für 71.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Alzheimer`s disease (AD) is the most common type of dementia in the elderly. Clinically, the disease is characterized by a progressive memory loss and cognitive decline, pathologically AD is characterized by senile plaques (SP), neurofibillary tangles (NFT), and synapse loss. AD is characterized by the presence of proteinaceous deposits in the extracellular and intracellular compartments of the brain. The intracellular deposits containing polymerized and hyperphosphorylated tau protein. While the extracellular deposits consist of -amyloid protein (A ), which is composed of 40-42 amino acid polypeptide. The present study focuses on evaluating the role of treatment with different nutraceuticals including essential fatty acid, coenzyme, enzyme inhibitors, amino acids, antioxidant and vitamins against Al-induced neurodegenerative damage characteristic of Alzheimer`s disease in aged rats. The present study demonstrated that the treatment with the selected nutraceuticals significantly ameliorates the neurodegeneration characteristic of Alzheimer`s disease as indicated by the tangible improvement in the specific biochemical markers and histological features of the brain. ····· 10361118010
für 53.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray ACTIVIDADES ENZIMATICAS EN SUELOS DE LOS ANDES VENEZOLANOS SE REALIZARON ESTUDIOS DE SUELOS ESCOGIDOS DE UN GRUPOI MAYOR ANALIZADOS PREVIAMENTE DELOS CUALES SE ESCOGIERON LOS DE DISTINTOS NIVELES DE CONSTRASTES FISICO,QUIMICOS LOS RESULTADOS MOSTRARON MAYORES NIVELES DE ACTIVIDADES DE LAS ENZIMAS(UREASA,DESHIDROGENASA,ARILSULFATASA Y FOSFOMONOESTERASA),SOBRE TODO EN LOS PRIMEROS DIAS,ESTO SE SUSTENTA CON ESTUDIOS DE CALIDAD DE MATERI ORGÁNICA A TRAVES DE UNA CINETICA QUE PERMITIO SEGUIR LA MATERIA ORGANICA LABIL Y NO LABIL,ASI COMO LA RESPIRACION EDAFICA. ESTOS SUELOS TENIAN UN HISTORIAL DE FERTILIZACION ORGANICA E INORGANICA. TAMBIEN PERMITIO LA DISCUSION METODOLOGICA DE LA DETERMINACION ENZIMATICA ····· 10361117499
für 35.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Como docente siempre presenté a estas moléculas como las más aristocráticas, especializadas y complejas de las biomoléculas presentes en los seres vivos. De ahí, el subtítulo que propongo, el de moléculas causantes de las funciones fisiológicas,portadoras de mensajes específicos y dirigidos en un sentido telonómico al control de de las grandes funciones biológicas. Se ha de considerar que las proteínas actúan como enzimas, que regulan una importante constante para la vida, el equilibrio ácido-base, participan en la respuesta inmmune, mantienen la presión coloi-osmótica u oncótica, intervienen en el proceso de la hemostasia y coagulación sanguínea, son transportadores de importantes moléculas, muchas de ellas y sus familiares polipeptidicos actúan como hormonas. Derivados de aminoácidos y péptidos actúan como neurotransmisores. También las proteínas están presentes en fenómenos de transducción y son imprescindibles sus señales como mediadores de la acción hormonal. Todos estos motivos y otros muchos que no han sido aquí señalados avalan la realización una monografía histórica de tan singulares moléculas. ····· 10361117408
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray El sistema de calidad HACCP, es un sistema de gestión de calidad abierto y específico para cada producto y proceso productivo, reconocido internacionalmente para abordar los peligros biológicos, químicos y físicos mediante la previsión y prevención en lugar de la inspección y comprobación final del producto. Por ser un sistema abierto y definido solo por las características del producto y su proceso, es importante para su efectiva aplicación la regulación de los peligros de cada uno de ellos a fin de no dejar librado a la subjetividad del implementador su determinación. En la implementación por etapas del sistema HACCP, se trabaja con el árbol de decisiones para la identificación de los PCC, tarea que parece ser sencilla ya que si se siguen las preguntas en el orden dado, todo estaría resuelto, pero por el contario esta simplificación producto de la amplitud de la norma, puede generar un sistema en donde sobreabunden los PCC porque todo parece ser un riesgo potencial, o por el contrario nada es riesgoso en el proceso de elaboración. ····· 10361117264
für 71.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray D. bardawil es una de las principales fuentes naturales conocidas de b-caroteno, carotenoide de contrastada actividad antioxidante, beneficioso en la prevención y evolución de patologías que cursan con degeneración oxidativa. Ambas cualidades hacen que esta microalga sea actualmente objeto de explotación tanto para la producción biotecnológica de b-caroteno como para la obtención y comercialización de su propia biomasa como fuente de proteína y antioxidantes. La fase de producción de b-caroteno con Dunaliella implica el uso de condiciones de estrés inductoras de su acumulación, que paralelamente producen una ralentización del crecimiento del microalga. En este trabajo se analizan condiciones conducentes a la acumulación de carotenoides y que simultáneamente no ralenticen el crecimiento de la microalga, como es el caso de la aplicación de radiaciones UV de diferente rango. Asimismo, se analiza la idoneidad del litoral onubense (Andalucía) para la producción de carotenoides en cultivos exteriores con esta microalga. ····· 10361117113
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Las enzimas han desempeñado un papel importante en muchos aspectos de la evolución de la humanidad, de hecho son de vital importancia para la existencia de la vida. El hombre las ha utilizado por miles de años sin entender qué eran o cómo trabajaban, solamente aprovechaba sus propiedades. Sin embargo, desde hace algo más de un siglo se comenzó ha dilucidar el misterio de las enzimas y se ha aplicado este conocimiento para hacer un mejor uso de ellas. ····· 10361117100
für 53.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray El objetivo global del trabajo fue profundizar en aspectos estructurales y evolutivos de lectinas vegetales. Por una parte, se ha caracterizado las lectinas de algas marinas rojas Hypnea cervicornis e Hypnea musciformis. Las lectinas contienen 90 aminoácidos, presentan dos dominios homologos entre sí dispuestos en tandem y no muestran similitud con ninguna proteína descrita, indicando que son miembros fundadores de una nueva familia de lectinas. Por otra parte, se centró en la determinación de las bases estructurales del equilibrio dímero tetrámero dependiente del pH que presentan algunas lectinas de la tribu Diocleinae de la familia Papilionoideae de las leguminosas. Para ello, se ha empleado un abordaje basado en técnicas de Biología Molecular, Biofísica y Biología Estructural. Las proteínas recombinantes de Dioclea guianensis y Dioclea grandiflora son bioquimicamente indistinguibles de sus homólogas aisladas de semillas. Se ha logrado generar el equilíbrio dímero-tetrámero dependiente del pH a partir de la lectina r-DGL, tetramérica en el intervalo de pH de 4-8.5. La existencia del equilibrio dímero-tetrámero se correlaciona con una conformación retraída de los bucles 117-122. ····· 10361116639
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray El objetivo principal de esta tesis se ha centrado en el estudio de las diferencias entre ratas macho y hembra en la morfología, la función y la biogénesis mitocondrial del tejido adiposo marrón (TAM) y del hígado, mediante el análisis de distintas subpoblaciones mitocondriales obtenidas a través del fraccionamiento de la población mitocondrial total. Los resultados han puesto de manifiesto que las diferencias entre géneros a nivel mitocondrial tanto en el TAM y como en el hígado podrían ser atribuidas a la existencia de una subpoblación mitocondrial altamente diferenciada en las hembras, hecho que podría ser indicativo de un proceso de biogénesis mitocondrial distinto entre ambos géneros. Los resultados sugieren la existencia de un factor común a ambos tejidos que influiría en la regulación de dicho proceso. En este sentido, las hormonas sexuales podrían ser uno de los factores candidatos responsables de las diferencias observadas en el presente trabajo. ····· 10361116337
für 61.20€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray En la actualidad, la ciencia de la nutrición ha evolucionado a partir de conceptos clásicos (suficiencia nutricional básica) hacia los conceptos de nutrición `positiva` u `óptima` centrándose las investigaciones en la identificación de componentes biológicamente activos. En nuestra sociedad se producen con cierta frecuencia estados hipercatabólicos, como son los casos de enfermos politraumáticos, quemados, enfermos de cáncer o enfermedades relacionadas con el envejecimiento, etc., todos ellos asociados a un estado general de mal nutrición. Se sabe que la ingesta de proteínas de alta calidad, sustancias antioxidantes y ácidos grasos poliinsaturados de las series omega-3 y omega-6, contribuyen positivamente a la mejora de los pacientes en estados hipercatabólicos. Dichos principios se encuentran en la composición de los crustáceos. Estas premisas nos han llevado a plantearnos la posibilidad de obtener un alimento funcional a partir del cangrejo rojo (Procambarus clarkii)el cual pudiera ser útil para el tratamiento nutricional y mejora de los estados hipercatabólicos. ····· 10361116334
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Lipid oxidation is one of the key problems associated with the loss of quality of seafood. In the seafood industry, lipid oxidation is a serious problem, not only because it produce rancid odors and flavors, decreases shelf life and alter texture and appearance of foods, but also because it can decrease the nutritional quality and safety of seafood. It is the process by which oxygen reacts with unsaturated lipids present in the foodstuff. In the presence of an initiator, polyunsaturated fatty acids can become oxidized and form alkyl radicals. When exposed to oxygen, the alkyl radicals rapidly form peroxyl radicals and these radicals can react with more lipids to produce hydroperoxides. As a lipid hydroperoxide decomposes, it forms numerous volatile compounds such as hexanal and propanal, which impact the sensory quality of foods. Lipid oxidation in seafood can be mediated by enzymes like lipoxygenase, cycloxygenase and haem protein like haemoglobin and myoglobin. Oxidation of lipids is accentuated in the immediate post-slaughter period, during handling, processing, storage and cooking. This process leads to discoloration, off-odor and off-flavor development. ····· 10361116205
für 71.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray In recent years, there has been an amplified interest worldwide to identify herbal products which are pharmacologically effective and have low or no side effects for use in preventive medicine. There has been a great demand for the discovery and supply of plant derived novel molecules which can be used as herbal medicines and or therapeutic dietary supplements. Moreover, native preparations from leaves and other plant parts contain both dotes and antidotes to alleviate the undesirable effects if any, than isolated principles / drugs which may exert side / toxic effects often. Therefore, most of the global population turned to herbal medicines containing native preparations / dietary therapeutics. Plants produce significant amount of active compounds such as phenolics and flavonoids to prevent diseases and oxidative stress caused by reactive oxygen species. Ayurveda, Unani, Chinese and other traditional medical systems, provide substantial lead to find active and therapeutically useful compounds from plants. Mulberry (Morus indica L.) is among such plants, the leaves of which have been used as a feed for silkworm for centuries. This book deals with multibeneficial viz. hypoglycaemic. ····· 10361116143
für 61.20€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Osteoporosis is a serious disorder of the skeleton that increases bone fragility and the risk of fracture. Postmenopausal women are at increased risk of osteoporosis because of the decline in estrogen production that occurs following menopause. The aim of the present study is to determine the protective effect of nondigestible oligosaccharides (NDOs) from chicory roots and phyto soya extract rich with isoflavones whether using alone or in combination on the prevention of osteoporosis using ovariectomized (OVX) rats as model of postmenopausal women.The results obtained suggested that supplementation with chicory root extract or phyto soya extract rich with isoflavone prevent the bone loss,and the combination of these supplements may have an additive and cooperative effect on the prevention of osteoporosis ····· 10361116003
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Traditionally, drugs were discovered by testing compounds synthesized in time consuming multi-step processes against a battery of in vivo biological screens. Promising compounds were then further studied in development, where their pharmaceutical properties, metabolism and potential toxicity were investigated. Here we present a study on herbal lead compounds and their potential binding affinity to the effectors molecules of major diseases like endometrial cancer. Clinical studies demonstrate a positive correlation between the extent of PDK1 and malignant progression of pre cancerous lesions in endometrial. Therefore, identification of effective, well-tolerated anti cancer inhibitor represents a rational chemo preventive strategy. This study has investigated the effects of naturally occurring compounds that inhibits the target. Our results reveal that these compounds use less energy to bind to the target and inhibit its activity than the commercial drugs used. Their high legend binding activity to the target introduce the prospect for their use in chemo preventive applications in addition they are freely available natural compounds that can be safely used to prevent disease. ····· 10361115975
für 61.20€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Diabetes mellitus is a complex of metabolic disease characterized by hyperglycemia , diminished insulin production, impaired insulin action , or a combination of both resulting in the inability of glucose to be transported from the blood stream into the tissues, which in turn results in high blood glucose levels and excretion of glucose in the urine, The cell functions involved in the action of insulin receptor binding enzyme and transporter activities are controlled by membrane properties . Fatty acids composition of membrane phospholipids are affected by the composition of the dietary fat .Changes in the fatty acids composition of erythrocyte membrane , which are easily accessible cells, reflects changes in that of membrane phospholipids of less accessible tissues . The fatty acids composition of cell membrane can influence membrane associated phenomena such as the interaction between insulin and its receptors. Thus it is from interest to study the relationship between cell membrane phospholipids fractions and their role in insulin action, also to study the role of omega-3 fatty acids in reducing oxidative stress in diabetic rats. ····· 10361115963
für 53.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray A microsomal membrane bound alcohol oxidase enzyme was isolated from a hydrocarbon degrading Aspergillus terreus fungus that could oxidize short chain-,long chain-, secondary-, and aryl-alcohol substrates. High aggregating property of the protein was demonstrated by AFM, DLS and TEM analyses. Chemical analysis showed the presence of oleic acid and palmitic acid at a ratio of 2:1 in the purified protein. We have demonstrated a highly efficient method for dissociation and simultaneous deflavination of the alcohol oxidase protein using -ME. The potential applications of this approach on preparing apoprotein and its reassemble with FAD to a functional enzyme are envisaged in the preparation of enzyme electrodes for biosensor and biofuel cell applications. The findings obtained through this investigation have revealed many interesting facts about this novel microsomal alcohol oxidase enzyme.This investigation has opened up new avenue on the research to explore the architecture of alcohol oxidase proteins from fungal sources including their structure-function relationship and potential applications. ····· 10361115946
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Refining High Acid Olive Oil. The world production of olive oil reach 2,800,000 ton and 98% of this production is to be found in the Mediterranean Basin, where this agricultural system has been developing for thousands of years, characterized by its adaptation to the environment and its empiricism. Virgin olive oil is consumed unrefined, although a great proportion of the olive oil produced has to be refined to render it edible. Refining treatments are needed to remove or reduce the content of minor substances that may affect oil quality, such as phospholipids, FFA, pigments, peroxides, traces of metals, herbicides and volatile components. Phenolic compounds are among the substances eliminated during the different refining steps. At present, three types of olive oils are intended for refining: lampante olive oil, olive pomace oil and second centrifugation olive oil. Lampante olive oil is obtained from fruits by mechanical means, but it has undesirable organoleptic or chemical characteristics that make it unfit for consumption. The objective of the present work was to improve the quality of high-free fatty acid olive (HFFAO) oil. ····· 10361115932
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Industrial enzymes are considered to be the heart of Biotechnology. There is much scope of R & D resulting in developing number of new products and improving the process and performances of the existing products. Here, research work on two industrially important enzymes xylanase and starch phosphorylase are reported. Degenerate primers are designed for microbial endo-1,4- -xylanase gene. These primers may be exploited for amplification of the gene in a microbe. The approach may be exploited for production of xylanase using recombinant DNA technology. Besides, an alkalano- thermophilic xylanase enzyme is isolated from Bacillus haloduransans. Xylanase has been exploited in number of industrial uses SP is isolated from seeds of Pennisetum typhoides and immobilized on brick dust. The immobilized enzyme is found to have increased thermostability. Increased thermostability of the enzyme and property of repeated use may be exploited for production of glucose-1-phosphate, a cytostatic compound used in cardio-therapy. Commercial applications and Biotechnological exploitation of enzymes are described. ····· 10361115912
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Paraquat (PQ) is the most widely used herbicide in the world and found to controlling weeds in even more than 100 varieties of various crops. But the danger associated with its use is far bigger than its beneficial aspect. It is absorbed by skin, lung and gastrointestinal tract or inhaled due to their lipophilic character. Their harmful effects are thought to be mediated via cyclic reduction and oxidation process where oxygen plays a vital role as terminal electron acceptor. Detoxification system such as antioxidant enzymes exists in the body to eliminate ultimate toxicant or prevent its formation. Polymorphonuclear leukocytes (PMNs) are the most abundant circulating blood leukocytes which provide 1st line of defense against infection. The present study was undertaken to demonstrate PQ induced alterations in antioxidant enzyme activity and changes in the level of lipid peroxidation in PMNs of rat. This study will shed some light on the pathology and biochemistry of PQ toxicity and will be of great use for the students of medical science, biochemistry and to all individuals interested in the subject. ····· 10361115836
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray HLA-B27 is a class I surface antigen encoded by B locus in the Major Histocompatibility Complex (MHC) on the short (p) arm of chromosome no.6,presents microbial antigen to T cells. HLA B is a human gene that provides instruction for making a protein that plays a critical role in immune system.HLA-B27 is strongly associated with a certain set of autoimmune disease referred as the Seronegative Spondyloarthropathies , a group of disorders that include Ankylosing Spondylitis (AS) and other inflammatory joint diseases. It has been found that 90% of patients with this rheumatic disease have HLA- B27 antigen , compared with 10% of healthy controls. PCR for detection of HLA-B27 is extremely accurate and considered the standard method. The aim of this prospective study was to identify the positivity rate of HLA-B27 in different age group and sex of patients by using Sequence Specific Primer typing (SSP)-PCR approach in a selected population, suffering from Ankylosing spondylitis. Out of 40 samples,the positivity rate was maximum in age group of above 50 and also analyzed that males are more susceptible to this disease as compared to females. ····· 10361115828
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Collagen represents one of the mostly used biomaterials due to its excellent biocompatibility and biodegradability properties. The obtaining of collagen based biomaterials as support for local release of a desired amount of drugs has as motivation their use in the treatment of various skin affections (sores, burns, infections produced by various bacteria) and of soft tissues (periodontal disease, dental extractions). Besides its function as release support, collagen acts as a biological dressing for tissue regeneration. The objective of this work is to obtain last generation local delivery systems containing two antimicrobial drugs in collagenic systems (gels and matrices) to control the drug release for the treatment of different specific diseases: doxycycline an antibiotic used especially for the treatment of periodontitic disease and tannic acid an antiseptic for wound treatment. The development of such drug delivery systems bring about both theoretical and practical contributions in the field of biomaterials used as locally controlled drug delivery systems. The biomaterials obtained in this work are in clinical trial being used in medicine and dentistry with good results. ····· 10361115821
für 53.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Acute lymphocytic leukemia (ALL) is a malignant disorder common among children. Apoptosis or programmed cell death is greatly involved in the mechanism of cancer development as well as drug resistance to cancer and it is the primary mechanism through which most chemotherapeutic agents induce tumor cell death. Total leukocytic count, hemoglobin, platelet count and Bone marrow blast count were used for follow up of patients. CD95 % and Bcl-2 concentration used as a new markers. It was found that both CD95 % and Bcl-2 concentration are useful diagnostic markers that may help not only in diagnosis but also in follow up of ALL cases. However, further studies are still needed involving larger number of patients and comparing values at diagnosis with values after completing the whole treatment course. It`s also recommended to give Zn supplement to children with ALL in order to achieve rapid and permanent recovery. ····· 10361115781
für 61.20€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Because of the inability of antioxidants to cross cell membrane barriers, only tiny amount, and/or to their rapid clearance from cells and the serious un-modification of the injurious actions of oxidants, liposomes (as phospholipid bilayer vesicles) were put to use as a membrane example. The research gives understanding the molecular basis of the pharmacological behavior of these antioxidants and their effect on membrane dynamics. Liposomes have been made extensively use as biological models of vitro lipid oxidation research works. The resemblance between the liposomal and membrane bilayer core made liposomes a very beneficial tool to investigate significance of antioxidant-membrane interactions for antioxidant activity. The antioxidant activity of a compound was strongly influenced by numerous factors including the nature of the lipid substrate, the hydrophilic lipophilic balance of the antioxidant, the physical and chemical environments of the lipids, and various other interfacial interactions. ····· 10361115731
für 71.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Platelets are central players in maintenance of hemostasis and blood clotting. They are highly sensitive cells exhibiting variety of functional responses depending on the stimulus. Platelets remain hyperactive` in thrombotic disorders like coronary artery diseases, stroke and diabetes mellitus playing a critical role in their pathogenesis. Thus investigation of platelet behavior under different conditions is an important area of investigation to retain these cells in their resting state. Here we explore comparatively less studied areas of platelet biology and attempts to elucidate the signaling mechanism during platelet storage for transfusion purpose, physiologically important process of fibrin clot retraction and upon exposure to most commonly used nanoparticles nanosilver as a model of foreign stimuli. Nanosilver retards platelet activation indicating its potential to be promoted as an effective anti-thrombotic agent, or use as a stent material, where its anti-bacterial and anti-platelet properties could complement each other. This work is intended for diverse readership like biologists, material scientists, nanotechnologists, physicians as well as the pharma professionals. ····· 10361115700
····· lezzter Preis 44.10€ ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Lectins are proteins or glycoproteins of non immune origin which have a wide distribution in animals, plants, and microorganisms. Their medicinal role extends from simple antimicrobial action to anti- tumour properties.In view of the advancement in understanding the potential medicinal role of the plant lectins, a lectin from the leaves of Prunella vulgaris was isolated, purified, partially characterized and its antimicrobial activity evaluated. The lectin is specific for galactose and N-acetyl-galactosamine The molecular weight of the lectin as determined by SDS-PAGE was 32500 Da and that estimated from Sephadex G-100 gel filtration column was 65000 Da indicating that the purified lectin is a homodimer. The purified lectin also shows a significant antimicrobial activity against the infectious agents of some common diseases such as Salmonella typhi, Klebseilla pnuemonea and Escherhia coli. ····· 10361115608· 1 · ::::: · 2 ·· 3 ·· 4 ·· 5 ·· 6 ·· 7 ·· 8 · ::::: · 16 ·
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