für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Breast cancer is the second leading cause of cancer deaths and is the most common cancer among women. Although a number of biomarkers are being used in clinical practice, significant number cases for breast cancers are detected late and difficult to treat. Therefore, new biomarkers are in need to improve diagnosis and the therapeutics for breast cancer. The emergence of proteomics technologies has facilitated researcher comprehensive differential expression analyses of proteins in healthy and cancer individuals. The most commonly used proteomic techniques in breast cancer research are 2D-PAGE, SELDI-ToF MS, Protein Arrays, ICAT, iTRAQ and SILAC. Recent advancement in proteomics has also enabled to study the intracellular signalling pathways that may underlie the development of breast cancer. Thus, proteomics could play significant roles in identification of novel biomarkers and/or drug targets to improve existing prognosis and diagnosis of breast cancer. This book covers a selection of advances in the realm of proteomics and its promise for the discovery of biomarkers and drug targets, and sample preparation of cell culture and clinical martial for breast cancer research. ····· 1036118711
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Out of 4 isoforms of Pyruvate kinase a glycolytic enzyme, M2 is a prototype isoform expressed in embryonic and adult dividing cells. For the first time, we reported two missense mutations in Pyruvate kinase M2 isozyme (H391Y and K422R) from the cells of Bloom syndrome patients, prone to develop cancer. Results showed that despite the presence of mutations in the inter-subunit contact domain, the K422R and H391Y mutant proteins maintained their homotetrameric structure, similar to the wild-type protein, but showed a loss of activity by 75 and 20%, respectively. Interestingly, H391Y showed a 6-fold increase in affinity for its substrate phosphoenolpyruvate and behaved like a non-allosteric protein with compromised cooperative binding. The co-expression of homotetrameric wild type and mutant PKM2 in the cellular milieu resulted in the interaction between the two at the monomer level, which was substantiated further by in vitro experiments. Interestingly, in a unique observation, hetero-oligomeric populations of PKM2 with an altered activity and affinity led to an increased rate of polyploidy i.e genomic instability. ····· 1036118638
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Common (bread) wheat is an allohexaploid species (Triticum aestivum L.) with 3 compensating genomes AABBDD (2n=6x=42 chromosomes). Traditionally genetic and physical mapping in this most important cereal crop has been based on molecular markers (RFLPs, PCR, Insitu hybridization etc). The recent development in producing deletion lines of common wheat (using Aegilops cylindricum genome) has revolutionized the physical mapping of wheat chromosomes. During present study, deletion lines of chromosomes 5A of common wheat were used to identify RAPD (Randomly Amplified Polymorphic DNA) based molecular markers specific for short and/or long arm of chromosome 5A. Out of the 7 RAPD primers used, OPA-07 showed useful polymorphism for long arm deletion lines viz del5AL-10 and del5AL-23. By comparing the C-banding karyotype of the deletion lines, it is inferred that the primer (OPA-07) anneals to the distal half of the long arm of chromosome 5A. ····· 1036118442
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The book presents the principles of cancer biology in an organized, cogent, and in-depth manner. The book deals with What Is Cancer, Profile of a Cancer Cell, How Cancers Spread, Identifying the Causes of Cancer, Chemicals and Cancer, Radiation and Cancer, Infectious Agents and Cancer, Heredity and Cancer, Oncogenes, Tumor Suppressor Genes and Cancer Overview, Cancer Screening, Diagnosis, and Treatment, Preventing Cancer, Main Types of Cancer, Human Carcinogens. For all readers interested in the big picture view of cancer. The text can be used either as a first step towards a deeper understanding of the mechanisms of cancer progression or it can be used as a quick revision guide. It would be suitable for anyone, with or without a background in biology.The book includes many recent and topical references, and is intended to empower the student to move directly into the primary research literature. ····· 1036118432
für 49.41€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Cancer stem cells (CSC) have been detected in breast tumours and in breast cancer cell lines they are a subpopulation of tumour cells with tumour initiating capacity, which self-renew and give rise to progeny that constitute the tumour bulk. It has been suggested that CSCs are major drivers of relapse after treatment because they are relatively resistant to drug- and radiation-induced cell death. Analysis of breast cancer stem cells has a major significance in the field of cancer therapy. From a therapeutic perspective, it is important to focus on the CSC population most responsible for tumour initiation, metastasis and relapse. But it is not currently clear which characteristics most define the highly tumorigenic population. Regarding this, my project focused on two main characteristics of CSCs: expression of pluripotency factors such as OCT4, and slow cycling properties using existing breast cancer cell lines MCF7 and MDA-MB-231 that are known to contain a CSC population.Also, I attempted to leverage the marine bioproducts expertise of the Medical Biotechnology Department, and the Flinders Centre for Marine Bioproducts Development to screen for novel sponge-derived chemicals. ····· 1036118395
für 71.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Health and environmental problems and insect resistance to many of synthetic pesticides clearly indicate that basic research must be directed to the discovery of new safer types of pest control agents in order to insure high production and preservation of plant and animal agricultural product. In recent years increasing attention has been given to the control of pests using plant extracts. Thus, some investigators isolated many toxic natural products from several species of plants which are relatively resistant to insect attack. The cotton leafworm, Spodoptera littoralis (Boisd.) ranks among the most important pests which attack cotton. It is a polyphagous insect, it lives on a wide range of host plant which may markedly differ, both taxonomically and in their chemical composition. In Egypt, recorded 73 host plants for S. littoralis (=Pordenia litura), 16 for oviposition, 45 for feeding and 12 for both purposes. Plants are considered by far the richest source of bioactive organic chemicals (secondary plant metabolites on earth. ····· 1036118358
für 53.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The family Solanaceae is unique in representing crops like potato, tomato, eggplant, and pepper that are of importance to both arable and horticultural sectors. Its economic importance, and recent progress in molecular biology, has propelled the Solanaceae to the forefront of scientific importance in the fields of comparative genomics and plastome biology research. Tomato (Solanum lycopersicum L.) cv. MicroTom is a miniature-dwarf-determinate. It differs from standard tomato cultivars by only two recessive genes which provide the dwarf phenotype to MicroTom. Like the model plant species Arabidopsis thaliana, short life cycle, well-characterized genetics, and small DNA content per haploid genome, have recently led to its adoption as model research material for the Solanaceae. Efficient methods for in vitro propagation, regeneration, and transformation of plants are of pivotal importance to both basic and applied research. ····· 1036118316
für 71.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray This thesis outlines the toxic effects of three carbamate insecticides viz. Baygon, Carbofuran and Carbaryl on Hepatocytes, Lymphocytes and Spleenocytes In-Vitro. Both commercial formulations and technical grade insecticides have been used in this study and it was found that Carbaryl is more toxic to these cells. However Hepatocytes were not affected much, owing to their greater ability to detoxify carbamates. Osmotic fragility of RBC was also studied upon exposure to these carbamates In-Vitro and the results were the same wherein Carbaryl caused more hemolysis than the other carbamates. The prima fascia aim of this effort was to evaluate these carbamate insecticides as chemotherapeutic agents for cancer. Hence Squamous Cell Carcinoma was excised from the neck of a Bull and its cancerous nature confirmed by histopathological examination. The cells were separated and grown as adherent cultures in micro ELISA plate wells. Carbamate insecticides at 400 PPM were incubated for different time intervals and the cell count and protein content of the cells were made to access the effect of the carbamates. ····· 1036118287
für 53.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The Ramsar Convention of IUCN held in 1971 in Iran attracted global attention regarding conservation and management of wetlands. Subsequently, 3 wetlands in the Indian State of Himachal Pradesh have been declared as wetlands of international importance. The other lakes located in high altitude area of Himachal are not an international importance. It is important because of socio-cultural and ecological values and services it provides. Presently lakes are under threat due to anthropogenic pressures. Therefore, present study endeavour aimed to generate data base in terms of socio-cultural and ecological aspects i.e. physical aspects / land use, extent of water spread and its water quality, vegetation status of catchment s area and surrounding of lake. Further objective of the study was to determine the importance of these wetlands for the local people and to give an indication of the distribution of the benefits among various stakeholders. In this study threats to the high altitude wetlands have been identified and adequate measures for their conservation and management suggested. ····· 1036118256
für 35.91€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Molecular docking is an insilico technique which is used to predict the binding orientation of the small drug molecule candidates to their receptor targets in order to identify the affinity and activity of the small drug molecule. A binding interaction between a small molecule ligand and receptor may result in activation or inhibition of receptor. Here docking analysis is to perform of bioactive compounds derived from oats into the aldose reductase and histamine H1 receptors active site to determine the probable binding model against diabetics and itching respectively. Avena sativa L. known as `common oat`, is a cereal grain grown for its seed. In oats we have identified 14 phytocompounds, out of 14 bioactive compounds, 10 compounds satisfied the Lipinski`s properties and the docking studies were done using commercial tool Accelyrs Discovery Studio 2.1. Among 10 compounds, caffeic acid showed highest dock score 89.324 for diabetics and 82.793 for itching and low bond length with good hydrogen bond interaction. The results thus implied that caffeic acid can be developed into a potent drug for diabetics and itching. ····· 1036118179
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The continuous increase of heavy metals, including lead (Pb), in the air, land, and water, is recognized to be one of the main environmental problems produced by industrialization. According to the Environmental Protection Agency (EPA), Pb is identified as the most common heavy metal contaminant in the environment. Anthropogenic activities such as mining, smelting, burning of fossil fuel, and the manufacture of pesticides and fertilizers are some of the primary source of Pb contamination of the environment. The aim of the work in this book is to examine the effects of different concentrations of lead nitrate on the systemic movement of different RNA viruses. Knowing the factors that are involved in the viral movement inhibition will allow us to produce crops that are resistance to viral infection. ····· 1036118095
für 71.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray In this book we have tested and discussed in the light of national and international research finding the anti mutagenic and anticarcinogenic potential of some natural bioactivators like, vitamin`s of B-Complex and C, Carotenoids, Flavonoids, Sulforaphane, curcumin, ellagic acid etc. We have tested these bioactivators abainst genotoxicity induced by Cyclophosphamide, Hydrocortisone, and Aflatoxin B1(Mycotoxin) using in vitro method (Human lymphocyte culture)and in vivo method (in bone marrow cell of Albino mice). ····· 1036118093
für 53.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Odin iz istochnikov informatsii o roli gippokampa v kognitivnykh protsessakh eksperimental`noe povrezhdenie etoy struktury mozga. Ispol`zuya original`nuyu metodiku obucheniya zhivotnykh, sokhranenie/vosproizvedenie navykov, eksperimental`noe ugashenie reaktsiy, izuchali kognitivnye funktsii u krys posle povrezhdeniya dorsal`nogo gippokampa eksaytotoksinom kainovoy kislotoy. Predpolagaetsya, chto narushenie selektivnogo vnimaniya u zhivotnykh mozhet byt` osnovnoy prichinoy vyyavlennykh defektov. Pokazano, chto povedenie zhivotnykh normalizuetsya za schet kompensatornykh protsessov, proiskhodyashchikh ne tol`ko v samom gippokampe, no takzhe frontal`nykh oblastyakh kory. Etot vyvod baziruetsya na issledovaniyakh funktsional`nogo sostoyaniya mitokhondriy neokorteksa i gippokampa posle vvedeniya neyrotoksina, a takzhe na osnovanii ekspressii genov, vovlechennykh v regulyatsiyu sinapticheskoy peredachi. Rezul`taty predstavlyayut interes dlya neyrobiologov, izuchayushchikh mekhanizmy narusheniy i vosstanovleniya funktsiy mozga u cheloveka i zhivotnykh posle ishemicheskikh povrezhdeniy, pri travmakh, neyrodegenerativnykh zabolevaniyakh i normal`nom starenii. ····· 103615159
für 71.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray V knige na osnove literaturnykh i original`nykh materialov podvedeny itogi inventarizatsii biologicheskogo raznoobraziya vodnykh organizmov Baykal`skoy gornoy strany za poslednie desyatiletiya v taksonomicheskom, biogeograficheskom i ekologicheskom aspektakh (isklyuchaya samo ozero Baykal). Privedeny obshchaya fiziko-geograficheskaya kharakteristika regiona i issledovannykh vodoemov ocherki o vodoroslyakh termal`nykh i mineral`nykh istochnikov o taksonomicheskom sostave vodnykh lishaynikov, vysshey vodnoy rastitel`nosti, meyofauny, bryukhonogikh mollyuskov, bokoplavov, rucheynikov, khironomid, vodnykh listoedov i ryb v istochnikakh, gornykh vodoemakh i vodotokakh Baykal`skoy riftovoy zony i ee okruzheniya. Osoboe vnimanie udeleno prisutstviyu elementov fauny ozera Baykal za ego predelami, a takzhe reliktovym vidam (teplolyubivym, kholodolyubivym i galofil`nym). Dana klassifikatsiya vodnykh refugial`nykh ekosistem i osnovnykh biogeograficheskikh kompleksov vodnykh organizmov v Baykal`skom regione. Izdanie prednaznacheno dlya nauchnykh rabotnikov zoologov, botanikov, gidrobiologov prepodavateley, aspirantov i studentov biologicheskikh spetsial`nostey universitetov, a takzhe vsekh interesuyushchikhsya zhivoy prirodoy Baykal`skoy Sibiri. ····· 103615123
für 71.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray V rabote predstavleno ispol`zovanie nekonventsionnykh drozhzhey N. rolymorpha i ikh mutantov sverkhprodutsentov fermentov (AO alkogol`oksidazy, FdDG formal`degiddegidrogenazy), mutantnykh form AO s umen`shennym srodstvom k substratam, vydelenie fermentov i ikh bioanaliticheskoe primenenie v fermentativno-khimicheskikh i biosensornykh metodakh opredeleniya formal`degida, metanola i etanola v promyshlennykh stochnykh vodakh, produktakh pitaniya i vaktsinakh, predstavleno takzhe ispol`zovanie nekonventsionnykh drozhzhey Pichia stipitis i H. polymorpha v konstruirovanii rekombinantnykh shtammov s uluchshennymi parametrami alkogol`noy fermentatsii. Razrabotan novyy fermentativno-khimicheskiy metod odnovremennogo analiza formal`degida i metanola v ikh smesyakh, v kotorom opredelenie metanola osushchestvlyaetsya s uchastiem AO v usloviyakh khimicheskogo `maskirovaniya` formal`degida v reaktsionnoy smesi. Metod ispol`zovan dlya analiza promyshlennykh stochnykh vod i kommercheskikh preparatov formalina. Skonstruirovan novyy prototip dvukhfermentnogo amperometricheskogo biosensora s ispol`zovaniem AO metilotrofnykh drozhzhey i peroksidazy khrena, sposobnogo k analizu etanola, metanola i formal`degida. ····· 103614921
für 49.41€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray L`activité antibactérienne des alcaloïdes de deux plantes médicinales Fumaria bastardii et Fumaria capreolata a été évaluée par deux méthodes de diffusion sur gélose, la méthode des puits et celle des disques, contre quatre souches bactériennes résistantes aux antibiotiques d`origine hospitalière (S. aureus S56, K. pneumoniae E47, P. aeruginosa 604 et E. coli). Fumaria bastardii a fourni un taux d`alcaloïdes d`environ 2,42% relativement plus élevé que celui obtenu à partir de F. capreolata (1,17%). ····· 103614605
für 53.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The Chambal River is an important river in the Ganges river system. The Chambal River was declared as a National Chambal Sanctuary with an aim to provide fully protected habitat for the conservation and propagation of highly endangered crocodilian species and other aquatic animals. The study area was comprised of a 395 km of the National Chambal Sanctuary, from Pali to Chakarnagar. In the present study 46 species of fishes belonging to 16 families were observed during the course of present study and there is a general observation suggesting rapid decline in fish population due to large-scale illegal fishing. Two species of Crocodiles, the Gharial (Gavialis gangeticus) and Mugger (Crocodylus palustris) and seven species of freshwater turtles (Pangshura tentoria, Kachuga dhongoka, Batagur kachuga, Hardell thurjii, Aspideretes gangeticus, Lissemys -punctata anderoni,) were identified in the study area. The major human activities that destroyed the habitat in the Chambal River are in the form of extensive untraditional cultivation practices on the riverbanks, overgrazing, wood collection from riverside vegetation and sand mining. Sand Banks are very much useful for the aquatic animals ····· 103613804
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Dictyostelium discoideum is one of the simplest studied eukaryote that possesses true multicellularity and provides unique advantages for studying fundamental cellular processes with powerful molecular genetic, biochemical, and cell biological tools. Small RNAs play crucial roles in regulation of gene expression in many eukaryotes. Different methods for elucidation of microRNA from the genome are described briefly. However, in absence of availability of microRNA sequence data from closely related species, the identification of microRNA in D. discoideum is challenging. Here we report the probable microRNA candidates from the social amoeba D. discoideum. We have used two approaches for prediction of microRNA from the social amoeba D. discoideum. Using comparative genomics approach, we identfied 171 putative candidate microRNA and its precursor from D. discoideum genome sequence. In ab initio approach we have identified 79 putative candidate microRNA and its 116 precursor using neural network method. ····· 103613773
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Sleep and wakefulness are behavioral and physiological activities. Sleep has been defined as a reversible behavioral state of perceptual disengagement from and unresponsiveness to the environment. It is a modified form of the basic rest activity cycle. According to the American Psychiatric Association, sleep disorders are major disturbances of normal sleep patterns that lead to distress and disrupt functioning during the day (APA, 2000). Not only are sleep disorders extremely common, affecting virtually everyone at some point in their lives, but they can also lead to serious stress and other health consequences. This book throws light on the modulation of Na-K ATPase with Norepinepherine and Serotonin in presence and absence of blockers thereby affecting sleep patterns. ····· 103613703· 1 · ::::: · 29 ·· 30 ·· 31 ·· 32 ·· 33 ·· 34 ·· 35 · ::::: · 36 ·
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