für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray This book covers the Phytochemical investigation and evaluation of hypolipidemic activity of Melothria maderaspatana (Linn) in high fat diet fed rats. Melothria maderaspatana is a plant drug belonging to family cucurbitaceae, mostly prevalent in south India. Melothria is a large genus of herbs with 105 species found in warmer region of world. Melothria maderaspatana Linn, is a high valued medicinal significance. It aimed to isolate phytoconstituents and then to characterized them by various methods like TLC, FT-IR, 1H-NMR, spectroscopy. Then aqueous extract of Melothria maderaspatana plant was used for the investigation of hypolipidemic activity in rats. This book will provide food of thoughts for researchers and academicians regarding the future trends and research methodologies on phytochemical investigations on plant Melothria maderaspatana (Linn). ····· 1036121349
····· lezzter Preis 49.00€ ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray a)Introduction to the problem:This study reveals the concept of mixed solvency, which explains that all substances whether liquids, gases or solids possess solubilizing power. Till now this concept have been utilized extensively in the field of pharmaceutical analysis and formulation with an aim to preclude the use of organic solvent, avoids the problem of residual solvent toxicity, reduce the individual concentration of solubilizers and thereby reduce their associated toxicity, replace relatively toxic class-II solvent by safer class-III solvent, potentiation of weaker solvent by use of proper choice of solubilizers and at last economic as well as eco-friendly. This concept can also be applied in formulation development of NDDS like microspheres, SEDDS etc and herbal extraction. In future, this concept shall prove a boon in pharmaceutical field and also in non-pharmaceutical field. b)Abstract:The objective is to explore mixed solvency concept in preparation of floating microspheres of furosemide. The prepared microspheres showed better result and prolongs the drug release (12h). c)Target groups: Pharmaceutics & pharmaceutical analysis. ····· 1036121307
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Transdermal and topical formulations are becoming increasingly important and their use in therapy is becoming more widespread.Emulgels are emulsions, either of the oil-in-water or water-in-oil type, which are gelled by mixing with a gelling agent. They have a high patient acceptability since they possess the advantages of both emulsions and gels. Therefore, they have been recently used as vehicles to deliver various drugs to the skin. ····· 1036121248
für 55.71€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Aldosterone plays an important role in the pathophysiology of Heart Failure. ACEIs reduces the aldosterone level but it again reach to pre-treatment level after 3-6 months of therapy. The studies like EPHESUS and RALES showed the effectiveness of Eplerenone and Spironolactone in patients having clinical evidence of heart failure after recent Myocardial Infarction. But no direct comparative study between Eplerenone and Spironolactone has been undertaken to show beneficial effect of aldosterone blocker in post MI patient. The current book shows the direct comparative study between Eplerenone and Spironolactone in acute MI patients. ····· 1036121235
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray This monograph is useful as a reference for Postgraduate students and Ph.D research scholar of Pharmacy and Analytical Chemistry. The main purpose of this monograph is to discuss a development of method for fluroquinolone antibacterial drugs as ion pair using acidic dyes. This manuscript comprise of seven parts containing introduction, aim and objective, plan of work, Experimental work and results, Discussion, summary and results and references. ····· 1036121136
····· lezzter Preis 44.10€ ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Patients who have problems in swallowing encounter difficulties in taking tablets, particularly pediatric and geriatric patients. Such problems can be resolved by means of orodispersible tablets. These tablets disintegrate instantaneously when put on tongue, releasing the drug that dissolves or disperses in the saliva.Metronidazole is active against a wide variety of anaerobic protozoal parasites and anaerobic bacteria.The present study aim to prepare tablets that can rapidly disintegrate in oral cavity (orodispersible), another challenge with this model drug is to mask the bitter taste. Taste masking was achieved by using aminoalkyl methacrylate copolymer (Eudragit E-100) in the different ratio (1:2 and 1:3) by extrusion technique. The IR shows that there was no significant evidence for interaction between drug and polymers. Six formulations were prepared using taste masked granules and different disintegrants (LH-11) and Avicel PH-102 by varying concentration. ····· 1036121107
für 71.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray This book describes characterization of the intestinal absorption and bioavailability of -tocotrienol using in vitro, in vivo and in situ models..... investigates the carrier-mediated transport of -tocotrienol by NPC1L1 and compares its oral bioavailability, oral absorption and elimination kinetics to that of -tocopherol.... characterizes -tocotrienol and -tocopherol in vitro interaction kinetics with NPC1L1 transporter responsiple for both compounds non-linear kinetics....tests solid lipid nanoparticles as a model formulation to enhance the permeability of -tocotrienol and investigates the mechanism of intestinal uptake of -tocotrienol packaged in this delivery ssytem..... conducts preclinical pharmacokinetic tests required to predict the oral absorption kinetics of UK-343,664 (a substrate for P-gp and CYP3A4) in humans....and builds an in silico PBPK simulation model to investigate and explain the non-linear absorption kinetics of UK-343,664 obsrved in humans using the ACAT model (Gastroplus , Simulation Plus Inc., Lancaster, CA), and compare the simulation results with the in vivo results. ····· 1036121059
für 71.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The book deals with the metal complexes of Azithromycin, a macrolide and gemifloxacin, fourth generation fluoroquinolone antibacterial which were synthesized characterized and their antimicrobial activities against various Gram negatives, Gram positives and antifungal species were analyzed. Interaction of gemifloxacin with co-administered drugs was also studied and for this purpose their methods on RP-HPLC were developed for the first time. To support these findings gemifloxacin derivatives were synthesized and characterized by physicochemical and spectroscopic methods with above mentioned interacting drugs. Gemifloxacin analogues were synthesized with different aromatic and aliphatic amines, amides, carboxylic acid, and phenols. In this work, we focused on C-3 and C-7 positions of gemifloxacin. The target derivatives were characterized by FT-IR, 1HNMR and mass spectrometry. Antimicrobial and antifungal activity of these newly synthesized analogues was also carried out. Enzymatic inhibition activities of all synthesized derivatives were also carried out against two different enzymes including urease, and -chymotrypsin. The test showed low to moderate activity against both enzymes. ····· 1036121050
für 53.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Acute and chronic administration of Oxalis corniculata L. has anti-epileptic activity against MES and INH induced convulsions by reducing tonic hind limb extension phase and delaying onset of convulsion. It also observed that plant extract possess anti-psychotic activity against apomorphine induced stereotyped behavior and haloperidol induced catalepsy by reducing the stereotyped behavior as well as potentiated the cataleptic score. Anti-epileptic activity of Oxalis corniculata L. may be attributed to the involvement of either by blocking the Na+ channels or enhancing the GABAergic system in the neuronal of the brain. Furthermore, anti-psychotic activity of Oxalis corniculata may be due to involvement of dopaminergic pathway. The identification of active constituents with anti-epileptic and anti-psychotic activity from this plant may provide new directions for identification of active neuropharmacological agents, which could be given concomitantly during epilepsy and psychosis. These results suggest that the Oxalis corniculata L. have potential clinical application in the management of epilepsy and psychiatric disorders. ····· 1036120839
für 61.20€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The book aim on the molecular characterization of various plasmids present in Shigella dysenteriae type 1. This organism was responsible for spreading epidemic in various continents of the world. Further, efforts have been made to include the contents which may help to manage the shigellosis throughout the world. If the book is properly followed then this will not only help the prevention of shigellosis but also diarrheal diseases, not only in developing world but also in developed countries. Research scholars, teachers and medical practitioners will really found this book a ready reference for their respective fields. ····· 1036120777
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray During the past decade, traditional systems of medicine have become a topic of global importance. Current estimates suggest that, in many developing countries, a large proportion of the population relies heavily on traditional practitioners and medicinal plants to meet primary health care needs. Although modern medicine may be available in these countries, herbal medicines (phytomedicines) have often maintained popularity for historical and cultural reasons. Concurrently, many people in developed countries have begun to turn to alternative or complementary therapies, including medicinal herbs. Jatropha curcas is a multipurpose plant with many attributes and considerable potential. It is a tropical plant that can be grown in low to high rainfall areas and can be used to reclaim land, as a hedge and/or as a commercial crop. Thus, growing it could provide employment, improve the environment and enhance the quality of rural life. This book aims at providing brief biological significance of this plant in respect to treatment of diabetes along with its Pharmacognostic investigations. ····· 1036120743
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The development of sound bioanalytical method(s) is of paramount importance during the process of drug discovery and development culminating in a marketing approval.Bioanalytical method validation (BMV) employed for the quantitative determination of drugs and their metabolites in biological fluids plays a significant role in the evaluation and interpretation of bioavailability, bioequivalence, pharmacokinetic, and toxicokinetic study data. These studies generally support regulatory filings. It has been adopted universally as a standard procedure for validating bioanalytical assays used for pharmacokinetic, bioavailability, and bioequivalence studies intended for regulatory submission.The objective of this BMV is to review the sample preparation of drug in biological matrix and to provide practical approaches for determining selectivity, specificity, limit of detection, lower limit of quantitation, linearity, range, accuracy, precision, recovery, stability, ruggedness, and robustness of liquid chromatographic methods to support pharmacokinetic, toxicokinetic, bioavailability, and bioequivalence studies. ····· 1036120736
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The present study is aimed to develop floating, pulsatile, multiparticulate drug delivery system intended for chronopharmacotherapy in arthritis. Cross-linked beads were prepared by using low methoxylated pectin, sodium alginate, low methoxylated pectin + Sodium alginate and low methoxylated pectin + deacetylated gellan by acid- base reaction during ionotropic gelation. Beads were dried in oven at 500 degree Cenntigrate for 4hr. Aceclofenac was used as a model drug for encapsulation. Drug loaded multiparticulates were subjected to various characterization and evaluation parameters like entrapment efficiency, buoyancy study, surface topography. ····· 1036120715
für 61.20€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Hypertension is the term used to describe high blood pressure. Blood pressure is a measurement of the force against the walls of your arteries as your heart pumps blood through your body. An elevation of the systolic and/or diastolic blood pressure increases the risk of developing heart (cardiac) disease, kidney (renal) disease, hardening of the arteries (atherosclerosis or arteriosclerosis), eye damage, and stroke (brain damage). These complications of hypertension are often referred to as end-organ damage because damage to these organs is the end result of chronic (long duration) high blood pressure. For that reason, the diagnosis of high blood pressure is important so efforts can be made to normalize blood pressure and prevent complications. ····· 1036120628
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Tablets are solid unit dosage form of medicaments with or without suitable diluents and prepared either by molding or compression. They are solid, flat or biconvex disc in shape. They vary greatly in shape, size and weight which depend upon amount of medicament used and mode of administration. They also vary in hardness, thickness, disintegration and dissolution characteristics and in other aspects depending upon their intended use and method of manufacture. Tablets are the most widely used solid dosage form of medicament. Because of their advantages their popularity is continuously increasing day by day. Hypertension is a very common disorder, particularly past middle age. It is not a disease in itself, but it is an important risk factor for cardiovascular mortality and morbidity. The WHO-ISH guidelines defined it to 140 mm Hg systolic and 90 mm Hg diastolic, through risk appears to increase even above 120/90 mm Hg. ····· 1036120624
für 35.91€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Animal models are indispensable tools in the search to identify new antidepressant drugs and to provide insights into the neuropathology that underlies the idiopathic disease state of depression. Various paradigms have been developed and are instrumental in detecting the antidepressant-like potential of novel compounds in preclinical settings. The models commonly used are diverse and were developed originally based on the behavioral consequences of stress, drug, lesion or genetic manipulation. As new targets are developed, both serendipitous and through hypothesis-driven research, existing animal paradigms are being modified and new tests are being developed to detect antidepressant actions of compounds acting on a broad range of neural and genetic targets. This book is an attempt to club existing animal models with the treatment available in the management of depression so far. ····· 1036120493
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Nature is beautiful. Nature is endured with various plants, which are of tremendous help to human being. In the past, almost all the medicines used were from the plants, the plant being man s only chemist from ages.Historically, the majority of the natural product-based drugs were first discovered by traditional cell-based in vitro assays before their real molecular biological targets were identified. Thus most traditional cell-based in vitro assays can be viewed as detection methods of the fundamental and unique phenomena of living organisms. Large number of medicinal plants has been advocated in folklore medicines, for treating various disease and disorder. Two of such plants are Dolichos biflorus Linn. and Asparagus racemosus Willd. local communities for the treatment of different diseases are using the different parts of these plants for human being. Hence in current studies the plants has been selected for there pharmacological & phytochemical study. The detailed study of Dolichos biflorus Linn. and Asparagus racemosus Willd. is included in this book and various important finding of the plants are included in this research book. ····· 1036120483
für 35.91€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The main focus of this study was to evaluate Erioglossum rubiginosum extracts for cytotoxic and antimicrobial properties. The cytotoxic activities were investigated by using brine shrimp lethality test in Artemis salina. The antibacterial activities were evaluated by using disc diffusion method against a wide range of bacteria (both gram negative and gram positive bacteria) and antifungal activities were determined by poisoned food technique against Aspergillus niger and Candida albicans. The result of the study demonstrated that the plant possess low cytotoxic properties and significant antibacterial activities against gram positive bacteria Staphylococcus aureus, gram negative bacteria Salmonella typhi and Shigella dysenteriae compared to Cephradine. Interestingly, gram positive bacteria Bacillus cereus was found resistant towards this plant. On the other hand the investigated plant showed mild antifungal activity against Aspergillus niger and Candida albicans. Above data and experiment prove that the plant has significant biological activity. ····· 1036120388
····· lezzter Preis 53.10€ ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray In this study, controlled release matrix tablets containing cephelexin were prepared using HPMC15 cps and Eudragit L100 in different concentration by Direct compression method. Tablets were evaluated for physical properties,Hardness, friability, weight variation and In vitro dissolution study was carried on USP II apparetus (peddle type). The best formulations selected based on above parameters were subjected for Extend release study with use of different ratio of polymer as Eudragit and HPMC .The tablets with Eudragit were found to release drug for longer duration of time as compared to formulations containing HPMC. The drug release from the tablets was sufficiently sustained. ····· 1036120325
für 71.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The book will be very useful to research scholars, teachers and scientists working in the area of oxidative stress free radical hepatotoxicants linked with herbals. The book will provide details abaut free radicals its biochemical and physiological consequences mechanisms linked with liver disorders and subsequently the role of herbal medicine. In spite of the tremendous advances being made in allopathic medicine, no effective hepatoprotective medicine is available. The available therapeutic agents only bring about Symptomatic relief without any influence on the curative process, thus, causing the risks of relapses and danger of untoward effects. A large number of population still suffer, due to various reasons, from hepatic diseases.The book will also focused an insight approach for the development of hepatoprotective/antihepatotoxic drugs is one the major thrust areas in the field of herbal drug research. ····· 1036120321
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray In South Asia the irrational use of antibiotics prevails widely, which does not only increase the burden on the patient pockets but also is the major contributing factor for the development of antimicrobial resistance in this part of the world. In this book we have tried to measure the practices employed by doctors in prescribing different antibiotics with the help of a survey from the major institutes/Hospitals of Karachi. ····· 1036120053
für 53.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The search for pioneering phytotherapeutic approaches based on the use of new herbal compounds is gaining immense attention in modern therapy because of the lack of toxic adverse effects. Previous in vitro studies have demonstrated lemongrass essential oil as a valuable phytotherapeutic agent for a variety of purposes, covering the composition, medicinal properties, formulation development and toxicology. This book will give an overview of the historical and modern uses, ethnobotanical consideration, quality control, chemical composition and medicinal values, bioactivity reports and toxicity concerns of lemongrass essential oil. A microemulsion system has been formulated for skin delivery of lemongrass oil, making suitable for treating conditions like acnes and pimples. Drugs targeting acne vulgaris should have good inhibitory potential against P. acnes and also better performance to reduce pro-inflammatory lipids in sebum. Future research needs to include more comprehensive chemical characterisation of extracts, quality control and identification of bio-markers of clinical exposure with regards to composition and bioactivity. ····· 1036119986
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Anticancer drugs are known to produce serious side effects to other healthy tissues. The more serious effects are myocardiopathy and pulmonary toxicity. Therefore targeting such type drugs to the cancerous cell is essential because these drugs are new for the treatment of different type of carcinomas effectively. Usually a therapeutically profitable target agent relationship is far from ideal and undesirable side effects are usually observed. The alternative is to use simple functional molecules which transport the drug to the specific site and release it to perform task. This book provides the information about the formulation of docetaxel liposomes and its physico-chemical characterization. ····· 1036119915
für 53.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Floating drug delivery system or hydrodynamically balance systems have a bulk density lower than gastric fluid and thus remains buoyant in the stomach for a prolonged period of time without affecting the gastric emptying rate. While the system is floating on gastric contents the drug is released slowly at a desired rate from the system. After the release of drug residual system is emptied from the stomach. This results in increase in gastric residence time and a better control of fluctuation in plasma drug concentration. Development of oral controlled-release systems has been a challenge to formulation scientists because of their inability to restrain and localize the system in the targeted area of the gastrointestinal tract. ····· 1036119804· 1 · ::::: · 20 ·· 21 ·· 22 ·· 23 ·· 24 ·· 25 ·· 26 · ::::: · 27 ·
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