für 53.10€ kaufen ··· 9783844301687 ··· 10361113097 ··· The Signal Transducer and Activator of Transcription 1 (STAT1) is activated in response to interferons (IFNs) stimulations. In response to IFN- , STAT1 homodimerizes to form the gamma activating factor (GAF). In response to IFN- , STAT1 heterotrimerizes with STAT2 and ISGF3- to form the interferon sequence gene factor 3 (ISGF3). This work clearly demonstrates the distinct roles of the IFN- -induced-GAF complexes in anti-mycobacterial immunity and of IFN- induced- ISGF3 complexes in the anti-viral immunity in humans at the cellular and clinical levels by different molecular mechanisms. It also highlights the fact that a phenotype depends of the mutation and not only of the affected gene and moreover the importance of the homozygosis or heterozygosis state of the mutation in human genetic diseases. Hersteller: LAP Lambert Academic Publishing Marke: LAP Lambert Academic Publishing EAN: 9783844301687 Kat: Hardcover/Naturwissenschaften, Medizin, Informatik, Technik/Biologie/Genetik, Gentechnik Lieferzeit: Sofort lieferbar Versandkosten: Ab 20¤ Versandkostenfrei in Deutschland Icon: https://www.inforius-bilder.de/bild/?I=xBb9M4LfxOM9VqtHNKyBFZVvPD2f%2F%2FUgdX0x1LheeGA%3D Bild:
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