Four Binding Site Hypothesis for Anticonvulsant Activity
··· lezzter Preis 44.10 ··· 9783848486373 ··· 1036124926 ··· Despite the development of several new anticonvulsants, over 30% of people with epilepsy do not have seizure control and others do so only at the expense of significant dose-related toxicity and unusual adverse effects. The semicarbazones based pharmacophoric model for anticonvulsant activity comprises of following four essential binding sites: (i) An aryl hydrophobic binding site (ii) A hydrogen bonding domain (iii)An electron donor group and (iv) Another hydrophobic-hydrophilic site regulating the pharmacokinetic properties of the anticonvulsant. In pursuit for better antiepileptic drug and the importance of semicarbazones as anticonvulsant pharmacophore, a series of novel semicarbazone were designed, synthesized and evaluated for their anticonvulsant activity. The results of the present studying confirmed that the pharmacophoric model with four binding sites is vital for anticonvulsant activity. Hersteller: LAP Lambert Academic Publishing Marke: LAP Lambert Academic Publishing EAN: 9783848486373 Kat: Hardcover/Naturwissenschaften, Medizin, Informatik, Technik/Medizin/Pharmazie Lieferzeit: Print on Demand Versandkosten: Ab 20¤ Versandkostenfrei in Deutschland Icon: https://www.inforius-bilder.de/bild/?I=FqLVKTJeYm8Mi4DsSFlZsyXCkjwSXA2NlOq2hkDzags%3D Bild:
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