für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Anticancer drugs are known to produce serious side effects to other healthy tissues. The more serious effects are myocardiopathy and pulmonary toxicity. Therefore targeting such type drugs to the cancerous cell is essential because these drugs are new for the treatment of different type of carcinomas effectively. Usually a therapeutically profitable target agent relationship is far from ideal and undesirable side effects are usually observed. The alternative is to use simple functional molecules which transport the drug to the specific site and release it to perform task. This book provides the information about the formulation of docetaxel liposomes and its physico-chemical characterization. ····· 1036119915
für 53.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Floating drug delivery system or hydrodynamically balance systems have a bulk density lower than gastric fluid and thus remains buoyant in the stomach for a prolonged period of time without affecting the gastric emptying rate. While the system is floating on gastric contents the drug is released slowly at a desired rate from the system. After the release of drug residual system is emptied from the stomach. This results in increase in gastric residence time and a better control of fluctuation in plasma drug concentration. Development of oral controlled-release systems has been a challenge to formulation scientists because of their inability to restrain and localize the system in the targeted area of the gastrointestinal tract. ····· 1036119804
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The current book shows the effects of Tranexamic acid and its derivatives N-Phthaloyl Tranexamic acid and N-Acetyl Tranexamic acid on the metabolism and chemical modulation of glutathione in the blood and in aqueous media using UV-Visible spectrophotometer. This study also helps to understand the mechanism of action of N-Acetyl Tranexamic acid and N-Phthaloyl Tranexamic acid, in blood components. ····· 1036119790
für 61.20€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Microsphere carrier systems made from the biodegradable polymers have attracted considerable attention for several years in sustained drug delivery. However, the short residence time at the site of absorption could be overcome by coupling bioadhesion characteristics to microspheres and developing bioadhesive microspheres with the help of bioadhesive polymers. Neostigmine Bromide a cholinesterase inhibitor is widely used for the treatment of Myasthenia Gravis. It is presently marketed in conventional dosage form as a tablet in usual strength of 15-30 mg for peroral route. Extent of absorption of drug through oral route is only 1-2% of 30 mg of administered dose. Hence there is need of novel nasal drug delivery system for the treatment of Myasthenia Gravis. To overcome inherent drawbacks associated with conventional dosage forms of Neostigmine Bromide, an attempt is being made in the present research work to develop an alternative drug delivery system in the form of Nasal mucoadhesive microspheres to increase the rate and extent of absorption and to reduce the dosing frequency of the formulation. ····· 1036119736
für 71.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Poor ocular bioavailability of drugs ( 1%) from conventional eye drops (i.e. solution,suspension and ointments) is mainly due to the precorneal loss factor. Ocular efficacy is closely related to ocular drug bioavailability, which may be enhanced by increasing corneal drug penetration and prolonging precorneal drug residence time. Sparfloxacin and levofloxacin are newer generation hydrophobic fluoroquinolones. Poorly water soluble drugs are difficult to develop as conventional ocular drug delivery system. Nanotechnology can be used to formulate poorly water soluble drugs as nanosuspension which can be further incorporated in to matrix of hydrogel. This combination thus offers the opportunity to address many of the formulation related issues with such drugs. A variety of ocular drug delivery systems, such as hydrogels, microparticles, nanoparticles, microemulsion, liposomes and collagen shields have been designed and investigated for improved ocular bioavailability. Amongst them, hydrogels and polymeric nanoparticles are the most interesting approaches to achieve local sustained delivery system. In the present work various hydrogel based systems are developed and evaluated. ····· 1036119586
für 53.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The objective of the present study was to develop and validate a HPLC method with good sensitivity and specificity for the identification and quantification of trimetazidine in human plasma. Trimetazidine and caffeine (internal standard) were isolated from plasma samples by protein precipitation with methanol. The chromatographic separation was accomplished on a Xterra C18 Column with the mobile phase consisting of potassium di-hydrogen phosphate buffer-acetonotrile-triethylamine (90:10:0.04, v/v) (pH 4.16, adjusted with ortho-phosphoric acid), and the flow rate was set at 1.0 mL/min. Detection was performed on a spectrophotometric detector keeping the retention time at about 8.9 and 10.9 min for caffeine and trimetazidine, respectively. This method was successfully applied for pharmacokinetic studies in 8 healthy male Bangladeshi volunteers. After the administration of a single dose of 35 mg of modified release tablet, the resulting mean of major pharmacokinetic parameters such as AUC0-12, AUC0__, Cmax, Tmax and t1/2 of trimetazidine were 457.8 ± 294.4 ng.h.mL-1, 552.4 ± 386.1 ng.h.mL_1, 87.77 ± 43.17 ng.mL_1, 3 ± 1.49 h and 3.417 ± 1.134 h respectively. ····· 1036119521
für 53.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Leflunomide is a drug with limited water solubility. It exhibits four polymorphic forms I,II,III,IV. In the present study, form II polymorph was formulated using form I. Form II polymorph readily dissolves in water than does form I. The crystals of form I and II polymorph were characterized by IR, DSC, XRPD. Comparison of solubility of form I and form II was done by UV Spectrophotometer. There was a significant increase in solubility of form II. Aqueous film-coated tablets of form I and form II were prepared using the same processing parameters and compared for the rate of dissolution. Form II tablets showed a significant improvement in terms of dissolution rate, drug release and solubility. ····· 1036119375
für 71.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Green revolution is a summit discussed at a global level. Today each country has passed a resolution to save environment. As a pharmacist, we often handle different drugs and chemicals to formulate different delivery systems to make the society healthy. We can contribute maximum to save environment. To support the resolution, we applied a novel coating system i.e. solvent-free coating for solid oral formulations to impart varying characteristics to them. Novel solvent-free coating technique was used to coat pellets and was evaluated for different parameters. Results revealed that the novel process is less time consuming as there is no solvent to be evaporated and no additional curing step is required, making the process time & cost effective. With judicious selection of excipients, the same process can be employed for varying interests such as masking the bitter taste of actives, achieving the zero order release pattern of water soluble drugs and improving the dissolution rate of poorly water soluble drugs, which makes the process precise & ecofriendly. ····· 1036119342
für 71.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Sustained release pellets dosage form is increasingly becoming popular in recent time. Both physicians and patients prefer these types of dosage forms because of some unique features of sustained release pellets.One of them is its ability to withstand the risk of dose dumping which may occur in case of a single coated or matrix tablet and thereby reduces the risk of associated side-effects. Along with many other advantages, pellet dosage form has less dependence on gastric emptying, which ultimately leads to less chance of therapeutic failure.Salbutamol sulphate is a bronchodilator.Patients with asthma suffer from its night-time complications called nocturnal asthma. Our aim was to develop a sustained release preparation of salbutamol sulphate to treat this condition.Our study was aimed to evaluate the effect of various sustained release polymeric coating materials (Surelease®, Eudragit® RS, and Kollicoat® SR 30D) on the release kinetics of salbutamol sulphate from the coated pellets. Our study was also focused on the effect of curing (at 60ºC) on the release kinetics of salbutamol sulphate. ····· 1036119312
für 53.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray In recent years, in association with progress and innovation in the field of pharmaceutical technology, there has been an increasing effort to develop sustained release dosage forms for many drugs due to its advantages in safety and efficacy over immediate release drug products. The intent of this research was to design matrix tablets of Metformin hydrochoride using Ispaghula husk powder and to study its release retardant activity. Natural materials have advantages over synthetic ones since they are chemically inert, nontoxic, inexpensive, biodegradable and widely available. Tablets were prepared using wet granulation technique with increasing concentration of Ispaghula husk powder to the drug. Fourier transform infrared spectrophotometer (FTIR) and differential scanning calorimetry (DSC) studies were performed and the surface morphology and particle shape was evaluated by scanning electron microscopy (SEM). The drug release patterns were explained in different kinetic models and found better release compared to marketed products. From the study It is evident that Ispaghula husk powder can be used as a natural matrix forming polymer for preparing sustained release matrix tablets. ····· 1036119297
für 53.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray This study protocol, we have investigated antimicrobial, cytotoxic, antidiarrhoeal, analgesic and CNS depressant activity of the ethanolic extracts of leaves and fruits of Dillenia indicia. In the test of antimicrobial and antibacterial activity, it had been confirmed that leaf and fruit extract have inhibitory property for the growth of micro organism and it was also established by the test of MIC. The LC50 values of Dillenia indica in brine shrimp lethality bioassay were found significant. The plant parts showed antidiarrhoeal activity which was measured by castor oil induced method and charcoal plug method. All the samples showed significant analgesic activity. In the hole cross test for CNS depressant studies, the extracts also showed a decrease in locomotion in the test animals and in the open field test, the crude ethanolic extract of leaves and roots of D. indica showed a noticeable decrease in locomotion in the test animals. In the pentobarbitone induced hypnosis test, the crude ethanolic extract of leaves of D. indica at the doses 400 mg/kg significantly induced the sleep and also prolonged the duration of sleeping time in test animals as compared to control. ····· 1036119282
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Essential oils are secondary metabolites of various parts of plants. Essential oil extracted from plants have unique therapeutic benefits. These are used in various forms such as lotions ,ointment, lubricants, perfumes, fragrant bath perfumed water, massage and incense. The antimicrobial action of essential oil is one of the most extensively studied aspects of plant medicine. Dried tuberous roots of Cyperus rotundus is known as source of aromatics, used in perfumes and agarbatties. The reported constituents of volatile oil in Cyperus rotundu tubers vary with the source so in this study, the composition of essential oil obtained from Cyperus rotundus Linn. growing in Dehradun (Uttarakhand), India, a new location is compared with the previous study along with its antimicrobial activity. ····· 1036119280
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray OBJECTIVE: Analysis of beta blockers in formulated and unformulated samples demand a highly specific and rapid method as many beta blockers have serious stability problems. In the present Study, Analytical methods for the various Beta Blockers viz. Atenolol, Acebutolol, Bisoprolol, Betaxolol, Carvedilol, Nebivolol, Timolol, Sotalol etc. have been presented. A brief discussion on spectrum of activity and action mechanism of beta blocker has also been given. It include detail description of analysis of Beta blockers alone and in combined dosage form. A brief out line on current trend in method development and validation has also discussed in brief ····· 1036119215
für 49.41€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray `A Concise textbook of Community Pharmacy` is an essential guide for the community pharmacist for providing the relevant information in an easily digestible form. Community pharmacists play an important role in any country as they take responsibility for patient`s medicine related needs for access to healthcare. Rather than an exhaustive treatment, the book provides a concise introduction of the various topics of the community pharmacy practice. This book may serve as text book of pharmacy students of various universities as the selected topic forms an important part of the curricula of their courses. The book is highly suitable for pharmacy students, providing the knowledge and skills for best practice in community pharmacy setting. ····· 1036119085
für 35.91€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The Handbook of Experiments in Pharmaceutics is helpful for Graduate and diploma students ware enrolled in field of Pharmacy. The Handbook of Experiments in Pharmaceutics provides necessary information about various dosages form which are to be formulated at laboratory scale. This book is useful for primary methods of preparation, evaluation, use of various excipients, storage condition, labeling condition, direction and type of container to be used etc. ····· 1036119007
für 49.41€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Nitrogen containing synthetically and biologically important heterocyclic ring system namely pyrimidine have been reviewed. Based on review the pyrimidine derivatives will obtained by the various condensation methods. The structures of these compounds will evident by elemental analysis such as, IR, 1H NMR and mass spectral analysis. These biologically important pyrimidine and fused pyrimidine compounds will investigated for their antiinflammatory, antibacterial, antifungal and antiTB activities ····· 1036118925
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The purpose of this book is to provide guidance for the development of an analytical method on HPLC for the analysis of active pharmaceutical ingredients of pharmaceutical formulation. Topics included are basic method development and its validation according to ICH guideline. This manual will only cover the use of reverse phase chromatography. HPLC assays are used to demonstrate control of the process, to track and minimize impurities, and to maximize the yield and purity of the isolated product. Characterized working standards are utilized for quantification. In this thesis work has been carried out for the determination of Guaifenesin and Pseudoephedrine hydrochloride in cold and cough preparartios. ····· 1036118865
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Soft drinks and juices are very popular to all kinds of people. Especially children like to drink different kinds of soft drinks. In Bangladesh, most teenagers prefer soft drinks, energy drinks and juices. When consumed normally, soft drinks are safe for both children and adults and pose no risk to health. However, most of the soft drinks have low pH which is harmful for body if taken in excess. Stomach disorders e.g. indigestion, nausea, gas, gastric reflux etc. are symptoms that are caused by excess acidity in the gastric region. Frequent consumption of soft drinks may cause osteoporosis and increase the risk of kidney problems i.e. kidney stone formation. Over consumption of fructose, particularly in the form of soft drinks, leads to an increase in blood pressure. Soft drink consumption is a strong predictor of heartburn. Many different forms of arthritis are the result of acid accumulation from the blood into the joints and wrists. Soft drinks are responsible for doubling or tripling the incidence of tooth decay. Our study determined the pH levels of commonly available soft drinks and juices in Bangladeshi market and found out the different harmful health hazards. ····· 1036118778
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Molecular design software is software deals with molecular modeling, that provides special support for developing molecular models de novo. In contrast to the usual molecular modeling programs such as the molecular dynamics and quantum chemistry programs, such software directly supports the aspects related to the construction of molecular models: Molecular graphics interactive molecular drawing and conformational editing building of polymeric molecules, crystals and solvated systems partial charges development geometry optimization support for the different aspects of Force Field development ····· 1036118732
für 53.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Usage of plants as a medicine was the traditional system in India which was followed by certain physicians to cure various disease prevailing in the particular parts of the body, Medicinal plants are used in the form of decotions, extracts, pills, surnas. Now- a days, scientific proof is very much important to make the people to believe the usage of plants as medicine. because of the adverse effect of the allopathic medicines, now generations has started toward using the plants to cure as well as to prevent the occurrence of disease. ····· 1036118727
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray In 21th century, pharmacognosy research areas are expanded and new aspects of phytochemistry, analytical chemistry, ethnobiology, ethnomedicine, molecular biology, and phytomedicine are developed. The present book prepares a practical guidance for young scientists, researchers, pharmacognosy and phytochemistry students with little experience of pharmacognostical investigations. It is considered that the comprehensive practical methods, as the laboratory manual, were included for each natural product class together with the colored photos of the reactions, which have not been found in the previous related books. Previous practical pharmacognosy books contained mainly the microscopic analysis and concise phytochemical methods. For this reason, the authors tried to include more details about the phytochemical methods, biological and biochemical assays and molecular biological techniques related to natural products and medicinal plants. Thereafter publishing this book, the authors intend to develop the chapters adding more experimental methods, which may be useful in new aspects of pharmacognosy. ····· 1036118659
für 71.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Considering the worth of developing non-steroidal compounds for better management of estrogen linked pathologies including contraception, the present work was envisaged to seek rational possibilities in this area through precision based cheminformatics & pharmacological approaches. In foremost portion of the project, bioactive molecules were theoretically modeled through in silico approaches for deducing pharmacophores. The generated models showed importance of different biophore features for estrogenic activity. In the experimental section, a plant named tape-vine with documented ethno-therapeutic uses was evaluated for its contraceptive and estrogenic properties, judging the upcoming possibility of herbal resources to play significant role in healthcare. The sample was found to possess post-coital pregnancy interceptive activity through restriction of implantation & involvement of uterotrophic & hormonal effects. This specimen also demonstrated favorable effects on lipid and carbohydrate profiles suggesting its safe nature. Phytochemicals abundant in this plant specimen were also classified for estrogenic activities through models developed in theoretical section of this study. ····· 1036118640
für 32.31€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Provedena otsenka kommunikatsionnoy effektivnosti proizvoditeley i distrib`yutorov farmatsevticheskogo rynka na urovne aptechnykh organizatsiy. Vyyavleny osnovnye nedostatki vo vremya provedeniya kampanii po prodvizheniyu. Takzhe izuchena rasprostranennost` osnovnykh sredstv i vidov prodvizheniya v aptechnykh organizatsiyakh vo vremya provedeniya issledovaniya. Opredeleno, chto prodvizhenie v aptekakh predstavleno vsemi osnovnymi sredstvami. ····· 1036118637
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The drugs incorporated in controlled release drug delivery systems shows variations in bioavailability due to their selective absorption from specific part of stomach and upper gastro-intestinal tract. In this book, various gastro-retentive approaches have been described for increasing therapeutic performance of drugs having absorption potential from stomach. A major focus has been given on the hydrodyanamically balanced systems, its formulation aspects and effects of excipients and processing parameters. The various types of gastro-retentive drug delivery systems have been well illustrated with diagrammatic illustrations wherever necessary. Also major attention has been given on evaluation of these drug delivery systems. The currently available gastro-retentive drug delivery systems in market have been described. The future potentials of these drug delivery systems have been presented. This book will be useful for the students at graduate level, post graduate students and research scholars for understanding the basics of gastro-retentive drug delivery systems. ····· 1036118618· 1 · ::::: · 20 ·· 21 ·· 22 ·· 23 ·· 24 ·· 25 ·· 26 · ::::: · 27 ·
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