für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Rising human population throughout the world has detrimental effects on life supporting system on earth. Though considerable progress has been made on the contraception among females, progress on males are still limited. Numerous plants have been used historically to reduce fertility in male and modern scientific research has confirmed contraceptive potentials of Abrus precatorius seed extracts. Effects of different treatments on various male reproductive endpoints and contraceptive efficacy were evaluated. Histopathology revealed that marked atrophy of the seminiferous tubules characterized by disruption of the germinal epithelium and atrophy of the leydig cells as well as epididymal sperm counts were reduced drastically. Hormonal assay revealed a significant decrease in serum level of testosterone, FSH and LH resulting in suppressed spermatogenesis of male rats. These effects lead to the reduction of pregnancy rate of untreated fertile female rats while mated with the extract-treated male rats. The results showed that A. precatorius seed extract causes suppression of spermatogenesis and fertility, thereby suggesting the potential of this plant in the regulation of male fertility. ····· 1036188400
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The life of the modern civilization is associated with everyday use of the relatively new family of materials which are called synthetic plastics. Apart from all the beneficial properties such as wide range of applications or production costs these materials also reveal one serious drawback. They are extremely resistant and therefore, they tend to accumulate in the environment which causes serious environmental issue accumulation of solid waste. Potential solution of this problem could be an enhancement of biodegradability of these materials. Generally there are two approaches how to reach this goal. The first is to modify the properties of synthetic polymers in order to increase their biodegradability. The second strategy is to utilize biodegradable polymers which can be found in nature and which have similar mechanical properties as the synthetic ones. This book deals with both strategies, because it focuses on biosynthesis of bacterial polyesters polyhydroxyalkanoates as well as on the modification and subsequent biodegradation of synthetic polyurethanes. As authors hope, this can be another small step towards our sustainable future. ····· 1036188389
für 49.41€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray One of the most challenging aspects of treating tumors with chemotherapy is that the tumors can develop a resistance to the chemotherapy and survive while the rest of the healthy, non-cancerous cells perish. Higher doses of chemotherapy deliver fewer positive results and at the expense of greater side effects. The purpose of this book it to identify and exploit a weakness at the molecular level of the anti-apoptotic pathway utilized by cancer cells to turn off the `triggered cell death` mechanism of apoptosis and survive chemotherapy. We specifically target the interaction between the anti-apoptotic protein Bcl-2 Associated Athanogene (BAG-1) and the 70-kilodalton Heat Shock Protein (HSP-70) that is suspected of driving the chemotherapeutic resistance, and seek to disrupt that interaction via peptidyl-biomimetically engineered peptides that are predicted via an in-house computational software named `Contact` and experimentally verified via Biacore (c) binding assays. ····· 1036188210
····· lezzter Preis 79.00€ ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Studies described in this dissertation have focused on understanding the crosstalk between two different classes of membrane proteins: Receptor and non-receptor tyrosine kinases and gap junctions. The first part of the study was focused on the non receptor tyrosine kinase pp60v-Src, and the various signaling pathways it utilizes to acutely inhibit Cx43 gap junctional communication. Here we have identified the involvement of at least three signaling pathways which co-coordinately regulate the acute inhibition of Cx43 coupling. The second study was directed towrards understanding the underlying principle for the transient shut down of Cx43 gap junctional communication by epidermal growth factor. Here we generated a stable clonal pool of HeLa cells expressing a growth factor insensitive mutant of Cx43 that was lacking targets for ERK phosphorylation. We looked at the changes in immediate early response of cells to EGF at the transcriptional and translational level. ····· 1036187640
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray This study aimed to evaluate the chemopreventive and antioxidative effects of Eleusine indica and Thysanolaena latifolia against CCl4-induced liver damage. Rats were pretreated with E. indica and T. latifolia for fourteen consecutive days prior to the administration of CCl4 (two doses). Serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), malondialdehyde (MDA), glutathione (GSH), antioxidant enzymes and histopathological changes in rat liver were determined. Total phenolic content of E. indica and T. latifolia were found to be 14.9 ± 0.002 and 20.3 ± 0.007 mg/g total phenolic expressed as gallic acid equivalent per gram of extract respectively. The extracts were able to reduce the stable DPPH in a dose dependent manner. The IC50 value for E. indica and T. latifolia were found to be 2350 µg/ml and 1525 µg/ml. However, most of these changes were alleviated by prophylactic treatment of animals with E. indica and T. latifolia dose dependently. We concluded that E. indica and T. latifolia could be used as hepatoprotective agents and possess the potential to be used to treat or prevent degenerative diseases where oxidative stress is implicated. ····· 1036187568
für 61.20€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray This work mainly highlights the novel source of urease enzyme and its application. Urease was obtained from the vegetable wastes i.e., pumpkin seeds and was purified and characterized and further immobilized in calcium alginate beads. The alginate immobilized enzyme was used for the detection of hazardous metals in aqueous solutions. This immobilized urease was also used for the blood urea estimation which compared favourably with those obtained by Autoanalyzer used in clinical pathology laboratory. ····· 1036187451
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Arsenic contamination in drinking water poses a growing global health risk with large number of people knowingly or unknowingly getting exposed to it. Thousands of people have already been diagnosed with poisoning symptoms of arsenicosis and its other related diseases and many of them are still at risk not yet to be examined for the arsenic-related health problems. Millions of people in more than 70 countries are affected by arsenic pollution. Among appropriate techniques aimed at mitigating arsenic pollution in water, membrane filtration, owing to its higher efficiency, is highly acceptable. Also termed as green technology because of its low waste production and low energy consumption, it does not generate byproducts because there is no use of any chemicals in this process. Membrane filtration is generally used in a series for complete purification of water. This volume attempts to provide comprehensive information on all aspects of arsenic pollution and also discusses nanofiltration techniques to purify arsenic-contaminated water, which could ensure healthy living of masses in the arsenic-infested areas of the world. ····· 1036187404
für 53.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray First cadmium metallothionein like gene (PMCd1) from a ciliate, Paramecium sp. and a novel cadmium inducible metallothionein (TMCd1) gene has been identified and sequenced from the locally isolated ciliate Tetrahymena tropicalis lahorensis isolated from industrial wastewater. Both the genes (PMCd1 and TMCd1) are intronless, encoding 612 and 471 nucleotides respectively, with TGA as the stop codon and TAA coding for glutamine. The coding region of PMCd1 comprises 203 amino acids, including 37 cysteine residues with a conserved structural pattern arranged in 17 cys-x-y-cys, 1 cys-cys and cys contexts. The TMCd1 is quite different from the previously reported MT genes in T. pyriformis and T. pigmentosa. However, it shows 78% homology with four different Cd-MT genes reported from T. thermophila. The amino acids sequence of TMCd1 has a special feature of three CCCX6CCX6CCCX6CC and two CCX6CXCX2CXCC intragenic tandem repeats with a conserved structural pattern of cysteine. The translated protein of TMCd1 contains 30.12% cysteine residues, which is typical of Tetrahymena Cd inducible MT genes. A TATA box is located in the 5` flanking region at nucleotide 34-38 upstream region of ATG. ····· 1036187392
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Inherited night blindness is a group of genetically and clinically heterogeneous retinal disorders characterized by myopia, hyperopia, strabismus, nystagmus, reduced visual acuity and dry eyes. It is inherited as autosomal dominant, autosomal recessive and X-linked forms. Different genes are involved in night blindness that play an important function in physiology and morphology of human retina. Very few studies have been carried out on autosomal recessive congenital stationary night blindness specially in Pakistan. This project is also one of very few studies carried out in Pakistan. ····· 1036187344
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray This book is a research work on effects of smoking on Total Serum Cholesterol level in smokers. Due to harmful and even mortal effects of smoking, the factors affecting the health of smokers were estimated and statistically analyzed. Smokers, from district Peshawar, Pakistan were analyzed for its total serum Cholesterol level. The total serum cholesterol level was related with the brand and the No. of cigarettes smoked per day, age of subjects and duration of smoking. Statistical analysis shows an association between smoking and total serum cholesterol level. ····· 1036187259
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Global demand of energy is ever increasing and its resources due to extensive exploitation arc fastly diminishing. The days of inexpensive fossil energy are clearly numbered, the credibility of nuclear energy has fallen to new low, and fusion energy stands decades of more for practical realization. It is therefore imperative to turn to renewable raw materials for energy. At present there is worldwide interest in the process of converting photo synthetically derived substances into food. Chemicals and fuels. The imminent storage of fossil fuel has intensified the research for bioconversion of lignocelluosic material to fuels. The availability of solar energy needs to be linked up with cellulosic and hemicelluloses productivity. -glucosidase is one of the component enzymes of the cellulase complex and is widely distributed in nature. It catalyzes the hydrolysis of arly and alkyl glycosides as well as of cellobiose to glucose which is inhibitory to the endo and exo cellulases during cellulose hydrolysis. This book explain the production of Beta Glucosidase and its characterization. ····· 1036187033
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Alzheimer`s Disease is a progressive neurodegenerative disorder that is the leading cause of dementia and the fourth leading cause of death in the U.S. It is a complicated syndrome that appears to have a number of contributing factors. Three genes are implicated in increased susceptibility to Alzheimer`s. They are the genes that code for the amyloid precursor protein, and the presenillins PS1 and PS2. Apoprotein E also increases the risk. Oxidative stress and inflammation contribute to the pathology associated with Alzheimer`s Disease. A total of 17 epidemiologic studies have been performed in which non-steroidal anti-inflammatory drugs (NSAIDS) or corticosteroids were examined as a negative risk factor. The data from both case-control and population-based studies provide strong evidence that anti-inflammatory drugs may be beneficial to Alzheimer`s patients. ····· 1036186985
für 71.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Zearalenone is a lactone derivative of the resorcylic acid produced by various Fusarium species that are widely found in foods and animal feeds. Zearalenone exerts species-specific estrogenic effects, possibly because of the metabolism differences arising from reduction, hydroxylation, or glucuro-conjugation. Contamination can occur in the field through infringement of the plant or takes place during crop storage. Zearalenone is resistant to most common treatments that occur during food manufacturing and interacts with both types of estrogen receptors and substrates of several hepatic enzymes. The results of these diverse interactions are manifested by functional and morphological alterations of the reproductive organs. The main objectives of the present research were to elucidate the effects of contaminated aliments with zearalenone on the detoxification proteins. Complementary approaches have been used: development of analytical tools for pharmacokinetics studies determination of zearalenone in vivo effects on the detoxification enzymes expression and transformation within animal organism and assessment of zearalenone in vitro molecular mechanisms. ····· 1036186932
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Mutarotases are recently characterized group of enzymes that are involved in anomeric conversions of monosaccharides enhancing rate of metabolism. Mutarotase was extracted and purified from bovine kidney cortex by (NH4)2SO4 precipitation technique, dialysis and gel filtration chromatography. Polarimeter was used for assay of Mutarotase in this present project. Mutarotase increased activity from 0.478 to 1.711 U/ml by purification. It gained 13.4 folds purification at this final step. It is helpful in determining the glucose level and participates in glycolysis and gluconeogenesis. Activities and fold purification of Mutarotase can also be increased by much improved techniques of purification like ion exchange chromatography or FPLC hence enhancing the production of this enzyme. ····· 1036186778
für 53.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Diabetes is a metabolic syndrome characterized by hyperglycemia, hyper cholesterolemia and hyper triglyceridemia. Hence, there is a need to search the anti diabetic drugs which apart from lowering the blood glucose levels can also modify the atherogenic lipid profile without producing many side effects. An attempt has been made in the present study to evaluate the comparative property of Aloe vera gel and Fenugreek seeds and also along with the hypoglycemic drug name glibenclamide for 21 days. In the Aloe vera, Fenugreek and glibenclamide treated groups they showed a significant decrease in the levels of blood glucose and Glycosylated haemoglobin in our study. Also there was significant decrease in serum levels of triglycerides (TG), total cholesterol (TC) , low density lipoprotein cholesterol (LDL-C) and a concomitant increase in high density lipoprotein cholesterol(HDL-C) in Aloe vera, Fenu Greek and Glibenclamide treated groups. Fenugreek treated groups showed a significant decrease in TC, TG, LDL, and VLDL when compared to Aloe vera treated group. The significant decrease in diabetic index in Aloe vera and Fenugreek treated group shows its protection against diabetes mellitus. ····· 1036186733
····· lezzter Preis 24.00€ ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Das Teilen von Nahrung ist kein seltenes Phänomen unter Primaten. Es wurde unter anderem bei Kleideraffen, Gibbons, Schimpansen und auch bei den in dieser Studie behandelten Bonobos beobachtet. In den zuerst genannten Fällen kann dieses Verhalten meist auf Basis der Verwandtschaftsselektion erklärt werden. Betrachtet man jedoch das Teilen von Nahrung bei Bonobos, treten zwei Besonderheiten in den Vordergrund. Erstens teilen am häufigsten die aufgrund der patrilinearen Gruppenstruktur nicht oder nur entfernt verwandten Weibchen die Nahrung miteinander. Dies lässt die Frage aufkommen, welche Faktoren dieses Verhalten zwischen nicht-verwandten Tieren begünstigen. Zweitens tritt das Teilen von Nahrung oft zeitnah zu sexueller Interaktion auf. Hierzu beschreibt z.B. Frans de Waal (1998), einer der renommiertesten Forscher im Bereich Verhaltensforschung bei Primaten, Situationen, in denen die Bereitschaft eines Männchens zum Teilen von Nahrung mit einem Weibchen durch eine vorangegangene Kopulation positiv beeinflusst zu sein schien. Sowohl Weibchen als auch Männchen forderten dabei zur Kopulation auf, wobei Weibchen anschließend stets von der Nahrung des Männchens fressen konnten. Seine Beobachtungen interpretierte de Waal (1998) dahin gehend, dass Männchen Nahrung gezielt dazu einsetzen, um mit Weibchen zu kopulieren und Weibchen ihrerseits die sexuelle Attraktion der Männchen nutzen, um Zugang zu einer begehrten Nahrung zu erlangen. Nun kann dieses Verhalten in heterosexuellen Paarkonstellation leicht durch die Begrenzungsfaktoren des reproduktiven Erfolges beider Geschlechter erklärt werden, welche für Weibchen durch den Zugang zu hochwertiger Nahrung und für Männchen durch den Zugang zu fruchtbaren Weibchen bestimmt sind. Amy Randall Parish (1994) beobachtete jedoch ein ähnliches Verhalten zwischen Weibchen untereinander. Wenn Weibchen die Nahrung miteinander teilten, kam es dabei ebenfalls häufig zur sexuellen Interaktion in Form des für Bonobo-Weibchen typischen Genito-Genital-Reibens (GG-rubbing). Auch Parish vermutete einen engen Zusammenhang zwischen dem Teilen von Nahrung und dem Auftreten von Genital-Kontakt entsprechend eines Austausches von sexueller Interaktion und Nahrung zwischen den beteiligten Tieren (`Sex-for-Food-Exchange`). Sie konnte in einer experimentellen Studie an in Gefangenschaft lebenden Bonobos zeigen, dass dieser `Sex-for-Food-Exchange` regelmäßig unter Weibchen vorkommt. Bisher wurden jedoch keine Daten über den zeitlich direkten Zusammenhang von sexueller Interaktion und Nahrungsteilen zwischen weiblichen Bonobos erhoben. Ziel dieser Studie ist es deshalb, weitere Erkenntnisse über die Funktion von GG-rubbing im Sinne eines direkten `Sex-for-Food-Exchange` zwischen Bonobo-Weibchen zu erlangen. ····· 1036173874
····· lezzter Preis 32.31€ ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Endometrial carcinoma is one of the most common malignancies in the female genital tract and poses serious health hazards. The gene P53 safeguards cell integrity however a mutation in this gene increases the lifeline of the cells which are programmed for cell death. This particular gene participates in many human cancers including endometrial, ovarian and tubal carcinomas. In this study we screened exon 5 of p53 gene to find out whether this exon is a hotspot for mutations or not. We evaluated (n=45) samples of endometrial carcinoma and (n=45) controls from a local population. However, we were unable to find any nucleotide alteration in exon 5. It appears, therefore, exon 5 of p53 is not a hot spot for mutation in local population based on recent our findings. ····· 1036125953· 1 · ::::: · 8 ·· 9 ·· 10 ·· 11 ·· 12 ·· 13 ·· 14 · ::::: · 16 ·
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