für 61.20€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The book entitled Modern synthetic strategy for anti-viral nucleosides deals with the synthesis of four new series of nucleosides, their characterization and antiviral screening. Chemically, viruses are nucleoproteins containing either deoxyribonucleic acid (DNA) or ribonucleic acid (RNA) surrounded by a protective protein sheath. Nucleoside analogues are used as anti-viral therapeutic agents. The development of antiviral drugs encountered lots of difficulties and the research in antiviral chemotherapy gained less attention. Although vaccination is a valuable tool to fight viral diseases and in some cases is available and successful, the difficulty associated with state-wide or world-wide vaccination programs makes antiviral chemotherapy a more practical approach in the fight to epidemic viral infections.The importance of these nucleoside analogues was later confirmed with the emergence of HIV as the main etiological agent of AIDS. Due to growing awareness about environmental pollution, library synthesis of target nucleosides by using green protocols is desired. With this objective new nucleosides have been synthesized using green protocol and screened for their antiviralactivity. ····· 1036121384
für 35.91€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The first part of the present review is devoted to the synthesis of 2-aroyl-3-aryl aziridines. Scientists are interested in these classes of heterocyclic compounds, first of all by their photochromic properties and high sensitivity towards UV-VIS irradiation. In addition, these compounds are interesting from the viewpoint of reactivity, chemo- and regio-selectivity, stereochemistry and many other. The last part is concerned with chemical behavior of 2-aroyl-3-aryl aziridines in numerous organic reactions including photochemical transformations, cycloadditions, rearrangements, regio- and stereo-selectivity, 1,3-diolar reaction, ring expansion, ring opening, deamination and other. ····· 1036121193
für 53.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Inflammatory diseases and cancer are serious health problems for mankind. Many antiinflammatory and a few anticancer drugs are available in the market. Most of the drugs used clinically have serious side effects and hence there is a development of safer antiinflammatory and more active anticancer drugs. In continuation of our work in this direction, we have synthesized a number of pyridine, pyrazine, pyrimidine, pyrimidobenzimidazole, hemin & hematoporphyrin derivatives and evaluated them for their antiinflammatory, analgesics and/or anticancer activities. A few of them are very potent towards analgesics and antiinflammarory activites and one patent was also done on Thiazoline derivatives possessing anti-inflammatory and analgesic activities and their method of preparation. ····· 1036121174
für 53.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The presence of more water solublising group is characteristics of anionic mono azo dyes. Sulphonic groups are used almost exclusively for this purpose because these are readily accessible and are strong electrolytes and therefore almost completely dissociated in all acidity ranges occurring in the aqueous solution. These dyes are widely used for paper and leather, and their metal salts are used as pigments. The term `Acid Dyes` denotes a large group of anionic dyes with a relative low molecular weight that carry 1 to 3 sulphonic acid groups. They are mainly mono azo compounds but also includes bisazo, triphenyl methine, 4-oxoquinazoline derivatives and other name `Acid Dyes` is derived from the dyeing process, they are applied to wool [1-4], silk [5,6] and nylon. A solvent dye is a dye which is soluble in an organic solvent and is commonly introduced in the form of a solution in an organic solvent. Solvent dyes [1-2] are used to impart colour to organic solvents, hydrocarbon fuels, waxes, lubricants, plastics, and other hydrocarbon based non-polar materials. Their molecules are typically non-polar or little polar and they do not undergo ionization in solvent. ····· 1036120695
für 71.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The present work is devoted to the catalytic generation of silicon-based cuprates and their application in several C Si bond-forming reactions. A general procedure for the catalytic preparation of Cu Si nucleophiles via activation of Si B interelement linkages is described. This versatile copper(I)-catalyzed protocol involving formation of regioselective C Si bonds enables excess to a variety of organosilicon compounds. The detail investigations ascribing our preliminary attempts to transform into enantioselective variant in presence of different chiral ligands are also presented. In addition to this, the book also details on the study to explain the stereochemical surprises in reagent- controlled Lewis acid-mediated allylation of isatins with -chiral allylic stannane. ····· 1036120425
für 61.20€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Thiazolo[3,2-a]benzimidazole derivatives have been associated with diverse biological properties. Many of their therapeutic applications have been reported in the literature. Their activities extended to other applications rather than medicinal fields. They are used in magnetic recording disks and photographic agents. These considerable activities stimulated our interest in the synthesis of several new heterocyclic derivatives of potential biological activity pendant to thiazolo[3,2-a]benzimidazole moiety at C2. The present study was undertaken to explore the utility of 1-(3-methylthiazolo[3,2-a]benzimidazol-2-yl)ethanone, 3-methylthiazolo[3,2-a]benzimidazole-2-carboxylic acid ethyl ester and thiazolo[3,2-a]benzimidazol-3(2H)-one for the synthesis of a variety of fused heterocyclic ring systems which could possess interesting and useful biological and pharmacological properties. Many new thiazolo[3,2-a]benzimidazole derivatives have been synthesized, but there are still new aspects to explore and work on. In addition, more attention has to be paid for the molecular basis of mode of actions. Rational drug design methods could be applied and more drug candidates can be obtained. ····· 1036120395
für 61.20€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Biomimetic Modelling of Organic Synthesis: Studies Involving Cyclodextrins, briefely describes about the cyclodextrins and the structural features of its exterior surface and internal cavity, and its applications in biomimetic synthesis of selenazoles, thiazoles and amino thiazoles nucleophilic ring opening, oxidative deprotections, substitution and addition reactions in aqeous media. Cyclodextrins are mimicking enzymes in their capability to bind substrates selectively and catalyze chemical reactions through the reversible formation of host-guest complexes by non-covalent bonding. Based on this phenomena, in this work efforts have been made for attaining higher regioselectivities in various ring opening reactions. This work also explores the anionic reactions in aqeous media and in open air atmosphere and contributes greately to the green chemistry by minimising the usage of hazardous organic solvents. ····· 1036120386
für 61.20€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray This monograph describes introduction of Prins cyclisation, previous approaches to the versatile intermediate 1,3 diols and its application in the synthesis of polyketide natural products. Scope of the prins cyclisation in the synthesis of multisubstituted tetrahydropyrans from aldehydes and homo allylic alcohols, is expanded. A new approach for the stereoselective synthesis of polyketide precursors containing 1,3-diol units, flanked by divergent alkyl branches with different functional groups. Using this 1,3 diol strategy synthesized biologically active molecule Crocacin C (antifungal and highly cytotoxic metabolite), Basiliskamide A & B (showed the antifungal activity against Candida albicans and Aspergillus fumigates). This monograph is unique with dealing with synthetic protocols for above natural products utilizing Prins cyclisation and 1,3 diol strategy including full experimental procedures, analytical data, complete references section and most useful for synthetic organic chemists. ····· 1036120089
für 71.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray This book was written to stress basic concepts in organic chemistry and for students to appreciate some of its applications. My classroom experience had confirmed that a clear introduction to organic chemistry should communicate the excitement of its application to our daily lives.This book carefully develops the reasoning students need to understand basic reactions and the working methods of organic chemistry. The book is intended primarily to serve beginning chemistry students with little or no instruction on organic chemistry. Accordingly it provides a solid base for the subject that promotes understanding and critical thinking, while simultaneously limiting the scope to the presentation and introducing applications to agriculture, biochemistry & the chemical industry.Structure and nomenclature are important in appreciating the physical and chemical properties of organic compounds. Significant portion of the book is devoted to structure and naming of organic compounds. Reactions of organic compounds are determined to a large extent by functional groups. Characteristics and reaction patterns of common functional groups have been treated extensively. Over 300 MCQs are included. ····· 1036120032
für 53.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray This monograph introduces the excellent application of olefin metathesis approah for total synthesis biologically potent 10-membered lactone derived natural products, such as (+)-Mueggelone (a novel inhibitor of fish development), Herbarumin-I (Which interacts with bovine-brain calmodulin and inhibited the activation of the calmodulin-dependent enzyme cAMP phosphodiesterase and should have physiological effects of agrochemical and medicinal interest), and Stagonolides (which were shown to be a nonhost-speci c but selective phytotoxin. Leaves of C. arvense were most sensitive and leaves of tomato and pepper (both Solanaceae) were less sensitive to stagonolide, and demonstrated to be a strong inhibitor of root growth in seedlings of C. arvense and some other Asteraceae species). Herbarumins & Stagonolides could be served as eco-friendly effective plant pathogens compared to environmentally restricted chemical herbicides. This monograph is unique in dealing with the synthetic protocols for above natural products utilizaing olefin metathesis including full experimental procedures, analytical data, complete referenece sections and most useful for all synthetic organic chemists. ····· 1036119583
für 71.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Heterocycles in general and nitrogen heterocycles in particular constitute the lion s part of the classical divisions of organic chemistry and are of immense importance biologically, industrially, and indeed to the healthy functioning of any developed society. The majority of pharmaceuticals/ biologically significant/ agrochemicals/ commercially used available entities are heterocyclic compounds. They are available in living systems, viz. DNA-RNA bases, vitamins, enzymes, hormones etc. which play a crucial role in the biochemical processes. Relevant to the proposed project are the nitrogen heterocycles, which normally form the basic skeleton of alkaloids. To be specific, this proposed project involves the works on pyrimidines the RNA nucleobase, whose biochemical role is well known. This book entitled Pyrimidine Chemistry: Synthesis, Structure and Bioactivity of some Uracil Derivatives comprises of seven Chapters. Each chapter is divided into sections namely Introduction, Materials and Methods, Results and Discussion (including Bioactivity test), Conclusion, Experimental Section and References respectively (excluding Chapters 1 & 7). ····· 1036119185
für 61.20€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The Mannich reaction provides one of the most basic and useful methods for the synthesis of such compounds. The main objective of this study is to give the simple and one pot synthetic method for phenanthridines, azabicycles and cycloalkanones. Even though the Mannich reaction is one of the oldest reactions, the increasing popularity of the Mannich reaction has been fueled by the ubiquitous nature of nitrogen and oxygen in drugs and natural products as well as by the potential of this multicomponent reaction to generate diversity. From the above discussion it can readily be seen that the Mannich reaction offers great scopes and utilities. Because of its promising and challenging applications, the Mannich approach has been successfully used as the key step in the synthesis of first representatives of interesting azabicycles and unexpected analogs of phenanthridines and cycloalkanones have been achieved by simple three component one-pot fashion. The synthesized compounds were characterized by FT IR, 1H NMR, 13C NMR, mass spectral data and determine the actual spatial arrangement of atoms in the 3-D space, X-ray crystallography of the crystalline compounds were performed. ····· 1036119108
für 53.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The topic of this project is related to the investigation, design and development of novel synthetic methods and pathways to natural antioxidants and their synthetic analogues that can be utilized as pharmaceuticals, nutraceuticals and preservation agents for food and feed, particularly marine lipids. Distinctive interest is paid to the development and exploration of phenolic and benzoquinone class of compounds such as coenzyme Q10 (CoQ10) and Idebenol. Focal point is the development of practical, efficient, and cost-effective synthetic methods and pathways that will employ cheap and readily available materials, and `green` conditions and reagents. A novel total synthesis to Idebenone is concluded while the development of a synthetic path leading to CoQ10 has also been explored. Among the deliverables are: a) a novel `green` bromination protocol for activated arenes b) an oxidation protocol leading to two versatile intermediates c) a purification protocol of Heck coupling post-reaction mixtures for transition metal catalyst based on organic solvent nanofiltration and d) a palladium catalyzed Heck coupling protocol performed under microwave irradiation. ····· 1036119072
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The book entitled `Naturally occurring alkaloids and iridoids: Chemistry and biological importance` contains the overview about the bio-active alkaloids and iridoids. Since, these class of natural products having significant medicinal values, so the complete chemistry including biosynthesis and the structure elucidation on the basis of advanced NMR techniques has been discussed in brief. The isolation techniques for these constituents are being highly emphasized. Their role in the plants and animals and detailed classification are also included in the text. This is a reference book which contains more than 300 references. The book is a summary of various significant researches and other contributions in the form of reviews and books, and the source of the facts discussed in the book are being cited in the text. The matter of this book would be helpful for postgraduate students as well as researcher working in the field of natural products chemistry. ····· 1036119018
für 84.51€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray This book provides an overview in recent progress in the field of synthesis and interactions of pi-conjugated DNA binders through Click chemistry. The synbook of alkyne- and azide substituted oligoheteroaromatic compounds, were designed to be used as building blocks for Click reactions. The Pd-catalysed cross-coupling of azide-substituted building blocks to form oligoheteroaromatics is also described. The characterisation of the new pi-conjugated molecules utilising Click chemistry between alkyne- and azide-substituted compounds leading to a series of structurally-varied di- and tricationic oligoheteroaromatic putative DNA binders. The DNA-binding studies for the di- and tricationic oligoheteroaromatic compounds using a variety of biophysical techniques to quantify DNA binding and elucidate binding modes. Finally, the overall conclusions of the study, including future studies and applications are presented. ····· 1036118821
für 53.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray This Thesis discusses the basic principles of Lithographic techniques incorporating the use of positive and negative photoresists applications, synthetic techniques of photo imaging compounds and light sensitive materials, uses of novel chlorinating agents at mild conditions, direct esterification of sulfonicacid or salts, photochemical studies of photo activating compounds, resolution and optimization of the photo imaging compounds in nanolithographic applications. Preparative and HPLC standardization methods of photo activating compounds. Synthesis of photo acid generators for nanotechnology applications, these are used in the microelectronic industry. The microelectronic industry has made remarkable progress with the development of integrated circuit (IC) technology. Although EUV lithography at 13.5 nm wavelength has emerged as a promising candidate to meet the resolution requirements of the microelectronic industry roadmap, yet the development of advanced photoresist materials with all of the required imaging properties is still challenging and is one of the major subjects of current nanolithography research. ····· 1036118666
für 49.41€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Nativnye pentaciklicheskie triterpenoidy lupanovogo ryada (betulin, betulinovaya kislota) sostavlyajut vazhnyj klass biologicheski aktivnyh soedinenij s shirokim spektrom biologicheskogo i farmakologicheskogo dejstviya. Osobyj interes k jetim soedineniyam vyzvan ih protivoopuholevymi svojstvami. Betulinovaya kislota i ee nekotorye sinteticheskie proizvodnye otnosyatsya k gruppe veshhestv `mitokanov`, protivorakovyh soedinenij, izbiratel`no destabilizirujushhih mitohondrii i inducirujushhih apoptoz rakovyh kletok. Kniga posvyashhena issledovaniyam, napravlennym na modifikaciju struktury betulinovoj kisloty s cel`ju usileniya ee citotoxicheskoj aktivnosti. V pervoj glave proanalizirovany raboty, opublikovannye v jetom napravlenii za poslednie 10-15 let. Vo vtoroj glave obsuzhdajutsya rezul`taty issledovanij, poluchennye avtorami knigi. Jeti issledovaniya napravleny na razrabotku metodov sinteza kon#jugatov betulinovoj kisloty s lipofil`nym trifenilfosfonievym kationom - predpolagaemym sredstvom dostavki triterpenoida v mitohondrii opuholevyh kletok. Kniga rasschitana na himikov-organikov, rabotajushhih v oblasti napravlennogo sinteza, prirodnyh soedinenij, medicinskoj himii, aspirantov i studentov himicheskih vuzov. ····· 1036118549
für 58.41€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Ce livre a contribué à la caractérisation de cinq Plantes de Madagascar à travers la composition chimique de leurs huiles essentielles (HE). Quatre plantes aromatiques et médicinales (Cymbopogon giganteus var. madagascariensis, Tana bojeriana, Croton kimosorum et Croton sp.) poussent à l`état spontané dans la région sub-aride du sud-ouest de Madagascar (Toliara) alors que l`espèce Vepris madagascarica est présente dans la forêt dense humide du nord-est (Vohémar). Ainsi, nous avons étudié par combinaison CPG(IR), CPG-SM et RMN 13C la composition chimique d`huiles essentielles obtenues par hydrodistillation (appareil type Clevenger) et par entraînement à la vapeur d`eau (Alambic). ····· 103614735
für 26.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Los carbohidratos son las materias primas básicas para la síntesis de poliamidas, poliésteres, poliuretanos...., la utilización de productos naturales como materiales de partida para la obtención de polímeros tiene la doble finalidad de hacerlos menos dependientes de las materias primas fósiles de naturaleza perecedera y de favorecer la biodegradabilidad y biocompatibilidad de los mismos. De esta forma, su impacto medioambiental es menor que el de los polímeros clásicos,(Fishman, 1994). En el caso de los carbohidratos, cobra importancia la gran abundancia de los azúcares naturales, su diversidad estructural, su múltiple funcionalidad, su inocuidad para la salud humana y la hidrofilia de los materiales resultantes que aseguran una mayor degradabilidad hidrolítica (Gopferich, 1996). En este trabajo se presenta una posible alternativa a los clásicos materiales poliméricos a partir de monómeros de azúcar. ····· 103613124
für 88.20€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Desde el nacimiento de la química orgánica, allá por 1828 cuando Wöhler anunció la síntesis de la urea, los químicos orgánicos han sido alarifes del mundo molecular. Esta fascinación por diseñar y construir nuevas estructuras ha llevado a la preparación de moléculas de formas inusitadas y aplicaciones sin fin. Dentro de las estructuras que han despertado mayor interés en los últimos años se encuentran los dendrímeros. Ello es debido tanto a su distribución espacial como a sus propiedades y aplicaciones potenciales. El trabajo que aquí se presenta se enmarca en dos campos de investigación: el desarrollo de nuevos materiales con estructura dendrimérica y la evaluación de sus propiedades ópticas. A lo largo de la tesis se describe la preparación, caracterización, y estudios espectroscópicos preliminares de tres familias de dendrímeros conjugados: dendrímeros basados en poli (fenilenvinilenos), dendrímeros cuya arquitectura está basada en híbridos de poli (fenilenvinilenos) / poli(fenilenetinilenos) y dendrímeros alificos de PAMAM que incorporan cromóforos de oligo(fenilenvinilenos) de manera supramolecular. ····· 103612838
für 35.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray En los últimos años se ha convertido en un área emergente el empleo de catalizadores quirales en la reacción de epoxidación. En este campo, el uso de dioxiranos quirales constituye un proceso catalítico atractivo. Los dioxiranos pueden ser generados in situ a partir de cetonas y peroxomonosulfato de potasio (Oxone). Cuando se emplea una cetona quiral, su reacción con Oxone produce un dioxirano quiral que puedan reaccionar de forma selectiva por una de las caras enantiotópicas del alqueno que se utilice como sustrato. Después de la transferencia del átomo de oxígeno por parte del dioxirano al alqueno, la cetona quiral puede ser recuperada con alto rendimiento, sin pérdida de actividad, y por lo tanto puede ser empleada en otra reacción de epoxidación. El diseño de nuevas cetonas quirales para obtener con éxito el control de la estereoquímica en las reacciones de epoxidación mediada por dioxiranos es una cuestión importante en este ámbito. Los dioxiranos tienen dos sitios de reacción, la restricción de la posible competencia entre ellos es un factor importante en el curso de estereoquímica, y debe tenerse en cuenta durante el proceso de diseño de la cetona. ····· 103611961
für 26.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Los oxiranos juegan un papel importante como intermedios en síntesis orgánica, porque su reacción de apertura, tanto con electrófilos como con nucleófilos, permite la obtención de compuestos 1,2-difuncionalizados y la formación de nuevos enlaces carbono carbono. Esta reactividad química es responsable de la actividad biológica que exhiben los compuestos que contienen esta función. Así, determinados glicosil glicidoles (oxiranos derivados de alquenil glicósidos) presentan actividad citotóxica y pueden ser utilizados como agentes alquilantes en la quimioterapia anticancerosa.8 Por otra parte, los oxiranos pueden transformarse en otros compuestos de interés biológico, como los a-hidroxi-b-aminoácidos derivados de la isoserina. Los derivados de la isoserina constituyen el fragmento esencial en productos naturales de alto valor terapéutico.15,16 Los casos más relevantes son el taxol, anticanceroso, y sus derivados, cuya cadena lateral es N-acil-(2R,3S)-fenilisoserina la bestatina, un dipéptido modificador de la respuesta inmunológica, en el que uno de los aminoácidos es el ácido (2S,3R)-3-amino-3-fenil-2- hidroxibutanoico, y una serie de tripéptidos... ····· 103611330· 1 ·· 2 ·· 3 ·· 4 ·· 5 ·· 6 ·· 7 ·· 8 ·· 9 ·
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