für 53.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Bulbine natalensis Baker is a medicinal plant with succulent, aloe-like leaves from the Asphodelaceae family, commonly used by traditional healers to treat blood clotting-related diseases. This research tested the anti-platelet aggregation effect of B.natalensis` extracts on rat platelet aggregation separately induced by thrombin, ADP, collagen, epinephrine, papain, bromelain and trypsin. Fresh plant material was extracted sequentially using hexane, chloroform, ethyl acetate, methanol, and water. The chloroform extract had the highest yield. Phytochemical screening revealed the presence of anthraquinones, cardiac glycosides, saponins, tannins, flavonoids and alkaloids. The hexane extract revealed the highest contents of total phenols, flavonoids and proanthocyanidin. Hexane extract also displayed the highest ABTS scavenging activity. Studies reveal that B.natalensis is a good antioxidant. Anti-platelet aggregation activities on rat platelets were observed. The chloroform extract inhibited ADP-induced clotting by 100%. Two compounds were isolated but they were unstable. Based on the spectra obtained and comparing to existing literature data, they were envisaged to be a knipholone. ····· 1036120256
für 61.20€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The detection of biomolecules at single molecule sensitivity is critical to the study of live cell dynamics to explore a variety of biological processes. In this work, gold nanoparticles were used as intercellular sensors because they do not photobleach, are nontoxic, and rich in electrons which are needed for enhancement to develop a robust method. Another significant advantage is that these nanosensors work in a 3D space, thereby enabling live cell process monitoring. A hyperspectral imaging system was designed and installed to detect various target biomolecules, and eventually, the intracellular biomolecule detection was demonstrated. it is shown that both dark field and the Raman hyperspectral imaging systems are good for gold nanoparticle hyperspectral imaging. Dark field is a perfect tool to collect surface plasmonic resonance directly by Rayleigh scattering, with many validated applications. On the other hand, Raman spectroscopy is not known as a surface plasmon resonance sensor. In this reseach, dark field HSI was built for various applications including intracellular mRNA detection. The mechanism of plasmon resonance sensor was also studied using Raman spectroscopy. ····· 1036120111
für 71.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Glucocorticoids-induced osteoporosis is the most common form of secondary osteoporosis. Glucocorticoids seem to cause bone loss primarily by suppressing osteoblastic functions. This book, therefore, provides new insights for the protective and therapeutic effects of leptin, dehydroepiandrosterone, growth hormone and calcitonin on predinsolone-induced osteoporosis in rats. The study focused to elucidate the effective role of the studied hormones on both organic matrix and inorganic components of bone and on the process of bone resorption and formation in long term predinsolone administration. Our finding could be useful for the future strategies against side effect of long term administration of glucocorticoids on bone turnover and implicitly osteoporosis progression. ····· 1036120105
für 61.20€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Post-translational phosphorylation is one of the most common protein modifications that occur in animal cells. The vast majority of phosphorylation occurs as a mechanism of acute and reversible regulation of protein function. Studies of mammalian cells metabolically labeled with p32 orthophosphate suggest that as many as one-third of all cellular proteins are covalently modified by protein phosphorylation. Covalent attachment of a phosphate group to an amino acid side chain of a protein can cause a structural change, for example, by attracting a cluster of positively charged side chains. Such a change occurring at one site in a protein can in turn alter the protein s conformation elsewhere. Reversible protein phosphorylation is the predominant strategy used to control the activity of proteins in eukaryotic cells. The phosphates are transferred from ATP molecules by protein kinases and are taken off by protein phosphatases. In animal cells, serine, threonine and tyrosine are the amino acids subjected to phosphorylation. The protein kinases belong to a large family of enzymes, which contain a similar amino acid catalytic (kinase) domains. ····· 1036120033
····· lezzter Preis 44.10€ ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The antifungal peptides represent diverse structures for drug design. Unfortunately, they provide inferior drug candidates because of their low oral bioavailability, potential immunogenicity, poor in vivo metabolic stability and high molecular weight. Recent efforts have focused on the creation of non-natural peptide mimetics. Their artificial backbone makes most peptidomimetics resistant to degradative enzymes, thus, increasing the stability of peptidomimetic drugs in the body. In the present study, four antifungal peptidomimetics structures named C1 to C4 were designed based on the antifungal decapeptide crystallized structure of Pep-1 using bioinformatics tools. Minimum inhibitory concentrations (MIC) of these structures were estimated against Aspergillus niger N402, Candida albicans ATCC 10231, and Saccharomyces cerevisiae PTCC 5052. It was demonstrated that the N-terminal part of antifungal peptides is more active and important for antifungal activity than the C-terminal. Also, important factors/descriptors of 63 antifungal peptides have been studied using Artificial Neural Network (ANN). ····· 1036120023
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Tofu is a popular food because of the various nutritional and medicinal attributes associated with soybean products. A coagulated product of soy milk, it is usually made at the household level using various types of coagulants. The effect of the various types of coagulants on several nutritional contents and on the biochemical response of albino rats fed tofu for 14 days revealed that there was no significant difference (P 0.05) than those of other coagulants. It can be concluded that Tofu has both nutritional and medicinal properties. In this book the functionality of tofu and the hypocholesterolemic effect it has on human health are fully discussed. ····· 1036119928
für 61.20€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Photodynamic therapy (PDT) is an emerging treatment modality that employs the photochemical interaction of three components. These are light of suitable wavelength, photosensitizer, and singlet oxygen. The main objective of this work is the determination of pharmacokinetics of different photosensitizers after laser irradiation in different biological samples like cell lines and tissues to improve the efficacy of PDT. Present study investigates the dynamic behaviour of different photosensitizers under laser irradiation e.g. (a) biodistribution of Photofrin® (b) laser induced effects (c) depth of necrosis under exposure of different wavelengths of light sources (d) synergistic effect of toxicity of ZnO nanostructures bare and conjugated with photosensitizers like Aminolevulinic acid (5-ALA), Photofrin® and protoporphyrin dimethyl ester (PPDME) determined for the treatment of localized cancer cells. ····· 1036119884
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray This hand book is excellent dictionary of instant notes on introduction, history, structure, mechanism, specificity, catalysis, allosteric modulation, coenzymes, cofactors, thermodynamics, kinetics, types of inhibitions (competitive inhibition, uncompetitve inhibition, non-competitive inhibition and mixed inhibition), use of inhibitors, biological functions, control of activity, role of enzymes in pathogenesis, nomenclature & classifications ans industrial application of enzymes along with the needful and important references. It also includes the instant and brief key notes on mechanism of catalysis including the transition state stabilization, dynamics and function performed by the enzymes. Dedicated to All Mighty and my dear parents, `my father , Late Mr. Ram Kumar Sharma and my mother, Mrs. Sushila Sharma. ····· 1036119875
für 53.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Cellulose is used as a food source by many organisms. Plant fibers are major components of ruminant diets, and the anaerobic microorganisms, including bacteria, fungi and protozoa, inhabiting the rumen ecosystem play a vital role in their digestion. Thus cattle and sheep have symbiotic microorganisms in their rumen that produce various cellulases and hemicellulases. Cellulolytic enzymes have been isolated from rumen fungi and some of them are well characterized. Previous dogma has maintained that cellulose, ingested by xylophagous or herbivorous animals, is digested by cellulolytic symbiotes. The first evidence in conflict with this contention involved the demonstration of cellulolytic activities in symbiote-free secreting organs (e.g., the salivary glands of termites) or defaunated guts. It is now clear that cellulases are produced endogenously in a number of invertebrate taxa that includes insects, crustaceans, annelids, molluscs and nematodes, as well as by micro-organisms such as bacteria, fungi and protozoans . The ability of animals to hydrolyze cellulose in the absence of microorganisms has been the subject of various studies. ····· 1036119846
für 37.71€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray This monograph explores the topic of Fatty Acid Binding Proteins with special emphasis on the basis of binding specificity of these receptor proteins for hydrophobic compounds such as Fatty Acids. The text provides in-depth details about the structure determination of a particular Fatty Acid Binding Protein found in the muscle cells of Locusta migratoria. The rest of the text deals with the isolation of another Fatty Acid Binding Protein found in the kidneys of male rats and the transport properties of Sulfonylureas , a class of hydrophobic compounds used to treat type II Diabetes mellitus. ····· 1036119808
für 71.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Study was designed to examine the biochemical and molecular changes in chickpea (Cicer arietinum L.) in response fusarium wilt disease (Fusarium oxysporum f.sp. ciceris) in Gujarat condition in India. This book therefore, provides information to design experiment with histopathological, biochemical and molecular techniques for wilt pathogen and host tissues. This book also gives nice pictures of host pathogen interaction in root tissues of chickpea with Fusarium wilt pathogen. It is very usefull for plant biochemist, plant pathologist and molecular biologist. Standardize methodology of Aminoacids Analyzer, phenolics with HPLC, Native Acidic and Basic protein with SDS protein estimation, DNA extraction to RAPD marker and Antioxidant, hydrolytic and oxido-reductase enzymes with techniques for Chickpea plant. The book also provides different stages of disease development for wilt pathogen in chickpea. This experiment is useful for primary proteomics and biotechnological work in molecular biochemistry of host and pathogen in plants. ····· 1036119799
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Since the dawn of civilization, various plants have been utilized for their medicinal and edible values throughout the world. Sappan tree and ginger plant are two such plants which have been known for their antioxidative, hypolipidemic and hypoglycemic effects. Since antioxidants of dietary origin may not be adequate to promote health benefits, inclusion of these substances in drinking water may be of high significance. The present study was taken with this intention to evaluate the biological properties of sappan wood and a mixture of sappan wood and dried ginger in drinking water. The study showed that a decoction of sappan wood as well the combination of sappan wood and dried ginger had hypoglycemic, lipid lowering and antioxidant effect. Hence it promotes cardiovascular health. ····· 1036119601
····· lezzter Preis 61.20€ ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Allium is an important genus of family Amarylliadaceae, has 700 species, confined mainly to the northern temperate and alpine zones of the world. In Uttarakhand Himalayas about 15 less explored Allium species are found. Over exploitation of the wild Allium have led to considerable shrinking of the populations of Allium species. The study is targeted at the bio-chemical composition, mineral analysis, amino acid contents, DNA finger printing and phyto-chemical evaluation of four economically important and less explored Allium species namely: 1. Allium auriculatum Kunth.2. Allium ampeloprasum L.3. Allium ascalonicum L.4. Allium rubellum M. Bieb. It is concluded from the study that aerial and underground parts of these less explored Allium species have excellent neutraceutical properties, due to presence of ample quantity of nutrients, antioxidants, minerals, amino acid contents etc. These species can contribute significantly to meet out the nutritional requirement of growing population .In future, these plants species could be used not only as condiments for flavoring different food stuffs but also as green vegetables due to their demonstrated good nutritional qualities. ····· 1036119498
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Membrane proteins fulfil a wide variety of essential functions in the cell and many are (potential) drug targets. Since their natural abundance is usually very low, most membrane proteins have to be over-expressed for functional and structural studies. Unfortunately, over-expression of membrane proteins in E. coli is usually toxic. I have studied the effects of the expression of membrane proteins, including the human KDEL receptor, on BL21(DE3) and its derivatives. Saturation of the Sec translocon, a cytoplasmic membrane associated protein conducting channel that mediates the insertion/ biogenesis of membrane proteins, appeared to be the prime reason for the toxicity of membrane protein over-expression. The obtained data have resulted in many leads and ideas to further improve membrane protein over-expression yields in E. coli, e.g. we have engineered a plasmid (pLemo) that helps avoiding saturation of the Sec translocon upon membrane protein over-expression in E. coli. ····· 1036119387
für 53.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Present is the day of science and technology. Everyday each and every aspect of science and technology are being flourished. Neural disorder or dementia has become alarming at present age. Several neuro-imaging techniques have already been developed. But the success lies in the use of non-invasive neuroimaging. Prediagnosis of the disease `dementia` can mitigate this rate of acute sufferings of patients. Such a noninvasive technique is fMRI or Functional Magnetic Resonance Imaging. In this research a comperative analysis of different neuroimaging has been presented. Also Neuronal response in human visual and motor cortex in normal healthy patients have been studied.To do this Functional Magnetic Resonance Imaging or fMRI has been used that measures the hemodynamic response related to neural activity in human brain. ····· 1036119370
für 53.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Type 2 diabetes is usually caused by a combination of pancreatic -cell failure and insulin resistance in target tissues like liver, muscle and fat. Insulin resistance is characterized by an impaired effect of insulin to reduce hepatic glucose production and to promote glucose uptake in peripheral tissues. Many new pharmacological agents have been added to our armamentarium of treatments for DM in the last decade. The goal of all treatments is the same irrespective of the cause of the DM: namely, to normalize blood glucose. Incretin hormones (Glucagon like peptide, GLP and Glucose dependent insulinotropic peptide, GIP) are peptide hormones secreted by enteroendocrine cells that line the gastrointestinal (GIT) tract mainly from K & L cells of intestine, Following glucose or fat ingestion. These hormones are secreted in the blood and reach their various cellular targets. This study was done to: 1- Clarify the insulinotropic effect of the incretin hormones in the regulation of blood glucose level. 2- Show the interrelation between incretin hormones, the degree of metabolic control and oxidative stress in type 2 diabetes mellitus ····· 1036119365
für 71.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray This book has been prepared for students of undergraduate courses in medicine, dentistry, pharmacy, laboratory medicine, physiotherapy, veterinary science, agriculture, biochemistry, genetics, microbiology, biotechnology, molecular biology, etc. The main purpose is to provide an understanding of the basic concepts in biochemistry and biotechnology which are required for them in a simple and interesting manner. Though there are a lot of books providing extensive knowledge of these subjects in the market , it has been observed that most of the students, especially from non-English speaking countries feel intimidated by the complexities of these subjects. Hence, this book is an endeavour to fulfil their needs. Care has been taken to explain various topics in as simple a language as possible, without compromising on the quality of the subject matter. The text is supported with clear diagrams. Students, who are appearing for various competitive exams, will find this book equally helpful. This book will also serve as a handy tool for teachers and postgraduate students. ····· 1036119305
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray A critical analysis of research papers by the author on the interfacial mechanisms controlling the stability of protein stabilised foams and emulsions. Proteins can stabilise foams and emulsions, by forming a visco-elastic adsorbed layer on the surface of the bubbles and droplets. The influence of protein molecular structure and the competitive adsorption of surfactants on the interfacial properties and the subsequent effects on foam and emulsion stability are presented. Approaches to increase the resistance to competitive adsorption through using hydrophobic proteins and highly elastic interfaces are described. The displacement of proteins from interfaces by surfactants was found to be a physical displacement process which heavily depended on the visco-elasticity of the protein adsorbed layer. Finally, approaches to protect foams against competitive destabilisation using lipid binding proteins, and non-covalent crosslinking proteins at the interface are shown. This caused in increase in surface elasticity, and hence improved foam stability. ····· 1036119131
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Mitochondria mediated programmed cell death is still an enigma, largely fuelled by the little known mechanism of important Inter Membrane Space (IMS) protein release in the cytosol from the mitochondria. These proteins start execution phase of apoptosis in many cells, initializing the death of the cell. This book proposes a novel idea and supports it by ample and appropriate evidences.Ceramide (sphingolipid), self assembles to forms a channel in the Mitochondrial Outer Membrane (MOM), to mediate IMS protein release at the onset of apoptosis. This book, for the first time provides direct structural evidence of the channel. Until now all published data were functional in nature. Transmission electron micrographs and its software-assisted analysis (structural) were compared with electrophysiological data (functional),to show the nice convergence between them. The data presented in the book therefore relies on self-validation by comparing data from different sources. This book will be a great tool for advanced students and researchers interested in the field of apoptosis, which has an intertwined relation with cancer. The book thus will help eradicate this deadly disease. ····· 1036119023
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The electromagnetic radiation emitted from new technological devices forms a real hazard to the biological structure. The most important biological structure ever known is the brain. The interaction of such fields with the brain can cause changes in its function and consequently put the whole organism in danger. Research is now carried on to investigate the interaction mechanisms of EMF with the biological structures and the impact of such fields on the integrity of the organism. ····· 1036118975
für 61.20€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Anticancer activity of a Schiff base cobalt (II) complexes synthesized from cobalt (II) acetate, salicylaldehyde and glycin, viz. (SGCo)2 [N-salicylidene glycinato diaqua cobalt(II) dimer] has been studied against Ehrlich Ascites Carcinoma (EAC) cells in Swiss albino mice by monitoring the parameters like tumor weight, survival time, cell growth rate etc. It has been found that (SGCo)2 at dose 10 mg/kg (i.p.) significantly decreases tumor weight (by 54%), increases life span (by 62%) and reduces tumor cell growth rate (by 74%) in comparison to those of EAC cell bearing mice. It has also found that the compound has no long term toxic effect to the host. This compound can, therefore, be considered as a probable new potent anticancer agent. The efficiency is more or less comparable to that of standard drug bleomycin (at dose 0.3 mg/kg i.p.). Further experiments involving advanced techniques are necessary with other cell lines to find out its applicability as a new anticancer drug for future. The compound is also found to be moderately active as an antibacterial agent when tested against some pathogenic bacteria (S. sonnei, E. coli etc) and as an insecticide (against T. castaneum). ····· 1036118839
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray ROS and their proven involvement in some human physiopathologies have drawn significant interest over the last few decades. Oxidative stress has been associated with many diseases such as cancers. The development of disease can be attributed to the oxidative alteration of molecules such as proteins, lipids, carbohydrates and nucleic acids by ROS. The human body has developed its own defence system to deal with oxidative stress, but certain external factors such as UVR may result in elevated cellular ROS concentrations, overwhelming the body s defence system thus leading to disease. To neutralize this effect, exogenic antioxidants particularly polyphenols, may be helpful to counteract ROS by preventing oxidation caused by ROS. To assess the antioxidant capacity of selected phenols, polyphenolic compounds were successfully synthesized in this study through biocatalytic reactions using phenol oxidases, to produce natural polyphenols suggested to have higher antioxidant activity than their monomers. Production of natural antioxidants was significantly considered for eventual consumer satisfaction and world market success if putative antioxidant were to go market. ····· 1036118814
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray There are many plants in Kashmir valley which have been shown to possess medicinal properties. Among them is Euphorbia helioscopia which is known for its medicinal values. At present drug resistance is a worldwide problem and much emphasis is being laid on the natural plant sources to act as antibiotics which can overcome this problem. Euphorbia helioscopia which is known for its medicinal values has febrifuge and vermifuge activities in its roots and stem respectively. The root is anti helminthic. The milky sap is applied externally to skin eruptions. The seeds, mixed with roasted pepper, have been used in the treatment of cholera and the oil from the seeds has purgative properties. However, isolation of any antibacterial protein has not been reported till date. The essence of the work was to check the antibacterial activity of the plant following its purification and characterization from leaves using conventional protein purification techniques. The lectin is a homodimer (Mr 65000Da), thermostable between 0°C- 40°C but exhibits a narrow range of pH stability being optimally active at pH 7. The lectin shows antimicrobial activity against P. aeruginosa, K.pneumoniae and E. coli. ····· 1036118766
für 53.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray This book comprises the 9 chapters which includes the basic and fundamental study on the production of single cell protein, mushroom, biofertilizers,biocompost and yeast along with their production technologies using eco-friendly microbes.This book is excellent hand book on various technologies used in microbial production of industrially important biomass.This book is dedicated to All Mighty & my Parents. ····· 1036118578· 1 · ::::: · 9 ·· 10 ·· 11 ·· 12 ·· 13 ·· 14 ·· 15 · ::::: · 16 ·
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