····· lezzter Preis 44.10€ ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The objective of transdermal delivery system is to achieve optimum therapeutic management. But, it still remains a challenge in the field of pharmaceuticals for delivery of ionic species such as proteins and peptides. Development of iontophoretic system is a breakthrough in this field designed to improve the delivery rate of ionic compounds. This technique generates an electrical potential gradient that facilitates the movement of solute ions across the membrane. Iontophoresis is the process of increasing the penetration of drugs into the skin by application of an electric current. The drug is applied under an electrode of the same charge as the drug, and a return electrode opposite in charge to the drug is placed at a neutral site on the body surface. Electrical energy assists the movement of ions across the skin using the principle `like charges repel each other and opposite charges attract`. Iontophoresis seems to be an ideal candidate to sort out the limitations associated with the delivery of ionic drugs. In this book, efforts have been made to summarize all the aspects of iontophoretic delivery. ····· 1036125153
····· lezzter Preis 44.10€ ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The CNS stimulation study has been performed on the two semisynthetic adducts of caffeine with Schiff s base of pyrazolone and pyrazolone-pyrimidine nucleus. All the reference drugs and test compounds showed positive effect on CNS stimulation. The conclusion has been drawn from the fact that CNS stimulation effect for pentylene tetrazole is higher than caffeine, Molecule-I (pyrazolone ring) is less active than Molecule-II as the Molecule-II (pyrazolo-pyrimidine ring) is fused ring heterocyclic compound and the synergistic action with caffeine with Molecule-I having less activity than the Molecule-II but in case of leptazol (pentylenetetrazol), the synergistic activity of the two test compounds are equal but less than leptazol itself. The azole group is present in both caffeine and in leptazol but in fused ring heterocyclic chromophore and the same ring has been implemented in the two test compounds which have been semisynthesized by formation of Schiff s base of caffeine to keep the similar bioisosteric nature. So, the components that have been semisynthesized showed the specific CNS stimulation activity. ····· 1036125145
····· lezzter Preis 44.10€ ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray This book is a modest attempt to provide a simple text for those who desire to equip with knowledge of herbal standardization, qualitative phytochemical investigation and antibacterial activity of herbal drugs. The authors have attempted to give as many illustrations as possible to make the concepts and principles clear to the reader. The large number of review materials is incorporated at each chapter after exhaustive survey of literature. We believe that this book will cater to the immediate needs of the students, researcher and the faculty members of the subject and will serve as an excellent book of its field. The book contains seven chapters which are systemically organized for the better understanding of the subject. ····· 1036124985
····· lezzter Preis 44.10€ ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The aim of the present research work was to investigate the potential of emulgel in enhancing the topical delivery of ketoconazole. Emulsion in gel have emerged as one of the most interesting topical drug delivery system as it has dual release control system i.e. emulsion and gel. Also the stability of emulsion is increased when it is incorporated in gel. Emulgel formulations of Ketoconazole were prepared using 2 types of gelling agents: Carbopol 934 and Carbopol 940. The influence of the type of the gelling agent and the concentration of both the oil phase and emulsifying agent on the drug release from the prepared emulgel was investigated using a 23 factorial design. The prepared emulgel were evaluated for their physical appearance, viscosity, drug release, globule size, skin irritation test, antifungal activity, transmission electron microscopy, Ex vivo Syudy, In Vivo Study and stability. Commercially available ketoconazole cream was used for comparison. All the prepared emulgel showed acceptable physical properties concerning color, homogeneity, consistency, spreadability, and pH value. The antifungal activity and drug release were found to be higher for optimized formulation . ····· 1036124978
····· lezzter Preis 61.20€ ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The book provides an easy and up-to-date account of divergent vital topic in a simple, lucid and concise manner. The text of the book has been illustrated with simplified, well-labelled coloured diagrams and relevent pictures to make the sbject easy to understand and interesting to read for the students. Highlights Of The Book: - Exhaustive subject matter well supported with the relevant coloured photographs. - Contains standardization data of each ingredient of poly herbal formulation. - Also contains reviews of each ingredient. - Coloured photographs of HPTLC. - Comparative studies of in vitro acid neutralizing capacity with allopathic formulation. ····· 1036124937
····· lezzter Preis 61.20€ ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The method has also been developed for dissolution of antidiabetic drugs. Initially the solubility was determined in different dissolution media. The dissolution study of drugs was performed in 7.8 pH phosphate buffer in which these two drugs shows highest solubility. The dissolution was performed in pH 2.0 medium. The dissolution study was performed using Paddle with sinkers at 75 rpm. The amount of drugs were estimated. ····· 1036124935
····· lezzter Preis 44.10€ ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Cyclorins, hydrophilic carriers, are cyclic polysaccharides which have property of forming inclusion complex with various guest molecules with suitable polarity and dimensions. They have been used extensively for solubility enhancement of hydrophobic drug/water insoluble drugs. Diacerein is anthraquinone compound designed to treatment of osteoarthritis. The purpose of this research was to enhance the solubility and therefore dissolution of Diacerein by complexation with -cyclodextrin ( CD) and hydroxyl propyl -cyclodextrin (HP CD).This study represents the formulation of inclusion complex with CD and HP CD by kneading method and their characterization and evaluation of improvement in dissolution profile. Inclusion complex compared to pure drug and physical mixtures, remarkable enhancement in invitro drug release profile in PH 6.8 phosphate buffer was obtained in both inclusion complexes of CD and HP CD, especially with HP CD. Complexation of Diacerein with hydrophilic carriers like CD and HP CD offers a major enhancement in drug solubility. ····· 1036124932
····· lezzter Preis 44.10€ ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Despite the development of several new anticonvulsants, over 30% of people with epilepsy do not have seizure control and others do so only at the expense of significant dose-related toxicity and unusual adverse effects. The semicarbazones based pharmacophoric model for anticonvulsant activity comprises of following four essential binding sites: (i) An aryl hydrophobic binding site (ii) A hydrogen bonding domain (iii)An electron donor group and (iv) Another hydrophobic-hydrophilic site regulating the pharmacokinetic properties of the anticonvulsant. In pursuit for better antiepileptic drug and the importance of semicarbazones as anticonvulsant pharmacophore, a series of novel semicarbazone were designed, synthesized and evaluated for their anticonvulsant activity. The results of the present studying confirmed that the pharmacophoric model with four binding sites is vital for anticonvulsant activity. ····· 1036124926
····· lezzter Preis 53.10€ ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Oxicams such as tenoxicam, lornoxicam and meloxicam and sulphonanilides like nimesulide are widely used as nonsteroidal anti-inflammatory drugs and are available in a variety of pharmaceutical formulations as tablets, capsules, ampoules, vials and gels. Due to wide application of these drugs and use, there is still need for new, rapid, simple, accurate, sensitive and inexpensive analytical assays to be applied to typical formulations of these drugs during industrial process, development and scale up production and this was the aim of this research. The developed spectrophotometeric and spectrofluorimetric methods were simple , sensitive, rapid , convenient and economical and successfully applied for routine analysis of these drugs in both pure and pharmaceutical dosage forms. In addition this research guides the students in pharmaceutical analytical chemistry to the steps of drug analysis (optimization, validation and application). ····· 1036124897
····· lezzter Preis 44.10€ ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Quality Assurance is a wide ranging concept covering all matters that individually or collectively influence the quality of product.Ultraviolet Spectroscopy is an absorption spectroscopy in which the excitation of electrons is accompanied by changes in the vibrational and rotational quantum numbers.Simultaneous equation method is having special advantages over other methods because of its simplicity and rapidity in performing. Simultaneous equation is based on simple principle, that the absorbance of mixture at particular wavelength is additive of absorbances of individual component in sample mixture at that wavelength. ····· 1036124863
····· lezzter Preis 44.10€ ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Traditional physiotherapy approach to treatment is exclusively based on exercise and the use of modalities. However, there is a paradigm shift in management of diseases and the consequent impairments to a combination of pharmacotherapy and physiotherapy. This book presents the findings of a study that sought the opinion of physiotherapists regarding the inclusion of pharmacology in baccalaureate physiotherapy graduate curriculum. The outcome showed that undergraduate pharmacology education obtained during baccalaureate physiotherapy training is crucial and has positive impacts on clinical practice of physiotherapists. ····· 1036124860
····· lezzter Preis 44.10€ ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The present invention is aimed to formulate the non-enteric formulation of immediate release rabeprazole sodium tablet using acid-buffer technology. The formulation comprising the core tablet containing rabeprazole sodium compression coated with buffer containing super disintegrant. The coat formulation disintegrates fast which provide the higher pH environment then the core formulation gives drug release so degradation of rabeprazole sodium can prevent. From the above perception, the invention is aimed: 1.To study the pH stability of rabeprazole sodium in at different pH medium. 2.To select the proper buffer combination for better basic environment. 3.To formulate the fast release compression coated tablet of rabeprazole sodium. 4.To optimize the formulation using suitable experimental design. ····· 1036124843
····· lezzter Preis 61.20€ ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Transdermal drug delivery refers to the delivery of sufficient drug through the skin to the vasculature to produce therapeutic systemic concentrations. This route of drug delivery makes it possible to overcome the drawbacks normally associated with conventional routes of drug administration and offers a convenient and controllable means, thereby leading to enhanced patients compliance. This book presents a detailed review on various aspects of transdermal drug delivery as well as experimental data on the study of lamivudine (anti-retroviral agent) and meloxicam (anti-inflammatory agent) as potential drugs to be transdermally administered. It is therefore, recommended for the students of Pharmacy and Medical sciences, Academics, Clinicians as well as those who may be interested in this route of drug administration. ····· 1036124807
····· lezzter Preis 44.10€ ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray This book covers all the major Applications of a relatively new technique named Gas chromatography-Mass Spectrometry Which is a Hyphenated technique used to detect Various Components which was not Possible earlier due to various problems. By using this technique researches have been done in Various Fields like in petrochemical analysis, Geochemical analysis, environmental analysis and now even it is used these days in solving Various Court cases and forensics Ultimately after going through this it can be rightly said that this technique is `GOLD STANDARD FOR DETECTION` ····· 1036124802
····· lezzter Preis 44.10€ ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Clinical research is gaining importance as a career and as an industry, and is expected to provide jobs for thousands of B.Pharm,M.Pharm,MBBS and Science graduate.Continued progress in clinical research field has encouraged me to produce this book. This edition has been prepared by keeping in mind the basic need of Clinical Pharmacokinetic studies.Book provide an overview on four important domains these domains are clinical, Bioanalytical, Statistical and Data management. ····· 1036124797
····· lezzter Preis 44.10€ ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray This review gives clear insight on Biosimilars. Biosimilars the follow-on biologicals is the new area for a pharmaceutical industry to consider whether it suits its expertise, its business interest and offers for it opportunities for growth. This review explores Biosimilar Drug Development from the view-point of a biopharmaceutical company and proposes key points that a company needs to consider through the process of planning biosimilar drug development. It examines significant developments in the biosimilars market and will arm the reader with scientific, regulatory and strategic information needed to face new opportunities as well as the challenges of the biosimilars revolution. ····· 1036124757
····· lezzter Preis 68.00€ ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray This book contains a study carried out in Kanpur in India, it focus on Assessment & Importance of pharmaceutical care in patients with essential hypertension. Pharmaceutical care is an essential component of therapy, it can improve outcomes and reduce treatment cost by taking cognitive initiation to prevent, detect and resolve, drug related problems and educating and motivating patients in non pharmacological intervention of hypertension.The results from this study shows that the combination of pharmacist intervention can improve blood pressure control in patients with hypertension, this study also estimated the incidence of potential drug-drug interactions occurring in the Cardiology unit and also evaluated patient understanding of disease and medication adherence with help of suitably designed questionnaires. ····· 1036124735
····· lezzter Preis 71.90€ ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray When a patient has no alternative towards treatment of disease then Magnetic microspheres come into view.Magnetic Microspheres have basically two advantages that is Reticuloendothelial clearance can be minimised and target site specificity can be increased.For Drug targeting, various carrier systems have been exploited like liposomes, nanospheres, microspheres, macromolecules etc. The difficulty of targeting drugs in vivo using these carrier systems is that the body contains 3 major tubes: the vascular, extracellular & intracellular compartments. Despite having several advantages, one most important problem to this field is that all the systems so far developed, give release rates that are either constant or decrease with time. Microspheres are successfully utilized for drug targeting but they show poor site specificity and are rapidly cleared off by RES (reticuloendothelial system) under normal circumstances.Improvement of patient compliance can be accomplished by this method. 1)Although magnetic nanoparticles, emulsions, liposomes can be made but they are less stable than magnetic microspheres. 2) Magnetic microspheres are easily recyclable and can be used in different fields. ····· 1036124696
····· lezzter Preis 61.20€ ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The basic requirements for commercial formulation of solid unit dosage form particularly of tablet and capsule are good flowability, mechanical strength and compressibility and all of these requirements are fulfilled when the drug candidates are in granular or spherical form. Since all drugs does not posses the granular nature so by the help of granulation techniques fine powder can be converted into granules which may lead to some problems like more time consuming and chances of drug excipients interaction. The spherical crystallization technique is revolution in particle engineering field which convert fine powders in the granular form and made suitable for direct compression in the formulation of tablet as well as suitable for capsule filling. The book has the concept of how poorly flowable drugs can be converted in to spherical crystals those can be directly compress, which can reduce the cost of dosage form as well as speedup the productivity. ····· 1036124676
····· lezzter Preis 44.10€ ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Protein-tyrosine kinases (PTKs) play an essential role in the intracellular mitogenic signaling mechanism. In fact, many growth factor receptors themselves have intrinsic PTK activity, as evidenced by the cases of epidermal growth factor (EGF), nerve growth factor (NGF) and stem cell factor (SCF) receptors. In contrast to these receptor-type PTKs, many PTKs do not have a transmembrane domain in their structure. These are designated as non-receptor-type PTKs or cytoplasmic PTKs. Non-receptor PTKs can be further subdivided into a number of sub- families, one of which is the Tec family. The Tec family consists of five members, namely Tec, Btk, Itk/Emt/Tsk, Bmx and Txk/Rlk. Many members of this family are abundantly expressed in hematopoietic tissues, where they are presumed to function in the growth, differentiation or both processes of blood cells. This hypothesis is strengthened by the fact that the Btk kinase molecule is responsible for X chromosome-linked agammaglobulinemia (XLA) in humans and X chromosome-linked immunodeficiency (Xid) in mice. ····· 1036124664
····· lezzter Preis 53.10€ ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Coumarins are important class of compounds, isomeric to quinolones. They may become promising candidates for exploiting more useful therapeutically active molecules. DNA-gyrase has drawn much attention as selected target for finding potent anti-bacterial agents against multi-drug resistant strains such as methicillin-resistant Staphyloccus aureus (MRSA), vancomycin-resistant enterococci (VRE), penicillin-resistant Streptococci pneumonia (PRSP). The objective of the present study was, to study the molecular docking simulations on 5,7-dihydroxy-4-methyl coumarin analogues as probable candidates for inhibiting DNA gyrase subunit-B of S.aureus. In the present study, Docking simulations were carried out on the reported inhibitors of DNA-gyrase subunit A and B using docking software. Based on it, Series of 5,7-dihydroxy-4-methylcoumarin analogues (PH-1 to PH-9) were designed, synthesized, characterized and evaluated for its anti-bacterial activity against S.aureus and E.coli. Out of the nine test compounds, compound PH-4 showed good anti-bacterial activity against S.aureus and E.coli than rest of other compounds. ····· 1036124660
····· lezzter Preis 54.90€ ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Till date, pursuit for cost effective and animal sparing colon specific bio-relevant dissolution media has been a foremost challenge facing pharmaceutical scientists over many decades.It is problematic to mimic the dynamic and ecologically diverse features of the colon in dissolution vessel.With the knowledge of enormous colonic microflora, the predominant species Bacteroides, Bifidobacterium, Eubacterium, Streptococcus and Lactobacillus species were cultured in 12% w/v skimmed milk powder and 5%w/v grade `A` honey. Probiotic culture was added to the dissolution media in order to test the drug release of polysaccharide based formulations. USP dissolution apparatus I/II with gradient pH dissolution method were used to evaluate the drug release from formulations meant for colonic drug delivery. Drug release from 5-fluorouracil granules and metronidazole tablets were assed under gastric, small intestine conditions and also within a simulated colonic environment involving existing rat caecal, human fecal media and compared with novel probiotic media. The present method can be successfully applied for the drug release testing of any oral formulations meant for colonic delivery. ····· 1036124643
····· lezzter Preis 44.10€ ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Parkinson s disease is neurodegenerative disorder characterized by progressive loss of dopaminergic neurons in substantia nigra pars compacta. It is well known that the incidence of Parkinson`s disease is lower in women as compared with men. Although the reason for this gender difference is not clear, the level of female steroid hormones or their receptors may be involved in pathogenesis. Neuroprotective effect of estrogen is well recognized but progesterone showed conflicting results regarding neuroprotection. This book emphasizes on role of progesterone in pathogenesis of parkinson s disease. In recent years, there has been renewed interest in plant medicine for the treatment against wide variety of diseases. Herbal medicines are recognized by WHO as an essential building block for primary health care, especially in developing countries like India. This book also accentuates potential of herb Ocimum sanctum against experimentally induced parkinsonism in rodents. ····· 1036124640
····· lezzter Preis 44.10€ ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The purpose of this research was to mask the intensely bitter taste of Lumefantrine and to formulate oral-disintegrating tablet (ODT) of Artemether & Lumefantrine. Taste masking was done by complexing Lumefantrine with amino alkyl methacrylate copolymer (Eudragit E - 100) using solvent deposition method and acetone as a solvent for pH-sensitive polymer and was tested for drug content and in vitro taste in simulated salivary fluid (SSF) of pH 6.8. The complex with drug polymer ratio of 1: 0.1 that did not release drug in SSF was considered taste-masked and selected for formulation of ODTs. ····· 1036124636· 1 · ::::: · 18 ·· 19 ·· 20 ·· 21 ·· 22 ·· 23 ·· 24 · ::::: · 27 ·
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