für 71.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Gram-negative bacteria have evolved an array of secretion systems for protein transport across their membranes. The ability to secrete a diverse set of proteins to their target of choice provides bacteria with a menacing tool for pathogenesis. This work aims to enhance our understanding of bacterial pathogenesis by characterizing key aspects of bacterial secretion systems using mass spectrometry. Chapter 1 provides a general introduction of protein secretion pathways in Gran-negative bacteria, with a special emphasis on type III and type VI secretion systems. Chapter 2 highlights chemical cross-linking and mass spectrometry (CXMS) as a technique for studying protein-protein interactions in large molecular complexes. Chapter 3 describes a novel pipeline for acquisition and analysis of CXMS data. In Chapter 4, key interactions between the basal components of type III secretion systems (T3SS) are identified, and used to create a model of the core structure of T3SS. In Chapter 5, secretome of T6SS in P. aeruginosa is profiled to identify three novel substrates of the system. Evidence of the involvement of one of these substrates in inter-bacterial interactions is presented. ····· 1036199667
für 53.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Pigeonpea is an important high protein grain legume of the semi-arid tropics and caters to the protein requirement all over the world. Improvement of pigeonpea cultivars possessing resistance to pests and diseases, tolerance to abiotic stresses and low allergenic proteins in seeds is desirable. The use of transformation techniques for producing new breeding materials that would not be available in the germplasm among cross-compatible species holds much promise in attaining this goal. Genetic improvement of this crop through biotechnological methods has not yet been achieved mainly due to non-availability of standardized transformation techniques. To develop transgenic plants, standardizing methods of regeneration is equally important. Keeping this in view, in vitro regeneration techniques were standardized employing three different genotypes of pigeonpea and different explants of pigeonpea. Agrobacterium mediated transfer was used in transformation studies with different explants of all three genotypes. ····· 1036199610
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Proteinase inhibitors (PIs) are small proteins that are quite common in nature. PIs are present in multiple forms in numerous tissues of animals and plants as well as in microorganisms. Serine proteinase inhibitors are widespread in the plant kingdom. The present study was at investigating the biochemical properties of protease Lavatera cashmeriane seeds. Four protease inhibitors LC-pi I, LC-pi II, LC-pi III and LC-pi IV were purified from the seeds of Lavatera cashmeriane by ammonium sulphate precipitation and ion-exchange chromatography on DEAE-cellulose column. All were strong inhibitors of trypsin, chymotrypsin and elastase. The molecular weight of LC-pi I, LC-pi II, LC-pi III, and LC-pi IV was found to be 20.89, 14.12, 16.78 and 7.94kDa respectively by gel filtration chromatography and 10, 14, 16 and 7kDa respectively by SDS-PAGE. The SDS-PAGE revealed that LC-pi I is constituted of two subunits of 10,000 Da each. The optimum temperature for the inhibitors was found to be 30 C for all inhibitors. LC-pi I showed strong antibacterial activity against Klebsiella pnuemoniea, and Pseudomonas aeruginosa but was less active against E.coli. ····· 1036199583
für 53.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The glyoxalase system is made up of two enzymes that detoxify methylglyoxal and the other reactive oxoaldehydes, which are produced as a normal part of metabolism. In this book, the characterization of two GLX2-like isozymes from Arabidopsis thaliana and human GLX2 is presented. Our work demonstrates that GLX2-1 is not a glyoxalase 2 however, the protein does contain a dinuclear metal center. We found that GLX2-1 does catalyze the hydrolysis of beta-lactam antibiotics. Overall results suggest that different isozymes of GLX2 have different metal centers and different activities. Also, both the highly conserved metal binding domain (T-H-X-H-X-D-H) and the substrate binding ligands need to be concerned to be considered when classifying glyoxalase 2 enzymes. The results in this book further our understanding of the GLX2 enzymes. It has helped elucidate the structure, function, and mechanism of these enzymes. Our results are contributing to the ultimate goal in glyoxalase research in search of inhibitors that can be used as potential drugs in the treatment of glyoxalase system-related diseases, and the results also suggest that this enzyme may be the template for evolving new functions ····· 1036199557
für 53.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray This is a study on a purified Disintegrin like obtained by auto-proteolysis of metalloproteinase / Disintegrin like fraction obtained from Cerastes cerastes snake venom on expression of TNF- , and Heme-oxygenase-1 in white mice liver tissue injected intra-peritoneally with the purified Disintegrin like . Hepato-protective effect of the Disintegrin like against some hepatotoxins as CCl4 was investigated using molecular biology techniques and histopathology. ····· 1036199512
für 71.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Enzymes are biological catalysts which accelerate the chemical reactions in living things without being consumed. A catalyst is a material which builds a chemical reaction goes faster, without itself being altered. A catalyst can be utilized again and again in a chemical reaction: it is available again for same function. Enzymes are exceptionally the same apart from that they are simply denatured by heating. This book discussed about the history of enzymes, Production criteria, biotechnology, classification, Kinetics and Enzyme applications. Enzyme biotechnology involves the utilization of microorganisms such as yeast, mold or bacteria, and enzymes to make goods and services is a promising field in modern biotechnology. I am looking forward to work in a professional and competitive environment where It can put my best efforts, hard work and skills to bring up the organization and myself too. I am also a life long learner and am determined to become a knowledge professional for keeping abreast with changing technology. ····· 1036199163
für 71.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Schistosomiasis is one of the leading causes of morbidity and mortality associated with parasitic infections in endemic areas, affecting nearly 300 million people in 76 countries all over the world. Adult worms of Schistosoma mansoni reside in the mesenteric venous plexus of the bowel, from where the eggs are frequently swept back to the liver via the portal blood to induce delayed hypersensitivity response. The major pathology is granulomatous inflammation, which is a cellular response to antigens secreted by the internal membrane and miracidia of schistosome eggs. Subsequently, the granulomas heal, resulting in a unique form of periportal fibrosis followed by portal hypertension as the main complication. In the few past years, the schistosomiasis control initiative and endemic country programs treated millions of people with praziquantel (PZQ), the single antischistosomiasis drug in widespread use. There was already clinical and laboratory evidence for the existence of PZQ resistance parasites, and widespread use is expected to generate strong selective pressure for drug resistance. Thus, the new trend nowadays is the use of natural plant extracts as new safe and effective drugs. ····· 1036199018
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Considerable research efforts have been directed towards developing safe and efficient natural based polysaccharide particulate drug delivery systems. The present review outlines the major new findings on the natural based polysaccharides such as chitosan, alginate, pullan, scleroglucan, guargum, gallengum and their characteristics, applications are covered. Chemically modified natural based polysaccharides or its derivatives used in drug delivery research are discussed critically to evaluate the usefulness of these systems in delivering the bioactive molecules. From a literature survey, it is realized that research activities on polysaccharide/nanocomposite systems containing various drugs for different therapeutic applications and gene therapy have increased at a rapid rate. Hence, the present review is timely worthy. It not only deals in detail about these polysaccharides but also throws on the concept of drug delivery through these polymers. We hope that the monograph will be helpful for the Medical researchers. ····· 1036198951
für 32.31€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Medicinal plants continue to be an important therapeutic aid for alleviating the ailments of human kind. The search for eternal health and longevity and for remedies to relieve pain and discomfort drove early man to explore his immediate natural surroundings and led to the use of many plants, animal products and minerals and the development of a variety of therapeutic agents. From, the results showed that DLA tumour induced mice showed significant decrease in antioxidant defense when compared to the other control groups. The administration of FFFr to DLA induced mice significantly increased the activities of enzymic antioxidants and the levels of non enzymic antioxidants. So, these compounds from flavonoid fraction of Ficus racemosa bark can be used as potent anticancer agent. Further docking studies have to be carried out for designing future pharmaceuticals. To conclude, flavonoid fractions of Ficus racemosa leaves, fruits and barks might be responsible for their antioxidative and antitumorigenic potential and these fractions can be recommended as the antitumorigenic agent against DLA and other oxidative degenerative diseases. ····· 1036198900
für 61.20€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Increasing rate of urbanization coupled with industrialization has resulted in greater amount of waste-water discharge as well as higher level of exposure to xenobiotics. Human and animal exposure to environmental chemicals is rarely limited to a single compound. Rather, they are exposed concurrently or sequentially to multiple chemicals from a variety of sources.It is well documented in literature that toxic effects of a xenobiotic can be modified by the presence of other substances. As simultaneous exposure to two or more xenobiotics can take place in the environment and/or under occupational conditions, the investigation of interactions between toxic substances is an important problem in modern toxicology. Trichloroehtylene (TCE) is a common metal degreasing agent and has been used indiscriminately in the house based lock manufacturing and electroplating units. Although TCE is banned in America but unfortunately it is still being used in many developing countries as a solvent of choice in many industries as a metal degreaser. ····· 1036198894
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Built from a set of twenty standard amino acids, Proteins, the most abundant biological macromolecules found in living cells have great structural and functional diversity. Initially synthesized as linear polypeptide chains, they are required to fold to their unique native formats to gain function. Losing track during the folding process, proteins may misfold and end up as aggregates, causing neurodegenerative disorders. This book provides an overview of the protein folding scenario, the models and theories proposed, and consequences of misfolding have been discussed The book also provides a detailed in vitro study of the pH and solvent induced unfolding and aggregation of Hen Egg White Lysozyme. Evidence is presented for the presence of molten globule like intermediate at high pH and t-butanol induced amyloid like structure. ····· 1036198793
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray In this study, interaction of small molecular weight drug compounds with proteins has been characterized. The binding constants of interactions were first theoretically calculated using molecular docking simulations. Next, these interactions were experimentally investigated via Surface Plasmon Resonance (SPR). The theoretical binding constants, KD, predicted from theoretical calculations have been compared with the experimental values obtained from SPR. As a model protein, Escherichia coli (E.coli) DNA photolyase was used due to its known crystal structure. Among the eight drugs analyzed, theoretical and experimental values have shown similar binding affinities between selected drug and protein pairs. The results obtained in this study may be significant to characterize the unknown interactions of existing drugs with various proteins. ····· 1036198671
für 61.20€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The purposes of this book were investigated the effect of the overlap resulting from the beam divergence of the tangential fields onto a supraclavicular field in breast irradiation of patients undergoing breast radiotherapy, to examine the absorbed dose to the skin of patients in such treatments and to determine the dose in contralateral breast (CB) from 2-field and 3-field techniques used in post-mastectomy chest wall irradiations in a fabricated phantom as well as in patients. ····· 1036198537
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray All living matter exposed to radiation from natural to artificial source. We exposed to natural radiations in many ways as from cosmic rays, which originate in outer space and radioactive materials found in earth upon which we inhabit. During the past seven decade s use of radiations brought enormous benefits to the society in addition to its hazards. In this book attempt has been made to show the post irradiation effect of infra- red radiations on insulin glycemic balance of Indian palm squirrel, Funambulus pennanti (Wroughton). ····· 1036198536
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Several different domestic and industrial demands for starch rank this biopolymer among essential biomaterials relevant to economic advancement globally. Starch is widely applied in food, textile, pharmaceutical, paper, synthetic polymer industries and plays prominent role even in technological developments. Starch serves as the primary energy reserve in plants. This book expound on the effects of sucrose on the physicochemical properties of acetylated corn starch.Starch isolated from corn varieties including Abeleehi Dorke SR Obaatanpa Okomasa are subjected to chemical modification using acetic anhydride. Acetylation treatment and addition of sucrose substantially changes the physicochemical properties of corn starches. The extent of change induced is dependent on the concentration of sucrose present. Sucrose reduces retrogradation, peak viscosity, pasting stability, water binding capacity and gelation of acetylated corn starches. On the other hand, swelling power and solubility are increased. The higher the sugar concentration, the greater the effect of increase or decrease on a particular physicochemical property. Varietal differences also accounted for the changes observed. ····· 1036198486
für 61.20€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Secondary hyperparathyroidism (SHPT) develops frequently in patients with `End Stage Renal Disease` because the production of 1, 25 (OH) 2- vitamin D (calcitriol) decreases in the kidneys. That`s why patients may develop osteodystrophy or osteomalacia. The functional role of vitamin D3 under normal body condition is to regulate secretion of parathyroid hormone (PTH) synthesis and release. Parameters such as calcium, phosphate and vitamin D3 act upon PTH. In normal subjects, the homeostasis of these parameters is strongly interconnected but in renal failure, the metabolism of each of these parameters may be deregulated. The diseased kidney is unable to produce vital hormone that is called erythropoietin which increases synthesis of red blood cells. The anemic condition is seen in CKD (chronic kidney disease) because erythropoietin production become reduced. In Pakistan, CKD patients are continuously increasing annually. We conducted a blood and serosurvey study in Lahore metropolitan city of Punjab, Pakistan to see the co-relation between SHPT and CKD. This epidemiological research of public health will be beneficial for onward broad demographic surveillance programs. ····· 1036198465
für 71.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Alcohol and drug abuse is one of the major socio-economic and health problems in Kenya. Consequently, it was declared a national disaster by the Kenya government in the year 2010. However, according to sources available to the author, there is scanty data currently available in the study of genetic and molecular biology of alcoholism in Kenya. In this work, the following factors contributed to alcoholism in the Kenyan study group: ADH 2/ALDH 2 polymorphisms, alcohol intake, alcohol drinking duration, moderate and heavy drinking by young females, sensitivity to alcohol, and preference of alcoholic drinks. This book is based on a pioneer research report on alcohol drinking and alcoholism among Kenyan populations from five geographical regions. Socio-demographic and alcohol drinking parameters were identified as contributing factors to the risk of alcoholism in different communities. Dr. Korir observes that alcoholism should be considered as a disease and not a crime. The book is resourceful for designing a national policy on alcohol and drug abuse. It is also resourceful to the medical and health practitioners and other researchers in biochemistry and epidemiology. ····· 1036198389
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The focus of this research was the characterization of three metallroteins. The characterization was based on the information obtained from their structures and biochemical data obtained from in-vitro and in-vivo experiments. The structures of the three proteins studied were obtained by x-ray crystallography. The first protein studied was the hemerythrin-like domain from the Desulfovibrio vulgaris chemoreceptor H, DcrH-Hr. The second protein was the Bacillus subtilis M32 carboxypeptidase, BsuCP. And the third protein was one of the M32 carboxypeptidases from Leishmania major, LmaCP. ····· 1036198326
für 53.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray This book reports the results obtained by sequencing the genome and the transcriptome of the microalga N.gaditana using next generation sequencing technologies. The project fulfilled the two important aims of assembling a draft of the genome sequence using sole next generation short reads and providing a genetic background for a better understanding of N. gaditana biology in order to improve its value as a model organism for biotechnological applications related to biofuel production. This work by Elisa Corteggiani represented an exceptional advance in the understanding of the high priority biofuel organism Nannochloropsis gaditana. Species of algae adapted to salt-water cultivation, and capable of achieving high yields of lipids are the subject of intense global interest. Despite widespread research on species of Nannochloropsis, no reference genome was available, nor was information regarding changes in transcript abundance under triacylglycerol synthesizing conditions. The research presented in this book addresses these shortcomings and all the data presented will reveal very useful insights when fully analysed. ····· 1036198298
für 53.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray One of the main objectives of pursuing research on medicinal plants is to identify the active principle(s). The plants, with which we are intimately associated in our everyday life, possess the major active constituents of many medicines. Most of the currently used important drugs contain active ingredients from plants. This information demonstrates the importance of natural products in drug discovery. The beneficial effects of plants of whatever origins are usually due to the secondary metabolites present in it.Induced by this state of affairs, the present investigator decided to undertake the systematic chemical investigation of one or two important plants, preferably endemic to Southern Assam where the present investigator hails from and also pursues his academic activities, and to screen the plant extracts or the pure secondary metabolites for certain types of bioactivities. Tree fern, Cyathea gigantea, belonging to the family. Cyatheaceae, is on the verge of being extinction. This warning motivated the present investigator to select two plants, Cyathea gigantea and Cyathea brunoniana. for their systematic chemical analysis and screening for biological activities. ····· 1036192606
für 53.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray A number of biochemistry manuals are commercially available that cover various experimental protocols of biochemistry but these manuals are usually away from the approach of the students due to their high cost. The purpose of this manual is to provide the authentic material to the students in affordable price. Very simple language is used in the manual so it is easy to understand. This manual covers the basic principle, reagents, equipment and protocols for various experiments/techniques commonly used in the biochemistry research. I hope this manual will be very helpful for young researchers. The contributing authors are acknowledged for sharing their knowledge and experiences by writing different chapters. ····· 1036192505
für 53.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The book `Carboxylesterases ` provides insight into the world of esterases of plants, animals and microorganisms. This gives details of isolation, purification, characterization and classification of esterases from the seeds of Mucuna pruriens.It gives protocols for the isolation and purification of any protein from plant source. It also provides ample of information to the students who involved in protein chemistry research. ····· 1036192486
für 53.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The book provides a complete information regarding the Micropropagation of plants and the role of molecular technique-PCR in characterizing the variations created under invitro culture of these plants. It provides an insight, how micropropagation can be used as a tool for the conservation of the germplasm of critically endengered medicinal plants like that of Artemisia amygdalina. Furthermore it could be used as a guide by the researchers of this particular field. ····· 1036192374
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Many constituents in our diet are chemopreventive agents in animal models. Experiments with cultured cells revealed various potential mechanisms of action . Epidemiological observations show lower cancer rates in people whose diets are rich in fruits and vegetables . This has led to the theory that diets rich in fruits and vegetables contain a high concentration of antioxidants which are thought to be chemopreventive.Evidence based studies have also revealed that many debilitating ailments such as alzheimers disease,schizophrenia etc show a remarkable increase in free radicals.It may then be conceived that addressing oxidative stress may be a prerequisite to preventing or even attenuating many degenerative diseases.Experiments in animal models have revealed that there is a positive corellation between the oxidative state of the body and degenerative diseases. ····· 1036192073· 1 · ::::: · 6 ·· 7 ·· 8 ·· 9 ·· 10 ·· 11 ·· 12 · ::::: · 16 ·
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