für 71.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Methylxanthines especially theophylline have been recognized as potent bronchodilators for the relief of acute asthma for over 65 years. Recently, it was found that bacterial infection plays a role in asthma pathogenesis. Accordingly, the present work involves the synthesis of different series of 8-substituted theophylline derivatives as novel antiasthmatic candidates with potential antibacterial activity. A pharmacophore model was constructed to get useful insight into the essential structural features of bronchodilator activity. Forty-six of the target compounds were investigated for in vivo antiasthmatic activity using aminophylline as a reference standard. Antibacterial activity of all the target compounds was investigated in vitro against both Gram-positive and Gram-negative bacterial strains using ampicillin as a reference standard. Acute toxicity study was also performed. It is noteworthy to mention that compounds 6c, 8i1, and 14c combined both promising antiasthmatic and antibacterial activities. These compounds may act as a corner stone for further investigations by medicinal chemists in development of new theophylline derivatives for the treatment of bronchial asthma. ····· 10361131859
für 53.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Doxorubicin (DOX) is a widely used chemotherapy agent. The major adverse effect of DOX treatment incancer patients is the onset of cardiomyopathy and heart failure. Reactive oxygen species (ROS) are proposedto be responsible for DOX cardiotoxicity. Curcumin, a natural compound extracted from CurcumaLonga L., is known for its anti-oxidant properties. It has been identified as increased apoptosis in severalcancer cell lines in combination with doxorubicin, but there are few studies about the effect of curcuminand doxorubicin on normal cardiac cells. In this book we evaluated molecular mechanisms involved in the effect of Curcumin on apoptosis induced bydoxorubicin in rat cardiomyocytes (H9c2). ····· 10361119735
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Antipyretic activity of ethanol extracts of Echinops echinatus, Alhagi maurorum, Fagonia cretica, Cymbopogon jwarancusa and Panicum turgidum form Cholistan desert, Pakistan was determined. Plant extracts were prepared by soaking air dried and milled plant material in ethanol for one week, followed by filtration and evaporation at 35oC. Treatment does with concentrations of 250, 500 and 750 mg/kg of plant extracts were prepared. Fever was produced in rabbits, weighting 1000-1200 grams by injecting Escherichia coli suspension at a concentration of 0.01 ml/kg of body weight. The ethanol extracts of Fagonia cretica, at the dose of 500 mg/kg and Pancium turgidum, at the dose of 500 and 750 mg/kg showed significant antipyretic activity as compared to positive and negative control. The extracts of Cymbopogon jwarancusa, Alhagi maurorum and Echinops chinatus showed antipyretic activity but less than positive control. These results showed that ethanol extracts of Fagonia cretica and Panicum turgidum are more effective in lowering temperature as compared to Echinops echinatus, Alhagi maurorum and Cymbopogon jwarancusa. ····· 10361119719
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Bronchial asthma is an inflammatory disorder of the airways characterized by dyspnea, airway inflammation and bronchial hyper responsiveness and is a global health problem. The disease results from a complex interplay between genetic and environmental factors. Bronchial asthma is one of the disabling respiratory diseases affecting approximately 7 10% of the world population. WHO has recognized herbal medicine as an essential building block for primary health care of major countries including India. In spite of advances in modern system of medicine, there are various areas like tropical diseases, herpes, AIDS, cancer, bronchial asthma etc., which still remain a challenge to present day drug therapy. ····· 10361119346
für 71.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The study focuses on the formulation of particles for pulmonary drug delivery. The effect of particle shape and morphology on inhalation efficiency has been investigated. Carrier and drug model particles are formulated with a number of different surface morphology. Flowability, aerosolization and deposition behavior of particles with similar size range are investigated through in vitro experimentations. This study successfully optimizes that pollen-shape particle with fibrous surface morphology as optimum particle shape with favorable characterizing properties. ····· 10361119337
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Over the last 100 years, industrial activities have introduced a vast array of new chemicals into the home and environment and have greatly increased the possibility of toxic exposures in the general population. At present, more than 65,000 chemicals are commercially used by industry, including some 3,350 pesticides, 8,627 food additives, 1,815 pharmaceuticals, and 3,410 cosmetic ingredients (Lave, 1987 U.S. Congress, 1990). The immediate effects of these chemicals can be observed in the flora and fauna and on human health. Long-term effects lead to alterations in genetic and somatic components of cells. Chloroacetic acid is used in research and development laboratories, in medical and surgical hospitals and in chemical and pharmaceutical preparations. It is also used in fabric mills, in communication equipment (television, radio, telegraph) and in automotive stamping (NIOSH, 1990). Because of their widespread occurrence, toxicity to plants and aquatic organisms, and most importantly their suspected human carcinogenicity, there is a great need to find treatment methods for haloacetic acids. ····· 10361119254
für 71.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The bitter taste of the drug was masked by Kyron T 114, a weak cation exchange resins with the method of ion exchange resin complexation, Which was prepared by the batch technique and various parameters (i.e. resin ratio, pH, Temperature, swelling time and stirring time) was optimized to successfully formulate the resinate into ODT and it was confirmed by FTIR and DSC study. ODTs were produced by directly compressing a mixture containing superdisintegrant, diluent, glidant, lubricant, and sweetener. In preliminary trials selection of superdisintegrants (i.e., crosspovidone XL 10, cross carmellose sodium and sodium starch glycolate) and Selection of diluent (i.e. mannitol SD 200, Avicel pH 102 Avicel pH 112, Starch and pregelatinized starch) were made. The cohesive force of mannitol increase wetting time and Disintegration time so drug release was delayed. 32 factorial design was applied in which superdisintegrant and diluent ratio were taken as independent factor and disintegration time and wetting time were taken as response. ····· 10361119186
für 69.21€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray This book discussed the single platform assessment of targeting potential of anticancer drug loaded plain as well as folate anchored PPI dendrimer of different generations. This is the debut study to explore the effect of generation on the drug delivery aspects of plain and folate-conjugated PPI dendrimer. Folic acid used as a model targeting ligand due to its promising acceptability in cancer targeting. The folate conjugation is also expected to enhance biocompatibility of cationic dendrimer due to shielding of peripheral cationic groups. It is anticipated that the the developed dendrimer-based nano-formulation will generate a safe, effective and stable formulation that will help in successful transformation of dendritic formulations from laboratory to clinical stages. ····· 10361119121
für 53.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The present work deals with the antisecretory and gastroprotective effect of selenomethionine in swiss albino rat system by using 1. 4 hour Pylorus ligation model for antisecretory activity using the following pathophysiological and biochemical parameters in gastric juice and gastric mucosa a) Ulcer index measurement of the glandular portion of the stomach, b) Measurement of volume, pH, free and total acidity, peptic activity, DNA content of the gatsric juice and c) Total protein, carbohydrate estimation in gastric juice and gastric mucosa, 2. ethanol induced gastric ulcer model using a)Ulcer index measurement,b) Gastric wall mucous content estimation and c)Lipid peroxide level estimation, 3. stress induced ulcer model using a) Measurement of ulcer index, b)Estimation of gastric wall mucus content and 4. Aspirin induced gastric ulcer model of ulcer index measurement. Antiulcer and cytoprotective effect of Selenomethionine and reference drug Cemetidine in rats are studied in the above validated gastric ulcer models after a desired period of drug administration. This work works at the development of a novel gastroprotective molecule. ····· 10361119022
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Plant and plant products are being used as a source of medicine since long. Natural antioxidants that are present in plants and herbs are responsible for inhibiting or preventing the deleterious consequences of oxidative stress. Many Indian medicinal plants are considered to be potential sources of antioxidant compounds. However, the majority of rich diversity of these medicinal plants is yet to be significantly evaluated for such properties. Considering an increased quest to obtain natural antioxidants with broad-spectrum actions and potential antioxidant activity, this book highlights the various methods to assess antioxidant activity of medicinal plants. It also attempts to evaluate the antioxidant activity of some commonly used indigenous plants using different systems of in-vitro assays to provide scientific evidence about their antioxidant property and explore an antioxidant with promising activity. Our results further support the view that some traditionally used Indian medicinal plants are promising sources of potential antioxidants. ····· 10361118948
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray AAA`s... Quinolones and Fluoroquinolones: Man-made antibiotics... This book is designed to provide a detailed account on quinolones and fluoroquinolones. It is based on chemical and pharmacological principles which are necessary to understand synthesis, structure-activity relationships, and molecular mechanisms of drug action making it easy to read and understand for use by both undergraduate students of pharmacy and medicine, and postgraduate students of medicinalchemistry and pharmacology. Features at a glance: - Introduction to quinolone antibiotics - Classification - Structural developments, SAR and QSAR - Molecular mechanism of action - Antimicrobial spectrum & bacterial resistance - Synthesis of some important quinolones - Therapeutic uses. ····· 10361118790
für 71.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The presented book is concerned with the densitometric, spectrophotometric and kinetic spectrophotometric analysis of certain cephalosporin antibiotics namely cefaclor monohydrate, cefadroxil monohydrate, cefalexin anhydrous, cefradine anhydrous, cefotaxime sodium, ceftriaxone sodium, cefoperazone sodium, cefazolin sodium, cefixime, ceftazidime pentahydrate and cefpodoxime proxetil. It comprises three main parts in addition to general introduction about cephalosporin antibiotics and a literature review includes the official and reported methods for their determination. The presented thesis has awarded the prize of the best scientific master thesis in pharmaceutical and medicinal sciences on Assiut University level. ····· 10361118733
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Most of the reported works on Ricinus communis include: as purgative (due to Ricinoleic acid), in memory disorders (due to Ricinine), Cytotoxic effects (due to Ricin), hepatoprotective, anti-microbial, insecticidal, diuretic, hypoglycemic, in rheumatism, child birth induction and industrially as lubricant. Folk medicine reported its possible uses in: Epilepsy, various inflammatory conditions, Liver & Gall bladder disturbances, analgesic, in various types of abscess and sores, emetic, expectorant, asthma, in women problems and several other conditions. Dr. McGarey, in his book The Oil That Heals successfully used castor oil in various disorders. Although, it is reported in folk medicine that Ricinus communis possess antiepileptic activity, no systematic and scientific records are available. These findings generate great scope & demand further investigation. The present study is aimed at discovering the antiepileptic activity of the plant Ricinus communis, thereby enhancing its medicinal value. The study has been planned to investigate whether plant Ricinus communis possesses any kind of antiepileptic activity or not, and if present, up to what extent it is active. ····· 10361118717
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Diabetes mellitus has become a serious threat to public health throughout the world and there is a growing focus on the importance of medicinal plants and traditional health systems in treating the ailment. Medicinal herbs have been used by people for longer than we have been keeping written record and many studies have confirmed the benefits of these herbs with hypoglycemic effects in the management of diabetes. Herbal formulations are getting more importance in the treatment of diabetes because of their significant therapeutic effect, lesser side effects and cost effectiveness. This monograph emphasized the importance and utility of the herbs with potential anti-diabetic activity in the management of diabetes, based on the physiological mechanisms of the malady. All the drugs discussed in this monograph have exhibited significant pharmacological activity and hold definite promises in the management of Diabetes mellitus. ····· 10361118656
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray A novel Pentamethoxy Flavonol `Cordiofolinol` (P3) has been isolated from anti-inflammatory activity guided fractionation of methanol extract of Haldina cordifolia stem Bark with a gradient of methanol in chloroform. Further P3 was screened for anti-inflammatory activity on carrageenan and dextran induced inflammation model in rats at the dose level of 50 mg/kg body weight. Treatment of inflammed rats with P3 has showed significant reduction in inflammation caused by carrageenan (P0.01) and dextran (P0.05). Hence P3 can be considered as the principle component responsable for the anti-inflammatory activity for Haldina cordifolia bark. The characterization of P3 was done by spectral studies like IR, 1H-NMR, 13C-NMR & mass spectroscopy. On the basis of spectral studies the structure of P3 has been elucidated as 5, 7, 3`, 4`, 5` Pentamethoxy Flavonol. This is a novel Flavonol isolated from the bark of H. cordifolia for the first time and given a trival name Cordiofolinol. ····· 10361118592
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Current study aimed at the development of a matrix type sustain release Diclofenac tablet, using hydrophilic HPMC and hydrophobic polymer Cetyl alcohol. It was found that hydrophilic Methocel K15 MCR® matrices based tablets showed zero order and hydrophobic cetyl alcohol matrices based tablets were followed first-order kinetics except formulation six (F6 showed zero order profile). The result of dissolution study indicated that formulations containing cetyl alcohol showed better dissolution properties as compared to formulations containing Methocel K15 MCR® in terms of similarity and difference factor. By comparing the dissolution profiles with Voltaren SR® tablet in terms of difference factors and similarity factors, it was revealed that the formulation F-4, F-5 and F-6 exhibited similar drug release profile as that of Voltaren SR® tablet which indicated that these formulations could be bioequivalent with Voltaren SR® tablet in vitro. The present study demonstrated that Diclofenac could be successfully prepared using an appropriate amount of Methocel K15 MCR® and cetyl alcohol in the form of matrix tablets with similar dissolution profile of patent product Voltaren SR®. ····· 10361118500
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The in vitro antimicrobial and anti-inflammatory activities of extracts, essential oils and some compounds isolated from six species of genus Nigella, namely N. arvensis, N. damascena, N. nigellastrum, N. hispanica, N. orientalis, and N. sativa, are described in this work. The antimicrobial activities of extracts from seeds of N. arvensis and N. orientalis, as well as chemical composition of essential oils from seeds of both species are reported here. The significant influence of four different extraction methods on the antimicrobial activity and chemical composition of N. sativa seed essential is also described. In addition, the anti-inflammatory effect of four components of N. arvensis seeds, namely dithymoquinone, thymohydroquinone, thymol and thymoquinone, has been detected as a result of this research. This work also summarizes the current knowledge on botany, origin, geographical distribution, uses, biological effects and chemistry of all six species. Some suggestions for further research on chemical and pharmacological properties are also given. ····· 10361118123
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The greatest disadvantage in the presently available synthetic drugs Non Steroidal anti-inflammatory Drugs (NSAIDs) lies in their toxicity and reappearance of symptoms after discontinuation. Therefore the Future attemps for searching and developing anti-inflammatory drugs with high efficacy and low toxicity or without any unwanted effect from the plant sources are likely to yield fruitful result.Earlier we have reported that extracts of Gymnema sylvestre, Tinospora cordifolia and Piper longum have exhibited very good anti-inflammatory potential.Polyherbal formulations are found to be very effective in chronic illness and in contrast to the allopathic formulation thus To overcome adverse drug reaction associated with oral administration of NSAIDS, in the present study we have made an attempt to formulate topical gel containing extract of Gymnema sylvestre, Tinospora cordifolia and Piper longum (anti-inflammatory enhancer) and evaluate its anti inflammatory potential in topical application in Rats and compare it with the marketed Topical gel containing diclofenac sodium a potent anti- inflammatory agent. ····· 10361117988
für 61.20€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray In this work, the various topical formulations of mucin, honey and their admixtures (mucinated-honey) (MH) were investigated in wound treatment. Their wound healing effects, tissue re-epithelialization and efficacy in wounds were compared to those of silver sulphadiazine cream (SSD) which was employed as standard. Ointments were used and various quantities of mucin, honey were incorporated to give the required formulations. Histological examination coupled with visual scoring allowed the assessment of changes to the wounded area. MH showed enhanced wound healing when compared with mucin alone, honey alone or SSD. The combination resulted in up to 89% wound healing on day 15 compared to 74 % for honey and 80 for mucin alone. The wounds showed early resolution of oedema, fever, minimal scar, early establishment of angiogenesis, fibroblast cells and high density keratinocytes than mucin, honey or SSD formulations. Various ratios of mucin and honey showed enhanced activity against the three bacteria isolates tested. MH also decreased the bioload of wound better than mucin alone and honey alone. ····· 10361117930
für 71.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Development a new phytotherapeutic toothpaste using Calendula officinalis L. as active ingredient, with the following essential technological characteristics: a toothpaste wich can remove alimentary residues increase the hardness and polish of external surface of tooth prevent that dental plate stick to the teeth to leave the mouth fresh and pleasant to have a cheap price to be innocuous, pleasant and ease to use to have an economic pack that maintaining dentrifice stable even during storage and the period of time in the market and, to be adjustable to standard acceptable as British Standars in terms of abrasiveness to the dental enamel and dentine based on clinical essays appropriately done. Methods:1.On the laboratory: to elaborate, different formulations with glycolic extract changing type and amount of abrasive and thickner. After to assay technological tests, at different times and temperatures, and microbiological quality tests, the best formulation was selected.The dentifrice developed was approved for children use in accordance with the brazilian law and the regulations of Brazilian Odontology Association. ····· 10361117429
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray El presente estudio tiene como objetivo general determinar las características del uso de los medicamentos por los adultos mayores que asisten a los Programas del Adulto Mayor y los Centros del Adulto Mayor de Lima, es un estudio de corte transversal descriptivo se realizó en 502 adultos mayores (mayores de 60 años) pertenecientes a los Programas del Adulto Mayor y Centros del Adulto Mayor de Lima el 2007. EL OBJETIVO FINAL DE TODA EDUCACIÓN ES EL DESARROLLO DEL CARÁCTER EN EL INDIVIDUO . BHAGAVAN SRI SATHYA SAI BABA ····· 10361117284
für 53.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray El presente trabajo fue realizado con la finalidad de mejorar la dispensación, distribución y control de medicamentos y material medico de los pacientes del seguro integral de salud (SIS), en la sala Pediatría de Emergencia, unidad de cuidados intensivos (UCI), unidad de cuidados intermedios (UCIn) y la sala de neonatología del Hospital Nacional Dos de Mayo (HNDM), mediante la implementación del Sistema de Distribución de Medicamentos en Dosis Unitaria (SDMDU) . Los resultados obtenidos nos muestran la enorme ventaja de la aplicación del Sistema de Distribución de Medicamentos en Dosis Unitaria con respecto al sistema tradicional tanto para paciente por que recibe su medicación de forma segura, eficaz y oportuna como para el sistema sanitario ya que permite un ahorro del gasto publico.Permite poner al farmacéutico en un rol protagonico activo dentro del ciclo de la medicación participando directamente en la toma decisiones con respecto a la terapéutica del paciente. ····· 10361117127
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Las plantas medicinales son una alternativa en el tratamiento de enfermedades para numerosos pueblos, siendo el conocimiento de las propiedades medicinales de dichas plantas parte del patrimonio cultural de estos mismos. Este conocimiento que ha sido transmitido de generación en generación y que se ha ido formando de la observación y experimentación continua, llega finalmente a nosotros a través de recopilaciones por parte de estudiosos o mediante la tradición oral. ····· 10361116663
für 71.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray La cromatografía líquida micelar (CLM) ha sido aplicada con éxito en la monitorización de fármacos. La CLM es un variedad de cromatografía líquida en fase inversa (RPLC) que contiene micelas, generalmente de dodecil sulfato sódico, que actúan como modificadores de la fase móvil, y un solvente orgánico o alcohol de cadena corta, que mejora la eficacia y permite controlar tanto la fuerza eluyente como la selectividad de la fase móvil. Las fases móviles micelares, en comparación con las hidro-orgánicas, tienen la ventaja de permitir la inyección directa de muestras biológicas (suero, orina, saliva, sudor, etc.), y además son más ecológicas, baratas y estables. El objetivo fundamental de la monitorización de fármacos consiste en mejorar la asistencia terapéutica del paciente, tanto en patologías agudas como en las crónicas, y esto se lleva a cabo mediante el ajuste de la dosis del fármaco en función de las concentraciones plasmáticas obtenidas, de manera que se pueda combinar la máxima eficiencia del fármaco con el mínimo riesgo de toxicidad. También la monitorización es útil en la determinación de parámetros químicos y farmacológicos, tales como el tiempo de vida media y otros. ····· 10361116327· 1 · ::::: · 7 ·· 8 ·· 9 ·· 10 ·· 11 ·· 12 ·· 13 · ::::: · 27 ·
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