für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The investigation of the bioactive natural products has assumed a greater sense of urgency in response to the expanding human population and its subsequent demands for food, good health and increasing areas of land on which to live. Isolation is a part of natural product chemistry, through which it is possible to separate different components and biologically active ones can be incorporated as ingredients in the modern system of medicine. This book provides the detailed Isolation, Purification and characterization of the Gymnemic acids from the leaves of Gymnema sylvestre. ····· 10361134599
für 79.00€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The need to implement quality standards in drug research, development and testing the situation in developing countries and the role of WHO/TDR. The testing laboratory itself or in the community as a whole. However, GLP could result in tangible returns through the number of studies placed with research organisations in DECs, resulting in an overall increase in funding. It is clear that as funding is scarce sponsors will not invest in studies if the reliability of results cannot be assured. Specifically, WHO/TDR will be reluctant to allocate their limited funding to non-clinical safety studies unless the results can be reliable on and thus support decisions concerning the progress of products to clinical stages and eventually to product registration. ... the non-clinical safety testing of test items contained in pharmaceutical products ... required by regulations for the purpose of registering or licensing ...The purpose of testing these test items is to obtain data on their properties and/or their safety with respect to human health and/or the environment. (OECD Principles of GLP). ····· 10361134546
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Metronidazole is a nitroimidazole antibiotic medication used mainly in the treatment of infections caused by susceptible organisms, particularly anaerobic bacteria and protozoa. Short gastric residence times and unpredictable gastric emptying times can overcome using floating drug delivery system (FDDS). Floating dosage forms that are designed to stay in the stomach for a long time have the advantage of reducing the variability in bioavailability which occurs with some currently available immediate as well as modified release systems. ····· 10361134500
für 71.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Recent years have seen resurgence in the popularity and use of herbal supplements as aid in healthy lifestyle. With the growing demand there have also been a lot of debates about efficacy, quality and safety of these products. While a significant compendium of information has been compiled to resolve questions related to these issues, it is clear that more work needs to be done. Unfortunately, there is no universal method that can authenticate every plant sample or botanical supplement. For each sample, there needs to be a full understanding of the constituents being considered and what method(s) are specifically applicable to that material. However use of common approaches and research techniques should direct the developments in the field of pharmacognosy and natural products chemistry. This book presents applicability of such research methodologies using two specific botanicals as examples, namely Hoodia gordonii and Caralluma fimbriata. These two succulent plants are used as weight-loss supplements. Studies presented in this book have generated fundamental information about these plants and should answer some of the questions about H. gordonii and C. fimbriata. ····· 10361134477
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Efficiency in the drug discovery process relies on timely knowledge of biological drug-response in the course of disease and treatment, which ultimately rests on knowledge of protein function and regulation. As proteomics deals with the root level of the protein function, there is a very high probability that this will be one of the major tools of modern drug discovery process. Proteomics is being considered as one of the major drug discovery tools by the scientists. Global gene expression profiling by genomic and proteomic analyses has changed the face of drug discovery and biological research. Global pharmaceutical companies are ready to invest ~20% of their R&D investment for getting new biological entities through the use of new scientific methods such as genomics, proteomics and combinatorial chemistry. Attempt for implementation of these technologies increased day by day in the area of design and optimization of drug through biological target identification and validation. Soon, proteomics along with other new technologies will be in use to introduce novel ideas for developing new drugs and improving the quality of existing ones. ····· 10361134472
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Excessive amount of lipid-intake may result in hyperlipidemia, which is characterized by an abnormal elevation in one or more of the serum lipids such as total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-C) and triglycerides (TG). Hyperlipidemia is considered to be a major risk factor for cardiovascular diseases including atherosclerosis, myocardial infarction, heart attacks, and cerebrovascular diseases. Coronary heart disease (CHD) due to atherosclerosis is the leading cause of mortality in the United States and results in about 500,000 deaths each year. The circulatory system disorders are going to be the greatest killer in India by the end of year 2015 (kaul, Sapra and Ghosh, 1998). High saturated fat diet involved in the development of hypertension. ····· 10361134459
für 61.20€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Generic drugs used instead of originator products have to undergo obligatory bioequivalence studies before being approved on the market. The study was designed to validate a chromatographic and extraction method for the determination of doxazosin in human plasma and to carry out a pilot study on the bioequivalence between the test product, doxazosin mesylate 8mg slow release tablets and the reference product, Cardura®XL 8mg tablets. The study was determined in two healthy individuals after one single dose in a cross over study with a two week wash out period. A simple and sensitive liquid-liquid extraction method was validated for the quantification of doxazosin in human plasma using reversed-phase high performance liquid chromatography with fluorescence detection. The bioequivalence study showed significant variance between the generic and reference product and although further studies using larger number of individuals is recommended, such pilot studies gives an indication on the systemic exposure pattern and are beneficial to manufacturers as indicators of their products performance in vivo before embarking on full scale bioequivalence trials. ····· 10361134436
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The questions of whether medicines discovered today are safer, more efficacious, and more affordable than generic medicines or medicines that are centuries old could be answered no for most of the modern medicines. If so, then it is logical to revisit and revive these age-old medicines for the welfare of mankind.Curcumin is an important nutraceutical obtained from the root of the plant Curcuma longa Linn (family Zingiberaceae), is a perennial herb that has enormous potential for a variety of diseases, higher safety margin than the synthetic drugs and is cost effectiveness. Despite having wide spectrum of pharmacological actions, the medicinal properties of curcumin cannot be utilized due to its low in vivo bioavailability. Therefore in view of the foregoing, there is an extensive need for such combinatorial extracts which may enhance bioavailability of oral curcumin by inhibiting the enzymes responsible for the metabolism of curcumin. In the present investigation, Safety and Pharmacological evaluation of Combination consisting of Curcumin with piperine and quercetin in experimental animals was carried out. ····· 10361134426
für 71.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray One of the most feasible approaches for achieving a prolonged and predictable drug delivery profile in the GI tract is to control the gastric residence time (GRT) via gastroretentive drug delivery system which will provide us with new and important therapeutic options. Controlling the residence time of a drug delivery system in a particular region of GI tract can utilize several approaches which include floating drug delivery system, high density system and mucoadhesive system. Helicobacter pylori bacteria are the causative agents of gastric ulcers.Certain conventional dosage forms fail to eradicate the bacteria from the stomach so a novel drug delivery system is the need of the hour for proper elimination of these bacteria locally as well as systemically. The gastro retentive systems can be the remedy and the substitute for the conventional dosage forms, which will have more rationality with excellent efficacy towards the eradication of H.pylori infections. The focus of the research work in this book is to formulate,evaluate and optimize the newer gastro retentive dosage forms of various approaches. ····· 10361134414
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray A simple, precise, rapid, and reproducible reversed-phase high-performance liquid chromatography method is developed for the simultaneous estimation of metformin hydrochloride (MET), pioglitazone hydrochloride (PIO), and glimepiride (GLP) present in multicomponent dosage forms. Chromatography is carried out isocratically at 25 degrees C 0.5 degrees C on an Inertsil-ODS-3 (C-18) Column (250 x 4.60 mm, 5 microm) with a mobile phase composed of methanol-phosphate buffer (pH 4.3) in the ratio of 75:25 v/v at a flow rate of 1 mL/min. Detection is carried out using a UV-PDA detector at 258 nm. Parameters such as linearity, precision, accuracy, recovery, specificity, and ruggedness are studied as reported in the International Conference on Harmonization guidelines. The retention times for MET, PIO, and GLP are 2.66 + 0.5 min, 7.12 + 0.5 min, and 10.17 + 0.5 min, respectively. The linearity range and percentage recoveries for MET, PIO, and GLP are 10-5000, 10-150, and 1-10 microg/mL and 100.4%, 100.06%, and 100.2%, respectively. The correlation coefficients for all components are close to 1. ····· 10361134305
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Chemometrics-assisted spectrophotometric methods were developed for simultaneous determinations of binary mixtures of (1). benzoic acid and salicylic acid, and (2). resorcinol and salicylic acid mixture ( whitefield ointment, luna soap, and dorin emulsion). The uv absorption spectra of the studied compounds in the range of 200-400 nm, showed considerable degrees of spectral overlapping (between 87.6% for benzoic acid and salicylic acid mixture, and 96.2% for salicylic acid and resorcinol mixture). The resolution of the mixtures have been successfully accomplished by using four techniques namely,1D (first derivative), 1D ratio, CLS (classical least square) and PCR (principal component regression). Validation parameters such as calibration range, LOD, LOQ, precision and accuracy parameters(Between F- and t-values respectively) were calculated and a comparison between all the methods and some official methods were done. The analysis is useful to professionals in pharmaceutical and chemical analysis fields in resolving binary or ternary mixtures having significant spectral overlapping. ····· 10361134286
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The liver is an important target of the toxicity of drugs, xenobiotics, and oxidative stress. Liver diseases are serious public health issues in our nation, as it currently affects more than 60 million worldwide. Liver ailments remain one of the serious health problems. Wide prevalence of liver diseases and lack of hepatoprotective agents necessitated to develop satisfactory remedies for its protection. More than 600 drugs have been implicated in cases of hepatic injury thus, recognizing drug induced liver diseases is an important and challenging task for clinics. This book, therefore, provides the crucial role of cytochome P-450 in mechanisms of liver injury and methods of monitoring hepatic functions in animals. The book mainly focuses on hepatoprotective potential of cytochrome P-450 enzyme inhibitors against drug induced hepatotoxicity in preclinical rat models by assessing liver enzymes, antioxidant parameters and cytochrome P-450. The data should be especially useful to students, researchers working in the fields of hepatology, liver problems and drug screening, or anyone else who may be considering utilizing the methods drug development process and for marketing efforts. ····· 10361134271
für 35.91€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The studies demonstrated that microemulsion system comprising Mirtazapine Capmul PG 8 (6.78% v/v), Tween 20 (31.64% v/v), PEG 400 (15.82% v/v) and distilled water (45.76% v/v) and mucoadhesive microemulsion system (0.5% HPMC K4 M based microemulsion) were optimal for intranasal delivery of Mirtazapine. The mucoadhesive microemulsion systems are transparent and stable at ambient temperature for 3 months. Results of nasal Ciliotoxicity study confirmed that developed mucoadhesive microemulsion containing Mirtazapine had no cilio toxicity. Enhanced rate and extent Mirtazapine release following application on excised nasal mucosa from Mirtazapine mucoadhesive microemulsion may help in decreasing the dose and possibly maximize the therapeutic index. The formulated Mirtazapine intranasal mucoadhesive microemulsion represents a safe and viable approach to achieving rapid-onset systemic drug levels and higher bioavailability through bypass of the liver metabolism for the management of depression. ····· 10361134198
für 53.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Oral route has always been preferred route for formulators and has dominated over other routes of administrations. However this preferred route is limited to those drugs molecule that are permeable across the gastric mucosa and are at least sparingly soluble. Approximately 40% of new chemical entities exhibit poor aqueous solubility and present a major challenge to modern drug delivery system, because of their low bioavailability.SMEDDS are isotropic mixtures of oil, surfactant, co-surfactant and drug with a unique ability to form fine oil in water microemulsion upon mild agitation following dilution with aqueous phase. The hypothesis behind dissolution rate enhancement with SMEDDS is the spontaneous formation of the emulsion in the gastrointestinal tract which presents the drug in solubilized form, and the small size of the formed droplet provides a large interfacial surface area for drug absorption.SMEDDS is a promising approach to effectively tackle the problem of poorly soluble molecules. ····· 10361134076
für 71.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Rigorous regulations in pharmaceutical industry urge for more sophisticated approaches that could be used for design and characterisation of drug delivery systems. Microemulsions are promissing carriers of active pharmaceutical ingredients. Researchers in this field are focused on development of biocompatible microemulsions stabilised by nonionic surfactants mixtures. The efficiency of tensides mixtures for microemulsion formation, their microstructure, solubilisation capacity, and mechanisms of drug release are scarcely investigated. This book provides a new formulation strategy of microemulsions based on multicomponent surfactant mixtures by conducting phase behaviour study and developing arteficial neural network models suitable for microemulsion area modeling. There is also demenstrated evaluation of colloidal microstructure, drug solubilisation capacity, and in vitro drug release mechanism of a model drug ibuprofen. The comprehensive approach for nonionic microemulsion carriers design may be useful to formulators in pharmaceutical, cosmetic and food industries as well as for anyone else who are interested in research and application of such complex systems. ····· 10361133940
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Chlorophytum borivilianum(Liliacea) is an important medicanlplant ussed in our Traditonal System of Medicne to treat various diseases like anti-inflammatory, as aphorodiasac, nervine stimulant, in fertility and libido asoociated problems. Few active constitutents have been reported from the plant, which mainly inculdes sarsasapogenin, steroidal saponins, Asparocides,stogmasterol and phenolic compounds. In this work the importance of standardization is shown with respect to its morphology, micrscopy, various physicochemical parameters and other parametres like Fluroscence and thin layer chromatographic techniques which will depect the difference between geunine drug to that of adulterated drug. Thus this study deals with all the detail parametes that will help the drug for its authentication and identification of the plant. ····· 10361133936
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray In medicinal chemistry the chemist attempts to design and synthesize a medicine or a pharmaceutical agent which will benefit humanity. In the last century, the classical drugs were primarily discovered. Heterocyclic compounds represent an important class of biological active molecules. Specifically those containing quinoxaline derivatives have evoked considerable attention in recent years. They possess wide range of biological activities. Quinoxaline, also called a benzo-pyrazine, a ring complex made up of a benzene ring and a pyrazine ring. Numerous methods are available for the syntheses of quinoxaline derivatives which Extensive researches have generated numerous synthetic methods were carried. Although great success has been obtained, many of these processes suffer from some considerable drawbacks. Hence, the search for the better method, especially which will helps to green chemistry foundation is still being actively pursued. This manuscript describes the synthesis of biologically active substituted Schiff s bases of quinoxalines by Conventional method as well as by using Microwave synthesis. This synthesis is strictly followed by principles of green chemistry. ····· 10361133817
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Bangladesh is a land of medicinal plants. From previous time to till date medicinal plants are using as a traditional medicine. Research on natural products is now a prime issue. Azadirachta indica roots and leaves are very useful in blood circulation and purification. It is also good to use as a traditional medicine in the treatment of ulcer, malaria and inflammatory condition. From that point the aim of our research was to observe cytotoxic effects of methanolic crude extracts of roots of Azadirachta indica. ····· 10361133757
für 61.20€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Successful development of transdermal drug delivery involves a series of steps like drug candidate potential to be delivered across skin, selection of suitable polymers, development and in-vitro in-vivo performance. These issues become more critical while developing a transdermal drug delivery of combination of drugs. This book Transdermal Drug Delivery of Candesartan and Hydrochlorothiazide,Preformulation, Formulation considerations and Development explains these developmental aspects of transdermal drug delivery with thorough discussion and methodology involved in selection of potential drug candidates, selection of polymers, preformulation parameters, formulation considerations, skillfull development and in-vitro in-vivo performace evaluation of developed system. The book is thus a suitable guideline for graduate and postgraduate students and researchers in the field of transdermal drug delivery. ····· 10361133751
für 53.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Brain is the key target for many drugs used in obesity and aging. Currently marketed anti-obesity and anti-aging regimes are available in oral dosage forms having limited brain uptake due to the strict blood brain barrier. To overcome this barrier novel, practical and non-invasive intranasal route was attempted to deliver drugs in microemulsion or mucoadhesive microemulsion to the brain. Bromocriptine and cabergoline were selected as the test drugs as review of recent research reveal the possible application of these as anti-obesity and anti-aging therapeutics. The in-vivo pharmacokinetic studies in Swiss albino rats confirmed the intranasal route a rational approach to deliver these drugs selectively and effectively to the brain than intravenous or oral administrations. The in-vivo pharmacodynamic studies confirmed the efficacy of bromocriptine and cabergoline as anti-obesity and anti-ageing drugs. These preliminary but encouraging results are provoking to conduct long term studies in at least two more animal models followed by extensive clinical evaluation for a product for clinical use. ····· 10361133648
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Nanotechnology by manipulation of characteristics of materials such as polymers and fabrication of nanostructures is able to provide superior drug delivery systems for better management and treatment of diseases.The nanostrctures employed as drug delivery systems have multiple advantages which make them the superior to conventional delivery systems. This book provides the formulation of carvedilol nanoparticles using nanoprecipitation technique and it`s phsicoo-chemical characterization and invivo biodistribution studies. ····· 10361133607
für 53.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Microspheres made from lipids and polymers provide an interesting opportunity for use as drug delivery vehicles for numerous therapeutics that can range in size from small molecules to macromolecules like peptide/protein. In addition, cationization on the lipid-based microsphere systems has tremendous application for drug absorption enhancement and for ferrying compounds across cell membranes. Surely excipients play an important role not only to make an acceptable microsphere product but also to minimize/prevent the degradation of the incorporated drug molecules. Special emphasis is being given particularly on various instability problems and investigated mechanistic ways to obviate the possible instability problems of peptide/protein drug during microsphere preparation as well as its release from the microspheres. This book surveys a comprehensive list of published examples of excipients relevant to currently or previously marketed drugs. With this coverage, this book enlists a myriad of excipients available for the formulation scientist to design the lipidic and polymeric microspheres. ····· 10361133580
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Patient In-Home Care Program is inspired by the increased incidence of adverse drug reporting or non-compliance factors related to patient-related behavior. Patient is willing to get treatment but the problem lies beyond the drug therapy, its somehow inside the attitudinal practice of the patient. With this problem and clinical practice we aim to fulfill the theory of `Self-doctor`. Chronic or live long diseases like Diabetes mellitus, Hypertension etc.. needs a continuous and consistent management procedure and thus impact on the economic status of patient. through this program we hope to reduce the patient cost and ensure the beneficial patient related therapeutic outcomes. In this book vital information regarding the patient behavioral modification to ensure therapeutic compliance, is given to use for the betterment of Human race. ····· 10361133567
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Oriental medicine has been widely used across the East Asian countries. Hyeonggaeyeongyotang (aqueous extract of various herbs) is commonly used in Korea for the treatment of atopic dermatitis. It is usually given as a liquid dosage form packaged in a pouch. The extreme bitterness and inconveniences related to large dose volume reduce patient compliance. The present study investigated the conversion of an unpalatable liquid dosage form into novel drug delivery systems, which could improve the acceptability in terms of ease of administration, comparable bioavailability and superior taste. ····· 10361133514· 1 · ::::: · 5 ·· 6 ·· 7 ·· 8 ·· 9 ·· 10 ·· 11 · ::::: · 27 ·
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