für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Portulaca Olerecea L. is a well know herb commonly known as purslane in the U.S. It is herbaceous weed distributed all over India up to 170m in the Himalaya and in all warm countries. The leaves are sour, bitter, saltish reduce small tumors and inflammations good for ulcers, asthma, urinary discharges cures diarrhea, dysentery, leprosy, and piles (Ayurveda). The leaves are sour recommended in bilious conditions and low fevers allay thirst and headache stops vomiting good in diseases of the kidney and the spleen, in stomatitis of children, piles, scalds and burns should not be given to persons suffering from cold with or without cough (Unani). The present work reports antihepatotoxic potential of crude extracts of the plant against carbontetrachloride induced hepatotoxicity in Wistar rats using Silymarin as standard. ····· 10361100398
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Liquid chromatography-tandem mass spectrometry (LCMS/MS) is one of the most advanced techniques in the development of Methods for estimation of drugs in biological fluids. The current work includes basic techniques in Liquid Chromatography, Mass Spectrometry, Sample Preparation in bioanalyses, development of bioanalytical method for the quantitative estimation of Montelukast in human plasma and validating it according to FDA guidelines. The method finds its application in biequivalence studies of Montelukast, a cysteinyl leukotriene receptor antagonist used in the treatment of asthma and other allergic conditions. ····· 10361100381
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray This survey was done to identify the most preferred brands of Citicoline and Mecobalamin in IV, IM form, amongst the selected specialty doctors. So that Claris lifesciences ltd. can launch their new molecule in this class. It s a pre marketing survey before launch. The conducting survey was done on 100 doctors from Jaipur India. So this study was designed to know the preferred brands by doctors. The doctor s selection was done by the company around the Jaipur India. Doctors from government, private and corporate hospital has been taken into consideration. Questionnaire has been designed as a tool for research. Usefulness Of The Project The given project is very useful to find out Doctor s preference among various brands of Citicoline and Mecobalamin which are available in the market so that company can estimate a market premise and other brand s marketing strategy ····· 10361100300
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The use of plants and plant products as medicines could be traced as far back as the beginning of human civilization. Plants are the richest resource of drugs of traditional systems of medicine, modern medicines, nutraceuticals, food supplements, folk medicines, pharmaceutical intermediates and chemical entities for synthetic drugs. Medicinal plants are a source of great economic value all over the world. Nature has bestowed on us a very rich botanical wealth and a large number of diverse types of plants grow in different parts of Bangladesh. And Bangladesh is a less developing country. Most of the people living in remote area are fully dependent upon the traditional medicine practitioners for the treatment of their all types of ailments including life-threatening diseases. So, my approach involved to find out possible chemical and biological activities of the present species for its folk and further applications to human beings among the such and similar kind of humanity. ····· 10361100289
für 49.41€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray A variety of imidazole, and fused imidazole derivatives have been reviewed. Continuous efforts on combination of lead optimization and molecular modeling studies in synthesis and the structure activity relationship studies and biological activities of novel modified imidazole, and fused imidazole derivatives, allowed to identification of novel imidazole derivatives as potent anti TB, antimicrobial and antidepressant agents. ····· 10361100280
für 53.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The fluid bed granulation is a fairly complex process that can be divided in three steps: (1) Wetting and nucleation, (2) consolidation and growth and (3) breakage and attrition. Process parameters and physicochemical properties of the binder and granule substrate can have significant impact on these rate process and consequently the physical properties of the granule formed. The fluid bed granulation process is a influenced by various processing parameters like atomization pressure, binder addition rate, in let temperature, binder concentration etc. These process variables largely affect the granulation efficiency and the final granule characteristics so one should consider the process variable effect on granulation mechanism while developing a fluid bed granulation process for the any kind of the material that is to be granulated via this process. Granules prepared by this technology generally have good flow property but % porosity of the granules is higher then the granules prepared by the other convention granulation technique, has a good compressibility and good flowability. ····· 10361100141
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The research work in this book was carried out at Radiopharmaceutical division of Bhabha Atomic Research Centre, Mumbai. Radiolabelling of MAO inhibitor drug harmalol with iodine-125 was carried out and evaluated in the management of Parkinson s disease with the aim of its potential application as a diagnostic radiopharmaceutical. This book has been of great value for the students, academicians and researchers in the field of Pharmacy, Radiology, Pharmacology and medical sciences. ····· 10361100070
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Greying of hair is not new to all of us. The resons for greying may be different for different individuals like environmental factors ,genetic factors , etc . Masking those grey hair is a common practice and invitation to many effects and dreadful diseases and also decreases the quality of hair. To avoid all these life threatening practices giving nature a chance is the best option. Natural products which yield colour like pomegranate, herda, baheda ,amla, Cocoa powder can be used. Dangerous Chemicals in Hair Dye like. Hydrogen peroxide, ammonia are used for permanent hair dyeing. ····· 10361100002
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The project work focuses on the organic reaction monitoring by DPPH on the synthesised eight compounds of two series having variable electronegative atoms X=O/S/NH which have been screened for CNS depression study by synergistic activity by standard drug. This project is a comparison between the SAR study with antioxidant potentiality by DPPH by using logP values with IC50 values with lambda max in UV.The logP value of 4-carboxamido phenyl thio urea (-0.31) is lesser than 2-carboxy phenyl thiourea (1.53) , so the same property arises during potentiality of lmax in UV. The logP value of 4-carboxy phenyl thiourea (0.84) is greater than 2-carboxamido phenyl urea (0.47), so antioxidant potentiality of IC50 value for 2-carboxamido phenyl urea is -661.18 ppm which is more effective than 4-carboxy phenyl thiourea which is 43.79 ppm. ····· 1036199966
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Self emulsifying drug delivery systems, which are by no means a recent technological innovation, have not only proven their utility for mitigating the poor and variable gastrointestinal absorption of lipophilic drugs, but in many cases have shown the ability to reduce or eliminate the influence of food on the absorption of these drugs. A cursory review of literature will clearly underscore not only scientific interest in Self-Emulsifying formulations, but will reinforce the promise and versatility that this technology holds for addressing the constant and growing problems surrounding the oral delivery of many poorly soluble drug candidates. This book seeks to provide a comprehensive summary of both the theoretical and practical aspects of oral self-emulsifying formulations to formulators wishing to employ the technology as well as scientific and marketing executives who wish to gain a greater understanding of developing technology that is expected to assume increasing prominence in the years to come. It is the author s hope that the concepts and techniques described in this book will lead to the development of improved dosage forms for water-insoluble drugs. ····· 1036199881
für 61.20€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Waste is an integral part of our lives and over the years environmental awareness has increased. Ever since joining the European Union in 2004, Malta has been trying hard to conform to European standards as requested by legislation. Improvements have been registered in several sectors however the management of waste pharmaceuticals has not yet been given the right importance. Inappropriate disposal of pharmaceutical waste is resulting in serious repercussions on all living organisms and the environment. Various studies demonstrate serious adverse effects that will result if immediate action is not taken to properly manage pharmaceutical waste. This dissertation draws findings of a scientific study on the current pharmaceutical waste management practices in pharmaceutical industries, hospitals, community pharmacies and households in Malta with the latter two also compared to practices in Bonn, Germany. A guidance plan for the interdisciplinary management of consumers pharmaceutical waste is proposed. ····· 1036199845
für 61.20€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Michelia champaca L. (Magnoliaceae), an evergreen handsome tall tree, around 30 m high with yellow fragrant blossoms, native of Himalayas, and Southern parts of India, is an Indian medicinal plant which finds mention in several ancient writings and Ayurvedic texts. The plant assumes great significance in view of its rich chemical and pharmacological background however it cannot be put to good use in the absence of standards. Hence the pharmacognostic studies and preliminary determinations as per specified guidelines on the said plant were undertaken as a tool for standardization and to regularize monograph writing. Such studies provide a basis for correct identification and authentication and to assure the quality of starting material. The present study largely utilizes W.H.O. guidelines for determination of macroscopic characters, microscopic and histochemical detections, leaf constants, physico-chemical constants and allied features. The authenticated plant samples (leaves and stem bark) were successively Soxhlet extracted and the hexane, ethanolic and aqueous fractions were screened by chemical tests, chromatographic procedures and subjected to pharmacological evaluation. ····· 1036199666
für 53.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Oral drug delivery has been known for decades the most widely utilized route for administration among all the route that have been explored for systemic delivery of drugs via various pharmaceutical products of different dosage forms. The reasons that the oral route has achieved such popularity may be in part attributed to its ease of administration as well as the traditional belief that by oral administration the drug is well absorbed as the food stuffs that are ingested daily. In fact, the development of a pharmaceutical product for oral delivery, irrespective of its physical form involves varying extents of optimization of dosage form characteristics within the inherent constraints of GI physiology. Therefore, a fundamental understanding of various disciplines, including GI physiology, pharmacokinetics, pharmacodynamics and formulation design are essential to achieve a systemic approach to successful development of an oral pharmaceutical dosage form. The more sophisticated a delivery system, the greater is the complexity of these various disciplines involved in the design and optimization of the system. In any case, the scientific framework required for the successful development. ····· 1036199449
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The plant cedrus deodara, in India commonly known as deodar.Various parts of this plant are used in traditional system of medicine for the treatment of different ailments such as fever, inflammation, pain, ulcer, apoptosis, spasmodic, hyperglycemia, infections, insomnia, disorder of mind, disease of skin and blood. Recent in-vivo and in-vitro studies have indicated its anti-inflammatory, analgesic, anti-hyperglycemia, antispasmodic, insecticidal, anti-apoptotic, anti-cancer, immmunomodulatory, molluscidal, anxiolytic and anticonvulsant properties.so, I beleive that this project work will help for further evaluation of the active principles and the related molecular mechanism of the plant. ····· 1036199398
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The pharmaceutical industry is one of the most important and fast growing sectors in the world. By the end of year 2010, the global pharmaceutical industry is estimated to grow to $842 billion. The industry is technologically sophisticated and characterised by highly risky and lengthy processes, intense competition and large research and development expenditures. The key process of the pharmaceutical industry constitutes of the drug discovery and development process which takes nearly 10 to 15 years for development from the earliest stage in discovery to the time it is made available for use to the patients and costs an average of $800 million. Despite successfully translating discoveries into successful products, the process is plagued by increasing number of uncertainties which leads to an increased developmental time cycles. This delays the product s entry into the market thereby causing heavy losses to the pharmaceutical industry. This research presents techniques that enable pharmaceutical firms to reduce uncertainties as well as tackle the problem of time to market with a view to improving the product quality thereby increasing their profits significantly. ····· 1036199389
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Thunbergia grandiflora(Acanthaceae) has been investigated for isolation of its secondary metabolites and evaluation of biological activities of the crude extractive. One compound had been isolated, which was identified by extensive analyses of resolution NMR spectral data. The powdered leaf of T. grandiflora was extracted separately with methanol. The solid extract was then subjected to vacuum liquid chromatography (VLC). Repeated chromatographic separation and purification the leaves of Thunbergia grandiflora afforded one flavonoid named 5 hydroxy-4 ,6,7- trimethoxy flavone, C18H16O6. The Methanolic crude extract of Thunbergia grandiflora showed moderate analgesic activity. Out of all the samples only chloroform fraction methanolic crude extract were appeared mild potent in terms of both zone of inhibition & spectrum of activity against some gram positive, gram negative bacteria and fungi. In antidiarrhoeal test and brine shrimp lethality bioassay , hexane, carbon tetrachloride, chloroform and aqueous fractions exhibited insignificant activities whereas Carbon tetra chloride fraction showed some hypoglycemic effect at a dose of 300 mg/kg body weight compared to control group. ····· 1036199144
für 53.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Major depression disorder (MDD) is a pervasive mood altering illnesses affecting energy, sleep, appetite, libido and the ability to function. Optimal treatment necessitates long-term administration of antidepressants. The pharmacokinetics (PKs) of these drugs are highly variable between patients which may result from drug interactions, food, renal or hepatic impairment, age, gender, smooking or genetic polymorphism of the drug metabolizing enzymes. These high interindiviual PK variabilities are therefore prone to the occurence of sub- or supratherapeutic plasma concentrations when standard doses are administered. The two selected antidepressant drugs in this thesis were venlafaxine (V) and mirtazapine (M). The application of therapeutic drug monitoring (TDM) for phenotyping and real time PCR for genotyping was found to be a proper way of performig a high degree of pharmaceutical care to depressed patients by adjusting the dose of administered drug and thus improving therapeutic efficacy and reducing risk of adverse effects of an antidepressive pharmacotherapy with V or M. ····· 1036199088
für 71.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray This work has been carried out to investigate the chemical reactivity and synthetic potentiality of 2-thioxohydropyridine 11a-d via their reaction with several active halogencontaining compounds to afford the corresponding 2-alkylthiopyridine in some cases and thieno[2,3-b]pyridine directly in most cases. Thieno[2,3-b]pyridine-2-carbohydrazides obtained through the reaction of 2-ethoxycarbonylthienopyridines with hydrazine hydrate which in turn, used to obtain the corresponding pyrimidinones 20-26(a-d), 1,3,4- oxdiazoles 28, 30(a-d), pyrazolothienopyridine derivatives (32a-d) thienopyridine-3- amines (34a-d), pyrazolones (36a-d), pyrazolidine-3,5-diones (38a-d). 3- Aminopyrazolopyridine obtained via the reaction of 11a-e or 49a-e with hydrazine hydrate which in turn, reacted with nitrous acid to give the diazonium salts 51a-e which coupled with several active-hydrogen containing reagents to give the corresponding triazines. The structures of all newly synthesized heterocyclic compounds were elucidated by considering the data of IR, 1H NMR ( ppm), mass spectra as well as that of elemental analyses. Anti-Alzheimer, anti COX-2 and anti-Cancer activities were investigated for all newly ····· 1036199055
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray This book has been primarily design for the undergraduate, postgraduate and researchers in pharmaceutical chemistry. In a broader perspective, the students studying pharmaceutical sciences at undergraduate, postgraduate or researchers shall be grossly benefited by it s well planned, systematically developed, structured, illustrated, expanded and elaborated subject matter. It contains all the basic concepts and principles that a researcher should know about the different aspects of the synthesis including the biological activity of the pharmaceutical compounds. This book also provides spectral analysis of newly synthesize compounds. The book is well illustrated. Hopefully it will serve as a key to the undergraduate, postgraduate and researchers in pharmaceutical chemistry.The authors earnestly believe that the wide coverage various synthetic schemes would certainly render pharmaceutical chemistry to serve as an exclusive source of information s, ideas, inspiration towards research and finding newer possible practical solutions to problems encountered in the synthesis of pharmaceutical compounds. ····· 1036199009
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Bilayer tablet is new era for successful development of controlled release formulation along with various features to provide successful drug delivery system. Bilayer tablets can be a primary option to avoid chemical incompatibilities between API by physical separation and to enable the development of different drug release profiles. The manufacture of bilayer tablets produced by sequential compaction of loose powder layers has become of increased interest within the pharmaceutical industry due to the tailored release profiles of active ingredients that may be obtained. Bilayer tablet is suitable for sequential release of two drugs in combination, separate two incompatible substances and also for sustained release tablet. The immediate release layer of bilayer tablet has worked as the loading dose and the sustained release layer has maintained therapeutic plasma drug concentration for prolonged time. Using a modified tablet press may therefore be the best approach in producing a quality bilayer tablet under GMP conditions, especially when high production output is required. ····· 1036198997
für 53.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Stress is one of the leading causes of anxiety and depression disease, endocrine disease, gastrointestinal and metabolic disorder due to internal and external stressor in both developed and developing countries. Some drugs which are uses to treatment of stress themselves causes mental depression. Hence it is imperative to find out drugs with minimum side effect and for its effective adaptogenic activity. Glycyrrhiza glabra has been known to traditional medicinal system for its adaptogenic activity. Present study was undertaken scientifically to evaluate adaptogenic activity of Glycyrrhiza glabra roots. ····· 1036198925
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The oral administration is the most convenient and commonly used method for drug delivery. Traditionally, solid oral dosage forms have been designed to release their drug load in the upper region of the gastrointestinal tract, where conditions are more suited to drug dissolutions and absorptions. Recently, greater emphasis has been placed on controlling site of drug release from oral formulations for the purposes of improving patient compliance and treatment efficiency . Many protein and peptide drugs like insulin cannot be administered through the oral route because of their degradation by the digestive enzymes of the stomach and the small intestine. Colon-specific drug delivery systems offer several potential therapeutic advantages.The opportunity to reduce adverse effects in the treatment of colonic diseases like, ulcerative colitis, colorectal cancer, Chorn s diseases and amoebiasis by topical application of drugs, active at the mucosal level The elucidation of the mode of action of some nonsteroidal anti-inflammatory drugs (NSAIDs) such as sulindac (metabolized in the colon to the active moiety, sulindac sulfide) that were found to interfere with the proliferation of co ····· 1036198913
für 53.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray A promising strategy to overcome these problems involves the development of suitable drug carrier system. The In vivo fate of the drug is no longer mainly determined by the properties of the drug, but by the carrier system, which permit a controlled and localized release of the active drug according to the specific needs of the therapy. The size of the carrier depends on the desired route of administration and ranges from few nanometers to micrometers (implants). Implants and microparticles are too large for drug targeting and intravenous administration. Therefore, colloidal carriers have attracted increasing attention during recent years. Investigated systems include nanoparticles, nanoemulsions, liposomes, niosomes, nanosuspensions, micelles, and soluble polymer-drug conjugates. ····· 1036198799
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Drug-drug interactions are causing morbidity and mortality in mankind. Severe harmful interactions are recoded when drugs are prescribed without studying their pharmacokinetic and pharmacodynamic actions. Knowledge about drug interactions is necessary for pharmaceutical industries, regulatory agencies, clinical health care professionals and policy makers. The book focuses on research findings regarding influence of Fluoroquinolone (Ciprofloxacin) on the pharmacokinetics of Carbamazepine, investigated in healthy adult males. Carbamazepine is mostly prescribed drug for the treatment of epilepsy, neuropathic pain, schizophrenia, phantom limb syndrome and paroxysmal extreme pain disorder. Epileptic patients can have various types of infections like urinary tract, upper respiratory tract, skin and soft tissue, dental pain, typhoid and other infectious diseases. These patients often injured during fits and fluoroquinolones are used as first line of therapy to treat such kind of infectious disease. Since both drugs are prescribed commonly by the physicians and interaction may result, so the information about their pharmacokinetics given here are beneficial for physicians and researchers. ····· 1036198640· 1 · ::::: · 12 ·· 13 ·· 14 ·· 15 ·· 16 ·· 17 ·· 18 · ::::: · 27 ·
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