für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The work is planned for the removal of problem during motion Sickness especially in case of immediate and long term treatment is required.The work was focus for the development of single dosage form application for both fast and slow release action.The formulation can also be kept in to consideration of further clinical trials for their final approach. The commercial viability of the dosage form can be made very easy by conventional approach of manufacturing.The Scopolamine Hydrobromide was used a drug for the therapeutic effect. The film were prepared with different polymer to develop the best suitable approach for the development of novel drug delivery systems.The formulation can also be kept in future development by modifying several parameters.The project was planned for the patient convenience in terms dosage form intake and its dosing reduction with desire drug effect. ····· 10361113774
für 71.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The present work describes the investigation of extracts of the leaves and stem bark of F. exasperata for anti-inflammatory, anti-oxidant and antimicrobial activities as suggested by folklore medicine. It also describes the isolation and characterisation of the bioactive principles from F. exasperata. Anti-inflammatory activities of the extracts and isolates were investigated using the carrageenan-induced foot pad oedema model in the seven-day old chicks. Antioxidant protocols used included the DPPH scavenging,linoleic acid lipid peroxidation and ferric reducing power assays. The agar well diffusion and micro-dilution assays were used in the antimicrobial studies. The active principles were isolated by using column and thin layer chromatographic techniques and characterised by their NMR spectra data. The stem bark extract showed considerable anti-inflammatory, antioxidant and antimicrobial activities. Bergapten and oxypeucedanin hydrate, isolated from the stem bark, sitosterol and sitosterol-3-O-beta-D-glucopyranoside, isolated from the leaves contributed to the bioactivities of F. exasperata. The compounds were being isolated for the first time in the plant. ····· 10361113635
für 71.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Diabetes mellitus produces numerous neurophysiological & structural changes in the central and peripheral nervous system and it further leads to development of neuropathic pain & moderate cognitive deficits in diabetics. The etiology of diabetes associated neuropathic pain & cognitive decline is multifactorial and involves an underlying phenomenon of metabolic memory. The concept of metabolic memory, that is of diabetic vascular stresses persisting even after stringent glucose control, has been supported both in the laboratory and in the clinic in both type 1 & type 2 diabetes. Therefore, switching off the metabolic memory, could be an important strategy for the prevention of diabetic neurological complications. Insulin alone reverses the hyperglycemia but partially reversed neuropathic pain and memory deficits in diabetic rats. However, insulin in combination with tocotrienol, lycopene and sesamol not only attenuates the diabetic condition but also reverses neuropathic pain and memory loss by switching off various components of metabolic memory phenomenon. Thus, these interventions may find clinical application in therapeutic armamentarium of diabetics. ····· 10361113629
für 53.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Pharmacovigilance (PV) is the science relating to the detection, assessment, understanding and prevention of adverse effects, particularly long term and short term side effects of medicines. Spontaneous reporting of suspected ADRs is particularly important for anti-HIV drugs since many are licensed on the basis of limited safety data, and they are likely to be used in combination. Further, we believed that the detailed evaluation of the new information generated through pharmacovigilance activities is important for all the antiretroviral drugs to ensure their safe use. So we planned to provide an indirect measure of the quality of pharmaceutical care through identification of preventable ADRs and anticipatory surveillance of high-risk drugs used for the treatment of HIV/AIDS patients. We hope this book will give a strong platform for the people those who interested in Pharmacovigilance. ····· 10361113614
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The present work related to create smaller eye drops of glaucoma medications of the drug Timolol Maleate by reducing the dropper tip design. Most ocular diseases are treated with topical application of eyedrops. After instillation of an eyedrop, typically less than 5% of the applied drug penetrates the cornea and reaches intraocular tissues, while a major fraction of the instilled dose is absorbed and enters the systemic circulation. The low capacity of the precorneal area resulting in an optimal drop volume of about 20 µL and the risk of adverse systemic effects of drugs due to systemic absorption via the nasal mucosa. The present work is carried by reducing the dropper tip by inserting glass capillary. The drop sizes of different marketed products analyzed with the present formulations and the concentrations of drug in each drop analyzed and compared for the monthly and annually cost of medications. ····· 10361113538
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Until the advent of soft gelatin capsules there were no significant changes in capsule manufacturing. Then it became a trend for liquid substances to be filled into soft gelatin capsules and hard gelatin capsules were allocated for dry fill only. However, the filling of molten or thixotropic liquids into hard gelatin capsules is more advantageous when compared to liquid filled soft capsules and may be employed to overcome a number of problems which are frequently associated with the development and manufacture of conventional capsules. This book highlights the basis for development of liquid filled capsule dosage form and focuses light on utility of capsule shells made up from gelatin and Chitosan for liquid filling. It also contributes to ascertain that hard capsules may be used for delivery of Vitamin E and may act as a suitable alternative for soft gelatin capsules. The findings are fruitful for the researchers to compare the utility of hard capsules for delivery of liquid drugs with the soft gelatin capsules. ····· 10361113466
für 53.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray In search for new enzyme inhibitors of therapeutic importance, the present study was designed to find inhibitors of two enzymes of therapeutic significance, i.e., Lipoxygenase (EC 1.13.11.12) and NTPDase (Nucleoside triphosphate diphosphohydrolases) (EC 3.6.1.5) enzymes from extracts of medicinal plants used in folk medicine. Lipoxygenase inhibitors are involved in many inflammatory diseases, asthma, cancer, increase immune response to viral and bacterial infection, leukemia, lymphoma and autoimmune disorders. NTPDase inhibitors are currently target for various cardiovascular diseases and some types of cancer. ····· 10361113401
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Health and the Health Sector are one of the most sensitive components of any given society. Providing high-quality health care services for a society pertains to a nature of a complex procedure that is further complicated when influential elements such as Kosovo`s economy, political and social factors are infused in this process. As a final remark, I would like to conclude this work with the postulation that as soon as we start to craft and implement a thoroughly examined strategy for the Pharmaceutical sector with the significant scientifically proven components that will define all the responsibilities and duties (which would naturally be limited in time), then we will be faced with a myriad of newly created possibilities that will guide us toward the creation of a more secure environment for us all. ····· 10361113320
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Stroke is the second leading cause of death in the world. Ischemic stroke is characterized by rapid onset of neurological injury due to interruption of blood flow to the brain. Free radicals have been implicated in cerebral ischemia and reperfusion- induced neuronal injury. Hence anti-oxidants have shown neuroprotective effect.The present study investigates the effect of methanolic extracts of a natural anti-oxidant plant - Allium cepa on ischemia and reperfusion induced cerebral injury. Global cerebral ischemia was induced by bilateral carotid artery occlusion for 10 min followed by reperfusion for 24 hr. Cerebral infarct size was estimated using triphenyltetrazolium chloride staining. TBARS assay was employed to measure oxidative stress. Elevated plus maze was employed to evaluate short-term memory. Motor incoordination was evaluated using inclined-beam walking test.Pretreatment with onion extracts reduced cerebral infarct size, attenuated impairment in short term memory and motor coordination along with a decrease in mitochondrial TBARS. Hence, antioxidant plant extracts that attenuate cerebral injury may play an important role in neuroprotection. ····· 10361113160
····· lezzter Preis 68.00€ ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Radiotherapy is the most common modality for treating human cancers.Eighty percent of cancer patients need radiotherapy, either for curative or palliative purpose. Chemical modification is the concept in cancer therapy in which the state of tumor cells or normal tissues is modified such that the therapeutic gain can be achieved using conventional modalities. Radiosensitizers are the drugs that make cancer cells more sensitive to the effects of radiation therapy. Radioprotectors (also called radioprotectants) are drugs that protect normal (non cancerous) cells from the damage caused by radiation therapy. Therefore ,chemical modifier field is developing novel approaches to the cancer treatment and increasing the understanding of the basics of cancer biology. ····· 10361113125
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray A novel lupane-type triterpene `Diospyrosonate` (P1) has been isolated from anti-inflammatory activity guided fractionation of petroleum ether extract precipitate of Diospyros malabarica stem bark with a gradient of ethyl acetate in petroleum ether. Further P1 was screened for anti- inflammatory activity on carrageenan and dextran induced inflammation model in rats at the dose level of 50 mg/kg body weight. Treatment of inflammed rats with P1 has showed significant reduction in inflammation caused by carrageenan (P0.05) and dextran (P0.01). Hence P1 can be considered as the principle component responsible for the anti-inflammatory activity for Diospyros malabarica bark.The characterization of P1 was done by spectral studies like IR, 1H-NMR, 13C-NMR & mass spectroscopy. On the basis of spectral studies the structure of P1 has been elucidated as Betulin esterified at C-29 with a C-14 acid. This is a novel triterpenoid isolated from the bark of D. malabarica for the first time and given a trival name Diospyrosonate. ····· 10361113035
für 53.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Silymarin is a purified extract from milk thistle (Silybum marianun (L.) Gaertn), composed of a mixture of isomeric flavonolignans: silybin (its main, active component), isosilybin, silydianin and silychristin. This extract has been empirically used as a remedy for almost 2000 years, and remains being used as a medicine for many types of acute and chronic liver diseases. Despite its routinely clinical use as hepatoprotectant, the mechanisms underlying its beneficial effects remain largely unknown. The purpose of this study was to investigate the pharmacokinetics and bioaequivalence of two brands of Silymarin tablets in healthy male volunteers in local population. Pharmacokinetic parameters were calculated by non- compartmental method using Kinetica® PK/PD version 4.4 and MS Excel Windows professional XP. Maximum concentration of Silymarin in plasma (Cmax), time to these peak plasma concentrations (Tmax) and other bioparameters (AUC0- , AUMC0- , t1/2, Ke, MRT, Vd and ClT) were determined. ····· 10361112944
Seit 2011 sind 210 neue Arzneistoffe in Deutschland auf den Markt gekommen. Dieses Werk schlägt den Bogen von den Ursachen der Krankheiten zu den Struktur-Wirkungs-Beziehungen dieser neuen Arzneistoffe auf molekularer und systemischer Ebene. Von der Entwicklungshistorie über die Pharmakokinetik, Indikationen, Darreichungsformen und Dosierungen bis hin zur medizinisch-pharmazeutischen Chemie finden Ärzte und Apotheker, Pharmazeuten und Chemiker die zum Teil komplexen Zusammenhänge zwischen einzelnen Substanzen und Arzneistoffklassen sowie deren Wirkmechanismen und Metabolisierung verständlich beleuchtet.
Übersichtlich aufgebaut, fachlich fundiert und beinahe wie eine Ansammlung von kleinen Geschichten geschrieben ist dieses Buch mit zahlreichen Tabellen und Grafiken eine aktuelle und umfassende Synopsis der medizinischen Chemie der neuen Arzneistoffe und Fertigarzneimittel der Zulassungsjahrgänge 2011 bis 2017 - von A wie Afatinib® bis Z wie Zapatier®. ····· 10361108288
für 39.80€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Die Sprühgefriertrocknung (SFD) ist ein modernes Verfahren um proteinhaltige Mikropartikel herzustellen. Unter SFD versteht man eine Kombination aus der gewöhnlichen Gefriertrocknung und einem vorgeschaltetem Vernebelungsschritt der Proteinlösung in flüssigem Stickstoff. Durch niedrige Temperaturen und Unterdruck im Gefriertrockner wird das Eis der gefrorenen Pulverpartikel durch Sublimation getrocknet und es entsteht ein feines Pulver sphärischer Partikeln mit definierter Partikelgröße. Die Qualität und Unversehrtheit solcher Proteinzubereitungen kann stark durch unterschiedliche Faktoren während der Herstellung beeinträchtigt werden. Der Schwerpunkt dieser Arbeit war die Untersuchung von prozessbedingten Schädigungen der Proteinstruktur mit Hilfe eines Mehrwinkel-Lichtstreudetektors (MALS) und die Steuerung der Partikelmorphologie von SFD-Pulvern hoher Dichte. Das Arbeiten und die Vorzüge des eingesetzten Drei-Detektoren-Systems bestehend aus UV-DAD, MALS und RI-Detektor wurde näher erläutert (Kalibrierung, Normalisierung, Berechnung der absoluten Masse der zu untersuchenden Proben). Es konnte gezeigt werden, dass Molekulargewichte von Proteinen durch LS genauer errechnet werden können als es mit einer Kalibriergerade der Fall ist, zumal dieses Verfahren unabhängig von der Flussrate sowie der Zusammensetzung der (isokratischen) mobilen Phase ist. Bei unveränderten Versuchsbedingungen wurden Brechungsindexinkremente, Absorptionskoeffizienten sowie sekundäre Virialkoeffizienten bestimmt. Neben der SEC (Size exclusion chromatography) wurde die AF4 (Asymmetrical flow field-flow fractionation) als weiteres analytisches Verfahren zur Proteincharakterisierung etabliert. Bovine Carboanhydrase (bCA) wurde als Modelproteine für die SFD verwendet. Versuche mit 15 %igen bCA Lösungen lieferten ein umfassendes Bild über die Proteinschädigung der einzelnen Prozessschritte. Während die Zerstäubung der Lösung nur geringfügigen Schaden hervorrief, kam es beim Lösen hoher Konzentrationen und v.a. der Trocknung zu beträchtlichen Aktivitätsverlusten. Auffallend war eine Rückgewinnung der Enzymaktivität nach der Vernebelung von bCA in flüssigem Stickstoff, welche in der Literatur auch für andere Proteine beschrieben ist. Versuche mit unterschiedlichen Feststoffgehalten haben gezeigt, dass mindestens 5 %ige Feststofflösungen nötig sind, um runde Pulverpartikel herzustellen. Durch Variationen der Prozessparameter konnte ein umfassendes Bild zur Enzymschädigungen während der SFD gewonnen werden. Durch den Einsatz unterschiedlicher Zusatzstoffe konnte das Modellprotein vollständig stabilisiert werden. Auch bei der Sprühtrocknung (SD) von bCA waren hohe Aktivitätseinbußen zu beobachten, welche vergleichbar mit den Ergebnissen der SFD waren. Pulver die für die nadelfreie Injektion in die Haut (EPI = epidermal powder injection) eingesetzt werden müssen eine bestimmte Partikelform / -größe, sowie eine hohe Dichte aufweisen. Durch den gezielten Einsatz von Polysacchariden während der SFD von bCA und Albumin (bSA) konnte eine Schrumpfung und somit Verdichtung der Pulverpartikel herbeigeführt werden. Annealingversuche mit hilfsstofffreien Formulierungen zeigten keine sichtbare Veränderung der gefriergetrockneten Pulverpartikel. Temperaturerhöhung und verlängerte Annealingdauer führten zu keiner Verdichtung der Pulverteilchen. Erst eine Temperaturüberschreitung von Tg¿ während der Primärtrocknung erzeugte kollabierte Partikel. Quecksilberporosimetrie und BET-Messungen bestätigten die Ergebnisse der REM-Aufnahmen. Im Vergleich zu vorhergehenden Versuchen mit kurzen Gefriertrocknungsprogrammen hatten die geschrumpften Pulverpartikel weniger/keine Poren und nur etwa ein Drittel der ursprünglichen Gesamtoberfläche. Aktivitätsmessungen von redispergierten, geschrumpften bCA Partikel zeigten, dass die Proteinstruktur von kollabierten Pulverpartikeln zusätzlich geschädigt wurde. ····· 10361107275
für 71.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Till now, human still relies on plants for a variety of health problems in spite of the availability of synthetic drugs in therapy. Numerous plants have been used as folk medicine in diabetes treatment. In view of the existing hypoglycemic agents develop adverse effects, and global diabetes burden is estimated to rise from about 118 million in 1995 to 220 and 300 million people in 2010 and 2025 respectively, many researchers are actively seeking medicinal plants as the alternative biotherapeutic sources. The present monograph provides a quick and comprehensive review of 200 antidiabetic medicinal plants for researchers, industrialists, academicians, herbalists and general public. Information on common name, synonym, geographical distribution, parts used, potential active substance, effective dosage, mode of delivery, adverse effect and pharmacodynamic action of plants are summarized from scientific literatures and clinical studies. These monographs provide an excellent outline of herbs for future development into drugs and/or formulated into functional dosage forms. ····· 10361103059
für 49.00€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Medicinal herbs are the local heritage with global importance.World is endowed with a rich wealth of medicinal herbs.The different variety of plants with different therapeutic properties is quiet astonishing. Herbs have provided us some of the very important life saving drugs. Among the estimated 4,00,000 plant species, only 6% have been studied for biological activity, and about 15% have been investigated phytochemically. This shows a need for investigation of herbal drugs and its phytochemical analysis.In present work,Jatropha gossypifolia Linn, it`s phytochemical analysis include study of medicinal uses, chemical constituents(specially terpenoids), morphological characters, physical evaluation, extractions using different solvents, phytochemical screening, separation and isolation by using TLC, column chromatography, HPTLC,quantitative estimation of active compound by HPTLC and UV, Structure elucidation of isolated compound by GCMS,1H NMR, IR, and finally pharmacological screening. Importance of Phytochemical analysis is modification of inactive natural products by suitable biological and chemical means into patent drug. ····· 10361102922
für 61.20€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Over the recent years, interest has grown in using in-vitro and in-situ methods to predict as early as possible in-vivo oral absorption potential of a drug, to determine the mechanism and rate of transport across the intestinal mucosa and to alert the possible windows of absorption and also possible restrictions to the formulation approach. Since human in-vivo studies are not feasible, this prediction is of considerable interest at an early stage of drug development. This book is meant to provide an overview on various in-vitro and in-situ models for the study of drug transport, with an emphasis on in-situ perfusion and cell culture techniques, and data generated for each model for drugs with a broad range of physicochemical properties. ····· 10361102861
für 53.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Present work reports isolation, characterization and antihepatotoxic evaluation of Lychnis coronaria, Marrubium vulgare and Berberis pachyacantha from Kashmir region against carbon tetrachloride induced toxicity using Silymarin as standard. Methanol extracts possessed significant antihepatotoxic potential as compared to petroleum ether and chloroform extracts. Phytochemical evaluation of these plants resulted in isolation of thirteen compounds including two novel compounds isolated from M. vulgare and B. pachyacantha for the first time. Both these isolated compounds were found to possess significant liver protecting potential. ····· 10361102833
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Asthma remains a disease with clearly unsatisfactory therapeutics. With the mounting evidence in support of asthma being an inflammatory illness, anti-inflammatory agents have now become prerequisite for the long term management of asthma. Agents such as 2-agonists, antihistaminics, anticholinergics and inhalation steroids only treat symptoms and do not affect a cure to the underlying inflammation. On the other hand adenosine receptor modulators, selective PDE4 inhibitors, leukotriene modifiers and lipoxygenase inhibitors represent other therapeutic interventions with more targeted control by acting on different parts of immune system and the inflammatory processes. A combination of both of these approaches has been found to improve asthma control with a reduced dose of steroid. Development of PAF antagonists, thromboxane inhibitors, IL-4 modulators, antioxidants and anti-IgE are some of the cutting edge therapies, which offer better hope for asthma treatment. With many representative agents of each of these potential therapeutic targets, undergoing clinical studies, successful development of novel therapeutic agents in this field are not remote. ····· 10361102805
für 53.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The global pharmaceutical market was worth US $550 billion in 2004 and is exceeded around US $1100 billion in year 2010. The herbal industry shares about US $100 billion with good growth potential. The World Bank report trade in medicinal plants, botanical drugs products and raw materials is growing at annual growth rate of about 15% (WHO).Since ancient times, plants have been an exemplary source of medicine. Ayurveda and other Indian literature mention the use of plants in treatment of various human ailments. Research conducted in last few decades on plants mentioned in ancient literature or used traditionally for diabetes have shown anti-diabetic property. Natural products compounds discovered from medicinal plants (and their analogues there of) have provided nnumerous clinically useful drugs and still remain as an essential component in the search for new medicines. So, these traditionally used plants can be exploited effectively in order to find New Chemical Entity for treatment of diabetes. ····· 10361102795
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Cancer is common problems in today`s world. Herbal medicines are being increasingly sold in the market. Whether these are of proven efficacy or not is not known. There was no information available about the taxonomy of plant, side effects or toxicity, drug interactions. The plant information available is incomplete with majority of the preparations. This book, therefore, provides the methods and guidelines for testing the efficacy of such plants. The book mainly focuses on evaluation of safety and efficacy of extracts in preclinical behavioral models. The data should be especially useful to students, researchers working in the fields of phytochemistry and herbal drug screening, or anyone else who may be considering utilizing the methods drug development process and for marketing efforts. ····· 10361102440
für 71.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Research in the area of `Plant Cell Culture` technology has resulted in the production of many pharmaceutical substances for new therapeutics. Advances in the area of cell culture for the production of medicinal compounds have made possible the production of a wide variety of pharmaceuticals like alkaloids, terpenoids, steroids, saponins, phenolics, flavonoids and amino acids. During the past two decades, a considerable progress has been made to stimulate formation and accumulation of secondary metabolites using plant cell culture. This book, therefore describes new protocols for development of cell culture of medicinal plants and qualitative as well as quantitative estimation of secondary metabolites from culture thereof. It also highlights effect of elicitation treatment on production of secondary metabolites and pharmacological screening of same with various in- vitro and animal models. ····· 10361102398
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray There are 5 major periods of concern when considering use of an antimicrobial agent, or other drug, during pregnancy. The preconception period is important for both males and females because drug administration to either gender in animal models can affect embryonic development or result in embryonic death. Use of drugs during the first 7 days after conception probably represents an all-or-none effect on the fertilized ovum: Either the damage is so great that the embryo dies, or the damaged cells are replaced by undifferentiated cells that develop normally. Once implantation occurs, after 14 days, differentiation of the embryo begins. This is the period of time when most drug-associated congenital abnormalities are produced. Therefore, it is recommended to avoid any unnecessary use of medications during the first trimester. Exposure during the second and third trimesters presents a smaller risk because most organ systems are developed by this time.The last period of concern is during breast-feeding.All antimicrobial agents administered to the lactating mother can be detected in her milk, but detrimental effects have only occasionally been encountered. ····· 10361102354
····· lezzter Preis 53.10€ ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The aim of this book was to provide basic knowledge of the art for the development of controlled release matrix tablets of diclofenac sodium with synthetic (Hydroxypropyl Methyl Cellulose) and natural (Xanthine Gum) hydrophilic polymers using different concentrations by direct compression technique and to comparatively evaluate the formulations on the basis of in-vitro and in-vivo parameters. An in-vivo study was conducted on rabbits and the results were calculated using different software like SPSS and Kinetica. In conventional pharmaceutics, matrix based tablet formulations are considered economical and easy to manufacture. This book would be helpful for the students who are involved in the matrix based formulation development at MS and PhD level. ····· 10361102192· 1 · ::::: · 10 ·· 11 ·· 12 ·· 13 ·· 14 ·· 15 ·· 16 · ::::: · 27 ·
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