für 71.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Platelets are central players in maintenance of hemostasis and blood clotting. They are highly sensitive cells exhibiting variety of functional responses depending on the stimulus. Platelets remain hyperactive` in thrombotic disorders like coronary artery diseases, stroke and diabetes mellitus playing a critical role in their pathogenesis. Thus investigation of platelet behavior under different conditions is an important area of investigation to retain these cells in their resting state. Here we explore comparatively less studied areas of platelet biology and attempts to elucidate the signaling mechanism during platelet storage for transfusion purpose, physiologically important process of fibrin clot retraction and upon exposure to most commonly used nanoparticles nanosilver as a model of foreign stimuli. Nanosilver retards platelet activation indicating its potential to be promoted as an effective anti-thrombotic agent, or use as a stent material, where its anti-bacterial and anti-platelet properties could complement each other. This work is intended for diverse readership like biologists, material scientists, nanotechnologists, physicians as well as the pharma professionals. ····· 10361115700
····· lezzter Preis 44.10€ ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Lectins are proteins or glycoproteins of non immune origin which have a wide distribution in animals, plants, and microorganisms. Their medicinal role extends from simple antimicrobial action to anti- tumour properties.In view of the advancement in understanding the potential medicinal role of the plant lectins, a lectin from the leaves of Prunella vulgaris was isolated, purified, partially characterized and its antimicrobial activity evaluated. The lectin is specific for galactose and N-acetyl-galactosamine The molecular weight of the lectin as determined by SDS-PAGE was 32500 Da and that estimated from Sephadex G-100 gel filtration column was 65000 Da indicating that the purified lectin is a homodimer. The purified lectin also shows a significant antimicrobial activity against the infectious agents of some common diseases such as Salmonella typhi, Klebseilla pnuemonea and Escherhia coli. ····· 10361115608
für 61.20€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The book provides a general introduction to advanced computational techniques applied in various stages of drug discovery. In particular, it focuses on molecular modeling, ligand- and structure-based drug design methods, and data mining in chemical informatics. Application side of this book deals with the development of the first structure-based three-dimensional quantitative structure-activity relationship (3D-QSAR) model of butyrylcholinesterase - a putative drug target for the treatment of Alzheimer`s disease. The other part is comprised of detailed work conducted on 5-HT2C agonists. It describes pharmacophore modeling and 3D-QSAR studies. Comparative Molecular Field Analysis coupled with a genetic algorithm (CoMFA-GA) was carried out for aligned ligands. The last part describes the drug target MTB-Thymidine monophosphate kinase (TMPKMtub). The molecular modeling analyses resulted in identification of a cluster of water molecules that mediate key interactions between bound ligands and backbone atoms of the enzyme residues. ····· 10361115603
für 61.20€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray To study the antioxidative, antitumor and immunomodulatory activity of protein fractions of leaves of Cynodon dactylon and Terminalia catappa on Swiss albino mice. The protein fractions were administered intraperitoneally in mice. The antioxidative and antitumor activity were analysed by liver marker enzymes, enzymic and nonenzymic antioxidants, lipid peroxidation and histological status of liver. The assessment of immunomodulatory activity on humoral and cell mediated immunity were studied by lymphoid organ weight, total leukocyte count, neutrophil adhesion, phagocytic index, antibody titre and protein profile. The results of the study suggested the antioxidative efficacy by enhancing the antioxidative enzymic and non enzymic status, antilipidperoxidative role by inhibiting the lipid peroxide status, antitumorigenic against ELA tumor by increasing the ILS and immunostimulatory against the pyrogallol by the enhancement of the humoral and cell mediated immune responses by the administration of C. dactylonPF and T. catappaPF. Thus Cdpf and Tcpf could be exploited as an antioxidative, antitumorigenic and immunostimulatory agents to combat the oxidative degenerative diseases. ····· 10361115574
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Heat has prominent effects on physiological parameters.Along with the biochemical factors (ALT, AST, ALP, Total proteins and Albumin), blood formed elements (RBCs, WBCs and Platelets) are also affected by the long hours of heavy heat loads. Blood electrolytes also show significant variations by heat stress leading to the metabolic acidosis. Increased blood flow towards skin is promoted by the release of vasodilator from the sweat glands. Heat may also cause lethal damages to vital organs like heart, liver and kidney etc. Industrialized countries face major hazards in the form of occupational diseases while developing countries are stressed by occupational injuries. Steel consumption in construction industry is used as a barometer to measure the economic growth of any country. Metals production is directly associated with heat starting from raw ore handling upto the finished products. The heat produced is radiated into the ambient environment and also to the persons handling the metals. This book will provide a great help to understand the relationship of heat stress and various blood parameters in the workers of iron and steel industry. ····· 10361115563
für 71.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Reproduction is a physiologically costly process that consumes significant amounts of energy. The primary metabolic cue that modulates reproduction is the availability of oxidizable fuel. The organism`s metabolic status is transmitted to the brain through metabolic fuel detectors. There are many of these detectors and one of the most important fuel detectors is ghrelin. Ghrelin, a peptide hormone primarily secreted from the stomach and hypothalamus, has emerged as an orexigenic food intake controlling signal acting upon hypothalamic centers. Recently the potential reproductive role of ghrelin has received great attention. This work investigates the influence of food restriction on the secretion and gene expression of ghrelin and explores the effect of this hormone on the levels as well as gene expression of the reproductive hormones in adult male and female rats. So prolonged food restriction with a consequent excessive ghrelin could be one of the factors responsible for the suppression of reproductive axis in males and females. Thus ghrelin provides a link between energy homeostasis and reproductive capacity in adults. ····· 10361115523
für 71.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Living organisms are continually exposed to oxidants. During oxidative stress, reactions of oxidants with biological macromolecules can result in both direct damage and the formation of long-lived, reactive, hydroperoxides. The series of studies undertaken in this work focused on the early cellular events following generation of reactive singlet oxygen (1O2) and identified that long-lived protein hydroperoxides, a major product of protein oxidation, can play a significant role in cellular damage by selectively targeting both low-molecular mass and protein thiols. These findings are invaluable in providing an insight of the early molecular events of oxidative stress and a cornerstone for future research in developing a better strategy to prevent oxidative damage. ····· 10361115494
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray One of the treasures of Ayurveda is Triphala, which is a simple mixture of three dried fruits in equal proportion namely Emblica officinalis, Terminalia chebula and Terminalia bellerica. It is an effective modulator of inflammation and therefore an important medication for diseases of inflammatory origin. The active ingredients in Triphala possibly acted synergistically on key factors to control complex condition like inflammation. Data presented here suggested that Triphala and its ingredients reduced mucosal inflammation and restored the tissue architecture disrupted by induced IBD in rat model. Mechanism of action of Triphala was attributed to effieient scavenging of Nitric oxide induced at the cellular level. The oxidative damage as represented by lipid peroxides was effectively prevented by intervention of Triphala. This data supports usage of this simple yet effective formulation. In Ayurveda, Triphala is praised as medicine for bowel the current data supports this view and envisage an underlying synergy. Data presented in this book may be of immense use for researchers in this field, medical practitioners and IBD patients. ····· 10361115423
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray A reliable system for expression and purification of the recombinant Cyt2Aa1 toxin has been developed. The recombinant Cyt2Aa1 toxin has been produced, characterized, followed by the construction of the cysteine mutants V186C and L189C by site directed mutagenesis.The hemolytic activity of the V186C mutant exceeds that of wild type Cyt2Aa1 toxin and of the L189C mutant.Calcein release assay experiments have been done to examine the activity of the toxin with different artificial liposomes. It was found that Cyt2Aa1 toxin is very active with DMPC, DMPC+DMPG unilamellar liposomes. ····· 10361115421
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Go Green, Save Environment This work talked about the biohydroegn production from waste biomass. Nowadays we are using fossil fuels which is depleting drastically and creating lot of environmental problems like pollution and global warming. In order to avoid all these things and to be environmental friendly we need to use the renewable energy and cleaner fuels like hydrogen.So i hope this work could give some basic information about the hydrogen technologies. ····· 10361115224
····· lezzter Preis 71.10€ ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The book gives the methods for the synthesis and biological activities of chalcones and their modifications to various different sized heterocycles like flavonoids, flavanone, aurones pyrazoles, oxazoles, benzothiazepines, pyrimidines etc. This book also highlights anticancer,antifungal, antibacterial, antiHIV, anti-inflammatory and antioxidant potential of chalcones and their derivatives. The structure activity relationship of different chalcones and their derivatives is also discussed in the the present book which determine their ability to inhibit the growth of microorganisms, and evaluate the toxicological effects on surrounding life. ····· 10361115074
für 71.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Aging has been defined as a syndrome of changes that are deleterious, progressive, universal and thus far irreversible. Aging damage occurs to molecules, to cells, and to organs. Over the past years, several theories have tried to explain the concept of Aging and Aging processes. This book attempts to explain to discuss in detail, first of all, the concept of life expectancy and maximum life span, then the various theories of Aging and the diseases associated with Aging. It is also discusses in detail the processes of slowing down Aging. This book will be of great importance to those who seek to understand Aging, the theories of Aging and the process of Aging. ····· 10361114983
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Living organisms are exposed to a range of oxidizing species which have the potential to damage bio-molecules. Antioxidants protect cellular systems from potentially harmful effects of processes that cause excessive oxidation. The effect of free radicals on proliferating human and rat peripheral lymphocytes and scavenging effect of green tea polyphenols were studied. Exposure to Green tea Polyphenols (low concentration) induced an antioxidant defense mechanism in human and rat peripheral lymphocytes and rat liver.Green tea polyphenols also induce to increase the values of antioxidant defense system of cells such as SOD, POD and Catalase.further more the level of Reduced Glutathione was found to restore to an extent by treatment with polyphenols at low concentration ····· 10361114965
für 71.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Pro-inflammatory cytokines have been implicated in a wide range of central nervous system (CNS) disorders, including trauma, ischemia, multiple sclerosis and Alzheimer s disease. Tumour necrosis factor- (TNF- ) and interleukin-18 (IL-18), both pro-inflammatory cytokines, have previously been shown to attenuate long-term potentiation (LTP), a proposed model for learning and memory. This study investigated the mechanisms underlying the TNF- and IL-18 mediated inhibition of LTP. Initial experiments consolidate evidence on inducing LTP in the dentate gyrus of the hippocampus. Subsequent experiments consolidate evidence that TNF- and IL-18 can impair LTP in the dentate gyrus. ····· 10361114833
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Hepatitis infection is a major cause of chronic liver disease which infects more than 170 million persons worldwide, often leading to cirrhosis, hepatic failure and hepatocellular carcinoma. D-galactosamine-induced experimental model system in rats recognized to be much like viral hepatitis in humans from both morphological and functional points of view. Food derived antioxidants have a strong potential for long-term use as chemopreventive agents in disease states involving oxidative stress, such as hepatitis and alcoholic liver diseases because they are safe. Tea and cocoa are food sources rich in phenolic compounds and have several biological activities, such as the ability to scavenge superoxide and hydroxyl radicals, reduce lipid peroxyl radicals and inhibit lipid peroxidation . This study aimed to investigate the protective effect of some polyphenolic compounds, heavily present in green tea, black tea and cocoa, against liver injury and to know the potent effect of each in protecting the liver. ····· 10361114818
für 71.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The primary objective of this project was isolation and identification of new ABA-binding proteins in plants. This was to be achieved by employing a biologically active ABA derivative, which served as both an affinity and a photoaffinity probe. It has been proven that this probe was recognized by known ABA-binding proteins. Subsequently the probe was used to isolate putative ABA binding proteins, and this led to the discovery of Rubisco as a new ABA binding protein, among several other potential candidates. The binding of ABA to Rubisco was confirmed by various techniques and it was found that in addition to specific binding, ABA also affects Rubisco s enzymatic activity. This suggests that ABA may act as modulator of photosynthesis through the inhibition of this enzyme. ····· 10361114802
für 53.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The transcription system of archaea has both bacterial-like and eukaryotic-like features. Only a very limited number of archaeal transcription regulatory proteins have been identified to date, and transcription regulatory pathways are far from being well known. The primary goal of this study is to take advantage of the bioanalytical approaches and targeted proteomics strategy to discover and characterize new transcription factors in Pyrococcus furiosus (Pf), a model archaeal organism. It describes how a new transcription factor was discovered by using DNA-affinity protein purification, mass spectrometry identification and further protein characterization methods. The book is a good example for new biological discovery led by integration of multiple scientific strategies, including molecular biology, bioanalytical chemistry and bioinformatics. It will be useful to students and researchers who are interested in DNA-binding proteins, mass spectrometry methods, computation directed biological study and Archaeal biology. ····· 10361114648
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Alkaline proteases have been sought to have applications in several industries like detergent, dairy, leather, pharmaceutical, waste treatment etc. Proteases serve as important tools in determination of structures of proteins and polypeptides. The biotechnological promise of proteases makes them an ideal candidate for structure-function relationship studies and are also wide spread in nature. Microbes serve as preferred source of these enzymes because of their rapid growth, the limited space required for their cultivation and the facility with which they can be genetically manipulated to generate new enzymes with altered properties that are desirable for various applications. In order to withstand the market, enzymes from sources that are stable, active and more reliable have been identified and pure culture was obtained. The present study here in discloses the purification of an alkaline protease from a novel strain of Exiguobacterium sps. ····· 10361114577
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Biomedical electronics and instruments, equipment, diagnostic & detection tools success based on the success of high sensitive biosensors invention and development. Biosensors are the active electronic, semiconductor electronics, optoelectronics or other technologies related devices which sense biological signal from membrane in the form of antibodies, antigens, bacteria`s, viruses, glucose, oxygen, pH etc called signal/stimuli/receptor at the contact of membrane and biosensor with transducer along with biological sensing element called ion-electron-interfacing from where signal convert into detectable electrical signals through transduction principles and measured at computerized electronic signal processing system. This monograph strongly related only about optoelectronic biosensor, in which discussed investigated evanescent wave optical fiber biosensor is one of the strong light carry biological information sensation and high speed detection sensor. Book deal with review, research and fundamental modeling. ····· 10361114573
für 64.71€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The study of biology at a molecular level using biochemistry and molecular biology tools form the backbone of bio-medical sciences and play a pivotal role in the advancements of healthcare. Research and development in this field provided rapid advancements in bio-instrumentation and offer the researcher more dependable results with increased precision and accuracy that make the life of humankind better and increase animal and plant productivity. The commercial value of the scientific inventions warrants the requirement of knowledge of the intellectual propery rights (IPR) for availing the due credit. On the other hand, the researchers handling biological materials are at great risk and may be directly or indirectly involved in posing a threat to the life of others. Keeping in view of the above, this training manual entitled `Biochemical and Molecular Biology Techniques for Animal Biotechnology` immensely helpful to the beginners who are interested in this area of research. ····· 10361114456
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Various new stochastic processes are addressed. Firstly, it is shown that the anomaly in single anomalous random walkers in a random environment has two different origins, where only the one resulting in the slower dynamics determines the anomaly. Secondly, addressed are dynamics of many walkers in a channel (this process is at times called single file dynamics or the exclusion process). It is shown that the mean square displacement, MSD, of a walker in normal heterogeneous files scales like, MSD~t^ where =(1- g)/[2/(1+a)-g] `a` is related with the initial density of the walkers and `g` with their distribution in diffusion coefficients. Finally, studied are anomalous walkers in a file. These exhibit rich behaviors. Synchronized anomalous walkers and independent anomalous walkers are different, where the later actually form clusters causing a phase transition, and the former scale compactly with normal files. We think that the results in this book can help both mathematical scientists and experimentalists in various fields. The new results presented in this book are based on papers that we have written in the years 2008-2011. ····· 10361114437
für 71.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Immunosensors rely on antibody-antigen binding with a range of possible detection methodologies. In this study, electrochemical impedance spectroscopy (EIS) was used to monitor the sensor surface assembly and recognition of three different analytes of cardiac pathology, myoglobin, cardiac troponin I (cTnI) and soluble lectin-like oxidized LDL receptor-1 (sLOX- 1). Myoglobin is rapidly released into the circulatory system after an acute myocardial infarction (AMI) and rapidly rising levels make it the first biochemical marker of myocardial damage, whereas, cTnI is more persistence and specific making a diagnosis more reliable. Circulating levels of sLOX-1 serve as a marker for plaque instability or rupture before an AMI becomes apparent and facilitates early diagnosis of acute coronary syndrome (ACS). The immunosensors were able to detect a clinically relevant range of analyte concentrations. Quartz crystal microbalance and atomic force microscopy studies were carried out to elucidate binding characteristics and surface nanotopography. Additionally, radio-labelling studies were carried out to determine the apparent binding affinity (kd) of the immunosensors. ····· 10361114433
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Various compounds are synthesized and tested to sensitize tumor cells to radiation. Among the various nitro-heterocyclic hypoxic cell radiosensitizers,Sanazole commonly referred as AK2123 has been shown to have less toxicity in normal cells and have selective toxicity for hypoxic cells.The present work focuses on the radiomodifying property of sanazole and its nanoparticles complex in Dalton`s Lymphoma Ascites (DLA)cells.These data suggest that this approach could be used for tumors raising the hope of targeted therapeutic agents with the ability to interfere specifically with tumor cell growth. ····· 10361114341
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Triphala (tri - three, phala -fruits) made of Embelica officinalis, Terminalia belerica and Terminalia chebula fruits. Triphala is regarded as the safest non-habit forming laxative. There are many research studies conducted on Triphala for their best medicinal properties and found effective respectively, growth inhibitory activity against HIV, antioxidant activity, promotes healing of infected wound, antimutagenic activity, anti- arthritic activity, antidiabetic activity, antitumor activity, anticancer activity, hypolipidaemic activity, good radio protector, analgesic, antipyretic and ulcerogenic activities. I have intended this book to provide the most up-to-date information about Triphala. I have reviewed available data on Triphala. I have kept in mind a broad range of readers in both academia and industry. ····· 10361114196· 1 · ::::: · 2 ·· 3 ·· 4 ·· 5 ·· 6 ·· 7 ·· 8 · ::::: · 16 ·
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