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In-Silico Design & Synthesis of MurB Inhibitors as Antibacterial Agent

für 53.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray
Heterobicyclic oxazolo pyrimidinone are important class of compounds. They may become promising candidates for exploiting more useful therapeutically active molecules. The compounds having oxazolo pyrimidinone moiety are associated with interesting wide spectrum biological activities, such as antibacterial, kinase inhibition, adenosine receptor antagonism, tumour growth inhibition and some show to inhibit the ability of ricin to inactivate the ribosomes etc. The intermediate azlactones are also useful precursors for the synthesis of amino acids, peptides, heterocycles, biosensors and antitumor or antimicrobial compounds. In the present study, it was proposed to synthesize lead molecules of oxazolo pyrimidinone skeleton, apt for binding to the target enzyme, bacterial MurB based on the rational approach and to study their docking simulations using ArgusLab 4.0.1 and AutoDock 4.2 softwares. The synthesized test compounds were then characterized by TLC, melting point determination, UV, IR, 1H-NMR and mass spectral studies and tested for their antibacterial activity and compare with the standard drug. ····· 10361100846

Application of sewage sludge on an acid tropical soil

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Malaysia produces about 5 million metric tonnes of sewage sludge annually.The quantity of sludge is expected to increase every year and directly proportional to the increase in municipal wastewater that had to be treated.The use of sewage sludge as a fertilizer has not been practiced nor publicly accepted in Malaysia.Nevertheless, the application of sewage sludge to agricultural land is generally the most economical means of waste disposal and also provides an opportunity to recycle beneficial plant nutrients to soil for crop production.However, sewage sludge also contains varying amounts of heavy metals which may pose a hazard of metal toxicity to crops and the consumer of these crops.At present there are no guidelines or policies on land application of sewage sludge in Malaysia.Studies need to be conducted so that regulations and policies developed are based on scientific data. Therefore,this book provides an assessment on the feasibility of using sewage sludge as a fertilizer on agricultural land in Malaysia.Thus,the crop response, uptake of heavy metals by crops and the fate of these heavy metals in soils have been investigated and discussed in various chapters of this book. ····· 10361100833

Microwave-assisted extraction of phenolic compounds

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Moringa oleifera Lam. (MO), commonly known as drumstick tree, is one of Asian multipurpose tree. A few studies have reported the presence of phenolic compounds responsible for antioxidant activity in MO leaves. In this study, microwave-assisted extraction was employed to extract the phenolic compounds. To achieve high yield of total phenolic content (TPC), the extraction process parameters-extraction time, temperature, sample/solvent ratio, solvent composition, and microwave power-were optimized by using response surface methodology. The phenolic profile and antioxidant activities, based on ferric reducing/antioxidant power (FRAP) and 1,1-diphenyl-2-picryl-hydrazyl (DPPH) radical scavenging assays, of the extract obtained under the optimum conditions were also evaluated. ····· 10361100397

Analysis of Certain Compounds Containing Nitrogen and Oxygen

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Nitrogen and oxygen are constituents of molecules in every major drug class in pharmacology and medicine. Nitrogen and oxygen containing compounds include all of the major classes of pharmaceutically important drugs such as antiepileptics, antihypertensives, antivirals and vitamins. This work is devoted to the developmet of validated analytical methods for the determination of some compounds containing nitrogen and oxygen including pregabalin, oseltamivir, metoprolol, felodipine, metoclopramide and pyridoxine. The usefulness of different spectrophotometric, spectrofluorimetric and chromatographic methods was exploited. The proposed methods are of great value in quality control analysis of the studied compounds owing to their improved simplicity, sensitivity, low-cost, and its independence on expensive instruments, or critical analytical reagents. ····· 10361100367

Solid waste based adsorbents for wastewater treatment

für 61.20€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray
Water pollution is a serious threat to mankind in the present scenario and, hence, many techniques are in use for water treatment. Out of them the adsorption is a commonly used method as it is simple, fast, and universal in nature. Typically, activated carbon is used as a perfect adsorbent for wastewater treatment but it is overpriced and requires regeneration. The regenerated carbon exhibits lower adsorption capacity with further management problem of the effluent obtained from its regeneration. These facts have grown interest in the search for solid waste based low cost alternatives of activated carbon that can be used for water pollutant removal. This book tells how (i) to develop low cost adsorbents from waste materials (ii) to remove toxic pollutants by using developed low cost adsorbents (iii) to optimize adsorption parameters for the maximum removal of pollutants by using developed low cost adsorbent through batch process (iv) to transfer batch adsorption conditions to the column studies to evaluate the feasibility of the developed adsorption system in real samples (v) to ascertain adsorption mechanism for applying the developed adsorption system effectively & practically. ····· 10361100125

Green Chemistry: New Avenues in Chemical Research

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Green chemistry is not a new branch of science. It is a new philosophical approach that through application and extension of the principles of green chemistry can contribute to sustainable development. Presently it is easy to find in the literature many interesting examples of the use of green chemistry rules. They are applied not only in synthesis, processing and using of chemical compounds. Many new analytical methodologies are also described which are realized according to green chemistry rules. They are useful in conducting chemical processes and in evaluation of their effects on the environment. Great efforts are still undertaken to design an ideal process that starts from non-polluting initial materials, leads to no secondary products and requires no solvents to carry out the chemical conversion or to isolate and purify the product. ····· 1036199928

Optional Parameters for Sugar Manufacturing

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Any process technology can only survive on the basis of time to time modification over conventional methods. So the sugar industry also needs modification on continuous basis. In the present Monograph three basic issues have been compiled out of authors published work. The content of the Monograph relates to chemistry of sugar manufacturing, clarification and quality assessment of end product i.e. sugar. The sugar making is basically a chemically reactive system. As such chemical balancing of the entire clarification zone has been projected in initial part of this Monograph. Secondly the clarification process has been taken up and the option proposed is by means of mechanical system instead of using chemicals. Lastly the end product has been described for its quality assessment. Besides this, the means to enhance its quality has also been the part of compilation in the said Monograph. All the parameters dealt in the Monograph have been proposed in optional mode from conventional process linked with theoretical & practical observations. All the methods proposed in the Monograph may prove meaningful one or other day for the sugar industry. ····· 1036199885

Interaction of Drugs with Metal ions

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Metals have played an important role in medicine for years,ever since humans have walked the planet. Many are essential in our diets in varying quantities, although people have recently realized their significance.Metal ions bond with ligands in some process, to oxidize and reduce in biological systems.The important metal present in the body is iron which plays a central role in all living cells.Generally iron complexes are used in the transport of oxygen in the blood and tissues. An adult at rest consumes 250ml of pure oxygen per minute, this oxygen carried by the metal complex transport system known as heme, allowing the oxygen to leave the blood when it reaches the tissue. The heme group is metal complex, with iron as central metal atom, which bind or release molecular oxygen. ····· 1036199739

Coordination & Biological Aspects of Derivative of Lawsone

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The research work carried out for this project is based on the synthesis, structural investigation and its biological aspects. Thiosemicarbazone derivative at 1 or 2 position of the Lawsone ( 2-hydroxy-1,4-naphthalenedione ) is an its important derivative, Which possesses a powerful chelating ability, appreciable analytical utility and significant biological activity. Important conclusions are given as:1) Ni (II) forms complex with these ligands in a squire planar, distorted trigonal prism and capped trigonal prism geometry. 2) It shows the antibacterial and anti fungal activity ISBN: 978-3-8473-2220-7 ····· 1036199730

Developing Novel Biointerfaces and Biomaterials with SPR/SPR Imaging

für 71.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray
Much research has focused on the development of analytical methods to monitor a multitude of biological interactions including protein-carbohydrate and protein-lipid among others. Surface plasmon resonance (SPR) remains one of the most exciting techniques that allows for real-time data collection and label free detection amenable to many biological systems. This thesis focuses on the development of novel sensing interfaces/materials for biomolecular interaction analysis (BIA) with SPR and SPR imaging (SPRi). The first portion of this work focuses on the development of unique surface chemistry designs to examine biological interactions including the development of a high-density array to detect carbohydrate-lectin interactions with SPRi. The second part of this thesis focuses on the development of new substrates for both SPR and SPR imaging experiments. The fabrication of a nanometric thick layer of glass-on-gold to detect protein-lipid interactions with SPR is presented. Finally, the facile fabrication of gold-coated etched glass substrates for SPR imaging that reduces background resonance 5-fold in situ compared to the standard gold island array platform is presented as well. ····· 1036199712

Anionic phosphate gemini surfactants

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Gemini surfactants are a new class of surfactants. They are made up of two identical or different amphiphiles moieties having the structure of conventional (monomeric) surfactants connected by a spacer group. Geminis are known for their superior properties such as the low critical micelle concentration (cmc), high efficiency of reducing the surface tension of water, and micelle structural characteristics. Anionic geminis are further sub classified into four types i.e. sulphate, sulphonate, carboxylate and phosphate. Phosphate gemini surfactants are a class of gemini surfactants. Phosphate esters represent specialty surfactants fitting a number of niche markets. The phosphate gemini surfactants found application as antistatic agents, emulsifiers, wetting agents, and hydrotropes. The aim of this book is to provide up to date information on synthesis and characterization of higher fatty alcohols based anionic phosphate gemini surfactants. Physicochemical and surface active properties of synthesized anionic phosphate gemini surfactants have been studied thoroughly. ····· 1036199670

Studies on Nano Calcium Phosphate Reinforced Polymer Composites

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The field of material science became quite popular and pragmatic with a tremendous push for composite materials that exhibit the positive characteristics of both the components. Of late polymer nanocomposites have been making a large splash in the media and throughout several industries. Composites that exhibit a change in composition and structure over a nanometer scale have shown remarkable property enhancements relative to conventional composites. Most notable are increased gas barrier, resistance to small molecule permeation, improved ablative resistance, increase in atomic oxygen resistance and retention of impact strength without increasing the density of the base polymer, without degrading its optical qualities and without making it any less recyclable. Here, calcium phosphate nanoparticles were prepared by economically viable polymer induced crystallization technique, characterized and incorporated in PS and EVA. ····· 1036199605

Multiobjective optimization of natural gas transportation networks

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The optimization of a natural gas transportation network (NGTN) is typically a multiobjective optimization problem, involving for instance energy consumption minimization at the compressor stations and gas delivery maximization. However, very few works concerning multiobjective optimization of gas pipelines networks are reported in the literature. Thereby, this book aims at providing a general framework of formulation and resolution of multiobjective optimization problems related to NGTN. Firstly, the NGTN model is described. Then, various multiobjective optimization techniques belonging to two main classes, scalarization and evolutionary, commonly used for engineering purposes, are presented. The non dominated solutions are displayed in the form of a Pareto front. Finally, in the multiobjective cases, generic Multiple Choice Decision Making tools are implemented to identify the best solution among the ones displayed of the Pareto fronts. ····· 1036199499

Air organic pollutants destruction by using electron beam technology

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Organic pollutants emission poses a serious problem to the environment and human health. As the demand for reduced organic pollutants emissions increases, the market for effective and low-cost control technologies also improves. Electron beam (EB) is one of the most promising technologies to remove low concentration of organic pollutants from large quantities of off-gases. This book reviewed literatures on organic pollutants, their emission source, transformation in the atmosphere, health and environmental impacts, and present control technologies. The principle of radiation technology to treat organic pollutants in the gaseous phase was described. The detailed experimental set up and experimental results of selected representative organic pollutants` degradation under EB irradiation were reported and discussed, and mechanisms of their decomposition under EB-irradiation were elaborated with the aid of chemical model calculation. This text-reference book should be useful for practicing environmental engineers, chemical engineers, radiation chemistry and chemistry students, or anyone else who may be interested in pollution control technologies. ····· 1036199381

Modern Analytical Techniques to Study Novel Anticancer Compounds

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Analytical Chemistry is at the core of drug discovery and this work focuses on the use of modern techniques to study interactions of novel metallo anticancer compounds with biological targets which is crucial to better develop them. The studied compounds include supramolecular iron cylinders which should offer a new mode of binding to DNA, and steroid platinum and rhenium compounds aiming at better targeting cancer cells. In order to study these compounds interactions with DNA and proteins, a myriad of modern techniques were used including linear and circular dichroism, surface plasmon resonance, IR LASER imaging, gel electrophoresis, ESI-MS, fluorescence and UV-Vis spectroscopy. This work is a humble contribution in the very complicated quest of developing more selective anticancer compounds. ····· 1036199166

Purification methods for Montelukast & its intermediate stages

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Unfortunately asthma is one of the most common chronic diseases worldwide and the prevalence is increasing, especially among children. The prevalence of asthma symptoms in children varies from 0.30 % in different population with the highest prevalence occurring in Australia, New Zealand and England. The objective of present work is to purify Montelukast and its intermediate stages with improved potency, better compatibility to human body, greater bio availability and lesser serious side effects.Quality improvement(Purification) can be achieved by various methods, like chromatographic techniques, crystallization by salt formation and its reversal back to active pharmaceutical ingredient and simple re-crystallization. So, purification or quality improvement of any drug is the necessity for safety of human life. ····· 1036198777

The corrosion protection of stainless steel in phosphate industry

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This book provides a brief introduction to the corrosion of stainless steel for those studying the subject either as part of a degree course or in a professional context. The book examines the corrosion problem of stainless steel in a very scientific manner, taking into account its causes and protection with inhibitors very seriously. The corrosion of stainless steel can cause deterioration of industrial equipment resulting in vast economic losses. On the whole it incorporates the study of the following issues: introduction of corrosion, corrosion of stainless steel in phosphate industry, analysis of corrosion in phosphate industry, use of inhibitors for the protection of stainless steel in phosphate industry and the protection effect of inhibitors on stainless steel. This book is very suitable corrosion and metallurgical engineers, corrosion specialists, research scholars, engineering students, U G and P G students. ····· 1036198558

Ceria-Lanthana Solid Solution for Automotive Exhaust Gas Purification

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The worldwide effort to reduce the harmful effects of automotive exhaust has witnessed impressive progress over the past few decades. There has been a sustained interest in the development of new catalysts. Three-way catalysts (TWCs) constitute the most satisfactory and efficient solution to reduce pollutant emissions from automobiles. In this context, the research focus has been aimed at the development of more efficient catalyst with high level of heat resistance to ensure stability and reliability in long-term service. Cerium oxide was recognized as indispensable to the success of TWCs, due to its ability to change the oxidation states at the surface. This enables it to `store` and `release` oxygen in response to changes in the gas phase composition. This book is based on a comprehensive research study which provides an insight on the development of nano-sized ceria-lanthana solid solutions for the oxidation of CO and soot, and other catalytic applications. This book provides valuable information on correlations between the structural properties and catalytic performance. ····· 1036198436

Chiral Triazole Fungicides Separation

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In recent years, capillary electrophoresis (CE) has been developed as a separation analysis method suitable for routine applications. Its popularity may be attributed to its extremely high efficiency, short analysis time and wide application range. Micellar electrokinetic chromatography (MEKC) has become popular as a powerful technique to solve many chemical analysis problems not only of neutral analytes but charged ones by using capillary electrophoresis (CE) instrument without any alteration. The environmental impact due to the heavy application of agrochemicals to open fields must be reduced. As for the chiral agrochemicals, the use of only biologically active enantiopure isomers should also help to reduce the total amount of chemical released into the environment. Triazole fungicide is one of the most important categories of fungicides. It has excellent protective, curative and eradicant power against a wide-spectrum of crop diseases. Chirality is expected to play a crucial role in bioactivities of triazole fungicides. The purpose of this study is to investigate the applications of micellar electrokinetic chromatography (MEKC) in chiral triazole fungicides analysis. ····· 1036198367

Iron (II) and Ruthenium (II) Sulfur complexes modelling [MS] enzymes

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Transition elements are the main component of the active centers found in many proteins. The active centers of these proteins consists of the transition element atom linked to nitrogen atoms or oxygen or sulfur arising from some amino acids The active centers formed naturally in the biological processes to do a very distinctive job under physiological conditions for each protein, such as converting nitrogen to ammonia or fixing atmospheric nitrogen in order to be available to the plant. It was therefore necessary to find several attempts to identify the composition of the active centers and to shed light on the mechanism of the interaction of these proteins. From this stand point, the study was aimed at new attempts to explain the mechanism functioning of some of the interactions of enzymes and proteins through the design and preparation of some complexes of transition element models simulate the structure (structural model) and functional (functional models) of the nitroganases enzymes. ····· 1036198348

Effects of Heavy Metals on Omega-3 Fatty Acids

für 49.41€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray
Over the years, heavy metal pollution has continued to cause instability to aquatic ecosystems. The pollution is mostly from anthropogenic sources like mining activities, sewage treatment plants and non point sources such as agriculture. Lake Victoria being the largest fresh water lake in Africa, has suffered a lot of pollution emanating from the aforementioned sources. The lake plays a major economic role in the economies of the riparian nations especially from fishing. Fish is the major source of polyunsaturated fatty acids (PUFAs) such as omega - 3 and omega - 6 which are very beneficial to human body. Once an aquatic environment is polluted with heavy metal pollutants, it may lead to high intake of the pollutants by the fish hence lowering the levels of the essential fatty acids. This study was carried out so as to investigate if there was any impact of heavy metal pollutants on the types and levels of omega -3 in tilapia fish and also in microalgae which is the basic food of the fish. The results showed presence of heavy metal pollutants in water, sediments, microalgae and fish. Tilapia fish was found to have high proportions of PUFAs which have numerous benefits in the body. ····· 1036198259

Priestley in America 1794-1804

····· lezzter Preis 9.90€ ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray
This book is part of the TREDITION CLASSICS series. The creators of this series are united by passion for literature and driven by the intention of making all public domain books available in printed format again - worldwide. At tredition we believe that a great book never goes out of style. Several mostly non-profit literature projects provide content to tredition. To support their good work, tredition donates a portion of the proceeds from each sold copy. As a reader of a TREDITION CLASSICS book, you support our mission to save many of the amazing works of world literature from oblivion. ····· 1036196138

Elements of Chemistry, In a New Systematic Order, Containing all the Modern Discoveries

····· lezzter Preis 19.90€ ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray
This book is part of the TREDITION CLASSICS series. The creators of this series are united by passion for literature and driven by the intention of making all public domain books available in printed format again - worldwide. At tredition we believe that a great book never goes out of style. Several mostly non-profit literature projects provide content to tredition. To support their good work, tredition donates a portion of the proceeds from each sold copy. As a reader of a TREDITION CLASSICS book, you support our mission to save many of the amazing works of world literature from oblivion. ····· 1036195988

The Story of a Tinder-box

····· lezzter Preis 9.90€ ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray
This book is part of the TREDITION CLASSICS series. The creators of this series are united by passion for literature and driven by the intention of making all public domain books available in printed format again - worldwide. At tredition we believe that a great book never goes out of style. Several mostly non-profit literature projects provide content to tredition. To support their good work, tredition donates a portion of the proceeds from each sold copy. As a reader of a TREDITION CLASSICS book, you support our mission to save many of the amazing works of world literature from oblivion. ····· 1036195080

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