SIGMA1 Receptor Modulation of Dopamine Transporter: Molecular Analysis
··· lezzter Preis 71.10 ··· 9783848481354 ··· 1036124529 ··· Sigma ( ) receptors are well established as an indipendent receptor family with its characteristic binding profile and distribution in the central nervous system. Activation of 1 receptors alters several neurotransmitter systems, in particular the dopamine (DA) neurotrasmission however the exact role of 1 receptor in dopaminergic homeostasis remains unclear. The DA transporter (DAT) is the primary mechanism by wich dopaminergic neurons terminate the signal, thus regulating the temporal aspects of dopaminergic synaptic transmission. This study shows for the first time that, in cell models, 1 receptors directly modulate the DAT activity. Facilitation of DA uptake induced by (+)-pentazocine, a powerful 1 agonist, is reflected on the increased cell susceptibility to DA toxicity these effects are prevented by 1 selective antagonists. Since numerous compounds, including several drugs of abuse, activate 1 receptors, thus eliciting a severe dopaminergic neurons damage, the reported protective effect showed by 1 antagonists would indicate a novel pharmacological strategy to approach the dopaminergic neurodegenerative diseases (i.e. Parkinson`s Disease) therapeutical management. Hersteller: LAP Lambert Academic Publishing Marke: LAP Lambert Academic Publishing EAN: 9783848481354 Kat: Hardcover/Naturwissenschaften, Medizin, Informatik, Technik/Medizin/Pharmazie Lieferzeit: Print on Demand Versandkosten: Ab 20¤ Versandkostenfrei in Deutschland Icon: https://www.inforius-bilder.de/bild/?I=ur%2FifNFLJ3ie6LX5F3G94eQowB2ndLwW0KHUXn4kGwo%3D Bild:
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