····· lezzter Preis 54.90€ ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Gastrointestinal mucoadhesive drug delivery system targets the drug to its absorption site and maintain the dosage form at that site for an extended period of time. This results in enhanced drug absorption, which will in turn increase the bioavailability of the drug and thus will decrease the dosing frequency and dose related side effects of the drugs. Microparticulate delivery system is preferred over conventional tablet system as it has several advantages like it provides a wider surface area of contact between drug and the absorption site and also controlles the release of drug from the formulation over extended period of time. Thus the potential of above mentioned drug delivery device is promising and may be considered as a novel tool inorder to improve the therapeutic efficacy of various drugs with shorter half life and poor bioavailability. ····· 1036125596
····· lezzter Preis 44.10€ ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The medicinal value of different species of Ziziphus mauritiana has been known for a long time. There are various reports of this plant having antifungal, anthelmintic, antiasthmatic and antidiabetic activity. No information about it s antipyretic potential is been observed in the literature. In the present study leaves of Ziziphus mauritiana were extracted with five solvents in the order of increasing polarity using a soxhlet apparatus. All the extracts were qualitatively analyzed for their phytoconstituents and for antipyretic potential using Brewer s yeast induced pyretic albino rats of Wistar strain. The results were tested for their significance by using one way ANOVA analysis by comparing with that of the control group at corresponding hours. The results strongly favour the significant antipyretic potential of the petroleum ether extract of Ziziphus mauritiana leaves.has shown significant reduction in body temperature as compared with control group and its effect is comparable to the standard drug paracetamol. It was also observed that the active extract contains steroids and volatile oil. The TLC study of the active extract supports the presence of six major compounds. ····· 1036125549
····· lezzter Preis 53.10€ ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Paracetamol is one of the most commonly used drugs worldwide and it even has severe hepato-toxic effects in long term use i.e. chronic use. Our present work was aimed at reducing this toxicity by using some natural products since naturally obtained products have minimal toxic effects than synthetic ones. Terminalia chebula leaf powder was prepared and fed to rats who were receiving paracetamol and it showed promising results in countering paracetamol toxicity ····· 1036125528
····· lezzter Preis 53.10€ ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray It is hoped that the fundamental and experimental work described in this book could help students, researchers and innovators, and provides a step forward in the methodologies AFM, TEM and PCS by providing valuable information in Bionanotechnology field to aid a better design and characteristics of nonviral gene delivery bio systems for gene therapy applications. the current research through the acquisition of novel experiment structural data will contribute to theoretical models being developed at different counter research institutes that may be used to allow ab-initio design of highly efficient transfection vector. ····· 1036125501
····· lezzter Preis 61.20€ ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray This book is designed to provide a complete, authoritative, current, and readable pharmacology basic tools for students. Pharmacology is a basic medical science in its own right, it borrows freely from and contributes generously to the subject matter and techniques of many medical disciplines. This book provides basic knowledge of Pharmacology and its branches in an up-to-date and comprehensive manner. It is meant to serve students in medicine, osteopathy, dentistry, pharmacy, and advanced nursing, as well as undergraduate students. ····· 1036125500
····· lezzter Preis 44.10€ ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Various approaches have been paused to increase the duration of oral dosage form in the stomach, including floating systems, swelling and expanding system, modified shape system, high density systems and other delayed gastric emptying devices. (Magnetic systems, Super porous biodegradable hydrogel systems). Hydrodynamically balanced systems (HBS) incorporated buoyant materials enable the device to float. Raft systems incorporate alginate gels these have a carbonate component and, upon reaction with gastric acid, bubbles form in the gel, enabling floating. Swelling type of dosage form are such that after swelling, this product swell to extent that prevent their exit from the stomach through the pylorus. As, a result, the dosage form retained in the stomach for a longer period of time. These systems may be referred to as a Plug type system , since they exhibit tendency to remain logged in the pyloric sphincters. ····· 1036125486
····· lezzter Preis 44.10€ ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Present study investigates the serum levels of trace elements, immunoglobulins and vitamin C in drug addict patients before and after clinical intervention. In this study 10 ml of blood was collected from each of the drug abuse patients during admission and after 1 month of treatment and from each of the control subjects. Samples were then analyzed for determining the serum level of trace elements (Cu, Zn, Fe & Mg), immunoglobulins (IgG, IgA & IgM) & Vitamin C using atomic absorption spectroscopy, turbidimetry method and UV-spectroscopic method respectively. A higher serum Cu level (1.099±0.235 mg/L) in drug abusers than the control group (0.914±0.128 mg/L) was found. The decreased serum Fe level (0.980±0.232 mg/L) of drug abuser was increased to 1.029±0.225 mg/L after intervention. The increased serum Mg level (19.922 mg/L) of drug abusers was decreased to 19.237 mg/L after intervention. The serum concentrations of IgA (252.374±62.262 mg/dl) and IgM (149.935±57.617 mg/dl) were found higher in drug abuser patients than the control group. The concentration of vitamin C was decreased after treatment from 0.527±0.208 mg/dl to 0.510±0.318 mg/dl which was not significant. ····· 1036125464
····· lezzter Preis 53.91€ ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The European Commission introduced Quality Risk Management (QRM) for medicinal product wholesale dealers (MPWD) to ensure Good Distribution Practice (GDP), through the publication of the new EU-GDP guidelines in March 2013. This book serves as a template in the setting up of a QRM system by a MPWD. First, a Quality Management System (QMS) consisting of a number of Standard Operating Procedures (SOPs) regulating each distribution activity is set up. Then medicinal product distribution steps and risks are identified. Finally a QRM exercise is applied to the identified risks. Risks are classified as being acceptable or not acceptable. Corrective and Preventive action is proposed to mitigate unacceptable risks in the distribution of medicinal products. A model Quality Risk Management SOP and a Disaster Recovery SOP are proposed and also presented in this publication. ····· 1036125460
····· lezzter Preis 53.10€ ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The roots of Typha elephantina (Fam:Typhaceae) was subjected to phytochemical screening and pharmacological examination.The phytochemical screening showed the presence of alkaloids, flavonoids,quinones,glycosides and carbohydrates. The methanolic extract and its partitionate of roots of Typha elephantina were subjected to pharmacological investigations such as antioxidant activity,cytotoxic activity, antimicrobial assay, analgesic activity(peripheral and central), antipyretic activity,CNS depressant activity and thrombolytic activity.The study showed that the plant can be used for various purpose. ····· 1036125434
····· lezzter Preis 61.20€ ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The present study was performed to investigate the scientific basis for the traditional uses of the crude methanolic extract and its partitionate of the leaves of the plant Lasia spinosa (Fam: Araceae). The preliminary phytochemical screening showed the presence of alkaloids, flavonoids, tannins and glycosides. Crude methanolic extract with other partitionates were subjected to bioactivity guided investigations such as anti-nociceptive (central and peripheral), anti-inflammatory, antipyretic, antihelmintic, antidepressant, cytotoxicity, antioxidant, antimicrobial, antidiarrhoeal and thrombolytic activity. Analysis reveals Lasia spinosa can be used in different purpose. ····· 1036125433
····· lezzter Preis 71.10€ ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray It is always a matter of controversy whether the formulations use to enhance learning and memory produce placebo or real effects. The study incorporated in this book authenticates the usage of herbal formulations in learning and memory by apparently normal subjects. The first four chapters are devoted to give an overview of pathophysiology, therapeutic interventions including dietary and herbals and the evaluation methods available. A pharmacoepidemiological survey of marketed allopathic and herbal formulations was carried out initially. Based on the results of survey selected allopathic and herbal formulations were evaluated in animals. Further preliminary clinical study of two formulations authenticated the efficacy of the two products used to enhance learning and memory. In light of differences observed in the two formulations studied extensively, more such placebo-controlled trials in different subset of patient population are warranted. It is also indicated that trials are required elderly patients with or without dementia and those with mild cognitive impairment are required to be carried out to authenticate and avoid misuse of learning and memory enhancing medicines (LMEM). ····· 1036125403
····· lezzter Preis 44.10€ ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray In this ethnopharmacological study, the ethanolic extract of the whole plant parts (root, stem and leaves) of Cayratia trifolia (Linn.) Domin. (Family Vitaceae) was investigated for bioactivities namely analgesic, antioxidant, cytotoxicity, antimicrobial, antihelmintic and hypoglycemic activity. In light of the available literature, this study represents the first experimental investigation of biological activities of Cayratia trifolia in the perspective of their traditional use. ····· 1036125398
····· lezzter Preis 53.10€ ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Herbal plants are wide source of research. Pharmacological evaluation is crucial for many important ailments diseases. Inflammation is natural protective response for wide range of diseases. I would like to thank my parents , wife and daughter and oo course my guide dr. Sandhya k. Desaiand principal of the current college dr. Supriya shidhaye for constant motivation and support. A special thanks to mrs. Gayatri aggarwal, hod department of pharmacology for all support. ····· 1036125383
····· lezzter Preis 44.10€ ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Validation is defined as the establishing of documented evidence which provides a high degree of assurance that a planned process will consistently perform according to the intended specified outcomes. Validation studies are performed for analytical tests, equipment, facility systems such as air, water, steam, and for processes such as the manufacturing processes, cleaning, sterilization, sterile filling, lyophilization, etc. There will be a separate validation for the lyophilizer as an equipment item and for the lyophilization process for the cleaning of glassware and the cleaning of the facility and for the sterilization process and for the sterility test. Every step of the process of manufacture of a drug product must be shown to perform as intended. Validation studies verify the system under test under the extremes expected during the process to prove that the system remains in control. Once the system or process has been validated, it is expected that it remains in control, provided no changes are made. In the event that modifications are made, or problems occur, or equipment is replaced or relocated, revalidation is performed. ····· 1036125357
····· lezzter Preis 44.10€ ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Hygrophila ringens (L.) R.Br. ex Steudel belonging to Acanthaceae family has been investigated for isolation of its secondary metabolites and evaluation of biological activities of crude extractives with special emphasis to the analgesic activity, hypoglycemic activity, antioxidant activity, Brine shrimp lethality bioassay and antimicrobial study.One compound has been isolated which was identified by extensive analyses of high resolution 1H-NMR spectroscopic data.The methanolic crude extract at a dose of 100 &200 mg/kg body weight and ethyl acetate fraction at a dose of 100 & 200mg/kg body weight of Hygrophila ringens showed promising analgesic activity of 61.58%, 67.23% and 59.89%,64.41% of inhibition respectively compared to the standard (76.84%).In the brine shrimp lethality bioassay, Methanolic crude extract and ethyl acetate fraction of leaves of Hygrophila ringens exhibited potent cytotoxicity with the LC50 values of 1.931 g/ml , 4.454 g/ml and pet ether (9.099 g/ml) and carbon tetrachloride (11.390 g/ml), fractions showed moderate cytotoxicity respectively compared to Vincristine Sulphate (LC50 value 0.824 g/ml). ····· 1036125337
····· lezzter Preis 44.10€ ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray This is a study of total spending on drugs per person by State government of Goa, India.It also includes government spending on drug per patients by government. Project Brief(a)financial analysis.(b)estimation of per capita expenditure on drugs by government.(c)it suggests some recommendation to improve the quality of drug delivery system and its utilization. Duration of Study was April 2010 to march 2011. ····· 1036125312
····· lezzter Preis 54.90€ ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray A detailed review on HIV and its drugs was prepared. This broad spectrum of biochemical targets has been facilitated by the synthetic versatility of heterocyclic compounds, which has allowed the generation of a large number of structurally diverse derivatives. The objective of this review to systematically evaluate the pharmacological properties of various substituted heterocyclic compounds and collate these findings to be used as a guide for future structure-activity relationship and mode of action studies. This is the first review to comprehensively discuss the HIV and its drugs. ····· 1036125243
····· lezzter Preis 61.90€ ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray To develop & validate UV & HPLC methods for simultaneous estimation of Cefpodoxime Proxetil & Levofloxacin Hemihydrate in bulk drug and pharmaceutical dosage form.By application of analytical tequniques like various UV methods and HPLC for simultaneous estimation of CPD& LVX like Simultaneous equation method, Q-absorbance ratio method, First order derivative method and RP-HPLC method. Developed methods were applied to perform analysis of marketed formulation (Glevopod). Validation of developed methods was performed according to ICH Q2 (R1) guideline. Comparison of all developed and validated methods were carried out by using statistical tools.These all methods are sensitive, selective, accurate, precise and rapid for the simultaneous estimation of CPD & LVX in Bulk drug and Pharmaceutical dosage form. It can be successfully adopted for routine Q.C. analysis of two drugs in pharmaceutical dosage form without any interference from common excipients and impurity. ····· 1036125226
····· lezzter Preis 44.10€ ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The search for local raw materials of pharmaceutical use to substitute the imported ones has reached a considerable peak. The usefulness of these locally sourced materials cuts across various dosage forms and favourably compares with the imported materials.This book has highlighted the use of gum extracted from the bark of khaya senegalensis tree as a disintegrant in the formulation of Chloroquine phosphate tablets. It has also highlighted a comparison between the extracted gum and Microcrystalline cellulose as a disintegrant in the tablet formulations. ····· 1036125199
····· lezzter Preis 44.10€ ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Diabetes mellitus is the major metabolic disorder being faced throughout the world. The various types of diabetes are being reported with different type of symptoms and causes. To combat this metabolic disorder which has a number of complications associated with it various therapeutic molecules are available. But till date this disorder is not cureable with the available therapies. So there is still need for the invention of new molecules to overcome this disorder along with its complications with the help of various existing experimental animal models. ····· 1036125196
····· lezzter Preis 61.20€ ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Mucoadhesive drug delivery system which utilize properties of bioadhesion of certain water-soluble polymers which become adhesive on hydration and hence can be used for targeting a drug to a particular region of the body for extended period of time. The mucosal layer lie a number of regions of the body including the GIT, the urogenital tract, the airways, the ear, nose, mouth and eye. The oral mucosal sites differ greatly from the one another in terms of anatomy, permeability to an applied drug and their ability to retain a delivery system for a desired length of time. The Buccal and sublingual mucosal is relatively, permeable, giving rapid absorption and acceptable bioavailability of drugs and is convenient, easily accessible and generally well accepted ····· 1036125181
····· lezzter Preis 53.10€ ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Diazepines are pharmaceutically important compounds owing to their Central Nervous System Depressant activity. Among these 1,4-diazepines are regarded as privileged structures due to their clinical importance & commercial success. The immense work has been carried out on Diazepine nucleus. Investigators have followed variable routes for the synthesis, mostly 1,2-diamines are implemented as reagents using a catalyst that allows cyclization. Wide range of Biological activities exhibited by diazepines has attracted many workers to screen the analogues for all possible activities. Present book covers base catalyzed condensation reaction of 1, 2-diamines with carbonyl compounds, an efficient method for the synthesis of fused 1,4-diazepines. Synthesized compounds were characterized and screened for Cytotoxic, Anti-Microbial and Anti-convulsant Activities. ····· 1036125177
····· lezzter Preis 44.10€ ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The objective of transdermal delivery system is to achieve optimum therapeutic management. But, it still remains a challenge in the field of pharmaceuticals for delivery of ionic species such as proteins and peptides. Development of iontophoretic system is a breakthrough in this field designed to improve the delivery rate of ionic compounds. This technique generates an electrical potential gradient that facilitates the movement of solute ions across the membrane. Iontophoresis is the process of increasing the penetration of drugs into the skin by application of an electric current. The drug is applied under an electrode of the same charge as the drug, and a return electrode opposite in charge to the drug is placed at a neutral site on the body surface. Electrical energy assists the movement of ions across the skin using the principle `like charges repel each other and opposite charges attract`. Iontophoresis seems to be an ideal candidate to sort out the limitations associated with the delivery of ionic drugs. In this book, efforts have been made to summarize all the aspects of iontophoretic delivery. ····· 1036125153
····· lezzter Preis 44.10€ ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The CNS stimulation study has been performed on the two semisynthetic adducts of caffeine with Schiff s base of pyrazolone and pyrazolone-pyrimidine nucleus. All the reference drugs and test compounds showed positive effect on CNS stimulation. The conclusion has been drawn from the fact that CNS stimulation effect for pentylene tetrazole is higher than caffeine, Molecule-I (pyrazolone ring) is less active than Molecule-II as the Molecule-II (pyrazolo-pyrimidine ring) is fused ring heterocyclic compound and the synergistic action with caffeine with Molecule-I having less activity than the Molecule-II but in case of leptazol (pentylenetetrazol), the synergistic activity of the two test compounds are equal but less than leptazol itself. The azole group is present in both caffeine and in leptazol but in fused ring heterocyclic chromophore and the same ring has been implemented in the two test compounds which have been semisynthesized by formation of Schiff s base of caffeine to keep the similar bioisosteric nature. So, the components that have been semisynthesized showed the specific CNS stimulation activity. ····· 1036125145· 1 · ::::: · 17 ·· 18 ·· 19 ·· 20 ·· 21 ·· 22 ·· 23 · ::::: · 27 ·
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