für 53.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray A promising strategy to overcome these problems involves the development of suitable drug carrier system. The In vivo fate of the drug is no longer mainly determined by the properties of the drug, but by the carrier system, which permit a controlled and localized release of the active drug according to the specific needs of the therapy. The size of the carrier depends on the desired route of administration and ranges from few nanometers to micrometers (implants). Implants and microparticles are too large for drug targeting and intravenous administration. Therefore, colloidal carriers have attracted increasing attention during recent years. Investigated systems include nanoparticles, nanoemulsions, liposomes, niosomes, nanosuspensions, micelles, and soluble polymer-drug conjugates. ····· 1036198799
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Drug-drug interactions are causing morbidity and mortality in mankind. Severe harmful interactions are recoded when drugs are prescribed without studying their pharmacokinetic and pharmacodynamic actions. Knowledge about drug interactions is necessary for pharmaceutical industries, regulatory agencies, clinical health care professionals and policy makers. The book focuses on research findings regarding influence of Fluoroquinolone (Ciprofloxacin) on the pharmacokinetics of Carbamazepine, investigated in healthy adult males. Carbamazepine is mostly prescribed drug for the treatment of epilepsy, neuropathic pain, schizophrenia, phantom limb syndrome and paroxysmal extreme pain disorder. Epileptic patients can have various types of infections like urinary tract, upper respiratory tract, skin and soft tissue, dental pain, typhoid and other infectious diseases. These patients often injured during fits and fluoroquinolones are used as first line of therapy to treat such kind of infectious disease. Since both drugs are prescribed commonly by the physicians and interaction may result, so the information about their pharmacokinetics given here are beneficial for physicians and researchers. ····· 1036198640
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Caesalpinia pulcherrima commonly called as Featherly flower is an medicinal plant used for treating various diseases to cure human beings. The pharmacognostical features are shown in this book for its authentication and identification from different species of this plant. Some of the phtyconstituents have been reported which leads to the importance of this herb. Its quantitative and biological properties has been explored for its viability. Thus it will give a complete information about the herb. ····· 1036198522
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The herbal juice from V. amygdalina C.papaya and M. oleifera with ethanol and water as solvent were assessed for the antibacterial activities against Staphylococcus aureus and Escherichia coli. The chemical tests showed that the extracts have flavonoids, triterpenoids and tannins selectively. M.oleifera extract contains tannins, flavonoids and triterpenes in ethanol but only triterpenes in water. V.amygdalina extract contains more triterpenes and flavonoids in ethanol. C.papaya in ethanol shows flavonoids, triterpenes and tannins and triterpenes in water extracts. Sensory judgment however, showed desirable colors to all the extracts strong and weak odors for ethanol and water extracts respectively, and possessing oily for ethanol extracts, appearance was very good, good and moderately good for M.oleifera, V.amygdalina, C.papaya respectively, while not appealing for their water extracts. ····· 1036198475
····· lezzter Preis 44.10€ ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray In this work an attempt has been done to optimize the process of tabletting and enteric coating for Diclofenac sodium enteric coated tablet. Various optimized parameters are Blending, Granulation, Compression, and Coating. All materials required for preparing Diclofenac 50mg enteric coated tablet were accurately dispensed under specified condition. Optimization was done based on determining the relationship between independent variable and dependent variable. Independent variable like blending time before granulation was optimized based on content uniformity. Spray rate of binder for granulation was optimized for uniform and satisfied physical characterization. Spray rate of enteric coating suspension was optimized for efficient coating and process. ····· 1036198441
für 71.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Transdermal drug delivery system has become the focus of formulation research in the last decade owing to its advantages like easy accessibility, non invasiveness, compliance, safety and effectiveness. In United States around 40% of the drug delivery candidate products under clinical evaluation were related to transdermal or dermal systems. Nevertheless, its clinical application has been limited due to barrier properties of skin, especially the stratum corneum. To enhance the permeation of drugs through the skin many attempts have been made by the investigators that led to development of several technologies. The prodrug approach represents an alternative and promising method of enhancing the skin permeability of drugs by increasing the lipophilicity. Iontophoresis technique has been gaining much popularity by overcoming skin barrier to drugs and by expanding the range of drugs that could be administered through the transdermal route. This book describes about the synthesis of prodrugs of selected antihypertensive agents, assessment of physicochemical properties and in vitro assessment by passive permeation and iontophoresis for transdermal delivery. ····· 1036198385
····· lezzter Preis 49.00€ ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The plant African mistletoe is described as `all purpose plant` because of its use in folklore medicine to cure a variety of sicknesses. A good number of authors have recorded activities from this plant ranging from antimicrobial, antiinflammatory, antihypertensive, antidiabetic to antioxidant activities. Phytochemicals such tannins, alkaloids, terpenoids, glycosides, saponins and steroids have been detected from it and these confer the plant with a broad spectrum of activity. This is just a tip of the iceberg read and discover more things for yourself. ····· 1036198264
für 53.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Socotra Island (Yemen) is one of the best environments where many medicinal plants grow. Dracaena cinnabari (DC) grows there & widely used in folk medicine. This work aimed to analyze the plant chemically & to study the biological effects of some of its purified compounds & aqueous extract (AE) on rat isolated smooth muscles (ISM), perfused heart (PH), blood pressure (BP) and diuresis. Chemical analysis of the resin of DC resulted in the isolation of 5 flavonoids: 4,4 -dihydroxy-2 -methoxychalcone, 4,4 -dihydroxy-2-methoxydihydrochalcone, 7-hydroxy-3-(3-hydroxy-4-methoxybenzyl) chroman, 7-hydroxy-3-(4-hydroxybenzyl) chroman, and 2 ,4,4 -trihydroxychalcone. The last compound was isolated for the 1st time from DC. The 1st two compounds had a concentration dependent (CD) effect on rat ISM. Also, it had a CD stimulatory effect on the contractility & an inhibitory effect on heart rate of isolated PH. In addition, it reduced the arterial BP & caused an increase in the rate of urine excretion. The AE of DC caused similar results. Finally, the effects of AE of DC & some of its purified compounds on rat ISM, PH, BP & diuresis are well consistent with the use of this plant in folk medicine. ····· 1036198262
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray A simple rapid spectrophotometeric method has been developed for estimation of acarbose from bulk drug and tablet dosage form by using potassium permagnate and sodium hydroxide as oxidizing agent. The method is based on the formation of green colored complex of drug with 0.1 N alkaline potassium permanganate having absorbance maxima at 625 nm. The beer s law is obeyed in the concentration range of 10-70 µg/ml of the drug but more precisely it obeys in the range of 10-50 µg/ml. The slope and intercept values are 0.0118 and 0.0071, respectively. Results of analysis of this method were validated statistically and by recovery studies. The method is applied to the marketed tablet formulation. Result of analysis of tablet formation given as percentage of label claim+ standard deviation is 99.78 + 0.1053. The precision and accuracy was examined by performing recovery studies and was found to be 99.59 + 0.180.The developed method is simple, sensitive and reproducible and can be used for routine analysis of acarbose from bulk and tablet dosage form. ····· 1036192629
für 35.91€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Poly-pharmacy and multiple drug therapy assume importance in present day clinical practice, since newer molecules are invented everyday and newer challenges face clinicians in managing either a single disease or simultaneously occurring different diseases. The present study was under taken to verify the possible drug-drug interaction between an anti-hypertensive drug, Valsartan on hypoglycemic activity of Metformin. The whole study is divided into four phases, clearly explained in the study. ····· 1036192618
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The aim of this research was to formulate and evaluate in-situ liquid depot from bio-degradable polymers like PLGA 85:15 and PLGA 50:50.Isoniazid is a drug of choice for the treatment of tuberclosis. It requires prolong therapy, it has very short half life (Fast acetylators) of 1.1 + 0.1 to 2-3 hrs. Isoniazid is readily absorbed orally and penetrates all body tissues it is extensively metabolized in liver, most important pathway being acetylation metabolites are excreted in urine. The developed Isoniazid Insitu liquid depot was characterized for percent drug content (PDC), drug polymer interaction study, viscosity, and drug release study. The results of the study showed there were no interaction in drug and polymers after formulation, viscosity was found in all formulation between 1.02 to 1.57 poise and drug content was found to be very between 92.39 + 0.47% to 97.15 + 0.31%. It was found that the amount of drug released at after 168 hours was greater from PLGA 85:15 depots systems formulations as compared to PLGA 50:50 biodegradable liquid depot injections. The results of the characterization and evaluation of in-situ liquid depot established the safety for use and suitability. ····· 1036192352
····· lezzter Preis 53.10€ ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray This book is related to a study involving development and in vitro evaluation of sustained release pellets of ambroxol hydrochloride prepared by extrusion spheronization followed by fluid bed coating with the commercial aqueous polyvinyl acetate dispersion (Kollicoat SR 30 D) aqueous dispersion of ethyl acrylate and methyl methacrylate (Eudragit NE 30 D) and aqueous dispersion of acrylic and methacrylic acid esters (Eudragit RL 30 D and Eudragit RS 30 D). The release of ambroxol hydrochloride from coated pellets was investigated at different coating level. The release mechanism was explored and explained with zero order, first order, Higuchi equation and Korsmeyer s equation. The Mean Dissolution Time (MDT) value was calculated for all the formulations to determine the release retarding ability of the polymers. The results generated in this study showed that the profile and kinetics of drug release were functions of polymer type, polymer load and physico-chemical nature of the drug. This book will be helpful for the students and researchers of pharmacy discipline specially those who are engaged or interested in research related to modified release pellets dosage forms. ····· 1036192298
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray A green chemical synthetic protocol has been developed for the rapid parallel synthesis of a library of biologically potential 2-amino-4-arylthiazoles, employing water as a solvent under microwave irradiation (MWI). This novel process yields the target NCE s in very short time, good yield and purity. The judicious use of water as green solvent is attractive and cost effective & makes the process eco-friendly. Besides the general discussion on the biology and synthesis of 2-aminothiazoles, a short review on MWI and use of water as a green solvent is also included. The target NCE s bear good antifungal and antibacterial potential. ····· 1036192295
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Musa sapientum L. ssp. sylvestris (Family: Musaceae) is a popular edible fruit. Traditionally it has been used to treat intestinal disorders such as diarrhoea and dysentery. This book presents the research carried out on the methanolic extracts of Musa sapientum L. ssp. sylvestris fruit`s peel, pulp and seed for potential antioxidant, antidiarrhoeal, antimicrobial, cytotoxic and neuropharmacological activities. It also includes review of previous research works on different plants of Musa genus. In this work, the extracts exhibited promising antidiarrhoeal, antioxidant and neuropharmacological activities. The results of antimicrobial and cytotoxicity tests also support the antidiarrhoeal activity. These results justify and validate the folkloric uses of the fruit in intestinal disorders. ····· 1036192222
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray This approach was made by Dhir et al. based on X-ray Crystallography in terms of Toxicity versus Proximity on the basis of Ligand preparation and characterization by Nuclear Magnetic Spectroscopy, Infra red spectroscopy, Magnetic Susceptibility & CHN(Mass Analyzer) Techniques. DETP & DPTP have been found to be similar potential toxic as they have been used in fungicides and other antibacterial products. Approach has been made on the basis of Biomimetics. The study reveals that Cu complexes are much more potentially toxic than lead compounds because in lead compounds ligands may occupy all the centres or corners of the Pb(I/II)metal ions and very less void is left to interact physiochemically with various proteins/ amino acids or DNA of living cell to disrupt their cycle to become potential toxic and carcinogenic in nature. Thus Pb(I/II)metal ions are very toxic with less hydrophobic group while Cu(II) complexes are very toxic with big/steric ligands as compared to small one. This fact is strengthened on the basis of X-ray Crystal structure of one of the Copper (II) complexes. ····· 1036192179
für 55.71€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The aim of study was to Design and Evaluation of Miconazole Nitrate Microsponge for Sustained Release Topical Drug Delivery System by Quasi-Emulsion Solvent diffusion Method. The average size of microsponge formulation is less than 300µm. So it has good patient compliance. Microsponge formulation has ability to improve bioavailability & solubility of poorly soluble drug. The Miconazole Nitrate microsponge were prepared by using Eudragit RS100 as a polymer, PVA as an emulsifying agent, TEC as a plasticizer, DCM and methanol used as solvent. Optimization of Microsponge was done by using Central Composite Design.The optimized batch of Miconazole Nitrate loaded microsponge was evaluated by Particles size, shape and internal structure by SEM. Compatibility was evaluated by FTIR of optimized batch. In vitro dissolution study of miconazole nitrate microsponge confirmed that it gives sustained release effect up to 12 hour. Kinetic models of formulation confirmed that, it follows zero order kinetic. The optimized batch of microsponge was incorporated in to carbopol 934 gel, and it showed desired drug content, in vitro diffusion, spreadability, pH and viscosity as per standard criteria. ····· 1036192168
····· lezzter Preis 53.10€ ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray All type of tasting is done in Quality control department of Pharmaceutical industries are necessary as they play an important role in defining the quality of product manufacturing in pharmaceutical industries. The different type of tasting criteria are define in quality control labs. The various technique are used in quality control labs like H.P.L.C.,G.C ,spectrophotometer etc. HPLC are most widely used technique in Quality control labs. ····· 1036192149
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Staphylococcus aureus is a common cause of disease, particularly in colonized persons.259 nasal swabs were collected from 127 females and 132 males between age 3-15 years in primary and secondary schools in Ile- Ife, Osun state. The nasal carriage rate by the subjects was influenced primarily by age and found to be 33.3% in ages 3-5 years, 28.3% in ages 6-8 years, 24.1% in ages 9-11 years and 18.1% in ages 12-15 years showing a decreasing nasal carriage rate with increasing age of which there was a significant difference within the age groups of the subjects without significant difference of the nasal carriage of S.aureus in females and males at 5% level of significance and the overall nasal carriage of S.aureus is 22.0%. Resistance and susceptibility patterns to commonly used antibiotics in the community environment were determined, of which 94.6% of the S. aureus isolates were resistant to Ampicillin, 61.8% to Trimethoprim,60.0% to Tetracycline,9.1% to Chloramphenicol,3.6% to each of Sulphonamide and Streptomycin,and 1.8% to each of Ciprofloxacin and Cefoxitin. The clinical implication of this result is that students of lower age group are more susceptible to S.aureus infections. ····· 1036191946
für 71.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The plant Synedrella nodiflora (L) Gaertn is traditionally used by some Ghanaian communities to treat epilepsy. To determine if this use has merit, we studied the anticonvulsant and other neuropharmacological effects of a hydro-ethanolic extract of the whole plant using murine models. The anticonvulsant effect of the extract (10 1000 mg/kg) was tested on the pentylenetetrazole-, picrotoxin-, and pilocarpine-induced seizure models and PTZ-kindling in mice/rats. The effect of the extract was also tested in the formalin-induced pain, acetic acid-induced writhing assay, ethopharmacological paradigms, in vitro antioxidant properties. The extract showed potent effect in all the experimental models of seizures employed, antinociceptive, antioxidant, motor incoordination and sedative effects. In summary, the hydro-ethanolic extract of the whole plant of S. nodiflora possesses anticonvulsant effects, possibly through an interaction with GABAergic transmission and antioxidant mechanisms and muscle relaxant effects. These findings thus provide scientific evidence in support of the traditional use of the plant in the management of epilepsy. ····· 1036191932
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Science of pharmaceutical instrumentation technology has gaining new avenue day by day. A practical approach on chiral HPLC,book is useful for,B.Pharma.students,M.Pharma.students Pharmacists ,Professionals engaged in HPLC works, research students of this area. Book is very lucid and easy to understand. Book is informative for pharmacy students.Chirality deals with steroisomers which are compounds with the same molecular formula and structure but different spacial orientations around a stereogenic centre or axis commonly defined as a plane of symmetry. The molecular dissymmetry is based on the geometric nature of atoms like carbon, Sulphur, phosphorous and nitrogen. ····· 1036191926
für 53.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray The purpose of the present work was to design & evaluate sustained release tablets of Nifedipine, employing hydrophilic polymer to improve dissolution rates of the drug. METHOCEL K15MCR & METHOCEL K100LVCR were used in tablets prepared by direct compression. The formulated tablets were physicochemically characterized & results were found in acceptable limits. Poor aqueous solubility of Nifedipine leads to variable dissolution rates. The main effect & interaction terms were quantitatively evaluated using mathematical models. Dissolution data were fitted to zero order, first order, Higuchi`s, Korsmeyer-Peppas & Hixson-Crowell release kinetics to evaluate kinetic data. The drug release data fit well to the Higuchi expression, but a close relationship was also noted with zero order kinetics. Korsmeyer s plot indicated that the drug release mechanism from the matrix tablet was to be found Fickian mechanism. Regulated drug release study indicate that the matrix tablets of Nifedipine prepared using above polymers can successfully be employed as twice-a-day oral controlled release dosage form. ····· 1036191920
für 44.91€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Niosomes was developed and characterized for ocular drug delivery of diclofenac potassium. The present research study is a promising approach to improve corneal penetration and bio availability characteristics. Formulation also found to ensure a good entrapment efficiency and ocular bio availability of drug in-vivo. Niosome containing diclofenac potassium were prepared using surfactant and cholesterol in different ratio by Lipid film hydration technique. Niosomes were characterized For Entrapment efficiency, Particle size analysis, In-vitro drug release and In-vivo studies. Formulation with low cholesterol content which shown 82.1% Entrapment efficiency, 70.01% sustained release over a period of 10 h followed a non-fickian profile with zero order release profile. Scanning electron micrograph indicated that niosomes have a discrete spherical structure without aggregation. In-vivo study showed an availability of drug in aqueous humor for an extended time period even up to 8 hour and it showed a correlation with the release profile in-vitro. Niosome are considered the best as it showed good and high Entrapment efficiency and Vitro release with better bio availability. ····· 1036191891
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray Good Clinical Practice (GCP) is an international quality standard that is provided by International Conference on Harmonization (ICH), an international body that defines standards, which governments can transpose into regulations for clinical trials involving human subjects. Good Clinical Practice (GCP) is defined as a standard for the design, conduct, performance, monitoring, auditing, recording, analyses and reporting of clinical trials that provides assurance that the data and reported results are credible and accurate, and that the rights, integrity and confidentiality of trial subjects are protected. Good Clinical Practice (GCP) is an international ethical and scientific quality standard for designing, conducting, recording and reporting trials that involve the participation of human subjects. Compliance with this standard provides public assurance that the rights, safety and well-being of trial subjects are protected consistent with the principles that have their origin in the Declaration of Helsinki, and that the clinical trial data are credible.` ····· 1036191867
für 44.10€ kaufen ···· Rheinberg-Buch.de - Bücher, eBooks, DVD & Blu-ray We carried out a QSAR study on benzotriazine derivatives & studied 28 potent GABAA receptor ligands derivatives of benzotriazines, using a combination of various physicochemical, steric, electronic and thermodynamic descriptors to determine the quantitative correlation between binding affinity and structural features with potent anticonvulsant activity. Correlation between these properties and anticonvulsant activity was used to synthesize compounds possessing potent anticonvulsant activity. Most of the compounds showed an ability to inhibit the maximum electroshock (MES) and pentylenetetrazole (PTZ)-induced convulsions. Compound 1A, i.e. 2-(4-Chloro-phenyl)-5-nitro-1H-benzimidazole exhibited maximum activity. ····· 1036191662· 1 · ::::: · 13 ·· 14 ·· 15 ·· 16 ·· 17 ·· 18 ·· 19 · ::::: · 27 ·
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