für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The aim of this work was to study the different solid forms of Amantadine hydrochloride, possible co-crystals, produce new solid forms by using different selected solvents to produce new solid forms and diffraction quality crystals analyse the structure determine at where possible. By using different sophisticated equipment, methodology concluded that the new polymeric form such as SXD-Single Crystal X-ray Diffractions , PXRD- Powder X-ray Diffraction, DSC- Differential Scanning Calorimetry, STA-Simultaneous Thermal Analysis, TG-Thermo Gravimetric Analysis., VTPXRD-Variable Temperature Powder X-ray Diffractometer. The PXRD pattern was given interesting results when it compared with raw powder pattern. So sample was run for STA and the results was showing mass loss with endoderm and it was conclude as solvate and VTPXRD patterns was collected at different temperatures for final conclusion compared with raw pattern. ····· 1036188904
für 53.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The development of controlled release formulations continues to be a big success for pharmaceutical industry due to its ease of manufacturing process and reproducibility of desirable pharmaceutical properties. Controlled drug delivery systems are receiving more and more attention as they control the rate of drug release and sustain the duration of therapy. Oral controlled drug delivery systems release the drug with constant or variable release rates.A delivery system with a release profile that is characterized by a time period of no release (lag time) followed by a rapid and complete drug release (pulse release) can be called as an ideal pulsatile drug delivery system. In other words, it is required that a drug should not be released at all during the initial phase of dosage form administration. A timed, pulsatile delivery system provides one or more rapid release pulses at predetermined lag times or at specific sites resulting in better absorption of the drug, and thereby providing more effective plasma concentration time profile. Pulsatile drug delivery systems are generally classified into time-controlled pulsatile release and site specific delivery systems. ····· 1036188859
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Diabetic nephropathy is a serious complication of diabetes in which elevated blood sugar levels eventually damage the kidneys. Nephropathy means disease or abnormality of the kidney. Diabetic nephropathy is also called diabetic kidney disease. Diabetic nephropathy is the kidney disease that occurs as a result of diabetes. It is a leading cause of kidney failure in Europe and the USA. After many years of diabetes the delicate filtering system in the kidney becomes destroyed, initially becoming leaky to large blood proteins such as albumin which are then lost in urine. This is more likely to occur if the blood sugar is poorly controlled. Herbal medication is the most commonly used alternative therapy for treatment of diabetes and its complication. Present treatment for diabetic nephropathy requires two drugs hypoglycemic and angiotensin converting enzyme inhibitor, from the above study Tribulus terrestris aqueous extract showed significant anti-diabetic as well as renoprotective effect by decreasing serum creatinine, blood urea nitrogen, urinary albumin and creatinine clearance. ····· 1036188817
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Pharmacological effect of a drug is based on the structural features of drug. Often subtle change in structure of a drug leads into markedly changes in the Pharmacological effect of drug. Means for a molecule to act as a drug, it is necessary that various atoms should be placed in the perfect position. Heterocyclic compounds represent an important class of biologically active molecules. Among the heterocyclic compounds, Coumarin and coumarin-related compounds have proved to have significant therapeutic potential. Initially they were came from a wide variety of natural sources and now a day s new Coumarin derivatives are being discovered or synthesized on a regular basis. This book gives brief idea about an advanced method for the synthesis of certain biologically active Coumarin derivatives. ····· 1036188812
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Prodrug has been the concept of retro metabolic drug design that incorporates targeting, metabolism and duration of action consideration into the design process. The carboxylic groups of NSAIDs can be temporarily masked and its direct effect on gastric mucosa can be minimized. Ester prodrugs of has been synthesized using various carrier moieties as reduce their GIT irritation and improve bioavailability. Prodrugs of several NSAIDs, such as diclofenac, Aspirin, ketoprofen etc have been synthesized using 1, 4-dihydro-1-methylpyridine-3-carboxylate as a carrier to brain to treat Alzheimer s disease. Our aim is to reduce the gastric irritation due to direct contact of the drugs with the gastric mucosa and increased absorption using mutual prodrug approach. ····· 1036188788
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Herbal medicine involves the use of plants for medicinal purposes. The term `herb` includes leaves, stems, flowers, fruits, seeds, roots, rhizomes, and bark although in many traditions other naturally occurring substances including animal and mineral products are also used. Diabetes was known even in ancient times. The name of this disease, which is characterized by excessive flow of urine and insatiable thirst, was coined by the Graeco-Roman physician Aretaeus of Cappadocia (approx. 80 130 A.D.) and is derived from the Greek word diabainein ( to flow through ). The adjective mellitus, which comes from Latin and means honey-sweet , was added by the German physician Johann Peter Frank (1745 1821) in order to distinguish diabetes mellitus, or sugar diabetes , from diabetes insipidus. Johann Peter Frank was also who in 1790, by introducing a yeast fermentation test for the quantitative determination of urinary glucose, relieved the physicians of his time of the need to taste their patients urine. The present book highlights the use of various herbs in the treatment of the disease. ····· 1036188734
für 53.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Multiple drug administration increase chances of drug interaction, altering the responses of drugs. Generally multiple drug administration should be avoided for safe and cost-effective patient care. However in major parts of the world there is augmented load of cardiovascular disease, epilepsy and chronic non-communicable disorders such as diabetes mellitus. Hence it is essential to recognize the probable toxicities that might take place as a result of the drug-drug interaction upon simultaneous use of anti-hypertensive, anti-arrhythmic, anti-epileptic, and anti-diabetic drugs. This monograph provides useful information of biochemical, hematological and histopathological changes which might occur following administration of multiple drugs, hence it may serve as an effective tool to investigate the toxicities of multiple drug administration. This monograph is equally beneficial for both graduate and postgraduate students of pharmacology and toxicology to gain a better understanding about the probable mechanisms involved in cumulative toxicities. ····· 1036188704
für 61.20€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Metabolism of glucose in liver of a diabetic patient involves variety of enzymes and selective alterations in hepatic enzyme flux result in acute and/or chronic complications. Biochemical transformations in the hepatic and pancreatic cells become object of investigation. Detail study of contemporary medicines, physiology and endocrinology made significant attempt in understanding hepatic glucose homeostasis as a proper diagnostic tools. It has been proposed that alloxan acts as a diabetogenic owing to its ability to destroy pancreatic -cells possibly due to the free radical generation mechanism. Antioxidants can protect experimental animals and human from oxidant mediated damages. Modern therapeutic agents have high rate of obsolescence. Plectranthus amboinicus (Lour) Spreng belongs to the family Lamiaceae commonly known as Indian borage contain flavonoids. Hence present study has been planned to evaluate the antihyperglycemic effects of Plectranthus amboinicus leaves extract and their possible effect on pancreatic tissue in albino rats. Our approach has been notjust to emphasize pharmacological activity of herbs, but to explore the cellular mechanism by which they act. ····· 1036188625
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Herbal drug powders may be formulated into modern tablet dosage form by selecting suitable size reduction method to get a specific size of the particles and altering those particle size with the use of direct compression mechanism by the use of directly compressible vehicle at a particular concentration, which could be determined by the micromeritic analysis using Kawakita, Heckel, Leuenberger equations as well as the powder of a specific particle size may also be converted into tablet dosage form by the wet granulation method by using certain excipient at a specific concentration, which could be determined by the micromeritic analysis using Kawakita, Heckel, Leuenberger equations to get optimum size of granules having desired free flowing and compression characteristics to prepare tablet. The methods may be suitable to utilize in commercial field to produce herbal powder into modern tablet dosage forms and viable commercially as stable dosage forms. ····· 1036188384
für 53.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Colorectal cancer is second leading cause of deaths in the United States. Various approaches available for The poor site specificity of pH dependent systems, because of large variation in the pH of gastrointestinal tract, was well established. The timed-release systems release their load after a predetermined period of administration. These are designed to resist the release of the drug in stomach and small intestine and release of the drug takes place in colon. Methotrexate (MTX) is a used in the treatment of colon cancer and now a days rheumatic disease. MTX is a folate antimetabolite. MTX has since been used in the treatment of various malignancies including osteosarcoma, non-Hodgkin`s lymphoma, Hodgkin`s disease, cutaneous T cell lymphoma, lung cancer, colon cancer and breast cancer. The conventional dosage forms which are used for colorectal cancer normally dissolve and absorbs in the stomach and small intestine thus a very less quantity of dose of drug reaches to colonic region. Aim of present work is to develop and characterize colon targeted tablet of MTX for for treatment of colorectal cancer using different polymer and excipient by compression coating technology. ····· 1036188353
für 53.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Nowadays, pulmonary delivery tends to be considered as an attractive and promising route for the administration of active substances intended to treat local pulmonary (e.g. asthma, COPD etc.), as well as systemic diseases (e.g. diabetes). Traditional DPI formulations associate the use of micronized drug, usually 2-5 µm in diameter, such formulations deliver around 10-15 % of the drug loaded to the desired target within the lung bronchi. A significant disadvantage of many existing inhaled drugs is the relatively short duration of resultant clinical effects and most medications in aerosol form require inhalation at least 3-4 times daily. This may often lead to poor patient compliance with the therapeutic regime and increase the possibility of associated side effects due to the risk of self administration of the drug by the patients. Sustained release of such drugs in the lung would be particularly beneficial since they could be delivered to and retained at the targeted receptors for a prolonged period of time and thus minimize the biodistribution throughout the systemic circulation. ····· 1036188198
····· lezzter Preis 49.00€ ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray High-throughput screening (HTS) is a method for scientific experimentation especially used in drug discovery and relevant to the fields of biology and chemistry. Using robotics, data processing and control software, liquid handling devices, and sensitive detectors, High-Throughput Screening or HTS allows a researcher to quickly conduct millions of biochemical, genetic or pharmacological tests. Through this process one can rapidly identify active compounds, antibodies or genes which modulate a particular biomolecular pathway. The results of these experiments provide starting points for drug design and for understanding the interaction or role of a particular biochemical process in biology. ····· 1036188072
für 61.20€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Coumarins are naturally occurring benzopyrene derivatives have been identified from natural sources, especially green plants. The pharmacological and biochemical properties and therapeutic applications of simple coumarins depend upon the pattern of substitution. The coumarins have attracted intense interest in recent years because of their diverse pharmacological properties. Among these properties, their cytotoxic effects were most extensively examined. Moreover coumarins have simple structure with least toxicity made them first choice to select for biological screening. The research work was designed based on the research findings reported in various literatures supporting the anti oxidant,anti cancer and antimicrotubular activity of courmarin compounds derived from substitution at different position of coumarin scaffold. From literatures, it showed that coumarins with substitution at 4th and 7th position with various substituents like OH, -CH3, -COOH, Pyridine showed profound biological activity. Moreover coumarins have simple structure with least toxicity made them first choice to select for biological screening. ····· 1036188003
für 71.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Biochemistry is a scientific discipline panning the fields of chemistry and biology that involves the application of chemical techniques and tools, often compounds produced through synthetic chemistry, to the study and manipulation of biological system and study of the chemistry of biomolecules. For example, a biochemist would seek to understand the three-dimensional structure of a protein and how that structure relates to the chemistry of the protein. Chemical biologists attempt to utilize chemical principles to modulate systems to either investigate the underlying biology or create new function. In this way, the research done by chemical biologists is often closer related to that of cell biology than biochemistry. In short, biochemists deal with the chemistry of biology, chemical biologists deal with chemistry applied to biology. I hope it will be of interest to all bio-, medicinal and organic chemists curious about the study of how molecules in living cells work chemically. ····· 1036187920
für 53.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The basic concept of interaction is discuseed in the book. If these interactions between different herbs are studied, best utilization of the available herbal therapies can be done which can give a valuable treatment and cure with low number of side effects to the society. An attempt is made in this book to study the interataction of two well known herbal plants which are widely used in Indian system of traditional medicine for treating various diseases like hyperlipidemia, diabetes etc. The book contains seven chapters which covers the following topics: Introduction of herbs, hyperlipdemia and antioxidant Review of literature of the two well known antidiabetic and antihyperlipidemic plants Gymnema sylvestre R. Br. and Azadirachta india A. Juss. Aim and plan of work for the interaction study Material and methods used to interaction Result and discussion Summary and conclusion Annexures which include the approval certificate by Animal Ethics Commity to conduct the study. I wish that this book will help in consolidating my understanding of aspects of natural products and its interaction. ····· 1036187894
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Animal pharmacokinetic studies are an important area of study for biopharmaceutic and pharmacologic researchers and the facilities like University of Veterinary and Animal Sciences can harbor such services not only for the researchers involved in the development of Pharmacokinetic and Bio-equivalence study models in animals. Animal studies play important role in the preclinical phase of the Drug trials facilitating the process of formulation development resulting in the predictable pharmacokinetics of the formulation. The area has not been extensively used in the current research settings of Pakistan. Animal houses with pedigreed breeds and animals with induced disease states and adaptive changes can be an area of interest for multidisciplinary teams involving veterinarians, pharmacologist, pharmacist and pharmaceutical scientists. ····· 1036187884
für 55.71€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Helicobacter pylori (H. Pylori) infection is associated with many upper gastrointestinal diseases such as chronic gastritis, peptic ulcer and gastric carcinoma. Furazolidone is an effective drug in the treatment of GIT infections. Furazolidone has short half-life and need to administrate on frequent basis. This book discuss design, development and optimization of sustained release intra-gastric in situ floating gel system of Furazolidone for the potential use in treatment of gastric and duodenal ulcers associated with H. Pylori. Furazolidone gelling solution (FISG) was prepared using natural biodegradable polymers Xanthan gum, Gellan gum and Locust bean gum. The polymeric system was optimized by calcium carbonate and sodium citrate. Effect of beta CD was also evaluated. The optimized FISG was evaluated for gelling properties, floating lag time, rheological properties, drug content, FT-IR and DSC. All optimized solutions had shown pseudoplastic flow with good gel strength and gelled immediately at acidic pH 1.2. The dissolution study indicated sustained release of drug. The book will be useful for the researchers working in the areas of formulation development of pharmaceuticals. ····· 1036187813
für 53.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Significant efforts have been devoted to use the potentials of nanotechnology in drug delivery since it offers a suitable means of site-specific and/or time controlled delivery of small or large molecular weight drugs and other bioactive agents.Pharmaceutical nanotechnology focuses on formulating therapeutically active agents in biocompatible nano forms, These systems offer many advantages in drug delivery, mainly focusing on improved safety and efficacy of the drugs, e.g. providing targeted delivery of drugs, improving bioavailability, extending drug or gene effect in target tissue, and improving the stability of therapeutic agents against chemical or enzymatic degradation. Mucoadhesive nanoparticulate Drug Delivery System prolongs the residence time of dosage form at the site of application or absorption. They facilitate an intimate contact of the dosage form with the underlying absorption surface and thus improve the therapeutic performance of the drug. This book is an effort to provide information on such mucoadhesive drug delivery systems that are developed for oral, buccal, nasal, rectal and vaginal routes for both systemic and local effect. ····· 1036187679
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Majority of the studies are done on the other parts of the plants like bark, fruit and flower, and methods employed for the study is costly as by making use of high cost chemicals and equipments. The belief behind this book is to bring in one new method of screening the activity of plant parts for laboratory experiments at academic level. In this book different approach towards screening of biological activities like Antioxidants and Hepatoprotective has been included. Significance of this approach is proven in this study by comparing the effects and the extract of the plant part i.e. leaf, of high cost chemicals and conventional chemicals. In which conventional chemicals gives significant effect and presence of responsible constituents in it. ····· 1036187528
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Popularity among the common people increased the usage of medicinal plants/herbal drugs. Herbal adulteration is one of the common malpractices in herbal raw material trade . Medicinal plants constitute an effective source of traditional (e.g., Ayurvedic, Chinese, Homeopathy and Unani) and modern medicine. Herbal medicine has been shown to have genuine utility A major role of any herbarium is that of education, Most herbaria have collections specifically for use by students. These collections are typically kept separate to prevent unnecessary damage to the permanent collections. The teaching collections, in conjunction with the permanent reference collections, provide materials that are essential for teaching courses such as Plant Taxonomy, Plant Ecology, Plant Kingdom, and Plants and Human Affairs. Learning characteristics of plants, studying relationships between plants, and identifying unknown plants are just a few of the many educational uses for herbarium specimens. Just like a museum or library that offers educational programs and other services to the public, so does the herbarium. ····· 1036187260
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Combination of drugs is often formulated to increase the potency of the dosage form and to decrease the number of tablets taken for the management of diseases. In present work, methods of simultaneous estimation of Olmesartan Medoxomil and Amlodipine besylate in their combined dosage form are developed, as literature survey revealed that no method for simultaneous estimation of these drugs is reported. After studying the stability of both the drugs in methanol and acetonitrile, Olmesartan shows poor stability in methanol whereas in acetonitrile it shows good stability therefore acetonitrile is used for method development. Bioanalytical method validation was done by USFDA guidelines. Bioanalytical method validation was done by USFDA guidelines. Recoveries in all these method were in the range of 98-101%. Results obtained were statistically validated and were found to be reproducible. These methods can be applied for routine analysis of formulations containing these drugs. For analytical methods validation parameters such as linearity, precision, accuracy, specificity, limit of detection, limit of quantitation and robustness were determined according to ICH Q2B guidelines. ····· 1036187190
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Essential Drugs Company Limited (EDCL) is a 100% state owned Pharmaceuticals Company in Bangladesh. It has three plants in Dhaka, Bogra and Khulna, Bangladesh. It manufactures quality drugs at an affordable price & supplies to the Government Hospitals, Civil Surgeon s Offices, Health Institutions of Government, Non-Government and International (Non-profit makings) Organizations like UNICEF, WHO, ICDDRB etc. At present the company has been producing 155 Essential Drugs. EDCL has already developed a strong position in Bangladesh in Government Sector and is well positioned to sustain its growth and have a sound platform to serve export markets. ····· 1036187080
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray This book initially provides a review of floating drug delivery systems. This system has a bulk density lower than the gastric content. They remain buoyant in the stomach for a prolonged period of time, with the potential for continuous release of drug. Gastric emptying is much more rapid in the fasting state and floating systems really heavily on the presence of food to retard emptying and provide sufficient liquid for effective buoyancy. When microspheres come in contact with gastric fluid the gel formers, polysaccharides, and polymers hydrate to form a colloidal gel barrier that controls the rate of fluid penetration into the device and consequent drug release. The air trapped by the swollen polymer lowers the density and confers buoyancy to the microspheres. However a minimal gastric content needed to allow proper achievement of buoyancy. Hollow microspheres of Acrylic resins 57, Eudragit, PMAA, floating granules are the recent developments in this field. The book then presents studies conducted on producing microspheres containing Antidiabetic drug. The book also discusses various formulation and processing parameters and in-vivo study in wistar rats. ····· 1036187038
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray PROFESSIONAL EXPERIENCE ALKEM RESEARCH CENTER, NAVI MUMBAI Since 21st December 2009 Research Associate Responsible for all analytical method validation (Assay and Dissolution test) and new analytical method development by HPLC, UV spectrophotometer, AAS. Analyze, summarize and present results for all research projects. Regularly review ongoing research for trends. Provides insight on these findings and ensures key findings are shared with appropriate internal audiences. Developed new profitable business partners while analyzing latest market trends and tracking competitor s activities while providing valuable inputs for fine tuning sales & marketing strategies. Building cordial relationship through regular interactions & apprising them with company s value propositions. ····· 1036186975· 1 · ::::: · 15 ·· 16 ·· 17 ·· 18 ·· 19 ·· 20 ·· 21 · ::::: · 27 ·
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