für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Good Clinical Practice (GCP) is an international quality standard that is provided by International Conference on Harmonization (ICH), an international body that defines standards, which governments can transpose into regulations for clinical trials involving human subjects. Good Clinical Practice (GCP) is defined as a standard for the design, conduct, performance, monitoring, auditing, recording, analyses and reporting of clinical trials that provides assurance that the data and reported results are credible and accurate, and that the rights, integrity and confidentiality of trial subjects are protected. Good Clinical Practice (GCP) is an international ethical and scientific quality standard for designing, conducting, recording and reporting trials that involve the participation of human subjects. Compliance with this standard provides public assurance that the rights, safety and well-being of trial subjects are protected consistent with the principles that have their origin in the Declaration of Helsinki, and that the clinical trial data are credible.` ····· 1036191867
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray We carried out a QSAR study on benzotriazine derivatives & studied 28 potent GABAA receptor ligands derivatives of benzotriazines, using a combination of various physicochemical, steric, electronic and thermodynamic descriptors to determine the quantitative correlation between binding affinity and structural features with potent anticonvulsant activity. Correlation between these properties and anticonvulsant activity was used to synthesize compounds possessing potent anticonvulsant activity. Most of the compounds showed an ability to inhibit the maximum electroshock (MES) and pentylenetetrazole (PTZ)-induced convulsions. Compound 1A, i.e. 2-(4-Chloro-phenyl)-5-nitro-1H-benzimidazole exhibited maximum activity. ····· 1036191662
für 59.00€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray A possible tool for converting a standard LC method to a fast LC method is the use of monolithic silica columns. Studies comparing conventional particle-packed to monolithic silica columns concluded that methods for the small drug molecules were successfully transferred. Monolithic columns have also shown to be advantageous in developing methods for complex mixtures, by connecting two or more columns together to increase the separation efficiency. On the other hand, enantiomeric separation by capillary electrophoresis has been investigated. Initial selections of the best cyclodextrin for the chiral separation of ten tested basic compounds have been done using a proposed screening strategy and based on the measured resolution. It was observed that negatively charged CDs gave better results compared to the neutral CDs. ····· 1036191621
für 61.20€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Aquasomes are nanoparticulate carrier system but instead of being simple nanoparticles these are three layered self assembled structures, comprised of a solid phase nanocrystalline core coated with oligomeric film to which biochemically active molecules are adsorbed with or without modification. Alternatively aquasomes are called as bodies of water , their water like properties protect and preserve fragile biological molecules, and this property of maintaining conformational integrity as well as high degree of surface exposure are exploited in targeting of bio-active molecules like peptide and protein hormones, antigens and genes to specific sites. These carbohydrate stabilize nanoparticles of ceramic are known as aquasomes which was first developed by Nir Kossovsky. The pharmacologically active molecule incorporated by co-polymerization, diffusion or adsorption to carbohydrate surface of pre formed nanoparticles. Nanotechnology offers some new solutions in treating various diseases. ····· 1036191616
für 53.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The objective of the research work is to formulate and characterize antimigraine drug loaded chitosan nanoparticles. Migraine is characterized with severe headache and emesis which may results in loss of dose if administered orally. Therefore, the formulation is aimed to be delivered through intranasal route. Chitosan nanoparticles were prepared by ionotropic gelation method using tripolyphosphate as cross-linking agent and tween 80 as surfactant. The formulation was optimized using Taguchi L9 (34) orthogonal experimental design. The developed formulation was characterized for particle size distribution, zeta potential, entrapment efficiency, in vitro and ex vivo release. ····· 1036191502
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Microencapsulation technology is advancing rapidly because of its extensive applications in many industries including graphics, food, agriculture and especially pharmaceutical and medical fields. Microparticulate delivery systems in pharmaceutical science make it possible to prepare stable formulations of sensitive drug substances, eliminate incompatibilities, mask unpleasant tastes or odors and facilitate the handling of toxic materials. In addition, microparticles play an important role in the development of controlled- or prolonged-release dosage forms, as well as in developing drug delivery systems that improve the bioavailability of conventional drugs and minimize their side effects. The pharmaceutical applications of microparticles entail different routes of administration including oral, pulmonary, nasal, ocular and parenteral delivery. ····· 1036191499
für 53.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray A new, simple, accurate, precise and reproducible UV spectrophotometric method is being developed for the simultaneous estimation of amlodipine besylate, olmesartan medoxomil and hydrochlorthiazide in tablet dosage form. The stock solutions were prepared in methanol. The max for amlodipine besylate, olmesartan medoxomil and hydrochlorthiazide were 238.5nm, 256.5nm and 271.5nm respectively. The amlodipine besylate, olmesartan medoxomil and hydrochlorthiazide obeyed Beer s law in concentration range of 5-25µg/ml, 6-30µg/ml and 5-25µg/ml respectively. Results of analysis of simultaneous equation method were analyzed and validated for various parameters according to ICH guidelines. ····· 1036191460
für 53.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray In situ gel-forming systems have drawn much attention of current researchers to overcome the poor bioavailability from the conventional eye drops. The present work described formulation and pharmacoscintigraphic evaluation of timolol-maleate-loaded chitosan/hydroxy propyl methyl cellulose(HPMC)-based polymer matrix for enhanced ocular retention. Chitosan and HPMC ratio was optimized and formulation was characterized for various in vitro parameters. The ocular retention was studied on New Zealand rabbits by gamma scintigraphy, which is a very simple and noninvasive technique. For scintigraphy study, the drug timolol maleate was radiolabeled 99mTc by direct labeling method. The labeling procedure was optimized to get maximum labeling efficiency(98%). Plain drug eliminates rapidly as significant activity was recorded in kidney and bladder after 2 h of ocular administration. It was evident from the scintigraphic images and the time activity curve plotted from the data that the plain drug solution cleared very rapidly than developed in situ gel formulation.Developed formulation cleared at a slow rate and remained at corneal surface for longer time duration proving its efficacy. ····· 1036191400
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The book has been designed by authors based on the prodrug synthesis including the latest development in the field of prodrug methodology. We have mentioned the recent changes and developments without compromising the basic principle. New to the book Detail about prodrug methodology Brief account of HMG CoA reductase New educational features Novel prodrug method for Simvastatin Data tables Guideline for further reading This book have benefitted for all those who are students of chemistry, biochemistry, Pharmaceutical sciences, Medical sciences, biotechnology and related disciplines. ····· 1036191394
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Successful Technology transfer enables the production of new dosage form so it is important to remove the barriers to the free flow of technology as well as to the free flow of science. This book addresses the various concepts and recommendations on the activities necessary to conduct a successful transfer of technology guidelines. The intention is to describe the basic considerations needed for successful transfer in order to satisfy the regulatory authority. It imparts the knowledge of various issues like steps involved in technology transfer ,documentation needed,effective and failure factors, intellectual property rights on technology transfer, Role of R & D manager,it also emphasized on the policies which are needed to be rebuild to promote the effective technology transfer from R&D to production level.Ultimate goal of this book is to provide insight depth to pharmacy research scholar on various key concepts of Pharmaceutical Technology Transfer in order to carve their technical skills. ····· 1036191369
für 71.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Similar to the majority of biological molecules, DNA is degraded rapidly in the body. Its encapsulation into a delivery system increases circulation time and permits accumulation of the drug in certain organs. Lipid-based soft nanoparticles have the ability to encapsulate or complex DNA and shuttle it into the cells by overcoming cellular and molecular barriers. The use of state-of-the-art technology for the systematic evaluation of the gene transfer efficiency of the novel nanoparticles leads to the development of in vivo gene delivery systems for topical non-invasive administration. These delivery systems find application in the development of new gene therapy for dermatology, immunology/vaccines and neurodegenerative diseases. ····· 1036191367
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Health is a basic precondition for happiness and progress in the life of an individual as well as a community. Quality health care is the lifeline for the growth of any nation. We are undergoing a global health crisis characterized by mounting inequities within and between countries. Despite the tremendous medicinal advances and increasing average life expectancy, there is disturbing evidence of rising disparities in health status among people. We are frantic with worry as there is no cure in sight for AIDS so far. But then what about diabetes 1 Which is said to be common problem, which has serious consequences. Diabetes mellitus is a silent disease and is now recognized as one of the fastest growing threats to public health in almost all countries of the world2. It has been incapacitating people for a long time but it has eluted a cure for many decades now. ····· 1036191292
····· lezzter Preis 44.10€ ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The present study is an attempt to find out the safety and acceptability of single dose oral therapy of Albendazole with DEC in Microfilaraemic patients and to assess the toxicological profile of standard dose and high dose regimen of Albendazole with DEC when administered by oral route to albino mice. It was concluded that single high dose was safe & acceptable to the majority of the study participants. The responses from male compared to female subjects was good. Most of the subjects preferred to take medicine in less frequent dose. Also most of them refused to take the chewable one. From this study, it was also found to be a more effective regimen in reducing microfilaria and/or adult worm load, which was useful for maintaining persistent amicrofilaraemic state for a prolonged period. This regimen when applied to the global programme can effectively sustain the transmission blocking potential of the drug and thereby reducing the time required for elimination of the infection. ····· 1036191285
für 35.91€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Impurity profiling and drug degradation pathways are essentials features for regulatory acceptance of any new drug entity. Despite of technological advancements in pharmaceutical analysis, structural elucidation of drug molecules, impurities produced during formulation remains challenging tasks for researchers. Unique chemical behavior, complex properties and interactions of different functional groups involved in active pharmaceutical ingredients along with different chemical environments with excipients and storage condition further complicate the issues. Furthermore isolation and characterization of impurities with special references to toxic metabolites is essential for acceptance of new drug molecules by regulatory agencies. Recently discovered and patented nitrate esters of paracetamol having improved analgesic and anti-inflammatory activities then parent drug and less hepatotoxicity in overdose is selected as model drug entity. This book is an attempt to provide experimental insights into the chemical, analytical and establishment of drug degradation pathways in forced conditions in lucid manner for easy understanding to meet future expectations of scientific fraternities. ····· 1036191271
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Esta tesis está enfocada al estudio farmacocinético de distintos fármacos antiepilépticos en diferentes poblaciones de epilépticos: ya sea aquellos pacientes epilépticos denominados refractarios o de difícil control (que constituyen aproximadamente entre el 8 y el 10% del total de la población de epilépticos), en niños en monoterpia o politerapia de anticonvulsivantes y en adultos. Uno de los puntos capitales de la tesis es, profundizar en otros fluidos de monitorización como la saliva. Como proyección de la misma y de acuerdo a los datos obtenidos queda planteado el estudio de la incidencia de los transportadores de eflujo en la farmacocinética de las drogas anticonvulsivantes. En los subsiguientes capítulos que componen esta tesis, se incursiona en el estudio farmacocinético de la Carbamacepina y de su metabolito activo (epóxido), de la Oxcarbacepina y del Ácido Valproico utilizando como se mencionó anteriormente la saliva como fluido de monitorización clave para la evaluación del estado clínico del paciente y como posible fluido que permita inferir sobre los transportadores de eflujo. ····· 1036191033
für 35.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Profesores e investigadores del Centro de Bioactivos Químicos de La Universidad Central Marta Abreu de Las Villas realizaron un estudio con el propóleos rojo de la costa norte de la región central de Cuba. Se efectuó el tamizaje fitoquímico, así como la evaluación de la toxicidad aguda, dérmica y oftálmica de los mismos. En el tamizaje fitoquímico encontramos una gran variedad de metabolitos dentro de los que se destacan flavonoides, coumarinas, triterpenos y/o esteroides, fenoles y/o taninos, aceites esenciales, resinas, y principios amargos. Al determinar la toxicidad aguda por el método de las clases de toxicidad (ATC) se catalogó como no clasificado, según lo estipulado por la OECD. En el caso de la determinación de la irritabilidad dérmica y oftálmica se consideró el compuesto objeto de estudio como No Irritante Dérmico y Oftálmico. Dichos resultados forman parte del expediente maestro que posibilitó la comercialización de este propóleos como materia prima para la producción de cosméticos en la Industria Cubana (Suchel Camacho S.A). ····· 1036190998
für 71.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Conforme aumenta la cultura de la Sociedad ésta tiende cada vez mas a la automedicación. La automedicación suele considerarse como algo que debe evitarse todo lo posible. Sin embargo la automedicación bien realizada tiene sus ventajas. Implica al paciente en su tratamiento, disminuye los gastos de los Sistemas Sanitarios y, sobre todo, acelera el tratamiento y la curación del paciente. Pero la automedicación con antibióticos dificilmente puede considerarse conveniente para el paciente o para la sociedad. Es casi imposible que el paciente sea capaz de autodiagnosticarse con exactitud una infección bacteriana, y un mal uso de los antibióticos ocasionaría un aumento de las resistencias. En las farmacias muchos pacientes nos piden antibióticos para automedicarse. El farmacéutico está en una posición inmejorable para reconducir estas demandas y sustituir el antibiótico pedido por otro medicamento mas apropiado. O bien, derivar al paciente al médico si fuera necesario un examen mas detallado ····· 1036190723
für 88.20€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray El Conocimiento que poseen los pacientes acerca del tratamiento farmacológico que utilizan (CPM) es fundamental para asegurar un correcto proceso de uso. Si los pacientes no conocen el medicamento que tienen prescrito, con mucha probabilidad lo utilizarán de manera incorrecta, aumentando el riesgo de sufrir un resultado negativo asociado a la medicación. La comunidad científica habla frecuentemente del CPM, sin embargo, no se ha encontrado una definición precisa ni un instrumento válido y fiable para medir de manera general el conocimiento de cualquier paciente con cualquier patología y medicamento. Determinar qué conocen los pacientes acerca de los medicamentos que utilizan y qué factores pueden predisponer a una carencia de CPM, permitirá diseñar intervenciones sanitarias y estrategias específicas, con el fin último de contribuir a minimizar un importante problema de salud pública: la inefectividad e inseguridad de los medicamentos. ····· 1036190116
für 29.61€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Salvia officinalis L. (common sage) is an aromatic important species, widely used in medicine, cosmetology and food industry. Salviae officinalis folium represent official drug included in the 7th European Pharmacopoeia. Plant biotechnology can offer new opportunities by providing plant material for production of valuable secondary metabolites. In the present book we describe in vitro cultures of common sage as potential source of medicinally important compounds (carnosol, carnosic acid, rosmarinic acid). Various aspects of S. officinalis in vitro cultures such as micropropagation from shoot tips, sage shoot cultures growing on solid and in liquid media, encapsulation of shoot tips for obtaining synthetic seeds, genetic transformation by A. rhizogenes, production of metabolites in obtained cultures were determined and described with details in the book. The antioxidant potential of obtained plant material was also analyzed. The studies allow a look at the potential use in vitro cultures of this medicinal plant as a source of biological active compounds, which may be especially useful to biotechnological industry or anyone else who is interesting in plant in vitro cultures. ····· 1036189264
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Chlorophytum borivilianum is an important medicinal plant known as `Safed musli` .The potent antioxidant activity validates the innumerable therapeutic claims of the plant in the traditional Ayurvedic and Unani systems of medicine especially its use as a rasayana drug. In recent years Safed Musli has gained interest for its effectiveness in increasing male potency and is now considered as an alternative to viagra resulting in a phenomenal increase in its demand all over the globe. Markers are chemically defined constituents of an herbal substance which are of interest for control purposes independent of whether they have any therapeutic activity or not. Markers may serve to calculate the quantity of herbal substance(s) or herbal preparation(s) in the finished product if that marker has been quantitatively determined in the herbal substance(s) or herbal preparation(s) when the starting materials were tested. A compound was isolated from the water extract. It was subjected to structure elucidation studies and quantitative analysis by HPLC. The compound could serve as a marker and help in standardization of the drug. ····· 1036189219
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray There are the two type of HIV mainly they are HIV-1 and HIV-2. HIV-2 is less pathogenic and less transmissible compared to HIV-1. This is believed to be due to the lower viral load that is seen in HIV-2 infected patients. genetic variation and evolution in the pol gene was studied, with special interests in resistance-associated mutations in HIV-2 infected patients failing antiretroviral treatment. There is observation in some mutations known to cause resistance in HIV-1 such as M184V, Q151M and E219D but most resistance mutations appeared to differ from what is known in HIV-1. The main conclusion from this work is that specific algorithms for HIV-2 resistance interpretation are needed, because the algorithms for HIV-1 cannot be used. They were studied the evolution of co-receptor usage, neutralization escape and env gene sequence. It is reported that a switch from CCR5 to CXCR4 using virus during disease progression. They did not see a clear pattern of neutralization escape as is seen in HIV-1. A pattern of changes in the number of potential N-linked glycosylation sites during disease progression has been observed. HIV-2 has fewer potential N-linked glycosylation sites in V3. ····· 1036189062
für 53.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The focus of the pharmaceutical research is being steadily shifted from the development of new chemical entities to novel drug delivery systems of existing drug molecules to maximize their effectiveness in terms of therapeutic action and patent protection. This is made possible by the discovery of various compatible polymers (e.g. Carbopol polymers). Local delivery of the anesthetic agent(e.g.Lidocaine)leads to higher concentration of the drug at the intended site of action using a lower dose with an associated reduction in side effects relative to systemic administration.One of the most critical factors in enhancing the efficacy of a topical anesthetic is maintaining prolonged intraoral mucosal contact. Most topical agents come in gel form, which is difficult to localize to a particular site and easily diluted by saliva.To overcome these problems, bilayer buccal tablets were prepared with carbopol polymer.They seem to solve all these problems associated with the treatment of gingivitis and other periodontal diseases and adhere well to the gum and control the release of the drug for an extended period of time. Besides this,characteristics of carbopol polymers were also evaluated. ····· 1036188946
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The aim of this work was to study the different solid forms of Amantadine hydrochloride, possible co-crystals, produce new solid forms by using different selected solvents to produce new solid forms and diffraction quality crystals analyse the structure determine at where possible. By using different sophisticated equipment, methodology concluded that the new polymeric form such as SXD-Single Crystal X-ray Diffractions , PXRD- Powder X-ray Diffraction, DSC- Differential Scanning Calorimetry, STA-Simultaneous Thermal Analysis, TG-Thermo Gravimetric Analysis., VTPXRD-Variable Temperature Powder X-ray Diffractometer. The PXRD pattern was given interesting results when it compared with raw powder pattern. So sample was run for STA and the results was showing mass loss with endoderm and it was conclude as solvate and VTPXRD patterns was collected at different temperatures for final conclusion compared with raw pattern. ····· 1036188904
für 53.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The development of controlled release formulations continues to be a big success for pharmaceutical industry due to its ease of manufacturing process and reproducibility of desirable pharmaceutical properties. Controlled drug delivery systems are receiving more and more attention as they control the rate of drug release and sustain the duration of therapy. Oral controlled drug delivery systems release the drug with constant or variable release rates.A delivery system with a release profile that is characterized by a time period of no release (lag time) followed by a rapid and complete drug release (pulse release) can be called as an ideal pulsatile drug delivery system. In other words, it is required that a drug should not be released at all during the initial phase of dosage form administration. A timed, pulsatile delivery system provides one or more rapid release pulses at predetermined lag times or at specific sites resulting in better absorption of the drug, and thereby providing more effective plasma concentration time profile. Pulsatile drug delivery systems are generally classified into time-controlled pulsatile release and site specific delivery systems. ····· 1036188859· 1 · ::::: · 14 ·· 15 ·· 16 ·· 17 ·· 18 ·· 19 ·· 20 · ::::: · 27 ·
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