für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Las plantas medicinales son una alternativa en el tratamiento de enfermedades para numerosos pueblos, siendo el conocimiento de las propiedades medicinales de dichas plantas parte del patrimonio cultural de estos mismos. Este conocimiento que ha sido transmitido de generación en generación y que se ha ido formando de la observación y experimentación continua, llega finalmente a nosotros a través de recopilaciones por parte de estudiosos o mediante la tradición oral. ····· 10361116663
für 71.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray La cromatografía líquida micelar (CLM) ha sido aplicada con éxito en la monitorización de fármacos. La CLM es un variedad de cromatografía líquida en fase inversa (RPLC) que contiene micelas, generalmente de dodecil sulfato sódico, que actúan como modificadores de la fase móvil, y un solvente orgánico o alcohol de cadena corta, que mejora la eficacia y permite controlar tanto la fuerza eluyente como la selectividad de la fase móvil. Las fases móviles micelares, en comparación con las hidro-orgánicas, tienen la ventaja de permitir la inyección directa de muestras biológicas (suero, orina, saliva, sudor, etc.), y además son más ecológicas, baratas y estables. El objetivo fundamental de la monitorización de fármacos consiste en mejorar la asistencia terapéutica del paciente, tanto en patologías agudas como en las crónicas, y esto se lleva a cabo mediante el ajuste de la dosis del fármaco en función de las concentraciones plasmáticas obtenidas, de manera que se pueda combinar la máxima eficiencia del fármaco con el mínimo riesgo de toxicidad. También la monitorización es útil en la determinación de parámetros químicos y farmacológicos, tales como el tiempo de vida media y otros. ····· 10361116327
für 71.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Durante los últimos años, la aparición de floraciones tóxicas de cianobacterias ha aumentado considerablemente. Esta situación puede conllevar a una acumulación de cianotoxinas en distintas especies acuáticas, como es el caso de los peces, siendo estas toxinas transmitidas a través de la cadena alimentaria y de las aguas contaminadas usadas para la bebida. Concretamente, las microcistinas (MCs) son las cianotoxinas más ubicuas, cuya presencia en el agua supone un serio problema tanto de salud pública como para el medio ambiente. Asimismo, resulta de gran interés social, ético, científico y económico en el desarrollo de métodos alternativos a los ensayos de ecotoxicidad que permitan la reducción del uso de los animales de experimentación. En el presente libro, se presenta un estudio comparativo de los efectos bioquímicos y morfológicos de las tres MCs más frecuentemente encontradas en floraciones naturales (MC-LR, MC-RR y MC-YR) y de dos extractos de cianobacterias sobre dos líneas celulares de peces: PLHC-1 y RTG-2. ····· 10361116298
für 71.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The buccal mucosa is an alternative route for oral administration of drugs that show a strong first passage hepatic metabolism and high sensitivity to acidic environment in stomach, allowing improvement of its bioavailability. Nevertheless, administration of drugs in the buccal mucosa is limited due to its low permeability. Unlike that of the small intestine, the mucosa of the oral cavity has a stratified squamous epithelium with 20 to 40 layers of cells that act as a barrier against endogenous alterations and exogenous substances that reach the oral cavity. In addition, for an effective administration of drugs in the oral mucosa, it is necessary to increase the time of contact between the oral mucosa and the administered pharmaceutical form. From these characteristics, the objectives of this study are to increase the model drug (omeprazole) stability and solubility in the oral cavity environment (saliva), and simultaneously to use strategies to increase the drug absorption through the buccal mucosa. ····· 10361115950
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Microspheres constitute an important part of particulate drug delivery systems by virtue of their small size and efficient carrier capacity. Microspheres are the carrier linked drug delivery system in which particle size is ranges from 1-1000 µm range in diameter having a core of drug and entirely outer layers of polymer as coating material. Microsphere drug administration offers a number of advantages in therapeutics ,where the controlled release of drug delivery as well as the predictable and reproducible drug release kinetics are important feature of them.The main aim and objective of the present study was to investigate the possibility of obtaining a prolonged relatively constant effective level of Rabeprazole sodium using sodium CMC as polymer. ····· 10361115849
für 61.20€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray As on oral administration, Raloxifene Hydrochloride undergoes extensive first pass metabolism resulting in poor bioavailability. The Objective of the present study was to prepare a matrix patch of Raloxifene Hydrochloride to increase its bioavailability. The main aim of the work is to provide a safe, simple and alternative route of administration for the prevention of osteoporosis in post-menopausal women. This book gives insights into the innovative world of non invasive transdermal drug delivery. This compilation of work explains the preformualtion, formulation considerations, methodologies and evaluation parameters of developed system of transdermal patch. The book will serve as a guideline for the researchers in field of transdermal drug delivery. ····· 10361115754
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Sudden cardiac death (SCD) claims 100,000 lives in the UK and over 400,000 in the USA. In humans the spatial and temporal patterns of VF are poorly characterised. However,if VF is phase dependant like it is in animal models,then phase 2 VF would account for 87 % of VF related sudden cardiac deaths in humans. This would explain why most deaths (50-80 %) in the clinical setting occur within the first hours of the onset of myocardial ischemia. In every animal model examined to date ventricular fibrillation exhibits 2 phases. The acute phase of VF, Phase 1 VF, occurs early in the first 30 minutes of ischaemia and the late phase of VF, defined as phase 2 VF, occurs when irreversible myocardial necrosis sets in after more than 90 min of ischaemia. In animal models the second phase is by far the most lethal phase. Ironically,the pathophysiological mechanisms underlying phase 2 VF are poorly understood and it remains a neglected therapeutic target. There is an ever-growing body of evidence suggesting that heightened sympathetic activity combined with diminished parasympathetic activity may be the pathophysiological mechanism underlying the onset of phase 2 VF. ····· 10361115706
für 71.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Analytical methods development and validation play important roles in the discovery, development, and manufacture of pharmaceuticals. The current good manufacturing practice (cGMP) and Food Drug Administration (FDA) Guidelines insist for adoption of sound methods of analysis with greater sensitivity and reproducibility. This thesis describes analytical methods developed for drug determination in pharmaceutical dosage forms and biological matrixes including Chromatography (RP-HPLC) and Hyphenated Techniques (LC-MS/MS). Methods have been developed for separation and quantification of selected drugs from categories like Antihypertensive, Antihyperlipidemic, Skeletal Muscle Relaxant, Non-Steroidal Anti-inflammatory Drug (NSAID), Antibiotic, Anticonvulsant, Antiviral, and Analeptic. ····· 10361115645
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Increase in scientific investigations into indigenious wealth of herbal medicines gives ample evidence of medicinal plants as sources of drugs. Hepatocellular Carcinoma represents about 4% of all malignancies worldwide.Plants contain chemopreventive agents like phenolic compounds, nitrogen compounds and some other endogenous metabolites, which are rich in antioxidant activity. Thioacetamide, a model hepatotoxicant,initiates hepatocellular necrosis and further hepatocarcinogenesis. Thioacetamide thus produces oxidative stress on liver and causes hepatocellular carcinoma. This oxidative stress can be reversed by the use of antioxidants. Thus, the aim of this work was to evaluate the anticancer activity of hydroalcoholic extract prepared from Casearia esculenta, correlating the biochemical and histological changes in thioacetamide induced hepatocellular carcinoma in female Sprague Dawley rats. This research work should help shed some light on cancer research and experimental model development for hepatocellular carcinoma, and should be especially useful to research scholars, scientists and students working on hepatocellular carcinoma in experimental animals. ····· 10361115599
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Hepatocellular Carcinoma represents about 4% of all malignancies worldwide. A number of chemopreventive phytochemicals have been identified which react with prooxidants and prevent damages to DNA thereby preventing the onset of various diseases. Thioacetamide, a model hepatotoxicant, undergoes metabolic activation to form thioacetamide sulfoxide and further metabolized to form thioacetamide-S,S,- oxide thus initiating hepatocellular necrosis and further hepatocarcinogenesis. Thioacetamide thus produces oxidative stress on liver and causes hepatocellular carcinoma. This oxidative stress can be reversed by the use of antioxidants. Thus, the aim of this work was to evaluate the anticancer activity of hydroalcoholic extract prepared from Oroxylum indicum, correlating the biochemical and histological changes in thioacetamide induced hepatocellular carcinoma in female Sprague Dawley rats. This research work should help shed some light on cancer research and experimental model development for hepatocellular carcinoma, and should be especially useful to research scholars, scientists and students working on hepatocellular carcinoma in experimental animals. ····· 10361115587
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray There are many clinical and experimental evidences indicating the involvement of oxidative stress in pathogenesis of diabetes mellitus and its complications. Increased oxidative stress is due to excessive reactive oxygen species generation due to persistent hyperglycemia and a sharp reduction of antioxidants defenses and the tissue antioxidant status. An imbalance between oxidative stress and antioxidative defense mechanisms in diabetics can result in cell and tissue damage and accelerate diabetic complications. There is mounting evidence that a general increase in antioxidant status achieved by dietary supplementation can help to diminish oxidative stress in diabetics and profoundly contribute to reduce the severity of the disease. Plant antioxidants by virtue of their antioxidant activity, may exert beneficial implications for diabetes management. This book highlights the various methods to assess antioxidant activity of medicinal plants. It also contributes to ascertain the utility of plant antioxidants to markedly complement the anti- diabetic therapies by reducing the oxidative stress in diabetics and its associated complications. ····· 10361115570
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The goal in designing sustained release is reduce the frequency of dosing or to increase the effectiveness of the drug by localization at the site of action, reducing the dose required or providing the uniform drug delivery. The use of controlled release (CR) formulations offers many potential advantages such as, sustained blood levels attenuation of adverse effects and improved patient s compliance. It is important especially in the case of antihypertensive agents, to maintain constant blood levels, as other wise, dose dumping may cause hypo tension and sub-therapeutical levels may cause hypertension. The objectives of the present study was to Develop sustained release DTZ microsphere by using different drug-polymer ratio, in vitro characterization of DTZ, maintain more uniform drug plasma concentration, reduce dosing frequency, avoidance of night time dosing, to estimate drug release profile of the formulations, to choose the best formulation(s) based on the above evaluations and finally to subject the most satisfactory formulation(s) to accelerated stability studies. ····· 10361115520
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Simultaneous quantification of Lopinavir and Ritonavir in tablet by HPTLC method was developed and validated .The chromatograms were developed using a mobile phase of Chloroform: 1, 4 - Dioxane (7:3 %v/v) on pre-coated plate of silica gel GF aluminum TLC plate and quantified by densitometric absorbance mode at 210 nm. The Rf value for lopinavir and ritonavir was 0.74 and 0.58 respectively. The linearity of the method was found to be within the concentration range of 160-960 ng/spot for Lopinavir and for Ritonavir, it was 40-240 ng/spot. The lower limits of detection and quantification were 9.56 ng/spot and 28.96 ng/spot for Lopinavir and 6.82 ng/spot and 20.66 ng/spot for Ritonavir. The method was also validated for precision, specificity and recovery. This developed method was used to analyze fixed-dose tablet (Lopimune, Cipla Ltd) sample of Lopinavir and Ritonavir. ····· 10361115516
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray In this study we have investigated the sensitising effect that Prostaglandin E2 (PGE2) has on the action of bradykinin (BK) in both depolarising the resting membrane potential and in action potential generation and propagation in the isolated, desheathed vagus nerve using an extra cellular grease gap recording technique. Prostaglandin E2 sensitisation of the bradykinin induced depolarisation is mimicked by both activation of the protein kinase A and protein kinase C signalling pathways by a process that is completely blocked by the TRPV1 antagonist ruthenium red and staurosporin. This suggests a pivotal role for the vanilloid capsaicin sensitive receptor TRPV1 channel in the prostaglandin E2 and bradykinin induced response. ····· 10361115439
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray This book has been designed by authors mainly based on the synthesis of hydrazone derivatives and including the recent development in the field of chemistry. We have conferred about the mechanism and pathogenesis of the disease. New to the book Tuberculosis. Drug Design. QSAR. Biological Evaluation. This book useful for those who are student of chemistry, Pharmaceutical Sciences, Cheminformatics and Life Sciences. ····· 10361115432
für 71.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Pharmacists` professional roles have evolved throughout the years, with these changes resulting in a focus on collaborative pharmacist-patient professional relationships. The study was envisaged to determine pharmacists` perception regarding community pharmacy services and to determine the perceptions of the general public with regard to the community pharmacist and the current pharmacy service. Community pharmacist and general public questionnaires were updated and psychometrically evaluated through reliability and validity testing. The questionnaires were distributed amongst pharmacists and consumers. The data collected provides insight on issues relating to pharmacy services such as consultation areas, patient medication records, continuing professional development and implementation of pharmacist prescribing. ····· 10361115268
····· lezzter Preis 44.10€ ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray A simple, fast and precise (RP-HPLC) reversed phase high performance liquid chromatographic method is developed for the determination of Nitazoxanide. The linearity of Nitazoxanide was found in the range of 50 to 150 g/ml. The recovery was calculated by standard addition method. The average recovery was found to be 99.81% for our product. The proposed method was found to be accurate, precise and rapid for determination of Nitazoxanide. ····· 10361115247
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Phenytoin exhibits non-linear pharmacokinetics, narrow therapeutic index, marked inter-individual variations and causes wide variety of adverse effects which warrants the need for monitoring. The present study was taken up to monitor serum concentrations and to carry out preliminary pharmacokinetic modelling. HPLC method was standardized to estimate the serum concentration of phenytoin. Blood samples were withdrawn from the patients after the steady state has been reached. In the study period of 8 months, 20 patients were enrolled out of whom, 10 patients received oral phenytoin whereas 10 were given IV infusion. It was observed that there were a lot of variations in the PHT serum concentrations in different patients with peak values ranging from 5.11 to 80.59 µg/ml and trough concentrations ranging from 1.06 to 92.10 µg/ml. However seizure was well controlled in all the patients with no major toxicities observed. Preliminary population pharmacokinetic modelling was attempted using NONMEM, due to small sample size a robust model could not be developed that gives a definite correlation between the variables and pharmacokinetic parameters. ····· 10361115121
für 53.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray This study evaluates the hypotensive properties and the mechanism of action of the aqueous leaf extract of Leonotis Leonurus in anesthetized male Wistar rats, using computerized blood pressure recording system. The effect of aqueous leaf extract of L. leonurus on the blood pressure was investigated by infusing intravenous doses of 200 mg/kg to 1g/kg into anesthetized rats. Its underlying blood pressure lowering mechanism was also studied by challenging the parasympathetic, sympathetic and muscarinic systems of anesthetized rats by pretreating with, dobutamine, atenolol, and atropine. Pretreating the animals with reserpine and L. leonurus was also employed in order to challenge the adrenal system of rats. The results showed that the aqueous leaf extract of Leonotis leonurus produces a dose dependent fall in the systolic blood pressure, diastolic blood pressure and heart rate of the rats. This effect on heart rate may suggest the involvement of - adrenergic receptors in the cardiac effect of L. leonurus. ····· 10361114879
für 53.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray 2-Methoxyestradiol (2ME), a metabolite deriving from 17- estradiol, is a well-established antiangiogenic, apoptotic and antiproliferative agent in cell cultures and animal models. 2ME may also exert its cytotoxic activity by interacting with tubulin and by causing an impairment of the microtubular system. In this study was investigated the relative effectiveness of 2ME on glial and neural cell cultures in inducing morpho-functional changes and alteration of the microtubular system physiology. Results demonstrate that 2ME is more effective in neural cells than in glial cells. Moreover, the cytoxic activity of 2ME in both cell lines could be strictly related to an impairment of microtubule system physiology resulting in morpho- functional changes, block of mitosis and cell death. ····· 10361114860
für 61.20€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray This book focusses on the pharmacological and toxicological investigations of Saraca indica (Family :Caesalpiniaceae) , a well known plant in the Indian traditional medicinal system. The present investigation deals with the toxicological and biochemical evaluation of the alcoholic extract of bark of Saraca indica through acute and subacute toxicity studies. Also, The antidepressant and oestrogenic activities were evaluated. In addition, genotoxic assays were carried out to assess the effect of Saraca indica bark extract in swiss albino mice. ····· 10361114834
für 53.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Alternative medicines for diabetes Diabetes is a serious metabolic disorder with micro- and macrovascular complications that result in significant morbidity and mortality. Statistical Projections for India suggest that the number of diabetics will rise from 15 million in 1995 to 57 million in the year 2025 (King et al., 1998). Since time immemorial, individuals with diabetes have been treated orally in folk medicine with a variety of plant extracts. Recently, there has been increasing interest in the use of medicinal plants. In the present study the authors tried to investigate the anti diabetic properties of Ocimum sanctum and Aegle marmelos by evaluating the comparative anti hyperglycemic and hypolipidemic activities of these herbs in alloxan induced diabetic rats. The authors believe that these plants may complement the use of such effective anti diabetic drug as tolbutamide or chlorpropamide in the treatment of diabetes and also contribute to the development of new prescription drugs for treatment of diabetes as either biochemical models or templates for drug synthesis. ····· 10361114769
für 71.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Herbs have been used as medical treatments since the beginning of civilization and some derivatives have become mainstays of human pharmacotherapy. Over the past few years, the search for new plant-derived prototypes has been expanding exponentially all around the world. While advances in the novel development of phytomedicines have been growing at startling pace, continuous research is necessary to validate the pharmacological activities of many herbal remedies. Therefore, the present work by Ameer investigated the pharmacological activities of L. ferrugineus, a plant used in Malaysia folk medicine for management of hypertension. Very little academic literature exists on L. ferrugineus cardiovascular effects. Accordingly, this study has thoroughly characterized the hypotensive potential of this plant, elucidated the mechanism by which it exerts its effects and chemically defined its possible constituents using relevant scientific approaches. Data derived herein provided a scientific basis for the ethnopharmacological use of L. ferrugineus and thus contributed toward evidence- based phytomedicine. ····· 10361114767
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray All type of testing done in the Quality control (QC) Department of Pharmaceutical industries are necessary as they plays an important role in defining the quality of products manufactured in the pharmaceutical Industries. These different types of testing cited that whether the raw materials & the water used in the manufacturing of the Pharmaceutical products is right to use or not. Also plays an important role in determination of the different components of drugs in right concentration. HPLC technique is used most widely for the testing. This book gives a practical illustration of most of the Pharmaceutical Q.C. techniques followed in the labs including microbial limit tests, determination of total microbial count (TMC), total bacterial count (TBC), total fungal count (TFC), serial dilutions, tests for specified microbes, biochemical tests, chromatographic techniques (HPLC, Ion exchange chromatography, size exclusion chromatography, affinity chromatography etc.) with step wise directions for handling purpose. In this book we had also included some of the experiments practiced by most of the Q.C. labs, so that it helps students for better understanding the Q.C. practical works. ····· 10361114741· 1 · ::::: · 8 ·· 9 ·· 10 ·· 11 ·· 12 ·· 13 ·· 14 · ::::: · 27 ·
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