precursors of 9-membered enediynes, in which one of the triple bonds is replaced by the cyclopropenone group. UV irradiation of the photo-precursor results in the efficient decarbonylation and the formation of reactive enediyne. The latter undergoes clean cycloaromatization spontaneously with absence of any chemical additives. Synthetic strategies of a series of cyclopropenone containing nine-membered enediyne precursors and DNA-cleavaging activity of the photo-generated enediynes have been also discussed. ····· 10361115101
für 53.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Synthetic oligonucleotides act as a fuel for engine of modern molecular biology. One of the major application of these biomolecules is in construction of oligonucleotide microarrays or biochips. Microarrays are monolithic, flat surfaces that bear multiple probe sites and each bear a reagent whose molecular recognition of a complementary molecule can result to a signal that is detected by an imaging technology, most often fluorescence. Large-scale genotyping, gene-expression profiling, and disease diagnosis are some of the main applications of biochips. At the present time, this technology of arrayed nucleic acids is employed in many areas, from genetics to molecular medicine to industrial production. This book will give you an insight to efficient strategies for microarray fabrication using modified/unmodified oligonucleotides and glass microslides. In addition, chemical reagents for the estimation of functional group density on solid supports are discussed. ····· 10361115588
für 53.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Cyclic peptides are structurally diverse molecules exhibiting a broad spectrum of biological functions with inherent physiological advantages, ranging from insecticidal and antimicrobial to anti-inflammatory and immunosuppressing activities. The synthesis and study of cyclic peptide analogues thus presents a powerful advance in the design and discovery of novel peptide drugs. During the past 20 years, phakellistatins 1-18 have been isolated as prolin-rich cyclic peptides with potent activities against various cancer cell lines. The solid-phase total syntheses of two members of the series, phakellistatins 12 & 13, along with alanin-scanning analogues of phakellistatin 13 was carried out to verify the structure and bioactivities of the natural products. Interestingly, the synthetic peptides were found to be identical in structures to their natural counterparts, whereas the biological activity could not be reproduced. The present study is thus valuable for the readers interested in various methods of SPPS and structural characterization of peptides. Furthermore, the results of the present study highlight the potential uncertainty with the biologically active natural products. ····· 10361118463
für 53.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The work represented in the book is divided into five chapters in first chapter deals with derivatives of 4-amino coumarin. Second chapter developed a novel, rapid and efficient methodology for the synthesis of imidazo[1,2-a]pyridine derivatives. Third chapter deals with 1,3,4-oxadiazole. Fourth chapter modify known antiepileptic drug valproic acid to convert into various analogs. Fifth chapter deals with the biological activity of newly synthesized of 4-amino coumarin derivatives. ····· 10361118537
für 53.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Plants and their secondary metabolites are the rich source of drugs against several diseases. Therefore, our aim of study was to isolate and characterized several secondary metabolites from Lawsonia alba (Henna) using state of the art spectroscopic techniques e.g., UV, IR, Mass spectroscopy, 1H- and 13C-NMR spectroscopy and explore the bioactivities of crude plant extract, semipure frcations and pure constituents. ····· 10361131938
für 53.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray It has been nearly fifty years since the advent of solid phase method for the assembly of peptides. One of the main difficulties facing researchers in this field is that of obtaining quantities of peptides and proteins in a pure state. Isolation of proteins form natural resources can be laborious and often provides only tiny quantities. Investigations dealing with the quantitative aspects of polymer-supported reactions have shown that the insoluble support does have a significant dynamic influence on the bound substrates. An efficient polymeric support for peptdide synthesis should have optimum hydrophobic-hydrophilic balance compatible with the peptide being synthesized. This book illustrates the synthesis and characterization of a novel polymer support, polystyrene crosslinked with 1,6-hexanediol diacrylate for the successful synthesis of peptides. The compatibility of the new support is proved by synthesizing sequences of Thioredoxin, which is otherwise difficult to synthesize. Thioredoxin is a naturally occurring sulphur reducing protein containing 108 amino acids. The book is useful to researchers, scientists and academia in studying the intricacies of solid phase synthesis. ····· 10361133572
für 53.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray There are over 750,000 plants on earth relatively only a few of these have been studied scientifically. Modern pharmacology looks for one active ingredient and seeks to isolate it to the exclusion of all the others. Most research on plants continues to focus on identifying and isolating active ingredients rather than studying the medicinal properties of the whole plant. The isolation, purification and identification of active ingredients of one of such medicinal plants that was studied is Ficus platyphylla (Moraceae). Phytochemical analysis of Ficus platyphylla was uniquely designed to give professionals on natural products studies and students an overview of the phytochemical compounds, accepted analytical methods for the isolation of pure compounds and the spectroscopic techniques required for their identification. The research protocols adopted in an impecunious system leading to the isolation of a compound for the first time from the bark of Ficus platyphylla is discussed. ····· 10361134181
für 53.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Several reactions taught in Pharmaceutical and medicinal chemistry laboratory today are hazardous to environment and hence needs to be modified. With an impetus from Pollution control act, Green Chemistry a relatively newer branch has originated. This book discusses the concepts and the implementation of various green chemical reactions. Basic concepts of ionic liquids, organic synthesis and their applications for name organic reactions are discussed. In organic synthesis, ionic liquids have been extensively used for the variety of synthetic transformations. Ionic liquids have been emerging as a versatile class of green solvents with many projected advantages compared with conventional media. In the present book, we would account the synthesis of various kinds of nitrogen heterocycles using variety of ionic liquids too. ····· 10361134264
für 53.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray As a source of medicines, plants have formed the basis for sophisticated traditional systems and continue providing mankind with new remedies. About twenty five percentage of all medical prescriptions are based on substances derived from plants or plant-derived synthetic analogues. To avoid hazards associated with the wrong use of medicinal herbs, isolation and structure-elucidation, as well as the physiological activity assessment represent the scientific basis to safe medicaments. This book contains some methods of extraction, fractionation, separation and purification of natural products from a plant species, as well as structure elucidation by spectral tools. This book, therefore, provides young researchers in the field of Natural Products` Chemistry, who are willing to build up their competencies, with some practical techniques in extraction, separation, purification, spectral analysis, and structure-elucidation of natural products. This book describes working in low or moderately sophisticated lab equipment and facilities, which is a good start for beginners and for researchers in poor countries. ····· 10361134417
für 53.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Organic Chemistry: Structure, Mechanism, and Reactivity logically presents in simple and clear terms the required facts and principles needed to succeed in Organic Chemistry Examinations. The organic book contains Thirteen Chapters that were clearly written, better illustrated and presented in Three Sections: Part I Structure (Nomenclature and Atomic Structure & Bonding) Part II Mechanism (Organic Reactions & Reaction Mechanisms) and Part III- Reactivity (Organic Terms, Hydrocarbons, Alcohols, Carboxylic acids, Carbohydrates, Lipids & Esters, Aromatic Compounds, Aliphatic Nitrogen compounds and Aldehydes & Ketones). Each chapter of the book reflects basic sophistications of a well-tutored and experienced writer and these qualities of presentation will certainly stimulates interests in learners. Sufficient for candidates preparing for General Certificate of Education, Polytechnic, University and other relevant examinations. This book, therefore is an additional material that would be highly useful for both students and teachers of Organic Chemistry Keywords: Organic Chemistry, Structure, Mechanism, Reactivity, Curved Arrow, Reaction ····· 10361135553
für 53.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Transition metals (Pd, Ni, Cu, Fe, Au) have played significant role in organic chemistry for creating organic molecules. One metal palladium with different ligands is being used as efficient catalyst for C-C bond formation. Palladium catalyzed reactions are used in the synthesis of many natural products, pharmaceutical drugs and advance materials. In this research work, Heck, Suzuki and Sonogashira reactions of di and tri halogenated and dihydroxy heterocycles (benzothiophene, pyrazine, quinoxaline, pyrimidine, furan and flavone) with photophysical properties of some alkynylated products of Pyrimidines and furans, have been studied in detail. ····· 10361146376
für 53.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Cancer is the leading cause of death of patients below the age of 85. Traditional chemotherapeutics, such as Taxol ® and Taxotere ® have had a significant impact in the field of chemotherapy because of their unique mechanism of action of inducing apoptosis by stabilizing microtubules during mitotic cell division. However, studies have indicated that these drugs are not active in multi-drug resistant (MDR) cancer cells. MDR arises from the overexpression of ATP-binding cassette proteins which enable the cancer cell to remove cytotoxic agents from the cell via ATP dependent efflux pumps, resulting in the loss of efficacy of the drug. In addition to the problem of MDR, traditional chemotherapeutics have little or no specificity, which leads to systemic toxicity, causing severe and harmful side effects. Therefore, it is important to develop next generation taxoids with increased potency and activity in MDR expressing cancers, as well as to incorporate these cytotoxic agents to tumor-targeting delivery systems to ensure selective cytotoxicity and reduce systemic toxicity. In general, these delivery systems include a tumor-targeting module and a cytotoxic agent. ····· 10361146716
für 53.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Photochromic molecules attract much attention because of their potential application to optoelectronic devices, such as optical memory media, photooptical switching and display. Here we have synthesized novel compounds dithia-dithienylethenophane derivatives and investigated photochromic performance in solution. Our main intention is restricted the rotation and fixation in a suitable position of dithia-dithienyl-ethenophane by using bridge chain and benzene ring for enhancement the photocyclization quantum yield. Dithia-dithienylethenophane is the first example of a dithienylethene bridged with a benzene ring. The dithia-dithienylethenophane derivatives exhibited photochromic properties upon irradiation with UV/VIS light. The distances between the reactive carbon atoms of the energy minimized structures of the open form were related to photocyclization quantum yields and those of ortho, meta and para isomers are 3.96 Å, 4.26 Å, 4.68 Å and 0.51, 0.42, 0.11, respectively. The thermal stabilities of the ortho, meta and para isomer of dithia-dithienylethenophane were examined at 100oC in toluene and the both photoisomers of the ortho isomer were thermally stable. ····· 10361147071
für 53.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray This study comprises a brief literature survey on the chemistry and biological activity of the bridgehead nitrogen thiazolopyrimidines. In addition to, the synthesis of certain new substituted and fused thiazolopyrimidines, some of these compounds were subjected to preliminary screening for their antimicrobial activity.The structural elucidation of the new compounds was supported by elemental analyses, IR, 1H-NMR, in addition to mass spectrometry on demand. Some of the new compounds were subjected to preliminary antimicrobial testing and the data obtained are summarized. ····· 10361147147
für 58.41€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Ce livre a contribué à la caractérisation de cinq Plantes de Madagascar à travers la composition chimique de leurs huiles essentielles (HE). Quatre plantes aromatiques et médicinales (Cymbopogon giganteus var. madagascariensis, Tana bojeriana, Croton kimosorum et Croton sp.) poussent à l`état spontané dans la région sub-aride du sud-ouest de Madagascar (Toliara) alors que l`espèce Vepris madagascarica est présente dans la forêt dense humide du nord-est (Vohémar). Ainsi, nous avons étudié par combinaison CPG(IR), CPG-SM et RMN 13C la composition chimique d`huiles essentielles obtenues par hydrodistillation (appareil type Clevenger) et par entraînement à la vapeur d`eau (Alambic). ····· 103614735
für 61.20€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Over the last years, the synthesis of organic compounds can be occured by chemical catalysts which have expensive price and harmful effects on the body. This book has a large collection from researches for 100 years ago which talk about catalysts using in synthesis of organic compounds. Also, it contains synthesis of antimicrobial biginelli compounds using natural catalysts like quartz and granite which are very cheaper, available and not harmful, In addition to it s extremely useful and highly efficient. The product could be separated simply from the catalyst, and the catalyst could be reused more times. The antimicrobial activity of some selected synthesized compounds was tested and showed moderate activity. Also, it contains some reactions for these compounds. It should be useful to researchers in chemistry specially in this field. ····· 10361783
für 61.20€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The Mannich reaction provides one of the most basic and useful methods for the synthesis of such compounds. The main objective of this study is to give the simple and one pot synthetic method for phenanthridines, azabicycles and cycloalkanones. Even though the Mannich reaction is one of the oldest reactions, the increasing popularity of the Mannich reaction has been fueled by the ubiquitous nature of nitrogen and oxygen in drugs and natural products as well as by the potential of this multicomponent reaction to generate diversity. From the above discussion it can readily be seen that the Mannich reaction offers great scopes and utilities. Because of its promising and challenging applications, the Mannich approach has been successfully used as the key step in the synthesis of first representatives of interesting azabicycles and unexpected analogs of phenanthridines and cycloalkanones have been achieved by simple three component one-pot fashion. The synthesized compounds were characterized by FT IR, 1H NMR, 13C NMR, mass spectral data and determine the actual spatial arrangement of atoms in the 3-D space, X-ray crystallography of the crystalline compounds were performed. ····· 1036119108
für 61.20€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray This monograph describes introduction of Prins cyclisation, previous approaches to the versatile intermediate 1,3 diols and its application in the synthesis of polyketide natural products. Scope of the prins cyclisation in the synthesis of multisubstituted tetrahydropyrans from aldehydes and homo allylic alcohols, is expanded. A new approach for the stereoselective synthesis of polyketide precursors containing 1,3-diol units, flanked by divergent alkyl branches with different functional groups. Using this 1,3 diol strategy synthesized biologically active molecule Crocacin C (antifungal and highly cytotoxic metabolite), Basiliskamide A & B (showed the antifungal activity against Candida albicans and Aspergillus fumigates). This monograph is unique with dealing with synthetic protocols for above natural products utilizing Prins cyclisation and 1,3 diol strategy including full experimental procedures, analytical data, complete references section and most useful for synthetic organic chemists. ····· 1036120089
für 61.20€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Biomimetic Modelling of Organic Synthesis: Studies Involving Cyclodextrins, briefely describes about the cyclodextrins and the structural features of its exterior surface and internal cavity, and its applications in biomimetic synthesis of selenazoles, thiazoles and amino thiazoles nucleophilic ring opening, oxidative deprotections, substitution and addition reactions in aqeous media. Cyclodextrins are mimicking enzymes in their capability to bind substrates selectively and catalyze chemical reactions through the reversible formation of host-guest complexes by non-covalent bonding. Based on this phenomena, in this work efforts have been made for attaining higher regioselectivities in various ring opening reactions. This work also explores the anionic reactions in aqeous media and in open air atmosphere and contributes greately to the green chemistry by minimising the usage of hazardous organic solvents. ····· 1036120386
für 61.20€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Thiazolo[3,2-a]benzimidazole derivatives have been associated with diverse biological properties. Many of their therapeutic applications have been reported in the literature. Their activities extended to other applications rather than medicinal fields. They are used in magnetic recording disks and photographic agents. These considerable activities stimulated our interest in the synthesis of several new heterocyclic derivatives of potential biological activity pendant to thiazolo[3,2-a]benzimidazole moiety at C2. The present study was undertaken to explore the utility of 1-(3-methylthiazolo[3,2-a]benzimidazol-2-yl)ethanone, 3-methylthiazolo[3,2-a]benzimidazole-2-carboxylic acid ethyl ester and thiazolo[3,2-a]benzimidazol-3(2H)-one for the synthesis of a variety of fused heterocyclic ring systems which could possess interesting and useful biological and pharmacological properties. Many new thiazolo[3,2-a]benzimidazole derivatives have been synthesized, but there are still new aspects to explore and work on. In addition, more attention has to be paid for the molecular basis of mode of actions. Rational drug design methods could be applied and more drug candidates can be obtained. ····· 1036120395
für 61.20€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The book entitled Modern synthetic strategy for anti-viral nucleosides deals with the synthesis of four new series of nucleosides, their characterization and antiviral screening. Chemically, viruses are nucleoproteins containing either deoxyribonucleic acid (DNA) or ribonucleic acid (RNA) surrounded by a protective protein sheath. Nucleoside analogues are used as anti-viral therapeutic agents. The development of antiviral drugs encountered lots of difficulties and the research in antiviral chemotherapy gained less attention. Although vaccination is a valuable tool to fight viral diseases and in some cases is available and successful, the difficulty associated with state-wide or world-wide vaccination programs makes antiviral chemotherapy a more practical approach in the fight to epidemic viral infections.The importance of these nucleoside analogues was later confirmed with the emergence of HIV as the main etiological agent of AIDS. Due to growing awareness about environmental pollution, library synthesis of target nucleosides by using green protocols is desired. With this objective new nucleosides have been synthesized using green protocol and screened for their antiviralactivity. ····· 1036121384
für 61.20€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray This monograph features the studies directed towards the total synthesis of architecturally and biologically interesting polypropionate natural products (-)-Ebelactone-A and (-)-Maurenone utilizing desymmetrization as a key strategy. ( )-Ebelactone A, show structural characteristics in common with macrolide antibiotics. Ebelactones act as potent inhibitors of esterase s, lipases and N-formylmethionine amino peptidases, and they have shown to produce enhance immune responses. They are also reported to inhibit cutinases produced by fungal pathogens. Novel biological activity combined with unique and challenging structure of Ebelactone, made this compound an exciting target for the total synthesis. Secondly, this book described an efficient synthetic protocol for polypropionate natural product (-)-Maurenone, which was isolated by Faulkner et al. in 1986 from specimens of the pulmonate mollusc Siphonaria maura. This monograph is unique in dealing with many interesting synthetic protocols including full experimental procedures, analytical data for all synthetic materials and complete reference sections. This monograph can be served as a good hand book for synthetic organic chemists. ····· 1036121606
····· lezzter Preis 61.20€ ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The introduction part in this work presents a systematic and comprehensive survey of the methods of preparation and the chemical reactivity of cyanoacetamide derivatives. These compounds are important intermediates for the synthesis of a variety of otherwise difficulty accessible, synthetically useful and novel heterocyclic systems, for this reason. We focused our aim to use starting material possess a wide variety of potentially useful applications including biological, clinical and pharmacological areas. We found 4-aminoantipyrine (4AAP) possess the previously mentioned properties, so we used it as precursor to prepare polyfunctionally substituted heterocyclic compounds. The work divided into two parts, the first part discussed the utilization of N-(cyanoacetyl) aminoantipyrine for building new heterocyclic compounds. The second part discussed the formation of novel heterocyclic rings via the use of antipyrinylhydrazonomalononitrile as starting material. Both two parts followed by antimicrobial screening for the selected prepared compounds. ····· 1036125049
für 61.20€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray This book emphasizes mainly on polyurethanes, raw materials to synthesize it, its applications and synthesis of polyurethane-based block copolymers. Polyurethanes are arguably the most multifaceted family of polymers. Polyurethanes can be prepared range from soft elastomeric polymers to hard elastoplastics. Polyurethanes are used as structural materials, coatings, adhesives, hydrogels and sealants. This book presents the details of polyurethane synthesis and its chemistry, preparation of different kinds of polyurethane ionomers and block copolymers. ····· 1036186604
für 61.20€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray 1. All the 1,2,4-triazole derivatives prepared are pro-drugs since all have -N-C=O or -N-C=S links, which are enzymatically degradable, thus releasing both i.e. 1,2,4-triazole and the ligand at the target site. 2. The conjugate of curcumin with triazole has been found to be a more potent antifungal and antibacterial reagent. Further in vitro and in vivo experiments can be carried out. 3. 1,2,4-triazole dervative of isoproturon has been found to be most effective herbicide which could be used as a substitute of isoproturon. Further field trials are required. 4. The observed enhanced activity of all these synthetic compounds may be due to their combined effect at the receptor, producing synergism. 5. However, the validation of this synergistic effect needs further work. 6. The results have opened a new approach for designing novel and more effective pro-drugs. ····· 1036187592
für 61.20€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray This book is a result of an investigation of organic chemistry instructional techniques used in Kenya to determine their effectiveness in enhancing understanding of organic chemistry concepts. The author addresses the problem of students poor performance in organic chemistry. The book is based on a study conducted in the Rift Valley and Western provinces of Kenya in which quantitative data generation and analysis was largely employed. The major finding was that teachers instructional practices do not conform to the expectations of good teaching. Dr. Waswa argues that stakeholders such as: chemistry teachers, heads of department, heads of schools and quality assurance officers should encourage adherence to lesson plans by every organic chemistry teacher. This book is a must-read for chemistry teachers, chemistry teacher trainees, chemistry teacher trainers, Heads of Science departments, and Quality assurance Officers in Kenya and beyond. ····· 1036187711
für 61.20€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray In the last three decades, conjugated polymers have attracted much attention as active materials for optoelectronic applications, such as PLEDs, field-effect transistors, photovoltaic cells, optical switching devices, data storage devices etc. However, design and synthesis of -conjugated polymers with low oxidation potential, broad absorption spectrum, low band gap, efficient photoinduced charge transfer and separation, and ambipolar charge transport with high mobilities, effective -electron delocalization are crucial for the fabrication of the devices. In particular, tuning of the HOMO/LUMO energy levels of these polymers is of great importance for directing material properties towards the desired applications. A deeper understanding of structure-property relationship would help in designing new organic conjugated molecules by the judicious choice of functional substituents, and thus to tune their optical properties for applications in optoelectronic devices. In this context a series of donor-acceptor conjugated polymers are designed and are synthesized in this work. These polymers with good material properties are potential candidates for optoelectronic device applications. ····· 1036199414
für 61.20€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Plants have been one of the important sources of medicines even since the dawn of human civilization. Recently, in spite of tremendous development in the field of allopathy, plants still remain one of the major sources of drug in the modern as well as traditional system of medicine throughout the world. Over 60% of all pharmaceuticals are plant-based. In this work we tried to reinvestigate the two medicinal plants (Cynanchum acutum L.) and(Curcuma longa L.) hoping for isolation and characterization some further bioactive natural products. ····· 1036199692
für 61.20€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The present dissertation deals with the isolation and characterization of constituents from two Pakistani medicinal plants and their subsequent biological activities. The isolated compounds were characterized by using various sophisticated spectroscopic techniques. Indigofera hetrantha Wall. belongs to the family Leguminosae and has found diverse medicinal uses in the indigenous systems of medicine. Phytochemical studies on the ethyl acetate soluble fraction of Indigofera hetrantha, collected from Swat (Pakistan), have resulted in the isolation and structure elucidation of five new and four known therapeutic agents. Periploca aphylla Decne. (Asclepiadaceae) occurs in the northern areas of Pakistan and finds various uses in the indigenous system of the medicine. Photochemical studies on the ethyl acetate soluble fraction of Periploca aphylla, collected from Swat (Pakistan), have resulted in the isolation and structure elucidation of three new and six known therapeutic agents. ····· 10361100072
für 61.20€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The conventional cationic surfactants existing in the field of fabric softeners are diminishing worldwide on account of stringent environmental regulations. It is, therefore, need of the hour to synthesize fabric softening cationic molecules which shall impart remarkable softening and possess rapid and complete biodegradability. Esteramide quaternaries are, therefore, gaining edge over existing cationic species for fabric softening. The aim of the book is to provide latest information on synthesis and characterization of piperazine based esteramide quaternaries from renewable fatty feed stock. The physico-chemical and surface active properties of esteramide quats have also been studied thoroughly. Furthermore, development of cost- effective softeners derived from cheaper fatty acids has been emphasized. ····· 10361102998
für 61.20€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Through this book, we can see that the synthesis of steroids continuous to be a challenge for many teams of research. Indeed, due to the molecular biology, the bio-chemistry of steroids is going to be better understand. The steroids receptors are going to be better explored. the biological activities of those oxo steroids for which data are available have been given. we note that most of the efforts till now were concentrated on the synthesis of steroids containing a new ring fused to a ring A, ring D are bridging ring A and B ····· 10361113857
für 61.20€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Diamond display some of the most extreme physical properties even though its practical use in science and engineering has been restricted due its scarcity and expense. With the recent developments of techniques for the deposition of thin films of diamond on various substrates, it is now possible to explore these superior properties in various exciting applications.In this book, we have contributed to the development of easy, controllable and specific surface functionalization methods for the introduction of different functional groups on the diamond surface. These methods are based on chemical, photochemical, and electrochemical concepts. ····· 10361114383
für 61.20€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray This thesis reports the design and synthesis of guanidinium-based receptors as multiple hydrogen bond hosts for molecular recognition of anions with a special emphasis on small anions such as nitrate and the anti-inflammatory drug Naproxen.Despite its significant involvement in environmental pollution, little attention has been given to nitrate by supramolecular chemists. This books reports the design of several macrocycles combining a guanidinium and two urea moieties for an optimal complement of size, charge and binding sites to nitrate. Naproxen is the only Non-Steroidal Anti-Inflammatory drug (NSAID) marketed as a pure enantiomer. The industrial preparation of the drug involves the synthesis of the racemic acid followed by a resolution process to afford the desired compound (resolution accounts for two thirds of the production costs). Here, we propose as an alternative the use of a physical separation method (liquid-liquid extraction) employing a chiral receptor. ····· 10361118305
für 61.20€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray In this thesis, novel oxime ligands, bearing hydrazone, thiosemicarbazone and semicarbazone side groups which have not been described in the literature previously were synthesized and investigation of metal extraction and antibacterial properties. Their complexing properties were studied by the liquid-liquid and solid-liquid extraction. The ligands have been prepared and tested in vitro against different microorganisms in order to assess their antibacterial properties. ····· 10361118621
für 61.20€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Over the past half century, the absolute configuration of thiopeptide antibiotics such as Thiocillin I has baffled chemists until the first correct synthesis of Micrococcin P1 in 2009. At this point we had to answer two questions - first, does the absolute configuration hold true for its natural analogues Second, can we design a more efficient synthesis of the tri-substituted pyridine core The current synthesis sheds light on these problems especially for medicinal chemists who wish to explore the SAR for the purposes of drug development. ····· 10361118941
für 61.20€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The design and synthesis of nucleoside analogues as potential anticancer and antiviral agents is a very dynamic field of research. The core objective of this intense research is amendment in sugar and base moieties to make the nucleoside more apt for therapeutic response. The drug industry now a day is giving more emphasis on chiral molecules as these are much more specific to the target. Even the two enantiomers of a particular substrate may interact differently with different chiral pockets and show different kinds of activity. So it is imperative to devise routes to nucleosides, which yield desired molecular structures with specific stereochemistry. Carbohydrates with six chiral centers are nice starting materials for this purpose. Among the carbohydrates, D-glucose is a useful chiral template, as it is cheap, easily available. Three chapters of this book is dealing with the use of various simple and useful reactions on glucose molecule to synthesize chiral carbocyclic (Chapter 1), heterocyclic (Chapter 2) and bicyclic (Chapter 3) nucleosides and analogues. ····· 10361119084
für 61.20€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray This book is divided into two sections sections A and B. Section A describes the isolation and structure elucidation of seven known compounds [1-7] i.e. stigmasterol (1), -sitosterol (2), -sitosterol glucoside (3), oleanolic acid (4), harmine (5), 7,3`,4`-trimethoxyflavone (6), and 5-methylflavanone (7). Compounds [5-7] were for the first time reported from this plant. Section B describes the synthesis of 2, 4, 6-trichlorophenylhydrazones and 6-nitrobenzimidazole derivatives. These synthesized compounds were also biological screened for their glycation of protein, -chymotrypsin, carbonic anhydrase, urease, antioxidant (DPPH and superoxide anion scavenging assays) and phosphodiesterase activities. Interestingly, most of these synthesized compounds showed excellent medicinal activities. ····· 10361134593
für 61.20€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Homoallylic alcohols and amines are fundamental building blocks for many biologically active compounds. The allylation of carbonyl compounds with allyl organometallic reagents constitutes a simple and straight forward approach for their synthesis. Allyl indium reagents have emerged as a reagent of choice for allylation of carbonyl compounds under both aqueous and non-aqueous conditions. However, in application of this approach for the synthesis of homoallylic alcohols/ amines from ketones/ imines, the lower electrophilicity of ketone/imine carbon makes the transfer of allyl group to ketone/imine carbon much more challenging. The ease of hydrolysis of imine to carbonyl compound and amine further add to the difficulties. The present work is aimed to unravel the regio- and diastereochemical aspects in indium mediated allylation of ketones bearing proton donor groups (OH, COOH) alpha to carbonyl moiety and imines derived from heterocycles like pyridine-2-imines, quinoline-2-imines and indole-3-imines. In selected cases the homoallylic alcohols have been subjected to iodine mediated cyclization to provide 2,3-diaryltetrahydrofuran and 3-hydroxy-3,4-dihydrofuran-2(5H)-one derivatives. ····· 10361135682
für 61.20€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Native and modified cyclodextrins act as robust hosts for a variety of guest species in water, and therefore are at the centre of supramolecular chemistry. Covalently linked cyclodextrin dimers provide many advantages over their native counterparts in binding guest species in terms of their stability, selectivity or flexibility. The studies underpinning this book are based on the two beta-cyclodextrin dimers, N,N -bis((2AS,3AS)-3A-deoxy-beta-cyclodextrin-3A-yl) succinamide and N,N -bis(6A-deoxy-beta-cyclodextrin-6A-yl) succinamide and the two gamma-cyclodextrin dimers, N,N -bis((2AS,3AS)-3A-deoxy-gamma-cyclodextrin-3A-yl) succinamide and N,N -bis(6A-deoxy-gamma-cyclodextrin-6A-yl) succinamide, in which the two beta-cyclodextrin or gamma-cyclodextrin cavities are joined together through either the C3A or C6A carbons, respectively. The fascinating host-guest complexation events of these linked cyclodextrin dimers with various guest species ranging from small organic dyes to biologically important molecules and polymers will be presented. This book will appeal to people studying or working in the field of supramolecular chemistry. ····· 10361146479
für 61.20€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Biochemistry, sometimes called biological chemistry, is the study of chemical processes in living organisms, including, but not limited to, living matter. Biochemistry governs all living organisms and living processes. By controlling information flow through biochemical signalling and the flow of chemical energy through metabolism, biochemical processes give rise to the incredible complexity of life. Much of biochemistry deals with the structures and functions of cellular components such as proteins, carbohydrates, lipids, nucleic acids and other biomolecules although increasingly processes rather than individual molecules are the main focus. Over the last 40 years biochemistry has become so successful at explaining living processes that now almost all areas of the life sciences from botany to medicine are engaged in biochemical research. Today the main focus of pure biochemistry is in understanding how biological molecules give rise to the processes that occur within living cells which in turn relates greatly to the study and understanding of whole organisms. ····· 10361147315
····· lezzter Preis 62.10€ ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray La dieta mediterránea es objeto de numerosos estudios en cuanto a los efectos beneficiosos que produce en el organismo, principalmente por su incidencia positiva en la prevención de los accidentes cardiovasculares. El éxito de esta dieta es atribuido principalmente a su componente graso mayoritario, el aceite de oliva virgen. Su importancia radica en su alto contenido en ácido oleico y en compuestos fenólicos. Estos últimos destacan por su elevada actividad antioxidante, sobre todo los orto-catecoles. El hidroxitirosol y el tirosol son dos de estos biofenoles y se encuentran en diversas fuentes naturales, siendo especialmente importante su presencia en el olivo.El hidroxitirosol se ha convertido en objeto de numerosos estudios por parte de diferentes grupos de investigación de todo el mundo. Presenta una capacidad protectora frente a la oxidación mucho mayor que los aditivos antioxidantes habitualmente utilizados por la industria alimentaria, fundamentalmente tocoferoles y BHT.Además se ha demostrado que presenta actividad antimicrobiana, antihipertensiva, hipoglucémica, antiagregante plaquetaria, cardioprotectora y antiinflamatoria. ····· 1036124290
für 62.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Desde los orígenes de la humanidad el hombre se ha relacionado con las plantas, primero como fuente de alimentos y posteriormente, a medida que fue conociendo sus propiedades, las empleó como medicamentos entre otros propósitos. Actualmente, existe un gran interés en utilizar para este fin productos naturales de origen vegetal en lugar de sustancias sintéticas. La búsqueda de estos compuestos se realiza mediante investigaciones fitoquímicas que se basan en la determinación cuantitativa y el aislamiento de metabolitos que son evaluados para su posterior aplicación como fármacos u otras aplicaciones. En este libro se aborda el estudio del Agave brittoniana Trel.,especie endémica cubana conocida por la población como Maguey , vocablo que proviene de la cultura taína. Estas plantas crecen en la región central de la isla y pertenecen al género Agave (fam. Agavaceae) son ricas en azúcares, compuestos lipídicos, sapogeninas y saponinas esteroidales, metabolitos que se caracterizan por poseer una amplia gama de actividades biológicas. ····· 1036189996
····· lezzter Preis 67.41€ ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The present work is dedicated to the development and application of oxidative palladium(II)-catalyzed carbocyclizations. A general procedure for an aerobic palladium(II)-catalyzed endo cyclization of indole derivatives is presented. Further application of this new methodology in the synthesis of C-2 alkenylated indoles in diastereomerically pure form is also reported. The other methodologies involves hydroxy-directed diastereotopic group selection of prochiral bis(homoallylic) alcohols and enantioselective Fujiwara Moritani cyclizations. In addition to this, the book also details on the indole directed aerobic dehydrogenation of cyclohexenes. ····· 1036125898
für 71.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The study shows the phytochemical investigation on the leaves of Strobilanthes crispus L. The structures of the isolated compounds were elucidated with the aid of chromatographic and spectroscopic techniques including GC, GC-MS, EI-MS, IR, UV, 1D and 2D NMR. The extracts and the isolated compounds were tested for antibacterial activity using the micro-dilution antibacterial assay, and anti-cholinesterase activity using the microplate assay. ····· 1036115
für 71.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Heterocycles in general and nitrogen heterocycles in particular constitute the lion s part of the classical divisions of organic chemistry and are of immense importance biologically, industrially, and indeed to the healthy functioning of any developed society. The majority of pharmaceuticals/ biologically significant/ agrochemicals/ commercially used available entities are heterocyclic compounds. They are available in living systems, viz. DNA-RNA bases, vitamins, enzymes, hormones etc. which play a crucial role in the biochemical processes. Relevant to the proposed project are the nitrogen heterocycles, which normally form the basic skeleton of alkaloids. To be specific, this proposed project involves the works on pyrimidines the RNA nucleobase, whose biochemical role is well known. This book entitled Pyrimidine Chemistry: Synthesis, Structure and Bioactivity of some Uracil Derivatives comprises of seven Chapters. Each chapter is divided into sections namely Introduction, Materials and Methods, Results and Discussion (including Bioactivity test), Conclusion, Experimental Section and References respectively (excluding Chapters 1 & 7). ····· 1036119185
für 71.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray This book was written to stress basic concepts in organic chemistry and for students to appreciate some of its applications. My classroom experience had confirmed that a clear introduction to organic chemistry should communicate the excitement of its application to our daily lives.This book carefully develops the reasoning students need to understand basic reactions and the working methods of organic chemistry. The book is intended primarily to serve beginning chemistry students with little or no instruction on organic chemistry. Accordingly it provides a solid base for the subject that promotes understanding and critical thinking, while simultaneously limiting the scope to the presentation and introducing applications to agriculture, biochemistry & the chemical industry.Structure and nomenclature are important in appreciating the physical and chemical properties of organic compounds. Significant portion of the book is devoted to structure and naming of organic compounds. Reactions of organic compounds are determined to a large extent by functional groups. Characteristics and reaction patterns of common functional groups have been treated extensively. Over 300 MCQs are included. ····· 1036120032
für 71.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The present work is devoted to the catalytic generation of silicon-based cuprates and their application in several C Si bond-forming reactions. A general procedure for the catalytic preparation of Cu Si nucleophiles via activation of Si B interelement linkages is described. This versatile copper(I)-catalyzed protocol involving formation of regioselective C Si bonds enables excess to a variety of organosilicon compounds. The detail investigations ascribing our preliminary attempts to transform into enantioselective variant in presence of different chiral ligands are also presented. In addition to this, the book also details on the study to explain the stereochemical surprises in reagent- controlled Lewis acid-mediated allylation of isatins with -chiral allylic stannane. ····· 1036120425
····· lezzter Preis 71.10€ ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Los oxiranos juegan un papel importante como intermedios en síntesis orgánica, porque su reacción de apertura, tanto con electrófilos como con nucleófilos, permite la obtención de compuestos 1,2-difuncionalizados y la formación de nuevos enlaces carbono carbono. Esta reactividad química es responsable de la actividad biológica que exhiben los compuestos que contienen esta función. Así, determinados glicosil glicidoles (oxiranos derivados de alquenil glicósidos) presentan actividad citotóxica y pueden ser utilizados como agentes alquilantes en la quimioterapia anticancerosa. Dado que un importante número de productos naturales y compuestos farmacéuticos (anticolvusivantes, insecticidas piretroides ) está presente la unidad de ciclopropano la síntesis estereoselectiva de ciclopropanos constituye un objetivo de interés en Química Farmacéutica. En este trabajo hemos estudiado con detenimiento el uso de hidratos de carbono como auxiliares quirales en la ciclopropanación selectiva de alquenos unidos al esqueleto del azúcar. Hemos utilizado varias configuraciones del inductor, es decir, hemos variado la naturaleza del hidrato de carbono, el tipo de protección de los diferentes hidroxilos ····· 1036123529
····· lezzter Preis 71.10€ ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Furan and benzofuran derivatives have attracted particular attention due to their chemotherapeutic activity such as cytotoxic and antitumor antispasmodic, antimicrobial and several other useful activities. In view of the above mentioned facts, and in continuation of an ongoing program aiming at finding new lead structures with potential biological activities, it was rationalized to synthesize some new heterocycles containing furan and/or benzofuran moieties and to investigate their antimicrobial activities hoping to induce some biological synergism. ····· 1036124623
····· lezzter Preis 71.10€ ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The thesis entitled `Synthesis of Sphingolipids, Azasugars and N-Heterocyclic Compounds-their Bio-evaluatuin has been divided into two parts, Part A and Part B, each part is further divided into two Chapters. PART A: Chapter 1 deals with the importance of Sphingolipids and summarizes some of the important approaches towards these bioactive molecules and stereoselective synthesis of desired D-ribo-Phytosphingosine, D-erythro-Sphingosine and Sphinganine from D- Mannitol. Chapter 2 deals with the importance of azsugars and summarizes some of the important approaches towards these bioactive azasugars and stereoselective syntheses of desired 1-Deoxynojirimycin, D-Glucono- -lactam and D-Altrono- -lactam from D-Mannitol. PART B: Chapter 3 dealt with the introduction to Baylis-Hillman reaction and their applications and describes the syntheses of 2-pyridones and aminonicotinates. Chapter 4 dealt with the introduction to 1,4-Dihydro pyridines (1,4-DHPs) summarizes some of the earlier methods to 1,4-DHPs syntheses and describes the syntheses of 4-(2-chloropyridyl)-1,4-dihydropyridines derivatives and their evaluation of antituberculosis activity. ····· 1036125114
für 71.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The present investigation comprises a survey covering the antioxidant activities of compounds containing the oxadiazole, thiadiazole and triazole ring system, with particular reference to benzimidazole and indole derivatives. In this work, 34 intermediates and 128 new compounds derived from indole and benzimidazole were synthesized. The structures of new compounds were confirmed by both analytical and spectral data (IR, NMR and MS). The antioxidant activities were tested in vitro using DPPH radical scavenging assay. ····· 1036186950
für 71.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray This monograph is a condensed form of the fundamental knowledge on the named reaction Prins cyclization in organic synthesis. This monograph consists of three distinct chapters: chapter 1 provides detailed description of the Prins cyclization, contemporary approaches to the synthesis of chiral 1,3-diol units and application to the total synthesis of biologically active natural products chapter 2 describes the historical and biological background of the naturally occurring, cytotoxic 14-membered macrolide (+)-Neopeltolide, including their isolations, structural elucidation and previous synthetic approaches and my synthetic route to the total synthesis of (+)-Neopeltolide macrolactone, while chapter 3 provides information on the use of Prins cyclization for the synthesis of 4-iodo, 4-amido, 4-azidotetrahydropyran derivatives. This monograph is an indispensable reference for any chemist working with tetrahydropyran, dihydropyran and piperidine containing natural products. ····· 1036187432
für 71.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The electronic and optical behavior of conjugated small molecules constitutes one of the most extensively studied properties of this class of organic compounds. In particular, electron donor-acceptor compounds separated by -conjugation have attracted much research interest because of their applications as electroactive and photoactive materials in molecular electronic areas such as fluorescent technology, chemoluminescence, and photovoltaics. This work aims to demonstrate the synthesis and some of the interesting properties of new carbazole, indole, and diphenylamine donor-based donor-acceptor compounds. Basically, we have divided our compounds into two groups: (a) aromatic fumaronitrile core-based compounds and (b) 2,7-carbazole linker-based compounds. We designed and synthesized these compounds for possible applications in electroluminescent devices (such as OLEDs), organic sensors, organic nanoparticles, sensitizers in organic dye-sensitized solar cells (DSSCs), and other optoelectronic devices. We have shown their possible application in above mentioned fields by doing relevant experiments as discussed in the body of the book. ····· 1036191486
für 71.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The inflammation process involves a series of event that can be elicited by numerous stimuli (eg infectious agents, ischemia, and antigen-antibody interaction). The seriousness and enormous after effects of steroid therapy necessitated an accelerated research towards the development of NSAIDs since the past two decades. Quinazoline derivatives have been reported to possess significant activity as anti-inflammatory agents. Triazoles were reported to possess diverse pharmacological activities such as anti-inflammatory activity. In addition, triazine derivatives were found to posses antimicrobial activity. Combining these two structure features in one molecule might produce compounds with promising biological effects. In continuation of my interested research program in design and synthesis of heterocycles containing benzene sulfonamide moieties. In this book, I sought to synthesis and structure elucidation evaluation of some novel anti-inflammatory triazoloquinazoline and triazinoquinazoline having biologically active benzene sulfanilamide moieties. In addition, the acute toxicity of anti-inflammatory compounds was evaluated in order to assess its safety. ····· 10361112940
für 71.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray This book targets a broad readership for young researchers(Postgraduate students) in X-ray crystallography and Quantum Chemistry as it contains a wide and comprehensive coverage of all important aspects of the subject including up-to- date survey of recent revolutionary advances. Molecular structure determination using crystallographic technique of pyrazolo[3,4-d] pyrimidines, naturally occurring drugs as well as synthetic molecular crystals has been discussed.The optimized structures and the electronic properties of the molecules using quantum mechanical methods have also been discussed and results have been compared with crystallographic data, which could enable one to understand and evaluate different quantum mechanical methods. It should be a valuable asset to established researchers in this area due to very detailed explanation of the behavior of aromatic - interactions on the basis of experimental and theoretical results. The crystallographic and theoretical investigations on some synthetic and natural drugs attract the research in the area of drug design using Molecular modeling of the reported compounds with suitable targets. ····· 10361113318
für 71.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The work describes the isolation of some tetranortriterpenoids from meliaceae family along with their characterization using NMR, Single crystal X-ray Diffraction studies etc. Chemical modifications of some selected molecules have been reported and the antifeedant activity of all molecules have been assayed against spodoptura litura.Finally, some insilico studies were carried out, which pointed to some molecular parameters (descriptors) that might be responsible for the antifeedant activity of these molecules ····· 10361114133
für 71.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray This book is based on a research study in synthesis and characterization, properties and investigation of new monomers and polymers containing electroactive fragments. Some of the derivatives could be used as hole transporting materials as well as hosts in organic light emitting diodes or in electrographic photoreceptors. Also there are presented series of new crosslinkable derivatives their synthesis, characterizaton, preparation and investigation for electroactive polymeric networks. Some of the insoluble electroactive systems are suitable for preparation of multilayer organic light emitting devices. ····· 10361114444
für 71.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Several approaches to the synthesis of a natural acetyl cholinesterase (AChE) inhibitor, cyclophostin and an isosteric endophosphonate analog were explored. These bicyclic molecules posses a novel seven membered cyclic enolphosphate/phosphonate ring fused to a butyrolactone. Two basic synthetic strategies: a) lactonization followed by the seven membered ring formation and b) the seven membered ring synthesis followed by lactonization, were applied in these syntheses. The synthesis of the endophosphonate analog, following strategy a, gave an unexpected enolether lactone molecule. Alternatively, strategy b successful produced the endophosphonate analog as a separable mixture of two diastereomers. Synthesis of cyclophostin was explored by strategy b. Attempted C-acetylation of an acyclic phosphate intermediate resulted in an unanticipated formation of cyclopropane ring. Following an alternate approach by strategy a, the natural product and its unnatural diastereoisomer were produced. Biological studies with cyclophostin, endophosphonate analog and various synthetic intermediates lead to the discovery of new class of AChE inhibitor. ····· 10361114937
für 71.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Crystal structure plays an important role in determining chemical and mechanical properties of polymers.Elucidating the crystal structure of polymers is extremely difficult particularly in obtaining a sizeable crystal for XRD analysis.This work prove the viability of computer modelling approach interfaced with simulated XRD diffraction. High-performance aromatic polymers based on the 4,4`-biphenylene, 1,3-phenylene,isophthaloyl bis(4,4`-biphenylene) and p-terphenyl units were synthesized and their crystal structures investigated. The polymers show extreme thermal stability and are insoluble in almost all organic solvents.Oligomer and polymer crystal structures were constructed using computational modelling and quantitatively compared with simulated diffraction via Rietveld Analysis. Molecular mechanics force-fields were optimised from conformational and crystal packing data determined from oligomeric analogues by X-ray single-crystal and powder diffraction methods. ····· 10361115195
für 71.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Polypyrrole (PPy) as a conducting polymer has potential applications in electrical and electronic devices. This book therefore aimed to produce novel polypyrrole fibres via the development of nanostructured conducting polypyrrole by fibre spinning of PPy and to investigate the formed fibres for applications such as actuators, e-textiles, batteries, sensors and biomedical areas. As a result polypyrrole fibres have been produced for the first time. Subsequent work sought to improve the properties of these first generation PPy fibres by increasing the molecular weight, addition of carbon nanotubes (CNTs) and addition of a supporting polymer (alginate). The use of the host polymer also enabled a new fibre spinning method to be developed that included an in situ polymerization process. The highest conductivity and Young`s modulus of any conducting polymer based fibre reported to date was obtained by incorporating PPy into a CNT yarn. In summary, a range of novel fibres PPy materials have been developed for possible use in applications such as actuators, sensors, artificial muscles, batteries and biomedical applications. ····· 10361115206
für 71.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Organophosphate esters have wide scope in insecticides, herbicides and plasticizers industries etc. Since the organophosphate compounds have been reported biologically active, therefore it is essential to study the organophosphates systematically at all the faces of reactions. Now the emerging concern is the effect of Organophosphate esters on the environment. Many organophosphates are potent nerve agents, functioning by inhibiting the action of acetylcholinesterase (AChE) in nerve cells. Organophosphate esters are one of the most common causes of poisoning worldwide, in agricultural areas. This study is very important in present scenario. For researchers it is essential to pay desirable attention to the effect of each factor, as the rate of reaction is influenced by a number of factors such as ionic strength, concentration, temperature, solvent and catalyst etc. This book provides the detailed kinetic study on the hydrolysis of these Organophosphate esters. This study should be useful to Environmental Scientists ····· 10361115226
für 71.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Synthesis, Characterization, Anti-Proliferation, Benzimidazole Derivatives, FTIR, HRMS, 1D, 2D NMR spectroscopy, X ray crystallography, benzylation, addition/elimination, cyclization reactions, o- vanillin, o-, m-, p-phenylenediamines, 2-benzyloxy-3- methoxybenzaldehyde, 2-amino-N-benzylidene benzeneamines, bis-Schiff bases, six , five membered illusory rings, tetrahedral mechanism or addition/elimination mechanism, breast cancer cell line MCF 7, colon cancer cell line HCT 116, MTT assay, cytotoxicity, and IC50. ····· 10361116046
für 71.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray New materials are the lifeblood of solid state research and device technology. Contrary to what many believe, new materials are not usually discovered by device engineers, solid state theorists, or research managers they are mostly discovered by crystal chemists who are crystal growers. Some physical phenomena are only exhibited in single crystals and can only be studied and understood in single crystals. Thus the crystal grower - especially if he develops a proficiency in relating structure, bonding and other chemo-physical considerations to properties of interest is in a key position in determining the direction & success of solid state research and ultimately technology.There is a need for new lasers with exciting combination of light properties such as wide spectral tuning ranges & large bandwidth for communication systems. While a variety of materials have been studied for their NLO activity, the organic materials have been receiving the maximum attention because of their ultra fast response time, photo-stability and large first order hyper polarizability values.In this view some new organic compounds have been synthesised, grown, characterised, irradiated & discussed ····· 10361116107
für 71.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray El presente trabajo se divide en tres partes. La primera parte se ha dedicado al estudio fitoquímico de especies endémicas del Rif, por ejemplo el abeto de Marruecos (Abies marocana) y la especie de tejo que crece en los bosques del norte de Marruecos (Taxus baccata), con especial atención a la búsqueda de metabolitos útiles para la semi-síntesis de productos de alto valor añadido. Posteriormente, se abordó el desarrollo de nuevos métodos de síntesis basados en metales de transferencia monoelectrónica, con especial atención a los complejos de titanoceno(III). En este sentido, la parte más extensa de la tesis se ha dedicado al desarrollo de nuevos métodos de formación de enlaces C-C en sistemas que combinan complejos de titanio con otros metales. Finalmente, se realizó un esfuerzo considerable para aplicar los nuevos métodos desarrollados a la síntesis y confirmación estructural de algunos metabolitos escasos en las especies forestales del Rif. ····· 10361117160
für 71.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The phytochemical screening of the plant (Cissus multistriata) revealed the presence of important phytochemicals, such as saponins, steroids, flavonoids etc. Important glyconutrients such as xylose, fucose,mannose and galactose have been detected to be present in this plant. Based on the nutrients resident in this plant it is hoped that it can serve as better dietary supplement. From the result of this investigation, this plant does not possess anti diabetic properties as claimed by the users, but have demonstrated the potential of hypocholesterolemic capacity, hence can be used in the management of cardiovascular diseases. It is inferred from this work that the detected glyconutrients are contributory to the antimicrobial activities of this plant. The plant extract can be used in the management of hemolytic anemia and that the herbal extract is relatively safe at lower doses, exerts weak inhibition to Artemia salina (brine shrimps) hence cytotoxicity is quite low. The plant exhibited great antioxidant activity with the unripe fruit and stem having the highest. ····· 10361118508
für 71.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray This book describes the development of `smart` biomaterials based on the naturally derived poly-[(R)-3-hydroxybutyrate](PHB). The first part of this book focuses on biodegradable multiblock thermoresponsive poly(ether ester urethane)s consisting of poly(ethylene glycol) (PEG), poly(propylene glycol) (PPG) and PHB. The physical properties as well as applicative studies of these gels such as drug release and tissue engineering are presented. In the second part, the preparation of novel thermoresponsive micelles is presented. Using this copolymer, a thermoresponsive substrate was fabricated by drop-coating with an aqueous polymer solution, and used for the attachment and nonenzymatic temperature-induced detachment of human mesenchymal stem cells and mouse embryonic stem (ES) cells. The promising results from the studies show that these copolymers could be utilized as surface modifiers for tissue engineering applications. In summary, the synthesis of novel smart biomaterials and their application in the fields of drug delivery and tissue engineering are described in this book. ····· 10361119523
für 71.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray In recent years many specialised works on specific topics in heterocyclic chemistry have appeared, while at the same time the more general text-books on organic chemistry have not given this important part of the subject the attention it deserves. In fact, the chemistry of heterocycles lies at the heart of drug discovery. During the last few decades, a considerable attention has been devoted to synthesis of heterocyclic Compounds and their derivatives possessing such comprehensive bioactivities as antimicrobial, anti inflammatory, analgesic, antitumorial, antihypertensive, anti convalsant, anti cancer, anti HIV and antiviral activities. Literature survey reveals scant mention of the above compounds with antimicrobial properties and hence more and more derivatives are worth tested for the possible medicinal applications. So we have decided to synthesis Substituted Imidazolone, Chalcones, Isoxazolines, Pyrazolines, Pyrimidines, Schiff base, 4-Thiazolidinone and Azetidinone derivaties and tested them for antimicrobial activity. ····· 10361147446
····· lezzter Preis 79.00€ ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray In these environmental conscious days, the challenges for chemists and others is to develop new products, processes, procedures and services that achieve the societal, economic and environmental benefits. It requires a new approach which sets out to reduce the materials and energy intensities of chemical processes and products, minimize or eliminates the dispersion of harmful chemicals in the environment, maximize the use of renewable sources and the durability and recyclability of products in a way which increases industrial competitiveness. Keeping in view the immense importance of environmental technique both in industry and academia and continuation of the ongoing work being carried out by our research group for the past few years for developing clean, efficient, economical and environmental-friendly procedures, the present work has been carried out with the aim to explore newer environment friendly procedures using various silica supported reagents (acids and bases) in organic synthesis. In addition, efforts have also been made to use non-toxic, inexpensive and easily available reagents for the synthesis of synthetically important and potentially bioactive compounds. ····· 1036125060
für 80.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray El objetivo del presente trabajo es estudiar la síntesis y reactividad de hidantoínas 5-sustituidas. Este tipo de hidantoínas son importantes intermedios en la producción industrial de aminoácidos. El trabajo se divide en dos partes. Por un lado en la síntesis de 5-aril-hidantoínas y por otro en la síntesis y reactividad de 5-metilenhidantoínas. La primera estrategia se ha realizado mediante una alquilación de Friedel-Crafts. Este tipo de reacciones se pueden llevar a cabo a partir de urea, ácido glioxílico y el compuesto aromático one-pot. Otra posibilidad es el uso de un derivado de hidantoína como es el caso de 5-clorohidantoína o 5-bromohidantoína. En la segunda estrategia se ha introducido un grupo metileno en posición 5 de la hidantoína. Este grupo sirve de intermedio sintético para obtener un gran número de moléculas mediante reacciones tipo Michael, cicloadiciones, reacciones de Heck, etc. ····· 1036190730
für 84.51€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray This book provides an overview in recent progress in the field of synthesis and interactions of pi-conjugated DNA binders through Click chemistry. The synbook of alkyne- and azide substituted oligoheteroaromatic compounds, were designed to be used as building blocks for Click reactions. The Pd-catalysed cross-coupling of azide-substituted building blocks to form oligoheteroaromatics is also described. The characterisation of the new pi-conjugated molecules utilising Click chemistry between alkyne- and azide-substituted compounds leading to a series of structurally-varied di- and tricationic oligoheteroaromatic putative DNA binders. The DNA-binding studies for the di- and tricationic oligoheteroaromatic compounds using a variety of biophysical techniques to quantify DNA binding and elucidate binding modes. Finally, the overall conclusions of the study, including future studies and applications are presented. ····· 1036118821
für 88.20€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Desde el nacimiento de la química orgánica, allá por 1828 cuando Wöhler anunció la síntesis de la urea, los químicos orgánicos han sido alarifes del mundo molecular. Esta fascinación por diseñar y construir nuevas estructuras ha llevado a la preparación de moléculas de formas inusitadas y aplicaciones sin fin. Dentro de las estructuras que han despertado mayor interés en los últimos años se encuentran los dendrímeros. Ello es debido tanto a su distribución espacial como a sus propiedades y aplicaciones potenciales. El trabajo que aquí se presenta se enmarca en dos campos de investigación: el desarrollo de nuevos materiales con estructura dendrimérica y la evaluación de sus propiedades ópticas. A lo largo de la tesis se describe la preparación, caracterización, y estudios espectroscópicos preliminares de tres familias de dendrímeros conjugados: dendrímeros basados en poli (fenilenvinilenos), dendrímeros cuya arquitectura está basada en híbridos de poli (fenilenvinilenos) / poli(fenilenetinilenos) y dendrímeros alificos de PAMAM que incorporan cromóforos de oligo(fenilenvinilenos) de manera supramolecular. ····· 103612838
Die gut eingeführte 5. Auflage des Lehrbuchs Organische Chemie von Paula Y. Bruice ist mit vorliegendem Werk den Bedürfnissen der modernen Lehre hervorragend angepasst worden.Dieses Buch eröffnet einen modernen und einfachen Zugang zum Studium der Organischen Chemie. Das handliche Lehrbuch führt mit zahlreichen Bezügen zum Alltagsleben durch den Prüfungsstoff der Organischen Chemie. Es deckt von der Struktur und Bindung organischer Moleküle über die ausführliche Behandlung der wichtigsten Verbindungsklassen bis hin zur Bioorganik und Wirkstoffchemie alle wesentlichen Bereiche des Fachs ab und eignet sich auch für Studenten der Biochemie, Medizin und Pharmazie. Besonders ausführlich werden die Verbindungen von Organischer Chemie zu Biochemie und Biologie herausgearbeitet - den physikalischen und chemischen Eigenschaften bioorganischer Verbindungen sind sieben Kapitel des Buches gewidmet. Die Inhalte werden mit durchgängig vierfarbigen Grafiken und 3D-Modellen von Molekülstrukturen veranschaulicht. Musterbeispiele führen den Lesern die Lösung von Problemen Schritt für Schritt vor, bevor vergleichbare Problemstellungen im Selbststudium behandelt werden können. Die Hervorhebung wichtiger Merksätze in der Marginalspalte, Reaktionszusammenfassungen sowie Übungs- und Anschauungsmaterial auf der Companion-Website erleichtern Anfängern zusätzlich den Umgang mit der Materie.
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