für 61.20€ kaufen ··· 9783846510537 ··· 10361146898 ··· Epidemiological and genetic studies showed that severity of invasive group A streptococcal (GAS) sepsis is influenced by interactions of genetic factors of both bacteria and host. Systems biology approaches presented shed light on host mechanisms of differential response to invasive GAS sepsis. Using genome-wide association studies, we found association between differential susceptibility to GAS sepsis and quantitative trait loci (QTL) on mouse Chr 2 and X. Genes within these QTLs were prioritized based on bioinformatics and qPCR to explore mechanisms of host differential susceptibility. Collectively, data suggested that prostaglandin and interleukin 1 signaling pathways act as key modulators of a network of genes involved in immune responses to GAS sepsis. In addition, genome-wide transcriptome studies showed that pathways involving activation of interleukin 10 production and signaling are likely to be associated with resistance to infection. Despite differences between mouse and human immune systems, systems biology approaches results using mice corresponded well with results obtained from human studies demonstrating the power of this approach and better translation to humans. Hersteller: LAP Lambert Academic Publishing Marke: LAP Lambert Academic Publishing EAN: 9783846510537 Kat: Hardcover/Naturwissenschaften, Medizin, Informatik, Technik/Biologie/Genetik, Gentechnik Lieferzeit: Sofort lieferbar Versandkosten: Ab 20¤ Versandkostenfrei in Deutschland Icon: https://www.inforius-bilder.de/bild/?I=G8k8HsbaGNOAGDbaEY84I%2Fd%2FqlL%2Fc4xtxQTX4leBq%2Bs%3D Bild:
Affiliate Marketing
AdHoc MeldungenAffiliate & PublisherAdvertiser & MerchantAcademyAntwortenArtikelsucheAdventskalender
AffilitivProduktdatenPreisvergleich
